Minocycline reduces inflammatory parameters in the brain structures and serum and reverses memory impairment caused by the administration of amyloid β (1-42) in mice
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Alzheimer's disease (AD) is a neurodegenerative disorder and the most common type of age-related dementia. Cognitive decline, beta-amyloid (Aβ) accumulation, neurofibrillary tangles, and neuroinflammation are the main pathophysiological characteristics of AD. Minocycline is a tetracycline derivative with anti-inflammatory properties that has a neuroprotective effect. The aim of this study was to evaluate the effect of minocycline on memory, neurotrophins and neuroinflammation in an animal model of AD induced by the administration of Aβ (1-42) oligomer. Male BALB/c mice were treated with minocycline (50mg/kg) via the oral route for a total of 17days, 24h after intracerebroventricular administration of Aβ (1-42) oligomer. At the end of this period, was performed the radial maze test, and 24h after the last minocycline administration, serum was collected and the cortex and hippocampus were dissected for biochemical analysis. The administration of minocycline reversed the memory impairment caused by Aβ (1-42). In the hippocampus, minocycline reversed the increases in the levels of interleukin (IL-1β), Tumor Necrosis Factor- alpha (TNF-α) and, IL-10 caused by Aβ (1-42). In the cortex, AD-like model increase the levels of IL-1β, TNF-α and, IL-4. Minocycline treatment reversed this. In the serum, Aβ (1-42) increased the levels of IL-1β and IL-4, and minocycline was able to reverse this action, but not to reverse the decrease of IL-10 levels. Minocycline also reversed the increase in the levels of Brain-derived neurotrophic factor (BDNF) in the hippocampus caused by Aβ (1-42), and reduced Nerve Growth Factor (NGF) increases in the total cortex. Therefore, our results indicate that minocycline causes improvements in the spatial memory, and cytokine levels were correlated with this effect in the brain it. Besides this, minocycline reduced BDNF and NGF levels, highlighting the promising effects of minocycline in treating AD-like dementia.
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Treatment with anti-inflammatory medication tends to mitigate cognitive impairment in animal models of amyloid-β injection.
“treatment with antiinflammatory medication tends to mitigate cognitive impairment in animal models of amyloid-β injection [149, 150].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [149]
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Jack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70291-0 · Cited by 4,396 · see citing works
Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336 · see citing works
Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., & Selkoe, D. J. (2002) · Nature · doi:10.1038/416535a · Cited by 4,291 · see citing works
Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · see citing works
Preclinical Alzheimer’s Disease: Definition, Natural History, and Diagnostic Criteria
Dubois, B., Hampel, H., Feldman, H. H., Scheltens, P., Aisen, P., Andrieu, S., Bakardjian, H., Benali, H., Bertram, L., Blennow, K., et al. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.002 · Cited by 1,925 · see citing works
Innate immune activation in neurodegenerative disease
Heneka, M. T., Kummer, M. P., & Latz, E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3705 · Cited by 1,437 · see citing works
Holmes, C., Boche, D., Wilkinson, D., Yadegarfar, G., Hopkins, V., Bayer, A., Jones, R. W., Bullock, R., Love, S., Neal, J. W., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61075-2 · Cited by 1,416 · see citing works
Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial
Gilman, S., Koller, M., Black, R. S., Jenkins, L., Griffith, S. G., Fox, N. C., Eisner, L., Kirby, L., Rovira, M. B., Forette, F., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000159740.16984.3c · Cited by 1,329 · see citing works
Wu, D. C., Jackson-Lewis, V., Vila, M., Tieu, K., Teismann, P., Vadseth, C., Choi, D.-K., Ischiropoulos, H., & Przedborski, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01763.2002 · Cited by 1,183 · see citing works
A Meta-Analysis of Cytokines in Alzheimer's Disease
Swardfager, W., Lanctôt, K., Rothenburg, L., Wong, A., Cappell, J., & Herrmann, N. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.012 · Cited by 1,108 · see citing works
Zhu, S., Stavrovskaya, I. G., Drozda, M., Kim, B. Y. S., Ona, V. O., Li, M., Sarang, S. S., Liu, A. S., Hartley, D. M., Wu, D. C., et al. (2002) · Nature · doi:10.1038/417074a · Cited by 1,071 · see citing works
Chen, M., Ona, V. O., Li, M., Ferrante, R. J., Fink, K., Zhu, S., Bian, J., Guo, L., Farrell, L. A., Hersch, S. M., et al. (2000) · Nature Medicine · doi:10.1038/77528 · Cited by 1,056 · see citing works
Age, Neuropathology, and Dementia
Savva, G. M., Wharton, S. B., Ince, P. G., Forster, G., Matthews, F. E., & Brayne, C. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0806142 · Cited by 900 · see citing works
PET of Brain Amyloid and Tau in Mild Cognitive Impairment
Small, G. W., Kepe, V., Ercoli, L. M., Siddarth, P., Bookheimer, S. Y., Miller, K. J., Lavretsky, H., Burggren, A. C., Cole, G. M., Vinters, H. V., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054625 · Cited by 731 · see citing works
Peng, S., Wuu, J., Mufson, E. J., & Fahnestock, M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03135.x · Cited by 691 · see citing works
Neurofibrillary Tangles, Amyloid, and Memory in Aging and Mild Cognitive Impairment
Guillozet-Bongaarts, A. L., Weıntraub, S., Mash, D. C., & Mesulam, M. M. (2003) · Archives of Neurology · doi:10.1001/archneur.60.5.729 · Cited by 572 · see citing works
Conversion of Mild Cognitive Impairment to Alzheimer Disease Predicted by Hippocampal Atrophy Maps
Apostolova, L. G., Dutton, R. A., Dinov, I. D., Hayashi, K. M., Toga, A. W., Cummings, J. L., & Thompson, P. M. (2006) · Archives of Neurology · doi:10.1001/archneur.63.5.693 · Cited by 553 · see citing works
Butterfield, D. A., Swomley, A. M., & Sultana, R. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5027 · Cited by 526 · see citing works
Hock, C., Heese, K., Hulette, C., Rosenberg, C., & Otten, U. (2000) · Archives of Neurology · doi:10.1001/archneur.57.6.846 · Cited by 523 · see citing works
The importance of neuritic plaques and tangles to the development and evolution of AD
Tiraboschi, P., Hansen, L. A., Thal, L. J., & Corey-Bloom, J. (2004) · Neurology · doi:10.1212/01.wnl.0000129697.01779.0a · Cited by 477 · see citing works
Neuropathologic Substrate of Mild Cognitive Impairment
Markesbery, W. R., Schmitt, F. A., Kryscio, R. J., Davis, D. G., Smith, C. D., & Wekstein, D. R. (2006) · Archives of Neurology · doi:10.1001/archneur.63.1.38 · Cited by 460 · see citing works
The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease
Josiane, Tatiani, Francielle, Michelle, M., & Alexandra (2015) · Aging and Disease · doi:10.14336/ad.2015.0825 · Cited by 409 · see citing works
Strle, K., Zhou, J.-H., Shen, W. H., Broussard, S., Johnson, R. W., Freund, G., Dantzer, R., & Kelley, K. (2001) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v21.i5.20 · Cited by 408 · see citing works
The amyloid cascade hypothesis: are we poised for success or failure?
Karran, E., & De Strooper, B. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13632 · Cited by 402 · see citing works
Intracerebroventricular injections in mice
Laursen, S. E., & Belknap, J. K. (1986) · Journal of Pharmacological Methods · doi:10.1016/0160-5402(86)90038-0 · Cited by 393 · see citing works
Reimagining Alzheimer's Disease—An Age-Based Hypothesis
Herrup, K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4521-10.2010 · Cited by 386 · see citing works
An analysis of rat prefrontal cortex in mediating executive function
Kesner, R. P., & Churchwell, J. C. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.07.002 · Cited by 365 · see citing works
Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology
Guillot-Sestier, M.-V., Doty, K. R., Gate, D., Rodriguez, J., Leung, B. P., Rezai-Zadeh, K., & Town, T. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.068 · Cited by 363 · see citing works
Murray, C. A., & Lynch, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-08-02974.1998 · Cited by 359 · see citing works
Chakrabarty, P., Li, A., Ceballos-Diaz, C., Eddy, J. A., Funk, C. C., Moore, B., DiNunno, N., Rosario, A. M., Cruz, P. E., Verbeeck, C., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.11.020 · Cited by 354 · see citing works
Holsinger, R. M. D., Schnarr, J., Henry, P., Castelo, V. T., & Fahnestock, M. L. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00023-1 · Cited by 328 · see citing works
Longitudinal volumetric MRI change and rate of cognitive decline
Mungas, D., Harvey, D., Reed, B. R., Jagust, W. J., DeCarli, C., Beckett, L., Mack, W. J., Kramer, J. H., Weiner, M. W., Schuff, N., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000172913.88973.0d · Cited by 311 · see citing works
Nelson, P. T., Jicha, G. A., Schmitt, F. A., Liu, H., Davis, D. G., Mendiondo, M. S., Abner, E. L., & Markesbery, W. R. (2007) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/nen.0b013e31815c5efb · Cited by 292 · see citing works
Choi, Y., Kim, H., Shin, K. Y., Kim, E., Kim, M., Kim, H.-S., Park, C. H., Jeong, Y. H., Yoo, J., Lee, J., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301377 · Cited by 290 · see citing works
Westin, K., Buchhave, P., Nielsen, H., Minthon, L., Janciauskiene, S., & Hansson, O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030525 · Cited by 277 · see citing works
Inflammatory components in human Alzheimer’s disease and after active amyloid-β42 immunization
Zotova, E., Bharambe, V., Cheaveau, M., Morgan, W., Holmes, C., Harris, S., Neal, J. W., Love, S., Nicoll, J. A. R., & Boche, D. (2013) · Brain · doi:10.1093/brain/awt210 · Cited by 272 · see citing works
Janelsins, M. C., Mastrangelo, M. A., Oddo, S., LaFerla, F. M., Federoff, H. J., & Bowers, W. J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-23 · Cited by 260 · see citing works
The NLRP3 Inflammasome in Alzheimer’s Disease
Tan, M., Yu, J., Jiang, T., Zhu, X., & Tan, L. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8475-x · Cited by 249 · see citing works
Szczepanik, A. M. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00404-5 · Cited by 243 · see citing works
Has the amyloid cascade hypothesis for Alzheimer's disease been proved?
Hardy, J. (2006) · Current Alzheimer Research · doi:10.2174/156720506775697098 · Cited by 242 · see citing works
Dursun, E., Gezen-Ak, D., Hanağası, H., Bilgiç, B., Lohmann, E., Ertan, S., Atasoy, İ. L., Alaylıoğlu, M., Araz, Ö. S., Önal, B., et al. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.04.014 · Cited by 237 · see citing works
Increased proNGF Levels in Subjects with Mild Cognitive Impairment and Mild Alzheimer Disease
Peng, S., Wuu, J., Mufson, E. J., & Fahnestock, M. L. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.6.641 · Cited by 236 · see citing works
Resende, R., Ferreiro, E., Pereira, C., & Resende de Oliveira, C. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.036 · Cited by 235 · see citing works
Minocycline affects microglia activation, Aβ deposition, and behavior in APP‐tg mice
Seabrook, T. J., Jiang, L., Maier, M., & Lemere, C. A. (2006) · Glia · doi:10.1002/glia.20338 · Cited by 223 · see citing works
Role of Interleukin-4 in Regulation of Age-related Inflammatory Changes in the Hippocampus
Nolan, Y. M., Maher, F. O., Martin, D. S. D., Clarke, R. M., Brady, M. T., Bolton, A. E., Mills, K. H. G., & Lynch, M. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412170200 · Cited by 210 · see citing works
Hriţcu, L., Cioancă, O., & Hăncianu, M. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.02.002 · Cited by 197 · see citing works
Molecular mechanisms of neuropathological changes in Alzheimer’s disease: a review
Šerý, O., Povová, J., Mı́šek, I., Pešák, L., & Janout, V. (2013) · Folia Neuropathologica · doi:10.5114/fn.2013.34190 · Cited by 193 · see citing works
Relevance of Magnetic Resonance Imaging for Early Detection and Diagnosis of Alzheimer Disease
Teipel, S. J., Grothe, M. J., Lista, S., Toschi, N., Garaci, F., & Hampel, H. J. (2013) · Medical Clinics of North America · doi:10.1016/j.mcna.2012.12.013 · Cited by 192 · see citing works
Gezen-Ak, D., Dursun, E., Hanağası, H., Bilgiç, B., Lohman, E., Araz, Ö. S., Atasoy, İ. L., Alaylıoğlu, M., Önal, B., Gürvit, H., et al. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-130497 · Cited by 188 · see citing works
Angelucci, F., Spalletta, G., Iulio, F. D., Ciaramella, A., Salani, F., Varsi, A. E., Gianni, W., Sancesario, G., Caltagirone, C., & Bossù, P. (2010) · Current Alzheimer Research · doi:10.2174/156720510790274473 · Cited by 187 · see citing works
A visuospatial variant of mild cognitive impairment
Mapstone, M. E., Steffenella, T. M., & Duffy, C. J. (2003) · Neurology · doi:10.1212/01.wnl.0000049471.76799.de · Cited by 181 · see citing works
Liu, B., & Neufeld, A. H. (2000) · Glia · doi:10.1002/(sici)1098-1136(200004)30:2 · Cited by 177 · see citing works
The Neurotrophins and Their Role in Alzheimers Disease
Allen, S. J., Watson, J. J., & Dawbarn, D. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376190 · Cited by 177 · see citing works
Blasko, I., Lederer, W., OBERBAUER, H., Walch, T., Kemmler, G., Hinterhuber, H., Marksteiner, J., & Humpel, C. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000089137 · Cited by 170 · see citing works
Schulte‐Herbrüggen, O., Nassenstein, C., Lommatzsch, M., Quarcoo, D., Renz, H. E., & Braun, A. C. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.10.026 · Cited by 169 · see citing works
Biscaro, B., Lindvall, O., Tesco, G., Ekdahl, C. T., & Nitsch, R. M. (2012) · Neurodegenerative Diseases · doi:10.1159/000330363 · Cited by 164 · see citing works
Pedraza, C. E., Podlesniy, P., Vidal, N., Arévalo, J. C., Lee, R., Hempstead, B. L., Ferrer, I., Iglesias, M., & Espinet, C. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62275-4 · Cited by 164 · see citing works
Tha, K. K., Okuma, Y., Miyazaki, H., Murayama, T., Uehara, T., Hatakeyama, R., Hayashi, Y., & Nomura, Y. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02883-3 · Cited by 163 · see citing works
Mild cognitive impairment in different functional domains and incident Alzheimer’s disease
Aggarwal, N., Wilson, R., Beck, T., Bienias, J., & Bennett, D. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.053561 · Cited by 151 · see citing works
Amyloid β-Induced Nerve Growth Factor Dysmetabolism in Alzheimer Disease
Bruno, M. A., León, W., Fragoso, G., Mushynski, W. E., Almazán, G., & Cuello, A. C. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181aed9e6 · Cited by 148 · see citing works
Increased plasma levels of BDNF and inflammatory markers in Alzheimer's disease
Faria, M. C., Gonçalves, G. S., Rocha, N. P., de Moraes, E. N., Bicalho, M. A. C., Cintra, M. T. G., de Paula, J. J., de Miranda, L. F. J. R., Ferreira, A. C. D. S., Teixeira, A. L., et al. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.01.019 · Cited by 145 · see citing works
Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration
Liu, P., Reed, M. N., Kotilinek, L., Grant, M. K. O., Forster, C. L., Qiang, W., Shapiro, S. L., Reichl, J. H., Chiang, A. C. A., Jankowsky, J. L., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.021 · Cited by 143 · see citing works
Chételat, G., Fouquet, M., Kalpouzos, G., Denghien, I., De la Sayette, V., Viader, F., Mézenge, F., Landeau, B., Baron, J. C., Eustache, F., et al. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.11.037 · Cited by 143 · see citing works
Burbach, G. J., Hellweg, R., Haas, C. A., Del Turco, D., Deicke, U., Abramowski, D., Jucker, M., Staufenbiel, M., & Deller, T. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5599-03.2004 · Cited by 132 · see citing works
O'Donnell, E., Vereker, E., & Lynch, M. A. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00900.x · Cited by 125 · see citing works
Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease
Noble, W., Garwood, C., Stephenson, J., Kinsey, A. M., Hanger, D., & Anderton, B. (2009) · The FASEB Journal · doi:10.1096/fj.08-113795 · Cited by 123 · see citing works
Systemic immune system alterations in early stages of Alzheimer's disease
Zhang, R., Miller, R. G., Madison, C. A., Jin, X., Honrada, R., Harris, W., Katz, J., Forshew, D. A., & McGrath, M. S. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.01.002 · Cited by 121 · see citing works
Circulating Biomarkers of Cognitive Decline and Dementia
Solfrizzi, V., D'Introno, A., Colacicco, A. M., Capurso, C., Todarello, O., Pellicani, V., Capurso, S. A., Pietrarossa, G., Santamato, V., Capurso, A., et al. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.06.015 · Cited by 120 · see citing works
The keystone of Alzheimer pathogenesis might be sought in Aβ physiology
Puzzo, D., Gulisano, W., Arancio, O., & Palmeri, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.039 · Cited by 116 · see citing works
Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition
Chakrabarty, P., Tianbai, L., Herring, A., Ceballos-Diaz, C., Das, P., & Golde, T. E. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-36 · Cited by 116 · see citing works
Ferretti, M. T., Allard, S., Partridge, V., Ducatenzeiler, A., & Cuello, A. C. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-62 · Cited by 115 · see citing works
Cortisol, cytokines, and hippocampal volume interactions in the elderly
Sudheimer, K. D., O'Hara, R. M., Spiegel, D., Powers, B. N., KRAEMER, H. C., Neri, E., Weiner, M. W., Hardan, A. Y., Hallmayer, J. F., & Dhabhar, F. S. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00153 · Cited by 111 · see citing works
Anti-Inflammatory Impact of Minocycline in a Mouse Model of Tauopathy
Garwood, C. J., Cooper, J. D., Hanger, D. P., & Noble, W. (2010) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2010.00136 · Cited by 106 · see citing works
Amyloid β protein-induced neuronal cell death: neurotoxic properties of aggregated amyloid β protein
Ueda, K., Fukui, Y., & Kageyama, H. (1994) · Brain Research · doi:10.1016/0006-8993(94)91736-1 · Cited by 104 · see citing works
Parachikova, A. I., Vasilevko, V., Cribbs, D. H., LaFerla, F. M., & Green, K. N. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100204 · Cited by 101 · see citing works
Fahnestock, M., Scott, S., Jette, N., Weingartner, J. A., & Crutcher, K. (1996) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(96)00193-3 · Cited by 101 · see citing works
Alzheimer's Disease: Critical Notes on the History of a Medical Concept
Ramírez‐Bermúdez, J. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.11.008 · Cited by 100 · see citing works
The Anti-Inflammatory Role of Minocycline in Alzheimers Disease
Budni, J., Garcez, M. L., de Medeiros, J., Cassaro, E., Bellettini‐Santos, T., Mina, F., & Quevedo, J. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666160819124206 · Cited by 90 · see citing works
Self-citationNeocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old
Robinson, J. L., Geser, F., Corrada, M. M., Berlau, D. J., Arnold, S. E., Lee, V. M.-Y., Kawas, C. H., & Trojanowski, J. Q. (2011) · Brain · doi:10.1093/brain/awr308 · Cited by 88 · see citing works
Foyet, H. S., Hriţcu, L., Ciobica, A. S., Ștefan, M., Kamtchouing, P., & Cojocaru, D. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.11.011 · Cited by 84 · see citing works
Hellweg, R., Gericke, C. A., Jendroska, K., Hartung, H.-D., & Cervós‐Navarro, J. (1998) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00088-4 · Cited by 82 · see citing works
Sabbagh, M. N., Cooper, K., DeLange, J., Stoehr, J. D., Thind, K., Lahti, T., Reisberg, B., Sue, L., Vedders, L., Fleming, S. R., et al. (2010) · Current Alzheimer Research · doi:10.2174/156720510791162340 · Cited by 79 · see citing works
Podlesniy, P., Kichev, A., Pedraza, C. E., Saurat, J., Encinas, M., Pérez, B. F., Ferrer, I., & Espinet, C. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050787 · Cited by 77 · see citing works
Buoso, E., Lanni, C., Schettini, G., Govoni, S. M., & Racchi, M. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.05.002 · Cited by 66 · see citing works
Minocycline protects basal forebrain cholinergic neurons from mu p75‐saporin immunotoxic lesioning
Hunter, C. L., Quintero, E. M., Gilstrap, L., Bhat, N. R., & Granholm, A. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03439.x · Cited by 63 · see citing works
Dahmani, L., & Bohbot, V. D. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.07.002 · Cited by 63 · see citing works
Neurobiology of Delusions in Alzheimer’s Disease
Ismail, Z., Nguyen, M.-Q., Fischer, C. E., Schweizer, T. A., Mulsant, B. H., & Mamo, D. C. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0195-1 · Cited by 63 · see citing works
Foxe, D., Leyton, C. E., Hodges, J. R., Burrell, J. R., Irish, M., & Piguet, O. (2016) · Cortex · doi:10.1016/j.cortex.2016.07.003 · Cited by 59 · see citing works
Mun, M.-J., Kim, J.-H., Choi, J.-Y., & Jang, W. (2016) · Meta Gene · doi:10.1016/j.mgene.2016.01.001 · Cited by 53 · see citing works
Zhao, Q., Zhou, B., Ding, D., Teramukai, S., Guo, Q., Fukushima, M., & Hong, Z. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095755 · Cited by 48 · see citing works
Kuang, X., Scofield, V. L., Yan, M., Stoica, G., Liu, N., & Wong, P. K. Y. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.007 · Cited by 47 · see citing works
Ruiz-Muñoz, A. M., Nieto-Escámez, F. A., Aznar, S., et al. (2011) · NeuroToxicology · doi:10.1016/j.neuro.2011.05.014 · Cited by 32 · see citing works
Leukocyte CCR2 Expression Is Associated with Mini-Mental State Examination Score in Older Adults
Harries, L. W., Bradley-Smith, R. M., Llewellyn, D. J., Pilling, L. C., Fellows, A. D., Henley, W., Hernandez, D. G., Guralnik, J. M., Bandinelli, S., Singleton, A., et al. (2012) · Rejuvenation Research · doi:10.1089/rej.2011.1302 · Cited by 30 · see citing works
Gomes, G. M., Dalmolin, G. D., Cordeiro, M. N., et al. (2013) · Toxicon · doi:10.1016/j.toxicon.2013.08.059 · Cited by 22 · see citing works
Wang, H., Yu, Y., Liu, S., Zhao, M., & Xu, Q. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.02.056 · Cited by 13 · see citing works
Navigating the circuitry of the brain's GPS system: Future challenges for neurophysiologists
Craig, M. T., & McBain, C. J. (2015) · Hippocampus · doi:10.1002/hipo.22456 · Cited by 12 · see citing works
Yang, X., & Duan, X. (2013) · PubMed · doi:10.3969/j.issn.1673-5374.2013.04.004 · Cited by 5 · see citing works
Yang, Xiaochun, Duan, D., et al. (2013) · 中国神经再生研究：英文版 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Budni, J., Bellettini-Santos, T., Mina, F., Garcez, M.L., Zugno, A.I., 2015b. The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease. Aging Dis. 6 (5), 331-341.
- Ledeboer, A., Breve, J.J., Poole, S., Tilders, F.J., Van Dam, A.M., 2000. Interleukin-10, interleukin-4, and transforming growth factor-beta differentially regulate lipopolysaccharide-induced production of pro-inflammatory cytokines and nitric oxide in co-cultures of rat astroglial and microglial cells. Glia 30 (2), 134-142.
Cited by
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Kwon, H. S., & Koh, S.-H. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00221-2 · Cited by 2,595 · see citing works
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Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750 · see citing works
Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer’s Disease
Shal, B., Ding, W., Ali, H., Kim, Y. S., & Khan, S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00548 · Cited by 234 · see citing works
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Chen, X., Drew, J., Berney, W., & Lei, W. (2021) · Cells · doi:10.3390/cells10061309 · Cited by 236 · see citing works
Howard, R., Zubko, O., Bradley, R., Harper, E., Pank, L., O’Brien, J., Fox, C., Tabet, N., Livingston, G., Bentham, P., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2019.3762 · Cited by 194 · see citing works
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Panza, F., Lozupone, M., Solfrizzi, V., Watling, M., & Imbimbo, B. P. (2019) · Brain · doi:10.1093/brain/awz244 · Cited by 161 · see citing works
Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and Infection
Brown, M. R., Radford, S. E., & Hewitt, E. W. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.609073 · Cited by 67 · see citing works
Challenges of Repurposing Tetracyclines for the Treatment of Alzheimer’s and Parkinson’s Disease
Markulin, I., Matasin, M., Turk, V. E., & Salković-Petrisic, M. (2022) · Journal of Neural Transmission · doi:10.1007/s00702-021-02457-2 · Cited by 36 · see citing works
- Authors
- Garcez, M. L., Mina, F., Bellettini-Santos, T., Carneiro, F. G., Luz, A. P., Schiavo, G. L., Andrighetti, M. S., Scheid, M. G., Bolfe, R. P., & Budni, J.
- Affiliations
- Universidade do Extremo Sul Catarinense (BR)
- Corresponding author
- Budni, Josiane
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 77
- Pages
- 23-31
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2598570847
- Cited by
- 102
- References
- 99
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 7 · 2023: 9 · 2022: 11 · 2021: 12 · 2020: 19 · 2019: 11 · 2018: 9 · 2017: 2
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- UNESC
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- minocycline, Alzheimer's disease, memory impairment, neuroinflammation, neurotrophins, brain-derived neurotrophic factor, nerve growth factor, hippocampus, cerebral cortex, IL-1β, TNF-α, IL-10, IL-4, spatial memory, neuroprotection
- MeSH terms
- Animals, Brain, Cerebral Cortex, Hippocampus, Inflammation, Male, Memory Disorders, Minocycline, Peptide Fragments, Tumor Necrosis Factor-alpha, Interleukin-4, Amyloid beta-Peptides, Interleukin-10, Neuroprotective Agents, Maze Learning, Brain-Derived Neurotrophic Factor, Mice, Interleukin-1beta, Infusions, Intraventricular
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