Cited by 347Posttraumatic Stress Disorder ResearchSleep and related disordersMigration, Health and Trauma

The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.

Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: A systematic review

Open access

Berger, William, Mendlowicz, Mauro V., Marques-Portella, Carla, Kinrys, Gustavo, Fontenelle, Leonardo F., Marmar, Charles R., Figueira, Ivan·2009·Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI 10.1016/j.pnpbp.2008.12.004PMC PMC2720612

Open this paper in CoChat — free account

Abstract

The selective serotonin reuptake inhibitors (SSRIs) are considered the first-line pharmacological treatment for PTSD. However, even when treated with this class of drugs, response rates rarely exceed 60% and less than 20-30% of the patients achieve full remission. The aim of this study was to address this limitation by systematically reviewing the options left for the treatment of PTSD when patients do not respond satisfactorily to or tolerate SSRIs. A systematic review covering all original articles, letters and brief reports published in any language until October 2008 was conducted through searches in the ISI/Web of Science, PubMed and PILOTS databases. The search terms included the pharmacological class of each agent or its generic name plus "PTSD" or "stress disorder" in the title, in the abstract or as a keyword. Sixty-three articles were selected, covering the following categories: antipsychotics, anticonvulsants, adrenergic-inhibiting agents, opioid antagonists, benzodiazepines and other agents. None of the identified agents reached the level A of scientific evidence, 5 reached level B, 7 level C and 13 level D. The non-antidepressant agent with the strongest scientific evidence supporting its use in PTSD is risperidone, which can be envisaged as an effective add-on therapy when patients did not fully benefit from previous treatment with SSRIs. Prazosin, an adrenergic-inhibiting agent, is a promising alternative for cases of PTSD where nightmares and insomnia are prominent symptoms. So far, there is no consistent empirical support for using benzodiazepines in the prevention or in the treatment of PTSD, although these drugs could alleviate some associated non-specific symptoms, such as insomnia or anxiety. Further controlled clinical trials and meta-analysis are needed to guide clinicians in their search of effective pharmacological alternatives to antidepressants in PTSD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.pnpbp.2008.12.004

Cites

137 of 137 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234
A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378
Posttraumatic Stress Disorder in the National Comorbidity Survey
Kessler, R. C. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240066012 · Cited by 10,379
Untitled work
(1976) · Medical Entomology and Zoology · Cited by 8,899
The Impact of Event Scale: Revised
Weiss, D. S. (2007) · Springer eBooks · doi:10.1007/978-0-387-70990-1_10 · Cited by 3,074
Reliability and validity of a brief instrument for assessing post-traumatic stress disorder
Foa, E. B., Riggs, D. S., Dancu, C. V., & Rothbaum, B. O. (1993) · Journal of Traumatic Stress · doi:10.1002/jts.2490060405 · Cited by 2,537
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016
Amygdala, medial prefrontal cortex, and hippocampal function in PTSD
SHIN, L. M., RAUCH, S. L., & PITMAN, R. K. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.007 · Cited by 1,203

Show all 137 references

Research works printed but not linked: 1

Forster, 1995, Lithium for irritability in posttraumatic-stress-disorder, J Trauma Stress, 8, 143, 10.1002/jts.2490080110 · DOI

Sorted by citations

Items 101–200 of 347

To BDZ or not to BDZ? that is the question! is there reliable scientific evidence for or against using benzodiazepines in the aftermath of potentially traumatic events for the prevention of PTSD? A systematic review and meta-analysis
Campos, B., Vinder, V., Passos, R. B. F., Coutinho, E. S. F., Vieira, N. C. P., Leal, K. B., Mendlowicz, M. V., Figueira, I., Luz, M. P., Marques-Portela, C., et al. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811221080464 · Cited by 31
Self-citation
Ziprasidone ameliorates anxiety-like behaviors in a rat model of PTSD and up-regulates neurogenesis in the hippocampus and hippocampus-derived neural stem cells
Peng, Z., Zhang, R., Wang, H., Chen, Y., Xue, F., Wang, L., Yang, F., Chen, Y., Liu, L., Kuang, F., et al. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.01.032 · Cited by 30
REM desensitization as a new therapeutic method for post-traumatic stress disorder: a randomized controlled trial.
Ahmadi, K., Hazrati, M., Ahmadizadeh, M., & Noohi, S. (2015) · Acta medica Indonesiana · Cited by 27
Role of dopamine D3 receptor in alleviating behavioural deficits in animal models of post-traumatic stress disorder
Song, D., Ge, Y., Chen, Z., Shang, C., Guo, Y., Zhao, T.-Y., Li, Y., Wu, N., Song, R., & Li, J. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.03.001 · Cited by 27
Comorbid depressive symptoms in treatment-seeking PTSD outpatients affect multiple domains of quality of life.
Araújo, A. X., Berger, W., Coutinho, E., Marques-Portella, C., Luz, M. P., Cabizuca, M., Fiszman, A., Figueira, I., & Mendlowicz, M. (2014) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2013.09.004 · Cited by 36
Self-citation
Impact of Transcendental Meditation on Psychotropic Medication Use Among Active Duty Military Service Members With Anxiety and PTSD
Barnes, V. A., Monto, A., Williams, J. J., & Rigg, J. L. (2016) · Military Medicine · doi:10.7205/milmed-d-14-00333 · Cited by 27
Medical best practices for the treatment of torture survivors.
Mollica, R. F. (2011) · PubMed · Cited by 27
On the Road to Translation for PTSD Treatment: Theoretical and Practical Considerations of the Use of Human Models of Conditioned Fear for Drug Development
Risbrough, V. B., Glenn, D. E., & Baker, D. G. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_5010 · Cited by 28
Treatment of Post-Traumatic Stress Disorders with the Alpha-1 Adrenergic Antagonist Prazosin
Simon, P. Y. R., & Rousseau, P. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716659275 · Cited by 26
Augmenting the Treatment of PTSD with Ketamine—a Review
Duek, O. A., Kelmendi, B., Pietrzak, R. H., & Harpaz‐Rotem, I. (2019) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-019-00172-0 · Cited by 24
The integrative management of PTSD: A review of conventional and CAM approaches used to prevent and treat PTSD with emphasis on military personnel
Lake, J. (2015) · Advances in Integrative Medicine · doi:10.1016/j.aimed.2014.10.002 · Cited by 27
Off‐label use of second generation antipsychotics for post‐traumatic stress disorder in the Department of Veterans Affairs: time trends and sociodemographic, comorbidity, and regional correlates
Bauer, M. S., Lee, A. F., Li, M., Bajor, L., Rasmusson, A. M., & Kazis, L. E. (2013) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3507 · Cited by 26
The role of Ect in Posttraumatic Stress Disorder: A Systematic Review
Youssef, N. A., McCall, W. V., & Andrade, C. (2017) · Annals of Clinical Psychiatry · doi:10.1177/104012371702900111 · Cited by 25
Cannabidiol and Sertraline Regulate Behavioral and Brain Gene Expression Alterations in an Animal Model of PTSD
Gasparyan, A., Navarrete, F., & Manzanares, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.694510 · Cited by 25
The Missing Piece? A Case for Microglia’s Prominent Role in the Therapeutic Action of Anesthetics, Ketamine, and Psychedelics
VanderZwaag, J., Halvorson, T., Dolhan, K., Šimončičová, E., Ben‐Azu, B., & Tremblay, M. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03772-0 · Cited by 28
Psychopharmacological treatment for military posttraumatic stress disorder: An integrative review
Tawa, J., & Murphy, S. (2013) · Journal of the American Association of Nurse Practitioners · doi:10.1111/1745-7599.12016 · Cited by 28
Endocannabinoid System as Therapeutic Target of PTSD: A Systematic Review
Steardo, L., Carbone, E. A., Menculini, G., Moretti, P., Steardo, L., & Tortorella, A. A. V. (2021) · Life · doi:10.3390/life11030214 · Cited by 24
The South African Society of Psychiatrists (SASOP) Treatment Guidlelines for Psychiatric Disorders
Emsley, R. A., Flisher, A. J., Grobler, G. P., Seedat, S., & Szabo, C. P. (2013) · South African Journal of Psychiatry · doi:10.4102/sajpsychiatry.v19i3.942 · Cited by 25
Predicting stress resilience and vulnerability: brain-derived neurotrophic factor and rapid eye movement sleep as potential biomarkers of individual stress responses
Sweeten, B. L. W., Sutton, A. M., Wellman, L. L., & Sanford, L. D. (2019) · SLEEP · doi:10.1093/sleep/zsz199 · Cited by 25
Posttraumatic stress disorder (PTSD) in the German Armed Forces: a retrospective study in inpatients of a German army hospital
Bandelow, B., Koch, M., Zimmermann, P. L., Biesold, K.-H., Wedekind, D., & Falkai, P. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0289-8 · Cited by 25
Cannabidiol ameliorates PTSD-like symptoms by inhibiting neuroinflammation through its action on CB2 receptors in the brain of male mice
Xie, G., Gao, X., Guo, Q., Liang, H., Yao, L., Li, W., Ma, B., Wu, N., Han, X., & Li, J. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.05.016 · Cited by 23
Rat Models in Post-Traumatic Stress Disorder Research: Strengths, Limitations, and Implications for Translational Studies
Sarapultsev, A., Komelkova, M. V., Lookin, O. N., Khatsko, S. L., Gusev, E., Трофимов, А. Н., Tokay, T., & Hu, D. (2024) · Pathophysiology · doi:10.3390/pathophysiology31040051 · Cited by 23
Medical cannabis for treatment-resistant combat PTSD
Nacasch, N., Avni, C., & Toren, P. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1014630 · Cited by 23
Psilocybin as a lead candidate molecule in preclinical therapeutic studies of psychiatric disorders: A systematic review
Gattuso, J. J., Wilson, C., Hannan, A. J., & Renoir, T. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16017 · Cited by 24
Effects of a Post-Shock Injection of the Kappa Opioid Receptor Antagonist Norbinaltorphimine (norBNI) on Fear and Anxiety in Rats
Rogala, B., Li, Y., Li, S., Chen, X., & Kirouac, G. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049669 · Cited by 23
Treatments of Posttraumatic Stress Disorder in Civilian Populations
Grasser, L. R., & Javanbakht, A. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-0994-3 · Cited by 24
Effectiveness of Ketamine for the Treatment of Post-Traumatic Stress Disorder - A Systematic Review and Meta-Analysis.
Almeida, T. M., da Silva, U. R. L., Pires, J. P., Borges, I. N., Martins, C. R. M., Cordeiro, Q., & Uchida, R. R. (2024) · PubMed Central · doi:10.36131/cnfioritieditore20240102 · Cited by 35
The role of negative affect in the association between attention bias to threat and posttraumatic stress: An eye-tracking study
Mekawi, Y., Murphy, L. M., Munoz, A. P., Briscione, M. A., Tone, E. B., Norrholm, S. D., Jovanović, T., Bradley, B., & Powers, A. D. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.112674 · Cited by 22
Non-pharmacological and pharmacological approaches for psychiatric disorders: Re-appraisal and insights from zebrafish models
de Abreu, M. S., Giacomini, A. C. V. V., Genário, R., Rech, N., Carboni, J., Lakstygal, A. M., Amstislavskaya, T. G., Demin, K. A., Leonard, B. E., Vlok, M., et al. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172928 · Cited by 23
Development and treatment of cognitive inflexibility in sub-chronic stress–re-stress (SRS) model of PTSD
Prajapati, S. K., & Krishnamurthy, S. (2021) · Pharmacological Reports · doi:10.1007/s43440-020-00198-9 · Cited by 22
Amygdala‐related electroencephalogram neurofeedback as add‐on therapy for treatment‐resistant childhood sexual abuse posttraumatic stress disorder: feasibility study
Fine, N. B., Helpman, L., Armon, D. B., Gurevitch, G., Sheppes, G., Seligman, Z., Hendler, T., & Bloch, M. (2023) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13591 · Cited by 23
Electroacupuncture modulates glutamate neurotransmission to alleviate PTSD-like behaviors in a PTSD animal model
Cai, M., Park, H. R., & Yang, E. J. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02663-4 · Cited by 23
Pharmacotherapy for Co-Occurring Alcohol Use Disorder and Post-Traumatic Stress Disorder: Targeting the Opioidergic, Noradrenergic, Serotonergic, and GABAergic/Glutamatergic Systems
Verplaetse, T. L. (2018) · Alcohol research · doi:10.35946/arcr.v39.2.09 · Cited by 22
Rewarding information presented during reactivation attenuates fear memory: Methylphenidate and fear memory updating
Pérez, A. D. A., Popik, B., & Alvares, L. D. O. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108107 · Cited by 19
Myricetin Inhibited Fear and Anxiety-Like Behaviors by HPA Axis Regulation and Activation of the BDNF-ERK Signaling Pathway in Posttraumatic Stress Disorder Rats
Sur, B., & Lee, B. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/8320256 · Cited by 21
Beneficial effects of chronic oxytocin administration and social co-housing in a rodent model of post-traumatic stress disorder
Janezic, E. M., Uppalapati, S., Nagl, S., Contreras, M., French, E. D., & Fellous, J. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000270 · Cited by 23
Geriatric mental health disaster and emergency preparedness
Toner, J. A., Therese, M., Mierswa, & Howe, J. L. (2010) · Medical Entomology and Zoology · Cited by 20
Ginsenoside Rg3 modulates spatial memory and fear memory extinction by the HPA axis and BDNF-TrkB pathway in a rat post-traumatic stress disorder
Sur, B., & Lee, B. (2022) · Journal of Natural Medicines · doi:10.1007/s11418-022-01636-z · Cited by 19
Quetiapine Treatment for Post-traumatic Stress Disorder: A Systematic Review of the Literature
Crapanzano, C., Damiani, S., Casolaro, I., & Amendola, C. (2023) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2023.21.1.49 · Cited by 19
Efficacy and acceptability of atypical antipsychotics for the treatment of post-traumatic stress disorder: A meta-analysis of randomized, double-blind, placebo-controlled clinical trials
Liu, X., Xie, X., Wang, K., & Cui, H. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.05.027 · Cited by 19
Preventive effects of ginsenoside Rg1 on post-traumatic stress disorder (PTSD)-like behavior in male C57/B6 mice
Wang, Z., Zhu, K., Chen, L., Yang, L. O., Huang, Y.-F., & Zhao, Y. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.08.017 · Cited by 19
Noradrenaline transmission reducing drugs may protect against a broad range of diseases.
Fitzgerald, P. J. (2014) · Autonomic and Autacoid Pharmacology · doi:10.1111/aap.12019 · Cited by 19
Posttraumatic stress disorder: An integrated overview of the neurobiological rationale for pharmacology.
Kelmendi, B., Adams, T. G., Southwick, S. M., Abdallah, C. G., & Krystal, J. H. (2017) · Clinical Psychology Science and Practice · doi:10.1111/cpsp.12202 · Cited by 20
Effects of repeated anodal transcranial direct current stimulation on auditory fear extinction in C57BL/6J mice
Schuerbeek, A. V., Vanderhasselt, M., Baeken, C., Pierre, A., Smolders, I. J., Waes, V. V., & Bundel, D. D. (2021) · Brain stimulation · doi:10.1016/j.brs.2021.01.005 · Cited by 22
Defining response and nonresponse to posttraumatic stress disorder treatments: A systematic review.
Varker, T., Kartal, D., Watson, L., Freijah, I., O'Donnell, M. L., Forbes, D., Phelps, A. J., Hopwood, M., McFARLANE, A. C., Cooper, J., et al. (2020) · Clinical Psychology Science and Practice · doi:10.1111/cpsp.12355 · Cited by 18
The Neurotransmission Basis of Post-Traumatic Stress Disorders by the Fear Conditioning Paradigm
Traina, G., & Tuszyński, J. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216327 · Cited by 19
HIGH AND LOW THRESHOLD FOR STARTLE REACTIVITY ASSOCIATED WITH PTSD SYMPTOMS BUT NOT PTSD RISK: EVIDENCE FROM A PROSPECTIVE STUDY OF ACTIVE DUTY MARINES
Glenn, D. E., Acheson, D. T., Geyer, M. A., Nievergelt, C. M., Baker, D. G., Risbrough, V. B., & MRS Team (2016) · Depression and Anxiety · doi:10.1002/da.22475 · Cited by 18
Prospective Study of the Effectiveness of Paroxetine on the Onset of Posttraumatic Stress Disorder, Depression, and Health and Functional Outcomes After Trauma
Borrelli, J., Starr, A. J., Downs, D. L., & North, C. S. (2018) · Journal of Orthopaedic Trauma · doi:10.1097/bot.0000000000001342 · Cited by 18
Cannabis use and posttraumatic stress disorder comorbidity: Epidemiology, biology and the potential for novel treatment approaches
Kondev, V., Winters, N. D., & Patel, S. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2020.09.007 · Cited by 21
Selective dopamine D3receptor antagonism significantly attenuates stress‐induced immobility in a rat model of post‐traumatic stress disorder
Rice, O. V., Ashby, C. R., Dixon, C., Laurenzo, W., Hayden, J., Song, R., Li, J., Tiwari, A. K., & Gardner, E. L. (2018) · Synapse · doi:10.1002/syn.22035 · Cited by 17
The Quality, Readability, Completeness, and Accuracy of PTSD Websites for Firefighters
Killip, S. C., Kwong, N. K. R., MacDermid, J. C., Fletcher, A. J., & Carleton, R. N. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17207629 · Cited by 17
Neuroendocrinological treatment targets for posttraumatic stress disorder
Yoon, S., & Kim, Y. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.11.021 · Cited by 19
Enhancing Access to Psychiatric Care for Posttraumatic Stress Disorder in Veterans with Mild Traumatic Brain Injury through Integrated Services
Baig, M. R., Tapia, R. N., Meraj, A., Pugh, J. A., Roache, J. D., & Finley, E. P. (2019) · Psychiatric Quarterly · doi:10.1007/s11126-019-09668-7 · Cited by 16
Increased persistence of avoidance behaviour and social deficits with L.rhamnosus JB-1 or selective serotonin reuptake inhibitor treatment following social defeat
Liu, Y., Steinhausen, K., Bharwani, A., Mian, M. F., Neufeld, K. M., & Forsythe, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-69968-y · Cited by 16
BNC210, a negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor, demonstrates anxiolytic- and antidepressant-like effects in rodents
O'Connor, S. M., Sleebs, B. E., Street, I. P., Flynn, B. L., Baell, J. B., Coles, C., Quazi, N., Paul, D., Poiraud, E., Huyard, B., et al. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109836 · Cited by 15
Therapeutic and Economic Benefits of Service Dogs Versus Emotional Support Dogs for Veterans With PTSD
Richerson, J. T., Wagner, T. H., Abrams, T. E., Skelton, K. H., Biswas, K., Illarmo, S., McSherry, F., Fallon, M. T., Frakt, A. B., Pizer, S. D., et al. (2023) · Psychiatric Services · doi:10.1176/appi.ps.20220138 · Cited by 15
A multi-centre, double-blind, 12-week, randomized, placebo-controlled trial to assess the efficacy of adjunctive N-Acetylcysteine for treatment-resistant PTSD: a study protocol
Maier, A., Dharan, A. L., Oliver, G., Berk, M., Redston, S., Back, S. E., Kalivas, P. W., Ng, C. H., & Kanaan, R. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02793-9 · Cited by 16
The Endocannabinoid 2-Arachidonoylglycerol Bidirectionally Modulates Acute and Protracted Effects of Predator Odor Exposure
Kondev, V., Morgan, A., Najeed, M., Winters, N. D., Kingsley, P. J., Marnett, L. J., & Patel, S. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.05.012 · Cited by 17
Genome to Phenome: A Systems Biology Approach to PTSD Using an Animal Model
Chakraborty, N., Meyerhoff, J., Jett, M., & Hammamieh, R. (2017) · Methods in Molecular Biology · doi:10.1007/978-1-4939-6952-4_6 · Cited by 14
Therapeutic potential of nociceptin/orphanin FQ peptide (NOP) receptor modulators for treatment of traumatic brain injury, traumatic stress, and their co-morbidities
Yacoub, O. N. A., Awwad, H. O., Zhang, Y., & Standifer, K. M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107982 · Cited by 15
Psychoactive Drugs in the Management of Post Traumatic Stress Disorder: A Promising New Horizon
Elsouri, K. N., Kalhori, S., Colunge, D., Grabarczyk, G., Hanna, G., Carrasco, C., Espino, A. A., Francisco, A., Borosky, B., Bekheit, B., et al. (2022) · Cureus · doi:10.7759/cureus.25235 · Cited by 17
Closed-loop brain stimulation augments fear extinction in male rats
Sierra, R. O., Pedraza, L. K., Barcsai, L., Pejin, A., Li, Q., Kozák, G., Takeuchi, Y., Nagy, A. J., Lörincz, M. L., Devinsky, O., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39546-7 · Cited by 16
A multi-centre, double-blind, 12-week, randomized, placebo-controlled trial of adjunctive N-Acetylcysteine for treatment-resistant PTSD
Kanaan, R., Oliver, G., Dharan, A. L., Sendi, S., Maier, A., Mohebbi, M., Ng, C. H., Back, S. E., Kalivas, P. W., & Berk, M. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115398 · Cited by 15
Posttraumatic Stress Disorder and Neuroprogression in Women Following Sexual Assault: Protocol for a Randomized Clinical Trial Evaluating Allostatic Load and Aging Process Acceleration
Coimbra, B. M., Yeh, M. S. L., D'Elia, A. T., Maciel, M. R., Carvalho, C. M., Milani, A. C. C., Mozzambani, A. C. F., Juruena, M. F., Belangero, S. I., Jackowski, A. P., et al. (2020) · JMIR Research Protocols · doi:10.2196/19162 · Cited by 14
Eye Movement Desensitization and Reprocessing for Posttraumatic Stress Disorder in Bipolar Disorder
Oh, D., & Kim, D. (2014) · Psychiatry Investigation · doi:10.4306/pi.2014.11.3.340 · Cited by 13
Patient-reported outcomes in post-traumatic stress disorder Part II: Focus on pharmacological treatment
Kapfhammer, H. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.2/hkapfhammer · Cited by 13
Trastorno por estrés agudo y postraumático
Generelo, T. C., Gutiérrez, L. C., & Ruiz, H. (2019) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/j.med.2019.07.002 · Cited by 13
A Review of Interventions for Treatment-Resistant Posttraumatic Stress Disorder
Katz, C., Stein, M. B., Don, J., Seedat, S., & Saree, J. (2011) · InTech eBooks · doi:10.5772/23234 · Cited by 13
A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder
Feder, A., Costi, S., Rutter, S., Collins, A. B., Govindarajulu, U. S., Jha, M. K., Horn, S. R. G.-V., Kautz, M. M., Corniquel, M., Collins, K. A., et al. (2023) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.23021014 · Cited by 12
An insight into crosstalk among multiple signalling pathways contributing to the pathophysiology of PTSD and depressive disorders
‬‬‬‬‬‬‬Bommaraju, S., Dhokne, M. D., Arun, E. V., Srinivasan, K., Sharma, S. S., & Datusalia, A. K. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.110943 · Cited by 12
Absence of definitive scientific evidence that benzodiazepines could hinder the efficacy of exposure‐based interventions in adults with anxiety or posttraumatic stress disorders: A systematic review of randomized clinical trials
Melani, M., Paiva, J. M., Silva, M. C., Mendlowicz, M. V., Figueira, I. L. D. V., Marques‐Portella, C., Luz, M. P., Ventura, P. R., & Berger, W. L. (2020) · Depression and Anxiety · doi:10.1002/da.23078 · Cited by 13
Self-citation
An immunogenomic phenotype predicting behavioral treatment response: Toward precision psychiatry for mothers and children with trauma exposure
Aschbacher, K., Cole, S. W., Hagan, M. J., Rivera, L. M., Baccarella, A., Wolkowitz, O. M., Lieberman, A. F., & Bush, N. R. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.012 · Cited by 12
Explore the durability of repetitive transcranial magnetic stimulation in treating post‐traumatic stress disorder: An updated systematic review and meta‐analysis
Xu, G., Li, G., Yang, Q., Li, C., & Liu, C. (2023) · Stress and Health · doi:10.1002/smi.3292 · Cited by 14
Management of Treatment-Resistant Posttraumatic Stress Disorder
Starke, J., & Stein, D. J. (2017) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-017-0130-0 · Cited by 12
Anticonvulsants to treat post‐traumatic stress disorder
Wang, H. R., Woo, Y. S., & Bahk, W. (2014) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2425 · Cited by 12
Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder
Alexander, C., & Vasefi, M. (2021) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2021.08.001 · Cited by 12
Intranasal calcitonin gene-related peptide administration impairs fear memory retention in mice through the PKD/p-HDAC5/Npas4 pathway
Hashikawa‐Hobara, N., Yoneyama, Y., Fujiwara, K., & Hashikawa, N. (2022) · Scientific Reports · doi:10.1038/s41598-022-05518-y · Cited by 11
Repetitive transcranial magnetic stimulation for post-traumatic stress disorder: Lights and shadows
Concerto, C., Lanza, G., Fisicaro, F., Pennisi, M., Rodolico, A., Torrisi, G., Bella, R., & Aguglia, E. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i17.5929 · Cited by 12
Neuronal nitric oxide synthase inhibition accelerated the removal of fluoxetine’s anxiogenic activity in an animal model of PTSD
Sadeghi, M. A., Hemmati, S., Yousefi‐Manesh, H., Fekrvand, S., Foroutani, L., Nassireslami, E., Zoshk, M. Y., Hosseini, Y., Dehpour, A. R., & Chamanara, M. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114128 · Cited by 11
Individual behavioral profiling as a translational approach to assess treatment efficacy in an animal model of post-traumatic stress disorder
Sarkar, I., Snippe-Strauss, M., Zamir, A. T., Benhos, A., & Richter‐Levin, G. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1071482 · Cited by 10
Evaluation of cage leaving behaviour in rats as a free choice paradigm
Bert, B., Schmidt, N. B., Voigt, J., Fink, H., & Rex, A. (2013) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2013.01.001 · Cited by 11
Ventral hippocampal diacylglycerol lipase-alpha deletion decreases avoidance behaviors and alters excitation-inhibition balance
Kondev, V., Bluett, R. J., Najeed, M., Rosas-Vidal, L. E., Grueter, B. A., & Patel, S. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100510 · Cited by 10
A Neuroanatomic and Pathophysiologic Framework for Novel Pharmacological Approaches to the Treatment of Post-traumatic Stress Disorder
Norred, M. A., Zuschlag, Z. D., & Hamner, M. B. (2024) · Drugs · doi:10.1007/s40265-023-01983-5 · Cited by 13
Ketamine-enhanced prolonged exposure therapy in veterans with PTSD: A randomized controlled trial protocol
Shiroma, P. R., THURAS, P. D., Polusny, M. A., Kehle‐Forbes, S., Disner, S. G., Pardo, J. V., Gilmore, C. S., Tolly, B., Voller, E. K., McManus, E. S., et al. (2024) · Contemporary Clinical Trials · doi:10.1016/j.cct.2024.107569 · Cited by 10
The clinically relevant MEK inhibitor mirdametinib combined with D-cycloserine and prediction error disrupts fear memory in PTSD models
Raut, S. B., Joly, F., Haass, N. K., Eri, R. D., Canales, J. J., Benedek, D. M., Ursano, R. J., & Johnson, L. R. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03190-6 · Cited by 10
Activation of a novel α2AAR-spinophilin-cofilin axis determines the effect of α2 adrenergic drugs on fear memory reconsolidation
Saggu, S., Chen, Y., Cottingham, C., Rehman, H., Wang, H., Zhang, S., Augelli‐Szafran, C. E., Lu, S., Lambert, N. A., Jiao, K., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01851-w · Cited by 10
Cannabis-assisted psychotherapy for complex dissociative posttraumatic stress disorder: A case report
Ragnhildstveit, A., Kaiyo, M., Snyder, M. B., Jackson, L. K., Lopez, A., Mayo, C., Miranda, A. C., August, R. J., Seli, P., Robison, R. J., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1051542 · Cited by 10
Effects of transcranial direct current stimulation (tDCS) in “Kiss nightclub fire” patients with post-traumatic stress disorder (PTSD): A phase II clinical trial
MARCOLIN, K. A. D. S. F., Cunha, A. B. M., Yoneyama, B. C., & Ribeiro, T. A. (2023) · SAGE Open Medicine · doi:10.1177/20503121231160953 · Cited by 10
Diazepam suppresses the stress-induced dopaminergic release in the amygdala of methamphetamine-sensitized rat
Kawano, T., Oshibuchi, H., Kawano, M., Muraoka, H., Tsutsumi, T., Yamada, M., Ishigooka, J., Nishimura, K., & Inada, K. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.05.048 · Cited by 9
Paeoniflorin regulates the hypothalamic-pituitary-adrenal axis negative feedback in a rat model of post-traumatic stress disorder.
Chen, J., Ye, W., Li, L., Su, J., Huang, Y.-L., Liu, L., Wu, L., & Yan, C. (2020) · PubMed Central · doi:10.22038/ijbms.2020.41214.9738 · Cited by 10
Protective effect of propranolol and nadolol on social defeat-induced behavioral impairments in rats
Zaidi, S., Atrooz, F., Valdez, D., Liu, H., Kochi, C., Bond, R. A., & Salim, S. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.134892 · Cited by 10
The Effect of a PTSD Service Dog on Military Veterans’ Medication Regimens: A Cross-Sectional Pilot Study
Rodriguez, K. E., Anderson, L. M., Ott, C. A., & O’Haire, M. E. (2021) · Anthrozoös · doi:10.1080/08927936.2021.1898219 · Cited by 13
A Systematic Review of Quantitative and Qualitative Results of Randomized Controlled Trials Assessing the Effect of Yoga in Adult Women With Post-traumatic Stress Disorder: What Is Known So Far
Ali, M., Oble, M. J. P., Sonia, S. N., George, S., Shahi, S. R., Ali, Z., Abaza, A., Jamil, A., Gutlapalli, S. D., & Khan, S. (2023) · Cureus · doi:10.7759/cureus.47765 · Cited by 9
Perinatal exposure to bisphenol A impairs cognitive function via the gamma‐aminobutyric acid signaling pathway in male rat offspring
Guo, Y., Kang, Y., Bai, W., Liu, Q., Zhang, R., Wang, Y., & Wang, C. (2023) · Environmental Toxicology · doi:10.1002/tox.24007 · Cited by 10
Multi-component Treatment for Posttraumatic Nightmares in Vietnam Veterans: Two Case Studies
Wanner, J. L., Long, M. E., & Teng, E. J. (2010) · Journal of Psychiatric Practice · doi:10.1097/01.pra.0000386910.31817.b5 · Cited by 9
Efficacy and Safety of the Neuroplastogen TSND-201 for the Treatment of PTSD
Jones, A., Warner‐Schmidt, J. L., Kwak, H., Stogniew, M., Mandell, B., Ching, T. H. W., Stein, M. B., & Kelmendi, B. (2026) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2025.4625 · Cited by 8
The GR-FKBP51 interaction modulates fear memory but not spatial or recognition memory
Jiang, A., Zhou, C., Samsom, J., Yan, S., Yu, D. Z., Jia, Z., Wong, A. H. C., & Liu, F. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110604 · Cited by 8
PSYCHOLOGICAL INTERVENTION INCLUDING EMOTIONAL FREEDOM TECHNIQUES FOR AN ADULT WITH MOTOR VEHICLE ACCIDENT RELATED POSTTRAUMATIC STRESS DISORDER: A CASE STUDY
Sheldon (2014) · Current Research in Psychology · doi:10.3844/crpsp.2014.40.63 · Cited by 8
The Canadian Network for Mood and Anxiety Treatments (Canmat) Task Force Recommendations for the Management of Patients with Mood Disorders and Comorbid Anxiety Disorders
Schaffer, A., McIntosh, D., Goldstein, B. I., Rector, N. A., McIntyre, R. S., Beaulieu, S., Swinson, R., & Yatham, L. N. (2012) · Annals of Clinical Psychiatry · doi:10.1177/104012371202400103 · Cited by 7
Inhibition of phosphodiesterase-4 by rolipram alleviates anxiety-like behavior in mice with PTSD by modulating neuroinflammation and synaptic plasticity via cAMP signaling
Lin, Y., Ma, S., Sun, R., Ruan, M., Zhang, F., & Zhang, H. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115116 · Cited by 7

Authors: Berger, W., Mendlowicz, M. V., Marques-Portella, C., Kinrys, G., Fontenelle, L. F., Marmar, C. R., & Figueira, I.
Affiliations: Universidade Federal do Rio de Janeiro (BR)
Cambridge Health Alliance (US)
San Francisco VA Medical Center (US)
Corresponding author: Berger, William
ORCID: Berger, William
Mendlowicz, Mauro V.
Kinrys, Gustavo
Fontenelle, Leonardo F.
Marmar, Charles R.
Figueira, Ivan
Venue: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher: Elsevier BV
Published: 2009-03
Volume: 33
Issue: 2
Pages: 169-180
ISSN: 0278-5846 (ISSN-L)
DOI: 10.1016/j.pnpbp.2008.12.004
PMC: PMC2720612
OpenAlex: W1977428298
Cited by: 347
References: 137
Citations by year: 2026: 14 · 2025: 12 · 2024: 29 · 2023: 26 · 2022: 28 · 2021: 41 · 2020: 27 · 2019: 15 · 2018: 24 · 2017: 12 · 2016: 17 · 2015: 16 · 2014: 16 · 2013: 17 · 2012: 18
FWCI: 2.01
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Australian Government
Governo Brasil
National Institute of Mental Health (MH056350-06, R01MH056350)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
Keywords: post-traumatic stress disorder, pharmacotherapy, antidepressants, selective serotonin reuptake inhibitors, risperidone, prazosin, benzodiazepines, antipsychotic drugs, antiepileptic drugs, opioid antagonists, treatment-resistant PTSD, nightmares, insomnia, adjunctive therapy
MeSH terms: Animals, Anticonvulsants, Antidepressive Agents, Benzodiazepines, Humans, Narcotic Antagonists, Stress Disorders, Post-Traumatic, Antipsychotic Agents, Adrenergic Antagonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: A systematic review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks