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Cited by 91Psychosomatic Disorders and Their TreatmentsPsychoanalysis and Psychopathology ResearchNeural and Behavioral Psychology Studies

Frontal and occipital perfusion changes in dissociative identity disorder

Sar, Vedat, Unal, Seher N., Ozturk, Erdinc·2007·Psychiatry Research: Neuroimaging
DOI 10.1016/j.pscychresns.2006.12.017
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Abstract

The aim of the study was to investigate if there were any characteristics of regional cerebral blood flow (rCBF) in dissociative identity disorder. Twenty-one drug-free patients with dissociative identity disorder and nine healthy volunteers participated in the study. In addition to a clinical evaluation, dissociative psychopathology was assessed using the Structured Clinical Interview for DSM-IV Dissociative Disorders, the Dissociative Experiences Scale and the Clinician-Administered Dissociative States Scale. A semi-structured interview for borderline personality disorder, the Hamilton Depression Rating Scale, and the Childhood Trauma Questionnaire were also administered to all patients. Normal controls had to be without a history of childhood trauma and without any depressive or dissociative disorder. Regional cerebral blood flow (rCBF) was studied with single photon emission computed tomography (SPECT) with Tc99m-hexamethylpropylenamine (HMPAO) as a tracer. Compared with findings in the control group, the rCBF ratio was decreased among patients with dissociative identity disorder in the orbitofrontal region bilaterally. It was increased in median and superior frontal regions and occipital regions bilaterally. There was no significant correlation between rCBF ratios of the regions of interest and any of the psychopathology scale scores. An explanation for the neurophysiology of dissociative psychopathology has to invoke a comprehensive model of interaction between anterior and posterior brain regions.

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  • Sar et al. found that compared to healthy controls, patients (DID with comorbid BPD) showed decreased rCBF ratio in bilateral medial OFC and increased rCBF in medial/superior frontal regions and occipital regions bilaterally, with no significant correlation with dissociation.

    “Compared to HCs, patients showed decreased rCBF ratio in bilateral medial OFC and increased rCBF in medial/superior frontal regions and occipital regions bilaterally [63]. No significant correlation with dissociation was reported.”

    From Dissociation and Alterations in Brain Function and Structure: Implications for Borderline Personality Disorder (2017) · cites this paper as [132]

  • Wolf et al. (2012) found that compared to healthy controls, BPD patients exhibited decreased blood flow in the medial OFC and increased blood flow in the lateral OFC bilaterally, with no significant correlation with self-reported dissociation (DSS); instead, medial and lateral OFC blood flow was positively correlated with impulsivity.

    “Compared to HCs, patients exhibited decreased blow flow in the medial OFC, while increased blood flow was found in the lateral OFC bilaterally. Like in the study by Sar and colleagues [132], no significant correlation with self-reported dissociation (DSS) was observed. Instead, medial and lateral OFC blood flow was positively correlated with impulsivity, as measured with the Barratt impulsiveness”

    From Dissociation and Alterations in Brain Function and Structure: Implications for Borderline Personality Disorder (2017) · cites this paper as [132]

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Authors
Sar, V., Unal, S. N., & Ozturk, E.
Venue
Psychiatry Research: Neuroimaging
Publisher
Elsevier BV
Published
2007-12
Volume
156
Issue
3
Pages
217-223
ISSN
0925-4927 (ISSN-L)
DOI
10.1016/j.pscychresns.2006.12.017
OpenAlex
W2073489860
Cited by
91
References
43
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 8 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 10 · 2013: 5 · 2012: 10
FWCI
1.81
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
dissociative identity disorder, regional cerebral blood flow, orbitofrontal cortex, occipital cortex, frontal cortex, HMPAO SPECT, childhood trauma, borderline personality disorder
MeSH terms
Adult, Borderline Personality Disorder, Cerebrovascular Circulation, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Dissociative Identity Disorder, Occipital Lobe, Oximes, Stress Disorders, Post-Traumatic, Tomography, Emission-Computed, Single-Photon, Radiopharmaceuticals, Diagnostic and Statistical Manual of Mental Disorders

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