Cited by 222Functional Brain Connectivity StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMind wandering and attention

Altered default mode network activity in patient with anxiety disorders: An fMRI study

Zhao, Xiao-Hu, Wang, Pei-Jun, Li, Chun-Bo, Hu, Zheng-Hui, Xi, Qian, Wu, Wen-Yuan, Tang, Xiao-Wei·2007·European Journal of Radiology

Abstract

Anxiety disorder, a common mental disorder in our clinical practice, is characterized by unprovoked anxiety. Medial prefrontal cortex (MPFC) and posterior cingulate cortex (PCC), which closely involved in emotional processing, are critical regions in the default mode network. We used functional magnetic resonance imaging (fMRI) to investigate whether default mode network activity is altered in patients with anxiety disorder. Ten anxiety patients and 10 healthy controls underwent fMRI while listening to emotionally neutral words alternating with rest (Experiment 1) and threat-related words alternating with emotionally neutral words (Experiment 2). In Experiment 1, regions of deactivation were observed in patients and controls. In Experiment 2, regions of deactivation were observed only in patients. The observed deactivation patterns in the two experiments, which included MPFC, PCC, and inferior parietal cortex, were similar and consistent with the default model network. Less deactivation in MPFC and greater deactivation in PCC were observed for patients group comparing to controls in Experiment 1. Our observations suggest that the default model network is altered in anxiety patients and dysfunction in MPFC and PCC may play an important role in anxiety psychopathology.

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Crossref · 10.1016/j.ejrad.2007.02.006

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  • RSFC is associated with individual differences such as anxiety and depression.

    “Researchers have found that RSFC is associated with a variety of individual differences, such as, personality [3], depression [47, 48], anxiety [50, 107], autism [18], dementia [6] and Alzheimer’s disease [93].”

    From Predicting Brain Functional Connectivity Using Mobile Sensing (2020) · cites this paper as [107]

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Authors
Zhao, X.-H., Wang, P.-J., Li, C.-B., Hu, Z.-H., Xi, Q., Wu, W.-Y., & Tang, X.-W.
Affiliations
Tongji University (CN)
Corresponding author
Xi, Qian
Venue
European Journal of Radiology
Publisher
Elsevier BV
Published
2007-09
Volume
63
Issue
3
Pages
373-378
ISSN
0720-048X (ISSN-L)
OpenAlex
W1991128616
Cited by
222
References
23
Citations by year
2026: 7 · 2025: 12 · 2024: 11 · 2023: 10 · 2022: 13 · 2021: 15 · 2020: 16 · 2019: 9 · 2018: 9 · 2017: 13 · 2016: 10 · 2015: 16 · 2014: 11 · 2013: 10 · 2012: 11
FWCI
5.16
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Radiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
Keywords
anxiety disorders, default mode network, medial prefrontal cortex, posterior cingulate cortex, neural deactivation, threat words, emotional words, inferior parietal cortex, emotional processing
MeSH terms
Adult, Anxiety Disorders, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Models, Neurological, Case-Control Studies

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