Inhibition of central angiotensin II enhances memory function and reduces oxidative stress status in rat hippocampus
Abstract
While it is now well established that the independent brain renin-angiotensin system (RAS) has some important central functions besides the vascular ones, the relevance of its main bioactive peptide angiotensin II (Ang II) on the memory processes, as well as on oxidative stress status is not completely understood. The purpose of the present work was to evaluate the effects of central Ang II administration, as well as the effects of Ang II inhibition with either AT1 and AT 2 receptor specific blockers (losartan and PD-123177, respectively) or an angiotensin-converting enzyme (ACE) inhibitor (captopril). These effects were studied on the short-term memory (assessed through Y-maze) or long-term memory (as determined in passive avoidance) and on the oxidative stress status of the hippocampus. Our results demonstrate memory deficits induced by the administration of Ang II, as showed by the significant decrease of the spontaneous alternation in Y-maze (p=0.015) and latency-time in passive avoidance task (p=0.001) when compared to saline. On the other side, the administration of all the aforementioned Ang II blockers significantly improved the spontaneous alternation in Y-maze task, while losartan also increased the latency time as compared to saline in step-through passive avoidance (p=0.042). Also, increased oxidative stress status was induced in the hippocampus by the administration of Ang II, as demonstrated by increased levels of lipid peroxidation markers (malondialdehyde-MDA concentration) (p<0.0001) and a decrease in both antioxidant enzymes determined: superoxide dismutase-SOD (p<0.0001) and glutathione peroxidase-GPX (p=0.01), as compared to saline. Additionally, the administration of captopril resulted in an increase of both antioxidant enzymes and decreased levels of lipid peroxidation (p=0.001), while PD-123177 significantly decreased MDA concentration (p>0.0001) vs. saline. Moreover, significant correlations were found between all of the memory related behavioral parameters and the main oxidative stress markers from the hippocampus, which is known for its implication in the processes of memory and also where RAS components are well expressed. This could be relevant for the complex interactions between Ang II, behavioral processes and neuronal oxidative stress, and could generate important therapeutic approaches.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Impaired working memory has been correlated to oxidative stress and damage.
“Since impaired working memory has also been correlated to oxidative stress and damage [222]”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [222]
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Oxidative stress: oxidants and antioxidants
Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577 · see citing works
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886 · see citing works
Rajagopalan, S., Kurz, S. D., Münzel, T. F., Tarpey, M. M., Freeman, B. Α., Griendling, K. K., & Harrison, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118623 · Cited by 2,441 · see citing works
Memory, amnesia, and the hippocampal system
(1994) · Choice Reviews Online · doi:10.5860/choice.31-5148 · Cited by 1,533 · see citing works
(2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.9.1069 · Cited by 988 · see citing works
Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension
Laursen, J. B., Rajagopalan, S., Galis, Z. S., Tarpey, M. M., Freeman, B. Α., & Harrison, D. G. (1997) · Circulation · doi:10.1161/01.cir.95.3.588 · Cited by 820 · see citing works
Angiotensin II revisited: new roles in inflammation, immunology and aging
Benigni, A., Cassis, P., & Remuzzi, G. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000080 · Cited by 757 · see citing works
The brain renin–angiotensin system: location and physiological roles
McKinley, M. J., Albiston, A. L., Allen, A. M., Mathai, M. L., May, C. N., McAllen, R. M., Oldfield, B. J., Mendelsohn, F. A. O., & Chai, S. Y. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00306-0 · Cited by 504 · see citing works
Li, N.-C., Lee, A., Whitmer, R. A., Kivipelto, M., Lawler, E., Kazis, L. E., & Wolozin, B. (2010) · BMJ · doi:10.1136/bmj.b5465 · Cited by 486 · see citing works
Memory, amnesia, and the hippocampal system
Holmes, G. L. (1994) · Journal of Epilepsy · doi:10.1016/0896-6974(94)90099-x · Cited by 422 · see citing works
Santos, R. A. S., Campagnole‐Santos, M. J., & Andrade, S. P. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00138-5 · Cited by 382 · see citing works
Padurariu, M., Ciobica, A., Hritcu, L., Stoica, B., Bild, W., & Stefanescu, C. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2009.11.033 · Cited by 378 · see citing works
Self-citationDiener, H.-C., Sacco, R. L., Yusuf, S., Cotton, D., Ôunpuu, S., Lawton, W. A., Palesch, Y., Martin, R. H., Albers, G. W., Bath, P., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70198-4 · Cited by 359 · see citing works
Hemming, M. L., & Selkoe, D. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508460200 · Cited by 330 · see citing works
Maes, M., Fišar, Z., Medina, M., Scapagnini, G., Nowak, G., & Berk, M. (2012) · Inflammopharmacology · doi:10.1007/s10787-011-0111-7 · Cited by 325 · see citing works
Chabrashvili, T., Kitiyakara, C., Blau, J., Karber, A., Aslam, S., Welch, W. J., & Wilcox, C. S. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00476.2002 · Cited by 322 · see citing works
Brain Angiotensin II: New Developments, Unanswered Questions and Therapeutic Opportunities
Saavedra, J. M. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-005-4011-5 · Cited by 281 · see citing works
The CNS renin-angiotensin system
Halbach, O. V. B. U., & Albrecht, D. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0190-8 · Cited by 251 · see citing works
Use of antihypertensives and the risk of Parkinson disease
Becker, C., Jick, S. S., & Meier, C. R. (2008) · Neurology · doi:10.1212/01.wnl.0000303818.38960.44 · Cited by 230 · see citing works
Are ACE Inhibitors a “Magic Bullet” Against Oxidative Stress?
Münzel, T. F., & Keaney, J. F. (2001) · Circulation · doi:10.1161/hc3801.095585 · Cited by 226 · see citing works
Braszko, J. J., Kupryszewski, G., Witczuk, B., & Wisniewski, K. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90182-0 · Cited by 221 · see citing works
Savaskan, E., Höck, C., Olivieri, G., Bruttel, S., Rosenberg, C., Hulette, C., & Müller-Spahn, F. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00259-1 · Cited by 217 · see citing works
Anderson, C., Teo, K., Gao, P., Arima, H., Dans, A., Unger, T., Commerford, P., Dyal, L., Schumacher, H., Pogue, J., et al. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70250-7 · Cited by 216 · see citing works
Davies, N. M., Kehoe, P. G., Ben-Shlomo, Y., & Martin, R. M. (2011) · Journal of Alzheimer’s Disease · doi:10.3233/jad-2011-110347 · Cited by 212 · see citing works
Eckman, E. A., Adams, S. K., Troendle, F. J., Stodola, B. A., Kahn, M. A., Fauq, A. H., Xiao, H. D., Bernstein, K. E., & Eckman, C. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605827200 · Cited by 196 · see citing works
The role of angiotensin II in cognition and behaviour
Gard, P. R. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01283-9 · Cited by 189 · see citing works
Is inhibition of the renin–angiotensin system a new treatment option for Alzheimer's disease?
Kehoe, P. G., & Wilcock, G. K. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70077-7 · Cited by 180 · see citing works
The relevance of oxidative stress status in first episode and recurrent depression
Stefanescu, C., & Ciobica, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.05.022 · Cited by 179 · see citing works
Self-citationPădurariu, M., Ciobica, A. S., Dobrin, I., & Ștefănescu, C. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.05.088 · Cited by 171 · see citing works
Self-citationZhang, M., Mao, Y., Ramirez, S. H., Tuma, R. F., & Chabrashvili, T. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.029 · Cited by 169 · see citing works
(2009) · PubMed Central · Cited by 165 · see citing works
Protective effect of long-term angiotensin II inhibition
Basso, N., Cini, R., Pietrelli, A., Ferder, L., Terragno, N. A., & Inserra, F. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00393.2007 · Cited by 165 · see citing works
Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease
Danielyan, L., Klein, R., Hanson, L. R., Buadze, M., Schwab, M. G., Gleiter, C. H., & Frey, W. H. (2010) · Rejuvenation Research · doi:10.1089/rej.2009.0944 · Cited by 158 · see citing works
Angiotensin‐Converting Enzyme Inhibitors and Incidence of Alzheimer's Disease in Japan
Ohrui, T., Matsui, T., Yamaya, M., Arai, H., Ebihara, S., Maruyama, M., & Sasaki, H. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52178_7.x · Cited by 127 · see citing works
Effects of Cardiovascular Medications on Rate of Functional Decline in Alzheimer Disease
Rosenberg, P. B., Mielke, M. M., Tschanz, J. T., Cook, L., Corcoran, C., Hayden, K. M., Norton, M. C., Rabins, P. V., Green, R. C., Welsh-Bohmer, K. A., et al. (2008) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e318181276a · Cited by 126 · see citing works
Angiotensin Injected into the Neostriatum After Learning Disrupts Retention Performance
Morgan, J. M., & Routtenberg, A. (1977) · Science · doi:10.1126/science.402696 · Cited by 120 · see citing works
Angiotensin II type 1 receptor-mediated peroxide production in human macrophages
Yanagitani, Y., Rakugi, H., Okamura, A., Moriguchi, K., Takiuchi, S., Ohishi, M., Suzuki, K., Higaki, J., & Ogihara, T. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.335 · Cited by 118 · see citing works
Role of the mesotelencephalic dopamine system in learning and memory processes in the rat
Hefco, V., Yamada, K., Hefco, A., Hriţcu, L., Tiron, A., & Nabeshima, T. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)02115-0 · Cited by 115 · see citing works
Čulman, J., Blume, A., Gohlke, P., & Unger, T. (2002) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001442 · Cited by 114 · see citing works
Inaba, S., Iwai, M., Furuno, M., Tomono, Y., Kan‐no, H., Senba, I., Okayama, H., Mogi, M., Higaki, J., & Horiuchi, M. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.123612 · Cited by 114 · see citing works
The brain RAS and Alzheimer's disease
Wright, J. W., & Harding, J. W. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.09.012 · Cited by 109 · see citing works
López-Real, A. M., Rey, P., Soto‐Otero, R., Méndez‐Álvarez, E., & Labandeira-García, J. L. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20598 · Cited by 107 · see citing works
Brain serotonin depletion impairs short-term memory, but not long-term memory in rats
Hriţcu, L., Clicinschi, M., & Nabeshima, T. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.03.028 · Cited by 104 · see citing works
Yao, E., Fukuda, N., Matsumoto, T., Kobayashi, N., Katakawa, M., Yamamoto, C., Tsunemi, A., SUZUKI, R., Ueno, T., & Matsumoto, K. (2007) · Hypertension Research · doi:10.1291/hypres.30.1119 · Cited by 95 · see citing works
Angiotensin II blocks memory consolidation through an AT2 receptor-dependent mechanism
Kerr, D. S., Bevilaqua, L. R., Bonini, J. S., Rossato, J. I., Köhler, C. A., Medina, J. H., Izquierdo, I., & Cammarota, M. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2074-5 · Cited by 95 · see citing works
Opposing actions of angiotensins on angiogenesis
Machado, R. D. P., Santos, R. A. S., & Andrade, S. P. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00562-7 · Cited by 94 · see citing works
Saavedra, J. M. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9754-6 · Cited by 91 · see citing works
Cognitive-enhancing effects of angiotensin IV
Gard, P. R. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-s2-s15 · Cited by 90 · see citing works
Captopril and Enalapril Improve Cognition and Depressed Mood in Hypertensive Patients
Braszko, Karwowska-Polecka, Halicka, & Gard (2003) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp.2003.14.4.323 · Cited by 89 · see citing works
Angiotensin II disrupts inhibitory avoidance memory retrieval
Bonini, J. S., Bevilaqua, L. R., Zinn, C. G., Kerr, D. S., Medina, J. H., Izquierdo, I., & Cammarota, M. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.03.016 · Cited by 83 · see citing works
Antihypertensive Treatments, Cognitive Decline, and Dementia
Duron, E., & Hanon, O. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091552 · Cited by 81 · see citing works
Review: Angiotensin Peptides and their Pleiotropic Actions
Haulica, I. D., Bild, W., & Șerban, D. N. (2005) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.3317/jraas.2005.018 · Cited by 81 · see citing works
Self-citationMiners, J. S., Helmond, Z. V., Kehoe, P. G., & Love, S. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2010.00375.x · Cited by 80 · see citing works
Manschot, S., Biessels, G. J., Cameron, N. E., Cotter, M. A., Kamal, A., Kappelle, L. J., & Gispen, W. H. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04211-7 · Cited by 80 · see citing works
Kumaran, D., Malairaman, U., Kumar, M., Aneja, R., & Katyal, A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.023 · Cited by 73 · see citing works
Cognitive Effects Attributed to Angiotensin II may Result from its Conversion to Angiotensin IV
Braszko, J. J., Walesiuk, A., & Wielgat, P. (2006) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.3317/jraas.2006.027 · Cited by 73 · see citing works
Functional Interactions Between Neuronal AT1 and AT2 Receptors
Gelband, C. H., Zhu, M., Lu, D., Reagan, L. P., Fluharty, S. J., Posner, P., Raizada, M. K., & Sumners, C. (1997) · Endocrinology · doi:10.1210/endo.138.5.5236 · Cited by 71 · see citing works
Angiotensin II inhibits acetylcholine release from human temporal cortex: implications for cognition
Barnes, J. M., Barnes, N. M., Costall, B., Horovitz, Z. P., Ironside, J. W., Naylor, R. J., & Williams, T. J. (1990) · Brain Research · doi:10.1016/0006-8993(90)90294-l · Cited by 71 · see citing works
Angiotensin IV in the central nervous system
Halbach, O. V. B. U. (2003) · Cell and Tissue Research · doi:10.1007/s00441-002-0655-3 · Cited by 70 · see citing works
Bild, W., & Ciobica, A. S. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.07.024 · Cited by 69 · see citing works
Self-citationRaghavendra, V., Chopra, K., & Kulkarni, S. (2001) · Neuropeptides · doi:10.1054/npep.2000.0845 · Cited by 67 · see citing works
Ciobica, A. S., Bild, W., Hriţcu, L., & Haulica, I. D. (2009) · PubMed · Cited by 66 · see citing works
Self-citationHou, D., Wang, Y., Zhou, L., Chen, K., Tian, Y., Song, Z. J., Juan, B. A. O., & Yang, Q. (2008) · Chinese Medical Journal · doi:10.1097/00029330-200811020-00019 · Cited by 64 · see citing works
Effects of angiotensin II and its receptor antagonists on motor activity and anxiety in rats.
Braszko, J. J., Kułakowska, A., & Winnicka, M. M. (2003) · PubMed · Cited by 61 · see citing works
The sympathetic nervous system: the muse of primary hypertension
DeQuattro, V. L., & Feng, M. (2002) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001346 · Cited by 61 · see citing works
ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala
Sleegers, K., den Heijer, T., van Dijk, E. J., Albert Hofman, D., Bertoli‐Avella, A. M., Koudstaal, P. J., Breteler, M. M. B., & van Duijn, C. M. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.09.011 · Cited by 60 · see citing works
Tota, S., Kamat, P. K., Saxena, G., Hanif, K., Najmi, A. K., & Nath, C. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.047 · Cited by 60 · see citing works
Halbach, O. V. B. U., & Albrecht, D. (1998) · Peptides · doi:10.1016/s0196-9781(98)00044-8 · Cited by 57 · see citing works
Tota, S., Nath, C., Najmi, A. K., Shukla, R., & Hanif, K. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.015 · Cited by 57 · see citing works
Maul, B., Halbach, O. V. B. U., Becker, A., Sterner‐Kock, A., Voigt, J., Siems, W., Grecksch, G., & Walther, T. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0316-4 · Cited by 54 · see citing works
Braszko, J. J. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00349-7 · Cited by 52 · see citing works
Armstrong, D. L., Garcia, E., Ma, T., Quiñones, B. A., & Wayner, M. J. (1996) · Peptides · doi:10.1016/0196-9781(96)00030-7 · Cited by 52 · see citing works
Age‐Related Decline in Spatial Learning and Memory: Attenuation by Captopril
Wyss, J. M., Kadish, I., & van Groen, T. (2003) · Clinical and Experimental Hypertension · doi:10.1081/ceh-120024988 · Cited by 51 · see citing works
Organisation and functional role of the brain angiotensin system
Llorens‐Cortés, C., & Mendelsohn, F. A. O. (2002) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.3317/jraas.2002.029 · Cited by 51 · see citing works
Impaired retention by angiotensin II mediated by the AT1 receptor
Lee, E. H. Y., Ma, Y., Wayner, M. J., & Armstrong, D. L. (1995) · Peptides · doi:10.1016/0196-9781(95)00073-s · Cited by 48 · see citing works
Role of angiotensin II in the brain inflammatory events during experimental diabetes in rats
Vargas, R., Rincon, J. C., Pedreáñez, A. B., Viera, N., Hernández-Fonseca, J. P., Peña, C., & Mosquera, J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.03.021 · Cited by 48 · see citing works
Mavroudis, I. A., Fotiou, D. F., Manani, M. G., Njaou, S. N., Frangou, D., Costa, V., & Balogiannis, S. (2011) · International Journal of Neuroscience · doi:10.3109/00207454.2011.553753 · Cited by 46 · see citing works
Sharma, B., & Singh, N. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.03.029 · Cited by 45 · see citing works
Evidence for the involvement of cerebral renin‐angiotensin system (RAS) in stress analgesia
Haulicǎ, I., Neamtţu, C., Stratone, A., Petrescu, G., Branisteanu, D., Rosca, V., & Slătineanu, S. M. (1986) · Pain · doi:10.1016/0304-3959(86)90214-9 · Cited by 42 · see citing works
The effects of pergolide on memory and oxidative stress in a rat model of Parkinson’s disease
Ciobica, A. S., Olteanu, Z., Pădurariu, M., & Hriţcu, L. (2011) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-011-0119-x · Cited by 42 · see citing works
Self-citationReview: The renin-angiotensin system in the brain: an update
Čulman, J., Baulmann, J., Blume, A., & Unger, T. (2001) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.3317/jraas.2001.019 · Cited by 40 · see citing works
Angiotensin and Alzheimer´s disease: therapeutic prospects
Gard, P. R., & Rusted, J. M. (2004) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.4.1.87 · Cited by 38 · see citing works
Are angiotensin receptor blockers neuroprotective?
Thöne‐Reineke, C., Zimmermann, M., Neumann, C., Krikov, M., Li, J., Gerova, N., & Unger, T. (2004) · Current Hypertension Reports · doi:10.1007/s11906-004-0019-3 · Cited by 38 · see citing works
Learning and anxiety in angiotensin-deficient mice
Walther, T., Voigt, J., Fukamizu, A., Fink, H., & Bäder, M. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00078-3 · Cited by 36 · see citing works
Wang, D., Chabrashvili, T., Borrego-Conde, L. J., Aslam, S., & Umans, J. G. (2005) · Journal of Vascular Research · doi:10.1159/000089969 · Cited by 36 · see citing works
Shepherd, J., Bill, D. J., Dourish, C. T., Grewal, S. S., McLenachan, A. P., & Stanhope, K. J. (1996) · Psychopharmacology · doi:10.1007/bf02246450 · Cited by 33 · see citing works
Ciobica, A. S., Hriţcu, L., Năstasă, V., Pădurariu, M., & Bild, W. (2011) · Journal of Medical Biochemistry · doi:10.2478/v10011-011-0009-3 · Cited by 31 · see citing works
Self-citationMiller, S. J., Norton, L. E., Murphy, M. P., Dalsing, M. C., & Unthank, J. L. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01296.2006 · Cited by 29 · see citing works
Yaşar, S., Zhou, J., Varadhan, R., & Carlson, M. C. (2008) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100483 · Cited by 28 · see citing works
Braszko, J. J. (2005) · Clinical and Experimental Hypertension · doi:10.1080/10641960500298723 · Cited by 27 · see citing works
Yaşar, S., Lin, F., Fried, L. P., Kawas, C. H., Sink, K. M., DeKosky, S. T., Carlson, M. C., & Ginkgo Evaluation of Memory (GEM) Study Investigators (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.03.010 · Cited by 26 · see citing works
Tchekalarova, J. D., & Albrecht, D. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.12.040 · Cited by 24 · see citing works
Akhavan, M. M., Emami-Abarghoie, M., Sadighi‐Moghaddam, B., Safari, M., Yousefi, Y., & Rashidy‐Pour, A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.042 · Cited by 23 · see citing works
Pedreáñez, A. B., Arcaya, J. L., Carrizo, E., & Mosquera, J. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.07.018 · Cited by 23 · see citing works
Identification of Angiotensin IV Binding Sites in the Mouse Brain by a Fluorescent Binding Study
Halbach, O. V. B. U., & Albrecht, D. (2000) · Neuroendocrinology · doi:10.1159/000054590 · Cited by 20 · see citing works
Biphasic effects of angiotensin (1-7) and its interactions with angiotensin II in rat aorta
Haulica, I. D., Bild, W., Mihaila, C. N., Ionita, T., Boisteanu, C. P., & Neagu, B. (2003) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.3317/jraas.2003.013 · Cited by 20 · see citing works
Self-citationZhang, Z., Deng, L., Yu, H., Shi, Y., Bai, F., Xie, C., Yuan, Y., Jia, J., & Zhang, Z. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.02.074 · Cited by 19 · see citing works
Effects of ACE-inhibitors on learning and memory processes in rats.
Jg, N., Dp, G., & Fp, N. (2000) · PubMed · Cited by 19 · see citing works
Angiotensin-(1–7) stimulates oxidative stress in rat kidney
Gonzales, S., Noriega, G. O., Tomaro, M. L., & Peña, C. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(02)00032-0 · Cited by 18 · see citing works
Winnicka, M. M., Braszko, J. J., & Wisniewski, K. (1998) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(97)00152-3 · Cited by 18 · see citing works
No evidence for involvement of angiotensin II in spatial learning in water maze in rats
Chalas, A., & Conway, E. L. (1996) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)00062-9 · Cited by 16 · see citing works
Hanif, K., Snehlata, S., Pavar, M. C., Arif, E., Fahim, M., Pasha, M. A. Q., & Pasha, S. (2009) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318197c616 · Cited by 12 · see citing works
Antelava, N. A., Nv, G., Gogolauri, M. I., Kezeli, T., & Kz, P. (2007) · PubMed · Cited by 5 · see citing works
Mogi, M., Iwanami, J., Jing, F., Tsukuda, K., & Horiuchi, M. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.05.1911 · Cited by 1 · see citing works
Flagged first, then by citations
2 of the 108 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Stromal barriers and strategies for the delivery of nanomedicine to desmoplastic tumors
Miao, L., Lin, C. M., & Huang, L. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.08.017 · Cited by 264 · see citing works
Nanoformulations for combination or cascade anticancer therapy
Miao, L., Guo, S., Lin, C. M., Liu, Q., & Huang, L. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.06.003 · Cited by 178 · see citing works
Targeting Renin–Angiotensin System Against Alzheimer’s Disease
Gebre, A. K., Altaye, B. M., Atey, T. M., Tuem, K. B., & Berhe, D. F. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00440 · Cited by 116 · see citing works
Balmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103 · see citing works
“Since impaired working memory has also been correlated to oxidative stress and damage [222], it might be possible that high COMT activity is associated”
BackgroundSelf-citationMascolo, A., Sessa, M., Scavone, C., Angelis, A. D., Vitale, C., Berrino, L., Rossi, F., Rosano, G. M. C., & Capuano, A. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.10.069 · Cited by 68 · see citing works
Sun, H. B., Wu, H., Yu, X., Zhang, G., Zhang, R., Zhan, S., Wang, H., Bu, N., Ma, X., & Li, Y. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.02.014 · Cited by 65 · see citing works
Hou, Y., Zhang, H., Xie, G., Cao, X., Zhao, Y., Liu, Y., Mao, Z., Yang, J., & Wu, C. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.04.006 · Cited by 55 · see citing works
Gong, X., Hu, H. Z., Qiao, Y., Xu, P., Yang, M., Dang, R., Han, W., Guo, Y., Chen, D., & Jiang, P. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00318 · Cited by 52 · see citing works
Wright, J. W., Kawas, L. H., & Harding, J. W. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.11.004 · Cited by 51 · see citing works
Seo, T.-B., Kim, T.-W., Shin, M., Ji, E., Cho, H.-S., Lee, J. M., Kim, T.-W., & Kim, C. (2014) · International Neurourology Journal · doi:10.5213/inj.2014.18.4.187 · Cited by 49 · see citing works
Abareshi, A., Hosseini, M., Beheshti, F., Norouzi, F., Khazaei, M., Sadeghnia, H. R., Boskabady, M. H., Shafei, M. N., & Anaeigoudari, A. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.10.026 · Cited by 49 · see citing works
Thakur, K. S., Prakash, A. K., Bisht, R., & Bansal, P. (2014) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320313515038 · Cited by 48 · see citing works
Cuddy, L. K., Prokopenko, D., Cunningham, E. P., Brimberry, R., Song, P., Kirchner, R., Chapman, B., Hofmann, O., Hide, W., Procissi, D., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz2541 · Cited by 45 · see citing works
Gadelha, A., Vendramini, A. M., Yonamine, C. M., Nering, M. B., Berberian, A. D. A., Suiama, M. A., Oliveira, V., Lima-Landman, M. T., Breen, G. D., Bressan, R. A., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.181 · Cited by 45 · see citing works
Wright, J. W., & Harding, J. W. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142814 · Cited by 40 · see citing works
Deuterium-depleted water has stimulating effects on long-term memory in rats
Mladin, C., Ciobica, A. S., Lefter, R. M., Popescu, A., & Bild, W. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.09.037 · Cited by 38 · see citing works
Self-citationFoyet, H. S., Defo, S. H. T., Yewo, P. K., Antioch, I., Zingue, S., Asongalem, E. A., Kamtchouing, P., & Ciobica, A. S. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-2012-9 · Cited by 39 · see citing works
Self-citationCerebroprotective effects of RAS inhibitors: Beyond their cardio-renal actions
Kalra, J., Prakash, A. K., Kumar, P., & Majeed, A. B. A. (2015) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320315583582 · Cited by 37 · see citing works
Gong, S., & Deng, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1053136 · Cited by 35 · see citing works
Pădurariu, M., Antioch, I., Balmuș, I.-M., Ciobica, A. S., El-lethey, H. S., & Kamel, M. M. (2017) · International Journal of Veterinary Science and Medicine · doi:10.1016/j.ijvsm.2017.08.003 · Cited by 32 · see citing works
Self-citationSăvucă, A., Curpăn, A.-Ș., Hrițcu, L. D., Proca, T. M. B., Balmuș, I.-M., Lungu, P. F., Jijie, R., Nicoară, M., Ciobica, A. S., Solcan, G., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158331 · Cited by 33 · see citing works
Self-citationZhang, W., Chen, L., Zhang, L., Xiao, M., Ding, J., Goltzman, D., & Miao, D. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.01.013 · Cited by 31 · see citing works
Gomes, J. A. D. S., de Souza, G. C., Berk, M., Cavalcante, L. M., de Sousa, F. C. F., Budni, J., de Lucena, D. F., Quevedo, J., Carvalho, A. F., & Macêdo, D. S. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.08.005 · Cited by 30 · see citing works
Lee, S. H., Gomes, S. M., Ghalayini, J., Iliadi, K. G., & Boulianne, G. L. (2020) · eNeuro · doi:10.1523/eneuro.0235-20.2020 · Cited by 30 · see citing works
Targeting the renin angiotensin system for the treatment of anxiety and depression
Chrissobolis, S., Luu, A. N., Waldschmidt, R. A., Yoakum, M. E., & D’Souza, M. S. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.173063 · Cited by 30 · see citing works
Bild, W., Vasincu, A., Rusu, R.-N., Ababei, D. C., Stana, B. A., Stanciu, G. D., Savu, B., & Bild, V. (2022) · Biomolecules · doi:10.3390/biom12101429 · Cited by 29 · see citing works
Self-citationShkreli, L., Woud, M., Ramsbottom, R., Rupietta, A., Waldhauser, G., Kumsta, R., & Reinecke, A. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0553-y · Cited by 20 · see citing works
Cojocariu, R. O., Ciobica, A. S., Balmuș, I.-M., Guenné, S., Trifan, A. V., Stanciu, C., Hrițcu, L. D., & Lefter, R. M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3492767 · Cited by 27 · see citing works
Self-citationPossible combined effect of perindopril and Azilsartan in an experimental model of dementia in rats
Alzahrani, Y. M., Ahmad, M. A. A. A. S., Kamel, F. O., Ramadan, W. S., & Alzahrani, Y. A. (2020) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2020.03.009 · Cited by 26 · see citing works
Basmadjian, O. M., Occhieppo, V. B., Marchese, N. A., Silvero, M. J., Becerra, M. C., Baiardi, G., & Bregonzio, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.647747 · Cited by 23 · see citing works
Mohite, S., Sanches, M., & Teixeira, A. L. (2019) · Protein and Peptide Letters · doi:10.2174/0929866527666191223144000 · Cited by 24 · see citing works
Peters, R. K., Schuchman, M., Peters, J., Carlson, M. C., & Yaşar, S. (2016) · Current Hypertension Reports · doi:10.1007/s11906-016-0673-2 · Cited by 22 · see citing works
Lefter, R. M., Ciobica, A. S., Antioch, I., Ababei, D. C., Hrițcu, L. D., & Luca, A.-C. (2020) · Medicina · doi:10.3390/medicina56060267 · Cited by 22 · see citing works
Self-citationLiampas, I., Raptopoulou, M., Siokas, V., Bakirtzis, C., Tsouris, Z., Aloizou, A., Dastamani, M., Brotis, A. G., Bogdanos, D. P., & Dardiotis, E. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100909 · Cited by 21 · see citing works
Xu, T., Zhou, X., Jiao, G., Zeng, Y., Zhao, W., Li, J., Yu, F., Zhou, F., Yao, S., & Becker, B. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.05.007 · Cited by 20 · see citing works
Zhu, M., Chen, J., Wen, M., Sun, Z., Sun, X., Wang, J., & Miao, C. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8326-6 · Cited by 20 · see citing works
Kaur, P., Muthuraman, A., & Kaur, J. (2014) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320314556171 · Cited by 19 · see citing works
Seyer, B., Pham, V., Albiston, A. L., & Chai, S. Y. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.06.034 · Cited by 19 · see citing works
Systemic angiotensin II and exercise-induced neurogenesis in adult rat hippocampus
Mukuda, T., Koyama, Y., Hamasaki, S., Kaidoh, T., & Furukawa, Y. (2014) · Brain Research · doi:10.1016/j.brainres.2014.09.019 · Cited by 18 · see citing works
Aspects of animal models for major neuropsychiatric disorders
Lefter, R. M., Cojocaru, D., Ciobica, A. S., Paulet, M., Șerban, L., & Anton, E. (2014) · Archives of Biological Sciences · doi:10.2298/abs1403105l · Cited by 18 · see citing works
Self-citationRole of the Renin-Angiotensin-Aldosterone System in Various Disease Processes: An Overview
Gelen, V., Kükürt, A., & Şengül, E. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97354 · Cited by 18 · see citing works
Vesković, M. N., Mladenović, D. R., Jorgačević, B. Z., Stevanović, I. D., Luka, S. R. D., & Radosavljević, T. S. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214549521 · Cited by 17 · see citing works
Vasconcelos, G. S., Júnior, M. A. S., Monte, A. S., da Silva, F. E. R., Lima, C. N. D. C., Neto, A. B. M. L., Medeiros, I. D. S., Teixeira, A. L., de Lucena, D. F., Vasconcelos, S. M. M., et al. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110348 · Cited by 17 · see citing works
Chen, J., Chen, W., Zhu, M., Zhu, Y., Xu, P., & Miao, C. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.076 · Cited by 15 · see citing works
Ababei, D. C., Bild, V., Ciobica, A. S., Lefter, R. M., Rusu, R.-N., & Bild, W. (2019) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317519847042 · Cited by 15 · see citing works
Self-citationTaştemur, Y., Gümüş, E., Ergül, M., Ulu, M., Akkaya, R., Öztürk, A., & Taşkıran, A. Ş. (2020) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v19i3.26 · Cited by 15 · see citing works
Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Linares, A., Couling, L. E., Carrera, E. J., & Speth, R. C. (2016) · Journal of Visualized Experiments · doi:10.3791/53866 · Cited by 14 · see citing works
Yang, N., Gonzalez‐Vicente, A., & Garvin, J. L. (2019) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00462.2019 · Cited by 14 · see citing works
Moradganjeh, A., Ziai, S. A., & Roghani, M. (2013) · Pathophysiology · doi:10.1016/j.pathophys.2013.10.001 · Cited by 12 · see citing works
Lakkab, I., Ouakil, A., Hajaji, H. E., Lachkar, N., Lefter, R. M., Ciobica, A. S., Bali, B. E., Dobrin, R., Hrițcu, L. D., & Lachkar, M. (2022) · Brain Sciences · doi:10.3390/brainsci12121660 · Cited by 11 · see citing works
Self-citationThe Effect of Lipoic Acid on Cyanate Toxicity in Different Structures of the Rat Brain
Sokołowska, M. M., Lorenc‐Koci, E., Bilska‐Wilkosz, A., & Iciek, M. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9395-2 · Cited by 11 · see citing works
Barak, R., Goshtasbi, G., Fatehi, R., & Firouzabadi, N. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173706 · Cited by 9 · see citing works
Tully, P. J., Helmer, C., Peters, R. K., & Tzourio, C. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.08.002 · Cited by 9 · see citing works
Hippocampal asymmetry in angiotensin II modulatory effects on learning and memory in rats
Tashev, R. E., & Stefanova, M. (2015) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2015-2015 · Cited by 9 · see citing works
Huang, S., & Zhang, M. (2024) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.45 · Cited by 8 · see citing works
Effects of valsartan on morphine tolerance and dependence in rats
Kaeidi, A., Amirteimoury, M., Zare, M.-S., Nazari, A., Hakimizadeh, E., Hassanshahi, J., & Fatemi, I. (2021) · Research in Pharmaceutical Sciences · doi:10.4103/1735-5362.314827 · Cited by 8 · see citing works
Trevisan, M. T. S., Maia, I. R. D. O., dos Santos, S. J. M., Almeida, W. P., Ulrich, C. M., & Owen, R. W. (2018) · International Journal of Food Properties · doi:10.1080/10942912.2018.1460756 · Cited by 8 · see citing works
Massaoudi, Y., Anissi, J., Lefter, R. M., Lobiuc, A., Sendide, K., Ciobica, A. S., & Hassouni, M. E. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/8852418 · Cited by 8 · see citing works
Self-citationȘerban, D. N., Anton, E., Chiriță, R., Bild, V., Ciobica, A. S., Alexinschi, O., Arcan, O., Popescu, R., Păduraru, L., & Timofte, D. V. (2015) · Archives of Biological Sciences · doi:10.2298/abs140228051s · Cited by 7 · see citing works
Self-citationIrimia, R., Ciobica, A. S., Stanciu, C., & Trifan, A. V. (2013) · Archives of Biological Sciences · doi:10.2298/abs1303245i · Cited by 7 · see citing works
Self-citationEffect of Captopril on Brain Oxidative Damage in Pentylenetetrazole-Induced Seizures in Mice
Asgharzadeh, F., Hosseini, M., Bargi, R., Soukhtanloo, M., Beheshti, F., Mohammady, Z., & Anaeigoudari, A. (2019) · Pharmaceutical Sciences · doi:10.15171/ps.2019.38 · Cited by 5 · see citing works
Shkreli, L., Thoroddsen, T., Kobelt, M., Martens, M., Browning, M., Harmer, C., Cowen, P., & Reinecke, A. (2023) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2023.100286 · Cited by 6 · see citing works
Captopril and losartan attenuate behavioural sensitization in mice chronically exposed to toluene
Oros-González, A., Gallardo‐Ortíz, I. A., Montes, S., del Valle‐Mondragón, L., & Páez-Martı́nez, N. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113640 · Cited by 5 · see citing works
Effects of Goldblatt hypertension on rats’ hippocampal cholinergic system
Sepehri, H., Ganji, F., Nazari, Z., & Vahid, M. (2022) · Translational Neuroscience · doi:10.1515/tnsci-2022-0215 · Cited by 4 · see citing works
MacLachlan, R. A., Evans, C. E., Chai, S. Y., Good, M. A., Kehoe, P. G., & Miners, J. S. (2022) · Aging Brain · doi:10.1016/j.nbas.2022.100062 · Cited by 4 · see citing works
Ding, X., Ju, X., Lü, Y., Chen, W., Wang, J., Miao, C., & Chen, J. (2018) · Journal of Anesthesia · doi:10.1007/s00540-018-2565-x · Cited by 4 · see citing works
Arcan, O., Bild, W., Ciobica, A. S., Șerban, D. N., Anton, E., Petrariu, F. D., Timofte, D. V., & Popa, T. (2014) · Cited by 2 · see citing works
Self-citationShkreli, L., Woud, M. L., Browning, M. D., Kroj, A., Waldhauser, G. T., & Reinecke, A. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.01.103 · Cited by 1 · see citing works
Ababei, D. C., Balmuș, I.-M., Bild, W., Ciobica, A. S., Lefter, R. M., Rusu, R.-N., Stanciu, G. D., Cojocaru, S. I., Hăncianu, M., & Bild, V. (2023) · Brain Sciences · doi:10.3390/brainsci13081211 · Cited by 1 · see citing works
Self-citationSmith, J., Dobariya, P., Kadam, T. R., & More, S. S. (2026) · Frontiers in Drug Discovery · doi:10.3389/fddsv.2026.1855021 · Cited by 1 · see citing works
Degenerative Brain Diseases and White Matter Injury
Bartzokis, G., & Lu, P. H. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9123-1_14 · Cited by 1 · see citing works
Mini-Review on the Glucose Metabolism Modifications after Pancreatic Resection
Timofte, D. V., Ionescu, L., & Ochiuz, L. (2016) · International Letters of Natural Sciences · doi:10.18052/www.scipress.com/ilns.53.65 · Cited by 1 · see citing works
Mini-Review on the Glucose Metabolism Modifications after Pancreatic Resection
Timofte, D. V., Ionescu, L., & Ochiuz, L. (2016) · International Letters of Natural Sciences · doi:10.56431/p-3zq2cx · Cited by 1 · see citing works
Ciobica, A. S., Lefter, R. M., & Stoica, B. A. (2017) · Fìzìologìčnij žurnal · doi:10.15407/fz63.02.025 · Cited by 1 · see citing works
Self-citationRenin-angiotensin System: A New Promising Therapeutic and Mechanisms for Depression and AnxietyPreprint
Gong, S., & Deng, F. (2022) · doi:10.22541/au.166376718.84383561/v1 · Cited by 1 · see citing works
Establishing echocardiographic and arterial stiffness markers as predictors of cognitive decline
Mitu, F., Pădurariu, M., Joacăbine, C., Ciobica, A. S., & Chiriță, R. (2013) · Archives of Biological Sciences · doi:10.2298/abs1304299m
Self-citationThe Brain Renin−Angiotensin System
de Kloet, A. D., & Krause, E. G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00063-8
Guenné, S., Ouattara, N., Lefter, R. M., Timofte, D. V., Hilou, A., & Kiendrébeogo, M. (2019) · Bulletin of Integrative Psychiatry · doi:10.36219/bpi.2019.04.02
Effects of gonadotropins in female infertility associated with depression
Barbu, R. M., Gavrilescu, C. M., Stana, B. A., Popescu, R. I., Pohaci-Antonesei, C., & Bild, W. (2020) · Bulletin of Integrative Psychiatry · doi:10.36219/bpi.2020.4.08
Self-citationELECTRICAL FIELD STIMULATION OF THE RENIN ANGIOTENSIN ALDOSTERONE SYSTEM ON UTERINE SMOOTH MUSCLE
Stafie, L., Gavrilescu, C. M., Cojocaru, T., Panzariu, G. M., Oprișa, C., Pohaci, A. C., Forna, N. C., & Barbu, R. M. (2024) · Romanian Journal of Oral Rehabilitation · doi:10.62610/rjor.2024.2.16.66
Mohammed, N. A., El‐Tahawy, N. F. G., Abozaid, S. M. M., Abd-Elhady, H. K., Aly, M. K., Mehdar, K. M., Haredy, H. H., & Seleem, H. S. (2025) · Egyptian Journal of Basic and Applied Sciences · doi:10.1080/2314808x.2025.2570277
Shibata, T., Bhat, S. A., Cao, D., Saito, S., Bernstein, E. A., Okwan-Duodu, D. K., Tourtellotte, W. G., Bernstein, K. E., & Khan, Z. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1674330
- Authors
- Bild, W., Hritcu, L., Stefanescu, C., & Ciobica, A.
- Affiliations
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- Alexandru Ioan Cuza University (RO)
- Corresponding author
- Ciobica, Alin
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 43
- Pages
- 79-88
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2091505284
- Cited by
- 83
- References
- 108
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 10 · 2018: 4 · 2017: 4 · 2016: 9 · 2015: 10 · 2014: 10 · 2013: 6
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- POSDRU (/89/1.5/S/49944)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Keywords
- angiotensin II, central renin-angiotensin system, memory, hippocampus, oxidative stress, losartan, captopril, angiotensin II type 1 receptor, angiotensin II type 2 receptor, lipid peroxidation, malondialdehyde, superoxide dismutase, glutathione peroxidase, spatial memory, passive avoidance, spontaneous alternation
- MeSH terms
- Angiotensin II, Angiotensin-Converting Enzyme Inhibitors, Animals, Avoidance Learning, Behavior, Animal, Captopril, Glutathione Peroxidase, Hippocampus, Imidazoles, Male, Malondialdehyde, Memory, Memory, Short-Term, Psychomotor Performance, Pyridines, Superoxide Dismutase, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, Maze Learning, Losartan, Angiotensin II Type 1 Receptor Blockers, Rats, Angiotensin Receptor Antagonists, Angiotensin II Type 2 Receptor Blockers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review