The Danish PET/depression project: clinical symptoms and cerebral blood flow. A regions-of-interest analysis

Videbech, P.; Ravnkilde, B.; Pedersen, T. H.; Hartvig, H.; Egander, A.; Clemmensen, K.; Rasmussen, N. A.; Andersen, F.; Gjedde, A.; Rosenberg, R.

doi:10.1034/j.1600-0447.2002.02245.x

Cited by 161Treatment of Major DepressionNeural and Behavioral Psychology StudiesFunctional Brain Connectivity Studies

The Danish PET/depression project: clinical symptoms and cerebral blood flow. A regions-of-interest analysis

Videbech, P., Ravnkilde, B., Pedersen, T. H., Hartvig, H., Egander, A., Clemmensen, K., Rasmussen, N. A., Andersen, F. +2 more·2002·Acta Psychiatrica Scandinavica

DOI 10.1034/j.1600-0447.2002.02245.x

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Abstract

Objective: We wanted to explore associations between clinical symptoms of depression and the blood flow to specific regions of the brain. Furthermore, we wanted to compare the regions‐of‐interest (ROI) method with the functions‐of‐interest (FOI) approach. Method: The resting blood flow to 42 ROI in the brain was obtained with positron emission tomography (PET) imaging in 42 representative in‐patients with major depression and 47 matched healthy controls. Results: The patients had increased blood flow to hippocampus, cerebellum, anterior cingulate gyrus, and the basal ganglia. A strong negative correlation was found between the degree of psychomotor retardation of the patients and the blood flow to the dorsolateral and supraorbital prefrontal cortices. The total Hamilton score was correlated with the blood flow to the hippocampus. Conclusion: Our findings support the notion that depressed patients have disturbances in the loops connecting the frontal lobes, limbic system, basal ganglia, and cerebellum.

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Psychomotor retardation is associated with reduced activity in higher-order prefrontal regions that connect to the basal ganglia, including the dlPFC and orbitofrontal cortex.
“For example, psychomotor retardation is associated with reduced activity in higher-order prefrontal regions that connect to the basal ganglia and are associated with the initiation, planning, and control of movement, including the dlPFC and orbitofrontal cortex (Bench et al., 1993; Videbech et al., 2002).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Videbech et al., 2002

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The Danish PET/depression project: PET findings in patients with major depression
Videbech, P., Ravnkilde, B., PEDERSEN, A. R., Egander, A., LANDBO, B., Rasmussen, N. A., Andersen, F. L., Stødkilde‐Jørgensen, H., GJEDDE, A. H., & ROSENBERG, R. (2001) · Psychological Medicine · doi:10.1017/s0033291701004469 · Cited by 100 · see citing works
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Abnormal resting state corticolimbic blood flow in depressed unmedicated patients with major depression: A 15O‐H2O PET study
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Assessment of changes in regional cerebral blood flow in patients with major depression using the 99mTc-HMPAO single photon emission tomography method
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The anatomy of melancholia – focal abnormalities of cerebral blood flow in major depression
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Authors: Videbech, P., Ravnkilde, B., Pedersen, T. H., Hartvig, H., Egander, A., Clemmensen, K., Rasmussen, N. A., Andersen, F., Gjedde, A., & Rosenberg, R.
Affiliations: Aarhus University Hospital (DK)
Aarhus University (DK)
Corresponding author: Videbech, P.
ORCID: Videbech, P.
Pedersen, T. H.
Andersen, F.
Gjedde, A.
Venue: Acta Psychiatrica Scandinavica
Publisher: Wiley
Published: 2002-07
Volume: 106
Issue: 1
Pages: 35-44
ISSN: 0001-690X (ISSN-L)
1600-0447
DOI: 10.1034/j.1600-0447.2002.02245.x
OpenAlex: W1966421091
Cited by: 161
References: 78
Citations by year: 2026: 1 · 2025: 3 · 2024: 7 · 2023: 3 · 2022: 8 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 9 · 2015: 3 · 2014: 4 · 2013: 9 · 2012: 9
FWCI: 5.65
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4 d)
Locations: Acta Psychiatrica Scandinavica (publishedVersion)
PubMed (publishedVersion)
Funders: Karen Elise Jensens Fond
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: major depressive disorder, cerebral blood flow, region of interest, hippocampus, cerebellum, anterior cingulate cortex, basal ganglia, prefrontal cortex, psychomotor retardation, limbic system
MeSH terms: Adult, Basal Ganglia, Cerebellum, Depressive Disorder, Female, Frontal Lobe, Hippocampus, Humans, Limbic System, Male, Middle Aged, Regional Blood Flow, Tomography, Emission-Computed, Motor Skills Disorders

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The Danish PET/depression project: clinical symptoms and cerebral blood flow. A regions-of-interest analysis

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