Common and dissociable regional cerebral blood flow differences associate with dimensions of psychopathology across categorical diagnoses
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The high comorbidity among neuropsychiatric disorders suggests a possible common neurobiological phenotype. Resting-state regional cerebral blood flow (CBF) can be measured noninvasively with magnetic resonance imaging (MRI) and abnormalities in regional CBF are present in many neuropsychiatric disorders. Regional CBF may also provide a useful biological marker across different types of psychopathology. To investigate CBF changes common across psychiatric disorders, we capitalized upon a sample of 1042 youths (ages 11-23 years) who completed cross-sectional imaging as part of the Philadelphia Neurodevelopmental Cohort. CBF at rest was quantified on a voxelwise basis using arterial spin labeled perfusion MRI at 3T. A dimensional measure of psychopathology was constructed using a bifactor model of item-level data from a psychiatric screening interview, which delineated four factors (fear, anxious-misery, psychosis and behavioral symptoms) plus a general factor: overall psychopathology. Overall psychopathology was associated with elevated perfusion in several regions including the right dorsal anterior cingulate cortex (ACC) and left rostral ACC. Furthermore, several clusters were associated with specific dimensions of psychopathology. Psychosis symptoms were related to reduced perfusion in the left frontal operculum and insula, whereas fear symptoms were associated with less perfusion in the right occipital/fusiform gyrus and left subgenual ACC. Follow-up functional connectivity analyses using resting-state functional MRI collected in the same participants revealed that overall psychopathology was associated with decreased connectivity between the dorsal ACC and bilateral caudate. Together, the results of this study demonstrate common and dissociable CBF abnormalities across neuropsychiatric disorders in youth.
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The p factor is associated with altered perfusion of the dorsal anterior cingulate cortex, reduced gray matter volume across the brain, and reduced brain activation in task control systems during a working memory task.
“Using cross-sectional samples of over 1000 children ages 11 to 23 years, in- vestigators found that increased p showed altered perfusion of the dorsal anterior cingulate cortex (34), reduced gray matter volume across the brain (35), and reduced brain activation in task control systems when engaged in a working memory task (36).”
From Methods and challenges for assessing heterogeneity (2020) · cites this paper as [34]
A common framework is comparisons between bifactor and correlated factor models using confirmatory factor analysis.
“A common framework is comparisons between bifactor (Figure 2A) and correlated factor models (Figure 2B) using confirmatory factor analysis (27,28,32–35,37–39).”
From Methods and challenges for assessing heterogeneity (2020) · cites this paper as [34]
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- Authors
- Kaczkurkin, A. N., Moore, T. M., Calkins, M. E., Ciric, R., Detre, J. A., Elliott, M. A., Foa, E. B., Garcia de la Garza, A., Roalf, D. R., Rosen, A., Ruparel, K., Shinohara, R. T., Xia, C. H., Wolf, D. H., Gur, R. E., Gur, R. C., & Satterthwaite, T. D.
- Affiliations
- University of Pennsylvania (US)
- Philadelphia VA Medical Center (US)
- Corresponding author
- Satterthwaite, T D
- ORCID
- Venue
- Molecular Psychiatry
- Published
- 2017-09-19
- Volume
- 23
- Issue
- 10
- Pages
- 1981-1989
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC5858960
- OpenAlex
- W2755945667
- Cited by
- 86
- References
- 75
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 10 · 2022: 10 · 2021: 11 · 2020: 17 · 2019: 14 · 2018: 9 · 2012: 1
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Pennsylvania
- National Institutes of Health
- National Institute of Mental Health (RC2MH089983, P50MH096891, R01MH112070, R01MH101111, K01MH102609, RC2MH089924, R01MH107703, K08MH079364)
- National Institute of Neurological Disorders and Stroke (R01NS085211)
- National Institute of Biomedical Imaging and Bioengineering (P41EB015893)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD085848)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- regional cerebral blood flow, psychopathology dimensions, psychiatric comorbidity, dimensional psychiatry, bifactor model, psychotic symptoms, behavioral symptoms, dorsal anterior cingulate cortex, subgenual anterior cingulate cortex, caudate nucleus, functional connectivity, arterial spin labeling, Philadelphia Neurodevelopmental Cohort, youth, neuroimaging biomarkers
- MeSH terms
- Adolescent, Mental Disorders, Brain, Brain Mapping, Cerebral Cortex, Cerebrovascular Circulation, Child, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Psychopathology, Philadelphia, Biomarkers, Young Adult
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