Abnormal functional connectivity strength in first-episode, drug-naive adult patients with major depressive disorder
Abstract
Background The pathogenesis of major depressive disorder (MDD) is complicated and equivocal. Previous studies have found an incidence of abnormal changes of neural networks, with plentiful evidence pointing the finger of suspicion firmly at the default mode network (DMN) and cortico-limbic networks. The aim of the present study was to use the approach of functional connectivity strength (FCS) to directly investigate the features of spontaneous brain activity in the case of first-episode, drug-naïve adult patients with MDD at rest.Methods Resting-state functional magnetic resonance imaging (MRI) scans were performed on 23 first-episode drug-naïve major depressive disorder (MDD) patients and 20 healthy controls (HCs). In this study, using graph-theory approaches(FCS), we computed the characteristics of brain connectivity. Simultaneously, we used a series of validated test procedures to evaluate the patients' cognitive function. Subsequently, the results were compared with the peak of FCS value and a correlation analysis was conducted.Results Compared with the HCs group, MDD patients showed significantly decreased FCS in bilateral posterior cingulate cortex (PCC)/precuneus and bilateral prefrontal cortex(PFC) and increased FCS in right posterior central gyrus, left thalamus and left temporal lobe. These brain regions belongs to the default-mode network and cortico-limbic networks. Finally, the correlation analyses showed the negative correlation of the FCS values in the left posterior cingulate cortex (PCC)/precuneus and Hamilton Anxiety Rating Scale (HAMA, r = -0.472, p = .023), Stroop Color Word Test-A(SCWT-A, r = -0.451, p = .031), Stroop Color Word Test-B(SCWT-B, r = -0.588, p = .003).Meanwhile, there was negative correlation between the FCS values in the left thalamus and SCWT-A(r = -0.473, p = .023), SCWT-B(r = -0.465, p = .025), SCWTC(r = -0.524, p = .010).In addition, the FCS values in the right PCC has negative correlation with Montgomery Asberg Depression Rating Scale (MADRS) (r = -0.433, p = .039).Conclusions DMN is an important node of MDD. FCS within the default mode network and cortico-limbic networks in patients with major depressive disorder has been changed in the early stage of MDD. FCS can provide favourable and additional evidence in the investigation of brain pathophysiology and therapy in depression.
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FCS alterations in these regions have been proven to be related to regulation of widespread cognitive, emotional, and executive control functions in MDD.
“The FCS alterations in these regions have been proven to be related to the regulation of widespread cognitive, emotional, and executive control functions in patients with MDD [6, 42-50].”
From Mapping neurophysiological subtypes of major depressive disorder using normative models of the functional connectome (2023) · cites this paper as [44]
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- Authors
- Shi, Y., Li, J., Feng, Z., Xie, H., Duan, J., Chen, F., & Yang, H.
- Affiliations
- Second Affiliated Hospital of Zhejiang University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
- Corresponding author
- Yang, Hong
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 97
- Pages
- 109759
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2971897857
- Cited by
- 56
- References
- 91
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 12 · 2023: 8 · 2022: 11 · 2021: 12 · 2020: 1 · 2019: 1
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- The Science Technology Department of Zhejiang Province (2017C33096)
- The Health and Family Planning Commission of Zhejiang Province (2015107509)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- major depressive disorder, default mode network, cortico-limbic network, resting-state brain activity, first-episode drug-naive patients, posterior cingulate cortex, precuneus, thalamus, prefrontal cortex, cognitive function, anxiety, depression severity, graph theory, brain network abnormalities, Stroop task, Hamilton Anxiety Rating Scale, Montgomery-Asberg Depression Rating Scale
- MeSH terms
- Default Mode Network, Adolescent, Adult, Brain, Cerebral Cortex, Cognition, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Case-Control Studies, Young Adult, Stroop Test, Functional Neuroimaging, Limbic Lobe
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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