Cited by 274Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

Stress models of depression: forming genetically vulnerable strains

Henn, Fritz A., Vollmayr, Barbara·2005·Neuroscience & Biobehavioral Reviews

Abstract

Among the most useful models for depressive disorders are those, which involve a stress induced change in behaviour. Learned helplessness is one such model and is induced through exposure to uncontrollable and unpredictable aversive events. Learned helplessness as induced in rats using foot shock is well characterized and has good face validity and predictive validity as a model of depression, including alterations in HPA axis activity and REM sleep characteristic of depression. The data concerning the validity will be briefly reviewed. The model can also be used to look at the role of genetics through selective breeding. These studies will be reviewed and the utility of the genetic strains for understanding the interaction of stress and affect will be examined. A second model of depression using exposure to chronic stress also has high face and predictive validity. A new form of this approach, recently described, also is suitable for the examination of genetic factors leading to depressive like behaviour and this will be presented.

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Registry

Crossref · 10.1016/j.neubiorev.2005.03.019

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55 of 55 references verified0 citation errors · 0 not checkable

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  • Chronic restraint stress is widely used to induce a depressive phenotype.

    “This is widely used to induce a depressive phenotype (33)”
  • The lateral habenula is implicated in negative mood states in both animal and human research.

    “The LHb is implicated in negative mood states in both animal and human research.”

    From Deep brain stimulation for depression. (2022) · cites this paper as [40]

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Authors
Henn, F. A., & Vollmayr, B.
Affiliations
Central Institute of Mental Health (DE)
Corresponding author
Henn, Fritz A.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2005-01
Volume
29
Issue
4-5
Pages
799-804
ISSN
0149-7634 (ISSN-L)
OpenAlex
W1988912854
Cited by
274
References
55
Citations by year
2026: 2 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 14 · 2020: 10 · 2019: 13 · 2018: 11 · 2017: 14 · 2016: 17 · 2015: 14 · 2014: 14 · 2013: 25 · 2012: 11
FWCI
0.88
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
depression, animal models of depression, learned helplessness, chronic stress, hypothalamic-pituitary-adrenal axis, REM sleep, genetic susceptibility, selective breeding, genetic strain, footshock, face validity, predictive validity
MeSH terms
Animals, Behavior, Animal, Depression, Disease Models, Animal, Helplessness, Learned, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Predictive Value of Tests, Sleep, REM, Stress, Psychological, Reproducibility of Results, Mice

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