Cited by 135Schizophrenia research and treatmentBipolar Disorder and TreatmentNeuroscience and Neuropharmacology Research

Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region

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Wang, Alice Y., Lohmann, Kathryn M., Yang, C. Kevin, Zimmerman, Eric I., Pantazopoulos, Harry, Herring, Nicole, Berretta, Sabina, Heckers, Stephan +1 more·2011·Acta Neuropathologica

Abstract

GABAergic interneurons synchronize network activities and monitor information flow. Post-mortem studies have reported decreased densities of cortical interneurons in schizophrenia (SZ) and bipolar disorder (BPD). The entorhinal cortex (EC) and the adjacent subicular regions are a hub for integration of hippocampal and cortical information, a process that is disrupted in SZ. Here we contrast and compare the density of interneuron populations in the caudal EC and subicular regions in BPD type I (BPD-I), SZ, and normal control (NC) subjects. Post-mortem human parahippocampal specimens of 13 BPD-I, 11 SZ and 17 NC subjects were used to examine the numerical density of parvalbumin-, somatostatin- or calbindin-positive interneurons. We observed a reduction in the numerical density of parvalbumin- and somatostatin-positive interneurons in the caudal EC and parasubiculum in BPD-I and SZ, but no change in the subiculum. Calbindin-positive interneuron densities were normal in all brain areas examined. The profile of decreased density was strikingly similar in BPD-I and SZ. Our results demonstrate a specific reduction of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region in BPD-I and SZ, likely disrupting synchronization and integration of cortico-hippocampal circuits.

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  • Reduced numbers of PV-INs have been reported in the hippocampus, entorhinal cortex, and subicular areas in schizophrenia.

    “Reductions in the number of PV-INs were reported in the hippocampus, entorhinal cortex, and subicular areas [1,[9][10][11].”

    From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [9]

  • The high frequency of interneuron pathologies in the hippocampus and adjacent cortical areas, such as in schizophrenia and bipolar disorder, may partly reflect extended developmental vulnerability.

    “The preponderance of interneuron pathologies in the hippocampus and adjacent cortical areas, such as the interneuron pathologies observed in schizophrenia and BPD, might be, at least in part, a reflection of this extended developmental vulnerability [1, 9, 122, 140-142].”

    From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [9]

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Authors
Wang, A. Y., Lohmann, K. M., Yang, C. K., Zimmerman, E. I., Pantazopoulos, H., Herring, N., Berretta, S., Heckers, S., & Konradi, C.
Affiliations
  • Vanderbilt University (US)
  • Harvard University (US)
Corresponding author
Konradi, Christine
Venue
Acta Neuropathologica
Published
2011-10-04
Volume
122
Issue
5
Pages
615-626
ISSN
  • 0001-6322 (ISSN-L)
  • 1432-0533
OpenAlex
W2141284711
Cited by
135
References
62
Citations by year
2026: 4 · 2025: 10 · 2024: 10 · 2023: 10 · 2022: 11 · 2021: 8 · 2020: 13 · 2019: 11 · 2018: 12 · 2017: 7 · 2016: 6 · 2015: 9 · 2014: 11 · 2013: 7 · 2012: 5
FWCI
5.03
Type
journal article
Language
en
Open access
Locations
  • Acta Neuropathologica (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01MH067999, R24MH068855, MH 068855, MH67999)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
bipolar I disorder, schizophrenia, parvalbumin interneurons, somatostatin interneurons, GABAergic interneurons, entorhinal cortex, parasubiculum, subiculum, parahippocampal region, interneuron density, network synchronization
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Autopsy, Bipolar Disorder, Cell Count, Female, Hippocampus, Humans, Interneurons, Male, Middle Aged, Nerve Net, Parvalbumins, Schizophrenia, Somatostatin, Case-Control Studies, Entorhinal Cortex, Parahippocampal Gyrus, Young Adult, Calbindins, S100 Calcium Binding Protein G

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