A network-based neurobiological model of PTSD: evidence from structural and functional neuroimaging studies

Akiki, Teddy J.; Averill, Christopher L.; Abdallah, Chadi G.

doi:10.1007/s11920-017-0840-4

Cited by 365Posttraumatic Stress Disorder ResearchFunctional Brain Connectivity StudiesTraumatic Brain Injury Research

A network-based neurobiological model of PTSD: evidence from structural and functional neuroimaging studies

Open access

Akiki, Teddy J., Averill, Christopher L., Abdallah, Chadi G.·2017·Current Psychiatry Reports

DOI 10.1007/s11920-017-0840-4PMC PMC5960989

Open this paper in CoChat — free account

Abstract

Purpose of review Although a fine-grained understanding of the neurobiology of posttraumatic stress disorder (PTSD) is yet to be elucidated, the last two decades have seen a rapid growth in the study of PTSD using neuroimaging techniques. The current review summarizes important findings from functional and structural neuroimaging studies of PTSD, by primarily focusing on their relevance towards an emerging network-based neurobiological model of the disorder.Recent findings PTSD may be characterized by a weakly connected and hypoactive default mode network (DMN) and central executive network (CEN) that are putatively destabilized by an overactive and hyperconnected salience network (SN), which appears to have a low threshold for perceived saliency, and inefficient DMN-CEN modulation. There is considerable evidence for large-scale functional and structural network dysfunction in PTSD. Nevertheless, several limitations and gaps in the literature need to be addressed in future research.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s11920-017-0840-4

Cites

84 of 84 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Exposure to a traumatic event is associated with substantial structural and functional changes in core regions of circuits mediating emotional reactivity and regulatory control.
“At the neurobiological level, studies indicate that exposure to a traumatic event is associated with substantial structural and functional changes in core regions of circuits mediating emotional reactivity and regulatory control (Akiki et al., 2017).”
From Rt-fMRI neurofeedback-guided cognitive reappraisal training modulates amygdala responsivity in posttraumatic stress disorder (2020) · cites this paper as Akiki et al., 2017
The Network-Based Neurobiological Model of PTSD section describes imaging evidence of alterations in the amygdala, medial prefrontal cortex and hippocampus, and the Central Executive Network section describes structural and functional changes relevant to emotional modulation and control. But the review primarily discusses people with PTSD; its Conclusions and Limitations caution that differences observed after trauma may reflect pre-exposure protective factors. It therefore does not establish the claim as broadly for exposure to a traumatic event. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Functional coherence within the central executive network and the default mode network is disrupted in PTSD.
“In addition, functional coherence within the central executive network as well as the default mode network is disrupted, contributing further to the psychopathology (Akiki et al., 2017).”
From Rt-fMRI neurofeedback-guided cognitive reappraisal training modulates amygdala responsivity in posttraumatic stress disorder (2020) · cites this paper as Akiki et al., 2017
Individuals with PTSD show hyperactivation and hyperconnectivity of the SN.
“Individuals with PTSD have shown hyperactivation and hyperconnectivity of the SN ( Thome et al., 2014 ; Abdallah et al., 2019 ; for a review, see Akiki et al., 2017 )”
From The brain-body disconnect: A somatic sensory basis for trauma-related disorders (2022) · cites this paper as Akiki et al., 2017

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391 · see citing works
<i>The Brain's Default Network</i>: <i>Anatomy, Function, and Relevance to Disease</i>
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761 · see citing works
The organization of the human cerebral cortex estimated by intrinsic functional connectivity
Thomas Yeo, B. T., Krienen, F. M., Sepulcre, J., Sabuncu, M. R., Lashkari, D., Hollinshead, M., Roffman, J. L., Smoller, J. W., Zöllei, L., Polimeni, J. R., et al. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00338.2011 · Cited by 9,182 · see citing works
The organization of the human cerebellum estimated by intrinsic functional connectivity
Buckner, R. L., Krienen, F. M., Castellanos, A., Diaz, J. C., & Yeo, B. T. T. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00339.2011 · Cited by 7,304 · see citing works
Large-scale brain networks and psychopathology: a unifying triple network model
Menon, V. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.08.003 · Cited by 4,168 · see citing works
Functional Network Organization of the Human Brain
Power, J. D., Cohen, A. L., Nelson, S. M., Wig, G. S., Barnes, K. A., Church, J. A., Vogel, A. C., Laumann, T. O., Miezin, F. M., Schlaggar, B. L., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.006 · Cited by 4,124 · see citing works
Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works
Functional-anatomic fractionation of the brain’s default network
Andrews-Hanna, J. R., Reidler, J. S., Sepulcre, J., Poulin, R., & Buckner, R. L. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.005 · Cited by 2,767 · see citing works
The Neurocircuitry of Fear, Stress, and Anxiety Disorders
Shin, L. M., & Liberzon, I. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.83 · Cited by 2,083 · see citing works
Functional organization of the hippocampal longitudinal axis
Strange, B. A., Witter, M. P., Lein, E. S., & Moser, E. I. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3785 · Cited by 1,738 · see citing works
Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma
Gilbertson, M. W., Shenton, M. E., Ciszewski, A., Kasai, K., Lasko, N. B., Orr, S. P., & Pitman, R. K. (2002) · Nature Neuroscience · doi:10.1038/nn958 · Cited by 1,635 · see citing works
Biological studies of post-traumatic stress disorder
Pitman, R. K., Rasmusson, A. M., Koenen, K. C., Shin, L. M., Orr, S. P., Gilbertson, M. W., Milad, M. R., & Liberzon, I. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3339 · Cited by 1,529 · see citing works
Neurocircuitry Models of Posttraumatic Stress Disorder and Extinction: Human Neuroimaging Research—Past, Present, and Future
Rauch, S. L., Shin, L. M., & Phelps, E. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.004 · Cited by 1,397 · see citing works
Emotion Modulation in PTSD: Clinical and Neurobiological Evidence for a Dissociative Subtype
Lanius, R. A., Vermetten, E., Loewenstein, R. J., Brand, B., Schmahl, C., Bremner, J. D., & Spiegel, D. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09081168 · Cited by 1,123 · see citing works
The prevalence of posttraumatic stress disorder in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans: A meta-analysis
Fulton, J. J., Calhoun, P. S., Wagner, H. R., Schry, A. R., Hair, L. P., Feeling, N. R., Elbogen, E. B., & Beckham, J. C. (2015) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2015.02.003 · Cited by 694 · see citing works
Neurocircuitry models of posttraumatic stress disorder and beyond: A meta-analysis of functional neuroimaging studies
Patel, R., Spreng, R. N., Shin, L. M., & Girard, T. A. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.06.003 · Cited by 546 · see citing works
Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder
Vermetten, E., Vythilingam, M., Southwick, S. M., Charney, D. S., & Bremner, J. D. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00634-6 · Cited by 487 · see citing works
Quantitative meta-analysis of neural activity in posttraumatic stress disorder
Hayes, J. P., Hayes, S. M., & Mikedis, A. M. (2012) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-2-9 · Cited by 452 · see citing works
Alterations in default network connectivity in posttraumatic stress disorder related to early-life trauma
Bluhm, R. L., Williamson, P. C., Osuch, E. A., Frewen, P. A., Stevens, T. K., Boksman, K., Neufeld, R. W. J., Théberge, J., & Lanius, R. A. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0925 · Cited by 422 · see citing works
Neural Dysregulation in Posttraumatic Stress Disorder: Evidence for Disrupted Equilibrium Between Salience and Default Mode Brain Networks
Sripada, R. K., King, A. P., Welsh, R. C., Garfinkel, S. N., Wang, X., Sripada, C. S., & Liberzon, I. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318273bf33 · Cited by 412 · see citing works
Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: a meta-analysis of structural MRI studies
Smith, M. E. (2005) · Hippocampus · doi:10.1002/hipo.20102 · Cited by 395 · see citing works
A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder
O'Doherty, D. C. M., Chitty, K. M., Saddiqui, S., Bennett, M. R., & Lagopoulos, J. (2015) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2015.01.002 · Cited by 375 · see citing works
Evidence for Acquired Pregenual Anterior Cingulate Gray Matter Loss from a Twin Study of Combat-Related Posttraumatic Stress Disorder
Kasai, K., Yamasue, H., Gilbertson, M. W., Shenton, M. E., Rauch, S. L., & Pitman, R. K. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.022 · Cited by 366 · see citing works
ABERRANT RESTING-STATE BRAIN ACTIVITY IN POSTTRAUMATIC STRESS DISORDER: A META-ANALYSIS AND SYSTEMATIC REVIEW: Theoretical Review: Brain Activity in PTSD during Rest
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Depression and Anxiety · doi:10.1002/da.22478 · Cited by 334 · see citing works
Magnetic Resonance Imaging of Hippocampal Subfields in Posttraumatic Stress Disorder
Wang, Z., Neylan, T. C., Mueller, S. G., Lenoci, M., Truran, D., Marmar, C. R., Weiner, M. W., & Schuff, N. W. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.205 · Cited by 300 · see citing works
Amygdala Volume Changes in Posttraumatic Stress Disorder in a Large Case-Controlled Veterans Group
Morey, R. A., Gold, A. L., LaBar, K. S., Beall, S. K., Brown, V. M., Haswell, C. C., Nasser, J. D., Wagner, H. R., McCarthy, G., & Mid-Atlantic MIRECC Workgroup, F. T. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.50 · Cited by 289 · see citing works
A causal model of post-traumatic stress disorder: disentangling predisposed from acquired neural abnormalities
Admon, R., Milad, M. R., & Hendler, T. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.05.005 · Cited by 269 · see citing works
Altered Resting-State Functional Connectivity of Basolateral and Centromedial Amygdala Complexes in Posttraumatic Stress Disorder
Brown, V. M., LaBar, K., Haswell, C., Gold, A. L., McCarthy, G., & Morey, R. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.197 · Cited by 263 · see citing works
Trauma, PTSD, and the Developing Brain
Herringa, R. J. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0825-3 · Cited by 248 · see citing works
Functional organization of the human anterior insular cortex
Mutschler, I., Wieckhorst, B., Kowalevski, S., Derix, J., Wentlandt, J., Schulze‐Bonhage, A., & Ball, T. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.03.101 · Cited by 238 · see citing works
Altered amygdala resting-state functional connectivity in post-traumatic stress disorder
Rabinak, C. A., Angstadt, M., Welsh, R. C., Kenndy, A. E., Lyubkin, M., Martis, B., & Phan, K. L. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00062 · Cited by 230 · see citing works
Altered default mode network (DMN) resting state functional connectivity following a mindfulness-based exposure therapy for posttraumatic stress disorder (PTSD) in combat veterans of Afghanistan and Iraq
King, A. P., Block, S. R., Sripada, R. K., Rauch, S., Giardino, N., Favorite, T., Angstadt, M., Kessler, D., Welsh, R., & Liberzon, I. (2016) · Depression and Anxiety · doi:10.1002/da.22481 · Cited by 225 · see citing works
Hippocampal network connectivity and activation differentiates post-traumatic stress disorder from generalized anxiety disorder
Chen, A. C., & Etkin, A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.122 · Cited by 212 · see citing works
Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies
Averill, L. A., Purohit, P., Averill, C. L., Boesl, M. A., Krystal, J. H., & Abdallah, C. G. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.11.064 · Cited by 184 · see citing works
Self-citation
The dissociative subtype of posttraumatic stress disorder: unique resting-state functional connectivity of basolateral and centromedial amygdala complexes.
Nicholson, A. A., Densmore, M., Frewen, P. A., Théberge, J., Neufeld, R. W., McKinnon, M. C., & Lanius, R. A. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.79 · Cited by 180 · see citing works
Hippocampal Volume in Adult Burn Patients With and Without Posttraumatic Stress Disorder
Winter, H., & Irle, E. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.12.2194 · Cited by 166 · see citing works
Thinner prefrontal cortex in veterans with posttraumatic stress disorder
Geuze, E., Westenberg, H. G. M., Heinecke, A., de Kloet, C. S., Goebel, R., & Vermetten, E. H. G. J. M. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.007 · Cited by 161 · see citing works
The Neurobiological Role of the Dorsolateral Prefrontal Cortex in Recovery From Trauma
Lyoo, I. K., Kim, J. E., Yoon, S. J., Hwang, J., Bae, S., & Kim, D. J. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.70 · Cited by 156 · see citing works
Topographical projection from the hippocampal formation to the amygdala: A combined anterograde and retrograde tracing study in the rat
Kishi, T., Tsumori, T., Yokota, S., & Yasui, Y. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20919 · Cited by 150 · see citing works
Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic
Krystal, J. H., Abdallah, C. G., Averill, L. A., Kelmendi, B., Harpaz-Rotem, I., Sanacora, G., Southwick, S. M., & Duman, R. S. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0829-z · Cited by 145 · see citing works
Self-citation
Association Among Clinical Response, Hippocampal Volume, and FKBP5 Gene Expression in Individuals with Posttraumatic Stress Disorder Receiving Cognitive Behavioral Therapy
Levy‐Gigi, E., Szabó, C. A., Kelemen, O., & Kéri, S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.017 · Cited by 143 · see citing works
Smaller amygdala volume and reduced anterior cingulate gray matter density associated with history of post-traumatic stress disorder
Rogers, M. A., Yamasue, H., Abe, O., Yamada, H., Ohtani, T., Iwanami, A., Aoki, S., Kato, N., & Kasai, K. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2009.06.001 · Cited by 138 · see citing works
Rostral anterior cingulate volume predicts treatment response to cognitive-behavioural therapy for posttraumatic stress disorder
Bryant, R. A., Felmingham, K. L., Whitford, T. J., Kemp, A. H., Hughes, G., Peduto, A. S., & Williams, L. M. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0816 · Cited by 138 · see citing works
Stress‐induced reduction in hippocampal volume and connectivity with the ventromedial prefrontal cortex are related to maladaptive responses to stressful military service
Admon, R., Leykin, D., Lubin, G., Engert, V., Andrews, J., Pruessner, J., & Hendler, T. (2013) · Human Brain Mapping · doi:10.1002/hbm.22100 · Cited by 138 · see citing works
Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction
Meabon, J. S., Huber, B. R., Cross, D. J., Richards, T. L., Minoshima, S., Pagulayan, K. F., Li, G., Meeker, K. D., Kraemer, B. C., Petrie, E. C., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa9585 · Cited by 138 · see citing works
Hypotheses and controversies related to effects of stress on the hippocampus: An argument for stress‐induced damage to the hippocampus in patients with posttraumatic stress disorder
Bremner, J. D. (2001) · Hippocampus · doi:10.1002/hipo.1023 · Cited by 137 · see citing works
Altered resting-state functional activity in posttraumatic stress disorder: A quantitative meta-analysis
Wang, T., Liu, J., Zhang, J., Zhan, W., Li, L., Wu, M. C., Huang, H., Zhu, H., Kemp, G. J., & Gong, Q. (2016) · Scientific Reports · doi:10.1038/srep27131 · Cited by 137 · see citing works
Amygdala Volume in Combat-Exposed Veterans With and Without Posttraumatic Stress Disorder: A Cross-sectional Study
Kuo, J. R., Kaloupek, D. G., & Woodward, S. H. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.73 · Cited by 136 · see citing works
White Matter Integrity in Highly Traumatized Adults With and Without Post-Traumatic Stress Disorder
Fani, N., King, T. Z., Jovanovic, T., Glover, E. M., Bradley, B., Choi, K., Ely, T., Gutman, D. A., & Ressler, K. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.146 · Cited by 135 · see citing works
Gray matter density in limbic and paralimbic cortices is associated with trauma load and EMDR outcome in PTSD patients
Nardo, D., Högberg, G., Looi, J. C., Larsson, S., Hällström, T., & Pagani, M. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.10.014 · Cited by 135 · see citing works
Untitled work
Nakao (2005) · doi:10.1016/j.pscychresns.2005.04.003 · Cited by 132 · see citing works
Grey matter reduction associated with posttraumatic stress disorder and traumatic stress
Li, L., Wu, M. C., Liao, Y., Ouyang, L., Du, M., Lei, D., Chen, L., Yao, L., Huang, X., & Gong, Q. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.04.003 · Cited by 128 · see citing works
Reduced white matter integrity in the cingulum and anterior corona radiata in posttraumatic stress disorder in male combat veterans: a diffusion tensor imaging study
Sanjuan, P. M., Thoma, R., Claus, E. D., Mays, N., & Caprihan, A. (2013) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2013.09.002 · Cited by 125 · see citing works
Neural processing correlates of assaultive violence exposure and PTSD symptoms during implicit threat processing: A network-level analysis among adolescent girls
Cisler, J. M., Scott Steele, J., Smitherman, S., Lenow, J. K., & Kilts, C. D. (2013) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2013.06.003 · Cited by 107 · see citing works
Default mode network subsystems are differentially disrupted in posttraumatic stress disorder
Miller, D. R., Hayes, S. M., Hayes, J. P., Spielberg, J. M., Lafleche, G., & Verfaellie, M. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.12.006 · Cited by 101 · see citing works
Smaller global and regional cortical volume in combat-related posttraumatic stress disorder.
Woodward, S., Schaer, M., Kaloupek, D., Cediel, L., & Eliez, S. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.160 · Cited by 100 · see citing works
Interactions Among the Brain Default-Mode, Salience, and Central-Executive Networks During Perceptual Decision-Making of Moving Dots
Chand, G. B., & Dhamala, M. (2015) · Brain Connectivity · doi:10.1089/brain.2015.0379 · Cited by 96 · see citing works
Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD
Wrocklage, K. M., Averill, L. A., Scott, J. C., Averill, C. L., Schweinsburg, B. C., Trejo, M., Roy, A. M., Weisser, V. D., Kelly, C., Martini, B. L., et al. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.02.010 · Cited by 94 · see citing works
Self-citation
Preclinical and Clinical Evidence of DNA Methylation Changes in Response to Trauma and Chronic Stress
Matosin, N., Cruceanu, C., & Binder, E. B. (2017) · Chronic Stress · doi:10.1177/2470547017710764 · Cited by 84 · see citing works
Brain Structural Abnormalities and Mental Health Sequelae in South Vietnamese Ex–Political Detainees Who Survived Traumatic Head Injury and Torture
Mollica, R. F., Lyoo, I. K., Chernoff, M. C., Bui, H. X., Lavelle, J., Yoon, S. J., Kim, J. E., & Renshaw, P. F. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.127 · Cited by 83 · see citing works
Greater hippocampal volume is associated with PTSD treatment response
Rubin, M., Shvil, E., Papini, S., Thapa-Chhetry, B., Helpman, L., Markowitz, J. C., Mann, J. J., & Neria, Y. (2016) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2016.05.001 · Cited by 83 · see citing works
STRUCTURAL AND FUNCTIONAL CONNECTIVITY IN POSTTRAUMATIC STRESS DISORDER: ASSOCIATIONS WITH FKBP5: 2015 Donald F Klein Investigator Award Finalist: Connectivity, PTSD, and FKBP5
Fani, N., King, T. Z., Shin, J., Srivastava, A., Brewster, R. C., Jovanovic, T., Bradley, B., & Ressler, K. J. (2016) · Depression and Anxiety · doi:10.1002/da.22483 · Cited by 80 · see citing works
Intrinsic connectivity networks in post-traumatic stress disorder during sub- and supraliminal processing of threat-related stimuli
Rabellino, D., Tursich, M., Frewen, P. A., Daniels, J. K., Densmore, M., Théberge, J., & Lanius, R. A. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12418 · Cited by 78 · see citing works
Default-Mode Network Abnormalities in Pediatric Posttraumatic Stress Disorder
Patriat, R., Birn, R. M., Keding, T. J., & Herringa, R. J. (2016) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2016.01.010 · Cited by 78 · see citing works
Neuronal circuits for fear and anxiety — the missing link
Apps, R., & Strata, P. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4028 · Cited by 75 · see citing works
White Matter Abnormalities in Post-traumatic Stress Disorder Following a Specific Traumatic Event
Li, L., Lei, D., Li, L., Huang, X., Suo, X., Xiao, F., Kuang, W., Li, J., Bi, F., Lui, S., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.01.012 · Cited by 75 · see citing works
Trauma-specific grey matter alterations in PTSD
Meng, L., Jiang, J., Jin, C., Liu, J., Zhao, Y., Wang, W., Li, K., & Gong, Q. (2016) · Scientific Reports · doi:10.1038/srep33748 · Cited by 71 · see citing works
Anterior hippocampal dysconnectivity in posttraumatic stress disorder: a dimensional and multimodal approach
Abdallah, C. G., Wrocklage, K. M., Averill, C. L., Akiki, T. J., Schweinsburg, B. C., Roy, A. M., Martini, B. A., Southwick, S. M., Krystal, J. H., & Scott, J. C. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.12 · Cited by 69 · see citing works
Self-citation
Circuit dysregulation and circuit-based treatments in posttraumatic stress disorder
Sheynin, J., & Liberzon, I. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2016.11.014 · Cited by 68 · see citing works
Cortical Thinning in Patients with Recent Onset Post-Traumatic Stress Disorder after a Single Prolonged Trauma Exposure
Liu, Y., Li, Y., Luo, E., Lu, H., & Yin, H. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039025 · Cited by 66 · see citing works
Neural networks supporting autobiographical memory retrieval in posttraumatic stress disorder
Jacques, P. L. S., Kragel, P. A., & Rubin, D. C. (2013) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-013-0157-7 · Cited by 63 · see citing works
Evidence for disrupted gray matter structural connectivity in posttraumatic stress disorder
Mueller, S. G., Ng, P., Neylan, T., Mackin, S., Wolkowitz, O., Mellon, S., Yan, X., Flory, J., Yehuda, R., Marmar, C. R., et al. (2015) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2015.09.006 · Cited by 61 · see citing works
PTSD REMISSION AFTER PROLONGED EXPOSURE TREATMENT IS ASSOCIATED WITH ANTERIOR CINGULATE CORTEX THINNING AND VOLUME REDUCTION
Helpman, L., Papini, S., Thapa-Chhetry, B., Shvil, E., Rubin, M., Sullivan, G. M., Markowitz, J. C., Mann, J. J., & Neria, Y. (2016) · Depression and Anxiety · doi:10.1002/da.22471 · Cited by 61 · see citing works
The Association of PTSD Symptom Severity With Localized Hippocampus and Amygdala Abnormalities
Akiki, T. J., Averill, C. L., Wrocklage, K. M., Schweinsburg, B., Scott, J. C., Martini, B., Averill, L. A., Southwick, S. M., Krystal, J. H., & Abdallah, C. G. (2017) · Chronic Stress · doi:10.1177/2470547017724069 · Cited by 58 · see citing works
Self-citation
Anterior cingulate cortical thickness is a stable predictor of recovery from post-traumatic stress disorder
Dickie, E. W., Brunet, A., Akerib, V., & Armony, J. L. (2012) · Psychological Medicine · doi:10.1017/s0033291712001328 · Cited by 52 · see citing works
Resting-state functional connectivity of anterior and posterior hippocampus in posttraumatic stress disorder
Lazarov, A., Zhu, X., Suarez‐Jimenez, B., Rutherford, B. R., & Neria, Y. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.06.003 · Cited by 47 · see citing works
Alterations in White Matter Microstructure as Vulnerability Factors and Acquired Signs of Traffic Accident-Induced PTSD
Sun, Y., Wang, Z., Ding, W., Wan, J., Zhuang, Z., Zhang, Y., Liu, Y., Zhou, Y., & Xu, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083473 · Cited by 36 · see citing works
Imaging in posttraumatic stress disorder
Robinson, B. L., & Shergill, S. S. (2010) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283413519 · Cited by 36 · see citing works
Neurobiology of posttraumatic stress disorder (PTSD): A path from novel pathophysiology to innovative therapeutics
Abdallah, C. G., Southwick, S. M., & Krystal, J. H. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.04.046 · Cited by 35 · see citing works
Self-citation
Amygdala-Hippocampal Volume and the Phenotypic Heterogeneity of Posttraumatic Stress Disorder
Pietrzak, R. H., Averill, L. A., Abdallah, C. G., Neumeister, A., Krystal, J. H., Levy, I., & Harpaz‐Rotem, I. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2470 · Cited by 32 · see citing works
Self-citation
The predictive value of dorsal cingulate activity and fractional anisotropy on long-term PTSD symptom severity
Kennis, M., van Rooij, S. J. H., Reijnen, A., & Geuze, E. (2017) · Depression and Anxiety · doi:10.1002/da.22605 · Cited by 25 · see citing works
Right temporal cortical hypertrophy in resilience to trauma: an MRI study
Nilsen, A. S., Hilland, E., Kogstad, N., Heir, T., Hauff, E., Lien, L., & Endestad, T. (2016) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v7.31314 · Cited by 22 · see citing works
581. The Default Mode Network in Posttraumatic Stress Disorder (PTSD): A Data-Driven Multimodal Approach
Akiki, T. J., Averill, C. L., Wrocklage, K. M., Scott, J. C., Alexander‐Bloch, A. F., Southwick, S. M., Krystal, J. H., & Abdallah, C. G. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.451 · Cited by 3 · see citing works
Self-citation

Flagged first, then by citations

Research works printed but not linked: 1

[51]Helpman L Papini S Chhetry BT Shvil E Rubin M Sullivan GM PTSD REMISSION AFTER PROLONGED EXPOSURE TREATMENT IS ASSOCIATED WITH ANTERIOR CINGULATE CORTEX THINNING AND VOLUME REDUCTION Depression and Anxiety 2016 33 5 384 91 10.1002/da.22471. 26864570 PMC4846556 · DOI

Sorted by citations

Lower synaptic density is associated with depression severity and network alterations
Holmes, S. E., Scheinost, D., Finnema, S. J., Naganawa, M., Davis, M. T., DellaGioia, N., Nabulsi, N., Matuskey, D., Angarita, G. A., Pietrzak, R. H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09562-7 · Cited by 484 · see citing works
The role of the salience network in cognitive and affective deficits
Schimmelpfennig, J., Topczewski, J., Zajkowski, W. K., & Jankowiak-Siuda, K. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1133367 · Cited by 347 · see citing works
The Biology of Human Resilience: Opportunities for Enhancing Resilience Across the Life Span
Feder, A., Fred-Torres, S., Southwick, S. M., & Charney, D. S. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.012 · Cited by 269 · see citing works
Trauma, PTSD, and the Developing Brain
Herringa, R. J. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0825-3 · Cited by 248 · see citing works
Synaptic plasticity and mental health: methods, challenges and opportunities
Appelbaum, L. G., Shenasa, M. A., Stolz, L., & Daskalakis, Z. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01370-w · Cited by 240 · see citing works
Effects of repetitive transcranial magnetic stimulation on resting-state connectivity: A systematic review
Beynel, L., Powers, J., & Appelbaum, L. G. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116596 · Cited by 230 · see citing works
Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review
Burback, L., Brémault‐Phillips, S., Nijdam, M. J., McFARLANE, A. C., & Vermetten, E. H. G. J. M. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230428091433 · Cited by 232 · see citing works
Default mode network abnormalities in posttraumatic stress disorder: A novel network-restricted topology approach
Akiki, T. J., Averill, C. L., Wrocklage, K. M., Scott, J. C., Averill, L. A., Schweinsburg, B., Alexander-Bloch, A., Martini, B., Southwick, S. M., Krystal, J. H., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.05.005 · Cited by 188 · see citing works
Self-citation
Theta-Burst Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder
Philip, N. S., Barredo, J., Aiken, E., Larson, V., Jones, R. N., Shea, M. T., Greenberg, B. D., & van ’t Wout-Frank, M. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.18101160 · Cited by 183 · see citing works
Moral injury and PTSD: Often co-occurring yet mechanistically different
Barnes, H. A., Hurley, R. A., & Taber, K. H. (2019) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.19020036 · Cited by 172 · see citing works
The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder
Abdallah, C. G., Averill, L. A., Akiki, T. J., Raza, M., Averill, C. L., Gomaa, H., Adikey, A., & Krystal, J. H. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021701 · Cited by 171 · see citing works
Self-citation
The sense of self in the aftermath of trauma: lessons from the default mode network in posttraumatic stress disorder
Lanius, R. A., Terpou, B. A., & McKinnon, M. C. (2020) · European Journal of Psychotraumatology · doi:10.1080/20008198.2020.1807703 · Cited by 164 · see citing works
The brain-body disconnect: A somatic sensory basis for trauma-related disorders
Kearney, B. E., & Lanius, R. A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1015749 · Cited by 154 · see citing works
Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia
Pinto, A. M., Geenen, R., Wager, T. D., Lumley, M. A., Häuser, W., Kosek, E., Ablin, J. N., Amris, K., Branco, J., Buskila, D., et al. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00873-6 · Cited by 153 · see citing works
The Role of Attachment Trauma and Disintegrative Pathogenic Processes in the Traumatic-Dissociative Dimension
Farina, B., Liotti, M., & Imperatori, C. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00933 · Cited by 111 · see citing works
Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder
Etkin, A., Maron-Katz, A., Wu, W., Fonzo, G. A., Huemer, J., Vértes, P. E., Patenaude, B., Richiardi, J., Goodkind, M. S., Keller, C. J., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aal3236 · Cited by 103 · see citing works
Determining the Hierarchical Architecture of the Human Brain Using Subject-Level Clustering of Functional Networks
Akiki, T. J., & Abdallah, C. G. (2019) · Scientific Reports · doi:10.1038/s41598-019-55738-y · Cited by 91 · see citing works
Self-citation
Classifying heterogeneous presentations of PTSD via the default mode, central executive, and salience networks with machine learning
Nicholson, A. A., Harricharan, S., Densmore, M., Neufeld, R. W. J., Ros, T., McKinnon, M. C., Frewen, P., Théberge, J., Jetly, R., Pedlar, D., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102262 · Cited by 91 · see citing works
Transcranial stimulation of alpha oscillations up-regulates the default mode network
Clancy, K. J., Andrzejewski, J. A., You, Y., Rosenberg, J. T., Ding, M., & Li, W. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2110868119 · Cited by 81 · see citing works
Imaging the effect of ketamine on synaptic density (SV2A) in the living brain
Holmes, S. E., Finnema, S. J., Naganawa, M., DellaGioia, N., Holden, D., Fowles, K., Davis, M., Ropchan, J., Emory, P., Ye, Y., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01465-2 · Cited by 78 · see citing works
“For example, magnetic resonance imaging (MRI) studies demonstrate lower grey matter volume and disrupted functional connectivity in prefrontal cortical (PFC) and limbic regions in both MDD [17, 18] and PTSD [19, 20], and post-mortem work indicates a lower number of synapses in the dorsolateral PFC (dlPFC) of depressed…”
Background
The Psychedelic Future of Post-Traumatic Stress Disorder Treatment
Zaretsky, T. G., Jagodnik, K. M., Barsic, R., Antonio, J. H., Bonanno, P. A., MacLeod, C., Pierce, C., Carney, H., Morrison, M. T., Saylor, C. F., et al. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666231027111147 · Cited by 85 · see citing works
A review of hippocampal activation in post‐traumatic stress disorder
Joshi, S. A., Duval, E. R., Kubat, B., & Liberzon, I. (2019) · Psychophysiology · doi:10.1111/psyp.13357 · Cited by 80 · see citing works
An Electroencephalography Connectomic Profile of Posttraumatic Stress Disorder
Toll, R. T., Wu, W., Naparstek, S., Zhang, Y., Narayan, M., Patenaude, B., Angeles, C. D. L., Sarhadi, K. J., Anicetti, N., Longwell, P., et al. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.18080911 · Cited by 74 · see citing works
Translating the neuroscience of adverse childhood experiences to inform policy and foster population-level resilience.
Weems, C. F., Russell, J. D., Herringa, R. J., & Carrión, V. G. (2021) · American Psychologist · doi:10.1037/amp0000780 · Cited by 73 · see citing works
Adverse Life Experiences and Brain Function
Hosseini‐Kamkar, N., Farahani, M. V., Nikolic, M., Stewart, K., Goldsmith, S. F., Soltaninejad, M., Rajabli, R., Lowe, C. J., Nicholson, A. A., Morton, J. B., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.40018 · Cited by 72 · see citing works
Ketamine, but Not the NMDAR Antagonist Lanicemine, Increases Prefrontal Global Connectivity in Depressed Patients
Abdallah, C. G., Dutta, A., Averill, C. L., McKie, S., Akiki, T. J., Averill, L. A., & William Deakin, J. F. (2018) · Chronic Stress · doi:10.1177/2470547018796102 · Cited by 70 · see citing works
Self-citation
Diverse therapeutic developments for post-traumatic stress disorder (PTSD) indicate common mechanisms of memory modulation
Raut, S. B., Marathe, P. A., van Eijk, L., Eri, R. D., Ravindran, M., Benedek, D. M., Ursano, R. J., Canales, J. J., & Johnson, L. R. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108195 · Cited by 71 · see citing works
A randomized, controlled trial of alpha-rhythm EEG neurofeedback in posttraumatic stress disorder: A preliminary investigation showing evidence of decreased PTSD symptoms and restored default mode and salience network connectivity using fMRI
Nicholson, A. A., Ros, T., Densmore, M., Frewen, P., Neufeld, R. W. J., Théberge, J., Jetly, R., & Lanius, R. A. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102490 · Cited by 72 · see citing works
Altered large-scale functional brain organization in posttraumatic stress disorder: A comprehensive review of univariate and network-level neurocircuitry models of PTSD
Ross, M. C., & Cisler, J. M. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102319 · Cited by 68 · see citing works
Prognostic neuroimaging biomarkers of trauma-related psychopathology: resting-state fMRI shortly after trauma predicts future PTSD and depression symptoms in the AURORA study
Harnett, N. G., van Rooij, S. J. H., Ely, T. D., Lebois, L. A. M., Murty, V. P., Jovanović, T., Hill, S. B., Dumornay, N. M., Merker, J. B., Bruce, S. E., et al. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-00946-8 · Cited by 67 · see citing works
Stress Response Modulation Underlying the Psychobiology of Resilience
Averill, L., Averill, C. L., Kelmendi, B., Abdallah, C., & Southwick, S. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0887-x · Cited by 49 · see citing works
Self-citation
Intrinsic connectivity network dynamics in PTSD during amygdala downregulation using real‐time fMRI neurofeedback: A preliminary analysis
Nicholson, A. A., Rabellino, D., Densmore, M., Frewen, P., Paret, C., Kluetsch, R. C., Schmahl, C. G., Théberge, J., Ros, T., Neufeld, R. W. J., et al. (2018) · Human Brain Mapping · doi:10.1002/hbm.24244 · Cited by 59 · see citing works
Are There Effective Psychopharmacologic Treatments for PTSD?
Akiki, T. J., & Abdallah, C. G. (2018) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.18ac12473 · Cited by 61 · see citing works
Self-citation
Annual Research Review: Pediatric posttraumatic stress disorder from a neurodevelopmental network perspective
Weems, C. F., Russell, J. D., Neill, E. L., & McCurdy, B. H. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12996 · Cited by 58 · see citing works
Changes in functional connectivity following treatment with emotion regulation therapy
Scult, M. A., Fresco, D. M., Gunning, F. M., Liston, C., Seeley, S. H., García, E., & Mennin, D. S. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00010 · Cited by 57 · see citing works
Psilocybin for Trauma-Related Disorders
Khan, A. J., Bradley, E., O’Donovan, A., & Woolley, J. (2022) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2022_366 · Cited by 55 · see citing works
Non-invasive vagal nerve stimulation decreases brain activity during trauma scripts
Wittbrodt, M. T., Gurel, N. Z., Nye, J. A., Ladd, S. L., Shandhi, M. M. H., Huang, M., Shah, A. J., Pearce, B. D., Alam, Z. S., Rapaport, M. H., et al. (2020) · Brain stimulation · doi:10.1016/j.brs.2020.07.002 · Cited by 55 · see citing works
Neural patterns differentiate traumatic from sad autobiographical memories in PTSD
Perl, O., Duek, O. A., Kulkarni, K. R., Kelmendi, B., Amen, S. L., Gordon, C., Krystal, J. H., Levy, I., Harpaz‐Rotem, I., & Schiller, D. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01483-5 · Cited by 54 · see citing works
A systematic review of the neural correlates of sexual minority stress: towards an intersectional minority mosaic framework with implications for a future research agenda
Nicholson, A. A., Siegel, M., Wolf, J., Narikuzhy, S., Roth, S. L., Hatchard, T., Lanius, R. A., Schneider, M. A., Lloyd, C., McKinnon, M. C., et al. (2022) · European Journal of Psychotraumatology · doi:10.1080/20008198.2021.2002572 · Cited by 51 · see citing works
White matter microstructural alterations in posttraumatic stress disorder: An ROI and whole-brain based meta-analysis
Ju, Y., Ou, W., Su, J., Averill, C. L., Liu, J., Wang, M., Wang, Z., Zhang, Y., Liu, B., Li, L., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.047 · Cited by 51 · see citing works
Self-citation
Rt-fMRI neurofeedback-guided cognitive reappraisal training modulates amygdala responsivity in posttraumatic stress disorder
Zweerings, J., Sarkheil, P., Keller, M., Dyck, M., Klasen, M., Becker, B., Gaebler, A. J., Ibrahim, C. N., Turetsky, B. I., Zvyagintsev, M., et al. (2020) · NeuroImage: Clinical · doi:10.1016/j.nicl.2020.102483 · Cited by 45 · see citing works
“83 At the neurobiological level, studies indicate that exposure to a traumatic event is 84 associated with substantial structural and functional changes in core regions of circuits 85 mediating emotional reactivity and regulatory control (Akiki et al., 2017).”
BackgroundInfluential
Posttraumatic Stress Disorder Is Associated with α Dysrhythmia across the Visual Cortex and the Default Mode Network
Clancy, K. J., Andrzejewski, J. A., Simon, J., Ding, M., Schmidt, N. B., & Li, W. (2020) · eNeuro · doi:10.1523/eneuro.0053-20.2020 · Cited by 52 · see citing works
Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field
Hinojosa, C. A., George, G. C., & Ben‐Zion, Z. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02558-w · Cited by 60 · see citing works
Review of otential sychedelic reatments for PTSD
Henner, R. L., Keshavan, M. S., & Hill, K. P. (2022) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2022.120302 · Cited by 49 · see citing works
Racial Discrimination and Resting-State Functional Connectivity of Salience Network Nodes in Trauma-Exposed Black Adults in the United States
Webb, E. K., Bird, C. M., deRoon‐Cassini, T. A., Tomas, C. W., Huggins, A. A., Fitzgerald, J. M., Miskovich, T. A., Bennett, K. P., Krukowski, J. L., Torres, L., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.44759 · Cited by 49 · see citing works
Elevated Tau in Military Personnel Relates to Chronic Symptoms Following Traumatic Brain Injury
Pattinson, C. L., Shahim, P., Taylor, P., Dunbar, K. E., Guedes, V. A., Motamedi, V., Lai, C., Devoto, C., Peyer, J., Roy, M. J., et al. (2019) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000485 · Cited by 48 · see citing works
The cerebellum and psychological trauma: A systematic review of neuroimaging studies
Blithikioti, C., Nuño, L., Guell, X., Pascual‐Diaz, S., Gual, A., Balcells‐Oliveró, M., & Miquel, L. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100429 · Cited by 49 · see citing works
Acute-stress-induced change in salience network coupling prospectively predicts post-trauma symptom development
Zhang, W., Kaldewaij, R., Hashemi, M. M., Koch, S. B. J., Smit, A. S., van Ast, V. A., Beckmann, C. F., Klumpers, F., & Roelofs, K. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01798-0 · Cited by 47 · see citing works
Posterior cingulate cortex targeted real‐time fMRI neurofeedback recalibrates functional connectivity with the amygdala, posterior insula, and default‐mode network in PTSD
Lieberman, J. M., Rabellino, D., Densmore, M., Frewen, P., Steyrl, D., Scharnowski, F., Théberge, J., Neufeld, R. W. J., Schmahl, C. G., Jetly, R., et al. (2023) · Brain and Behavior · doi:10.1002/brb3.2883 · Cited by 46 · see citing works
Mapping PTSD symptoms to brain networks: a machine learning study
Zandvakili, A., Barredo, J., Swearingen, H. R., Aiken, E., Berlow, Y. A., Greenberg, B. D., Carpenter, L. L., & Philip, N. S. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00879-2 · Cited by 46 · see citing works
Multi-domain potential biomarkers for post-traumatic stress disorder (PTSD) severity in recent trauma survivors
Ben‐Zion, Z., Zeevi, Y., Keynan, J. N., Admon, R., Kozlovski, T., Sharon, H., Halpern, P., Liberzon, I., Shalev, A. Y., Benjamini, Y., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00898-z · Cited by 46 · see citing works
One-year clinical outcomes following theta burst stimulation for post-traumatic stress disorder
Petrosino, N. J., Wout‐Frank, M. V. ‘., Aiken, E., Swearingen, H. R., Barredo, J., Zandvakili, A., & Philip, N. S. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0584-4 · Cited by 45 · see citing works
Homeostatic normalization of alpha brain rhythms within the default-mode network and reduced symptoms in post-traumatic stress disorder following a randomized controlled trial of electroencephalogram neurofeedback
Nicholson, A. A., Densmore, M., Frewen, P., Neufeld, R. W. J., Théberge, J., Jetly, R., Lanius, R. A., & Ros, T. (2023) · Brain Communications · doi:10.1093/braincomms/fcad068 · Cited by 42 · see citing works
Amygdala downregulation training using fMRI neurofeedback in post-traumatic stress disorder: a randomized, double-blind trial
Zhao, Z., Duek, O. A., Seidemann, R., Gordon, C., Walsh, C. J., Romaker, E. K., Koller, W. N., Horváth, M., Awasthi, J., Wang, Y., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02467-6 · Cited by 42 · see citing works
Alterations in brain network connectivity and subjective experience induced by psychedelics: a scoping review
Yu, Z., Burback, L., Winkler, O., Xu, L., Dennett, L., Vermetten, E. H. G. J. M., Greenshaw, A. J., Li, X., Milne, M., Wang, F., et al. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1386321 · Cited by 42 · see citing works
Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment
Abdallah, C. G., Averill, C. L., Ramage, A. E., Averill, L. A., Alkin, E., Nemati, S., Krystal, J. H., Roache, J. D., Resick, P. A., Young‐McCaughan, S., et al. (2019) · Chronic Stress · doi:10.1177/2470547019838971 · Cited by 40 · see citing works
Self-citation
Transdiagnostic alterations in neural emotion regulation circuits – neural substrates of cognitive reappraisal in patients with depression and post-traumatic stress disorder
Keller, M., Mendoza-Quiñones, R., Muñoz, A. C., Iglesias-Fuster, J., Virués, A. V., Zvyagintsev, M., Edgar, J., Zweerings, J., & Mathiak, K. (2021) · BMC Psychiatry · doi:10.1186/s12888-022-03780-y · Cited by 36 · see citing works
Increased functional segregation of brain network associated with symptomatology and sustained attention in chronic post-traumatic stress disorder
Zhu, H., Li, Y., Yuan, M., Ren, Z., Yuan, C., Meng, Y., Wang, J., Deng, W., Qiu, C., Huang, X., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.01.012 · Cited by 37 · see citing works
Salience Network Disruption in U.S. Army Soldiers With Posttraumatic Stress Disorder
Abdallah, C. G., Averill, C. L., Ramage, A. E., Averill, L. A., Goktas, S., Nemati, S., Krystal, J. H., Roache, J. D., Resick, P. A., Young‐McCaughan, S., et al. (2019) · Chronic Stress · doi:10.1177/2470547019850467 · Cited by 36 · see citing works
Self-citation
WONOEP APPRAISAL: The many facets of epilepsy networks
Scott, R. C., de la Prida, L. M., Mahoney, J. M., Kobow, K., Sankar, R., & de Curtis, M. (2018) · Epilepsia · doi:10.1111/epi.14503 · Cited by 37 · see citing works
A neurobehavioral account for decentering as the salve for the distressed mind
King, A. P., & Fresco, D. M. (2019) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2019.02.009 · Cited by 36 · see citing works
Evaluating the evidence for a neuroimaging subtype of posttraumatic stress disorder
Esterman, M. S., Stumps, A. D., Jagger-Rickels, A. C., Rothlein, D., Degutis, J. M., Fortenbaugh, F. C., Romer, A. L., Milberg, W., Marx, B. P., & McGlinchey, R. E. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz9343 · Cited by 35 · see citing works
Shame on the brain: Neural correlates of moral injury event recall in posttraumatic stress disorder
Lloyd, C. S., Nicholson, A. A., Densmore, M., Théberge, J., Neufeld, R. W. J., Jetly, R., McKinnon, M. C., & Lanius, R. A. (2021) · Depression and Anxiety · doi:10.1002/da.23128 · Cited by 35 · see citing works
Psychological resilience mediates the protective role of default-mode network functional connectivity against COVID-19 vicarious traumatization
Liu, X., Zhao, Y., Suo, X., Zhang, X., Pan, N., Kemp, G. J., Gong, Q., & Wang, S. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02525-z · Cited by 35 · see citing works
Multivariate classification of earthquake survivors with post‐traumatic stress disorder based on large‐scale brain networks
Zhu, H., Yuan, M., Qiu, C., Ren, Z., Li, Y., Wang, J., Huang, X., Lui, S., Gong, Q., Zhang, W., et al. (2020) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13150 · Cited by 34 · see citing works
Associations of perceived adverse lifetime experiences with brain structure in UK Biobank participants
Gheorghe, D. A., Li, C., Gallacher, J., & Bauermeister, S. (2021) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13298 · Cited by 34 · see citing works
Altered resting-state functional connectivity of the default mode and central executive networks following cognitive processing therapy for PTSD
Vuper, T. C., Philippi, C. L., & Bruce, S. E. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113312 · Cited by 33 · see citing works
Differential mechanisms of posterior cingulate cortex downregulation and symptom decreases in posttraumatic stress disorder and healthy individuals using real‐time fMRI neurofeedback
Nicholson, A. A., Rabellino, D., Densmore, M., Frewen, P., Steyrl, D., Scharnowski, F., Théberge, J., Neufeld, R. W. J., Schmahl, C. G., Jetly, R., et al. (2021) · Brain and Behavior · doi:10.1002/brb3.2441 · Cited by 33 · see citing works
Spectral decomposition of EEG microstates in post-traumatic stress disorder
Terpou, B. A., Shaw, S. B., Théberge, J., Férat, V., Michel, C. M., McKinnon, M. C., Lanius, R. A., & Ros, T. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103135 · Cited by 39 · see citing works
How the body remembers: Examining the default mode and sensorimotor networks during moral injury autobiographical memory retrieval in PTSD
Kearney, B. E., Terpou, B. A., Densmore, M., Shaw, S. B., Théberge, J., Jetly, R., McKinnon, M. C., & Lanius, R. A. (2023) · NeuroImage: Clinical · doi:10.1016/j.nicl.2023.103426 · Cited by 33 · see citing works
Conceptualizing traumatic stress and the structure of posttraumatic psychopathology through the lenses of RDoC and HiTOP
Hawn, S. E., Wolf, E. J., Neale, Z. E., & Miller, M. W. (2022) · Clinical Psychology Review · doi:10.1016/j.cpr.2022.102177 · Cited by 31 · see citing works
Efficacy and Safety of Intranasal Esketamine in Patients With Treatment-Resistant Depression and Comorbid Chronic Post-traumatic Stress Disorder: Open-Label Single-Arm Pilot Study
Rothärmel, M., Benosman, C., El‐Hage, W., Berjamin, C., Ribayrol, D., Guillin, O., Raphaël Gaillard, B., Berkovitch, L., & Moulier, V. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.865466 · Cited by 32 · see citing works
Why reliving is not remembering and the unique neurobiological representation of traumatic memory
Kearney, B. E., & Lanius, R. A. (2024) · Nature Mental Health · doi:10.1038/s44220-024-00324-z · Cited by 32 · see citing works
Salience and central executive networks track overgeneralization of conditioned-fear in post-traumatic stress disorder
Berg, H. E., Ma, Y., Rueter, A., Kaczkurkin, A. N., Burton, P. C., DeYoung, C. G., MacDonald, A. W., Sponheim, S. R., & Lissek, S. M. (2020) · Psychological Medicine · doi:10.1017/s0033291720001166 · Cited by 30 · see citing works
Frontal Lobe Circuitry in Posttraumatic Stress Disorder
Selemon, L. D., Young, K. A., Cruz, D. A., & Williamson, D. E. (2019) · Chronic Stress · doi:10.1177/2470547019850166 · Cited by 31 · see citing works
The hijacked self: Disrupted functional connectivity between the periaqueductal gray and the default mode network in posttraumatic stress disorder using dynamic causal modeling
Terpou, B. A., Densmore, M., Théberge, J., Frewen, P., McKinnon, M. C., Nicholson, A. A., & Lanius, R. A. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102345 · Cited by 31 · see citing works
Current and future functional imaging techniques for post-traumatic stress disorder
Prasad, A., Chaichi, A., Kelley, D. P., Francis, J., & Gartia, M. R. (2019) · RSC Advances · doi:10.1039/c9ra03562a · Cited by 32 · see citing works
Increased top-down control of emotions during symptom provocation working memory tasks following a RCT of alpha-down neurofeedback in PTSD
Shaw, S. B., Nicholson, A. A., Ros, T., Harricharan, S., Terpou, B. A., Densmore, M., Théberge, J., Frewen, P., & Lanius, R. A. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103313 · Cited by 33 · see citing works
The functional connectome in posttraumatic stress disorder
Breukelaar, I. A., Bryant, R. A., & Korgaonkar, M. S. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100321 · Cited by 31 · see citing works
“Brain–breath” interactions: respiration-timing–dependent impact on functional brain networks and beyond
Nakamura, N. H., Oku, Y., & Fukunaga, M. (2023) · Reviews in the Neurosciences · doi:10.1515/revneuro-2023-0062 · Cited by 30 · see citing works
Altered Resting-State functional connectivity in the anterior and posterior hippocampus in Post-traumatic stress disorder: The central role of the anterior hippocampus
Chaposhloo, M., Nicholson, A. A., Becker, S., McKinnon, M. C., Lanius, R. A., Shaw, S. B., & Initiative, A. D. N. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103417 · Cited by 26 · see citing works
Large-scale functional hyperconnectivity patterns in trauma-related dissociation: an rs-fMRI study of PTSD and its dissociative subtype
Shaw, S. B., Terpou, B. A., Densmore, M., Théberge, J., Frewen, P., McKinnon, M. C., & Lanius, R. A. (2023) · Nature Mental Health · doi:10.1038/s44220-023-00115-y · Cited by 27 · see citing works
Reduced local segregation of single‐subject gray matter networks in adult PTSD
Niu, R., Lei, D., Chen, F., Chen, Y., Suo, X., Li, L., Lui, S., Huang, X., Sweeney, J. A., & Gong, Q. (2018) · Human Brain Mapping · doi:10.1002/hbm.24330 · Cited by 26 · see citing works
Regulating posttraumatic stress disorder symptoms with neurofeedback: Regaining control of the mind
Nicholson, A. A., Ros, T., Jetly, R., & Lanius, R. A. (2020) · Journal of Military Veteran and Family Health · doi:10.3138/jmvfh.2019-0032 · Cited by 27 · see citing works
A conceptual framework for a neurophysiological basis of art therapy for PTSD
Malhotra, B., Jones, L. C., Spooner, H., Levy, C. E., Kaimal, G., & Williamson, J. B. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2024.1351757 · Cited by 26 · see citing works
Imaging of Posttraumatic Stress Disorder
Kamiya, K., & Abe, O. (2019) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2019.09.010 · Cited by 27 · see citing works
Examination of the association between exposure to childhood maltreatment and brain structure in young adults: a machine learning analysis
Price, M., Albaugh, M. D., Hahn, S., Juliano, A., Fani, N., Brier, Z. M. F., Legrand, A. C., van Stolk‐Cooke, K., Chaarani, B., Potter, A., et al. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-00987-7 · Cited by 23 · see citing works
Widely Impaired White Matter Integrity and Altered Structural Brain Networks in Psychogenic Non-Epileptic Seizures
Sone, D., Sato, N., Ota, M., Kimura, Y., & Matsuda, H. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s235159 · Cited by 25 · see citing works
Intrinsic connectomes underlying response to trauma-focused psychotherapy in post-traumatic stress disorder
Korgaonkar, M. S., Chakouch, C., Breukelaar, I. A., Erlinger, M., Felmingham, K. L., Forbes, D., Williams, L. M., & Bryant, R. A. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00938-8 · Cited by 23 · see citing works
Transcranial Direct Current Stimulation of the Ventromedial Prefrontal Cortex Modulates Perceptual and Neural Patterns of Fear Generalization
Roesmann, K., Kroker, T., Hein, S., Rehbein, M. A., Winker, C., Leehr, E. J., Klucken, T., & Junghöfer, M. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.08.001 · Cited by 24 · see citing works
Out of touch? How trauma shapes the experience of social touch – Neural and endocrine pathways
Stevens, L., Bregulla, M., & Scheele, D. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105595 · Cited by 24 · see citing works
An executive function subtype of PTSD with unique neural markers and clinical trajectories
Jagger-Rickels, A., Rothlein, D., Stumps, A., Evans, T. C., Bernstein, J., Milberg, W., McGlinchey, R., DeGutis, J., & Esterman, M. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02011-y · Cited by 23 · see citing works
Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder
Averill, C. L., Averill, L. A., Wrocklage, K. M., Scott, J. C., Akiki, T. J., Schweinsburg, B. C., Southwick, S. M., Krystal, J. H., & Abdallah, C. G. (2018) · Complex Psychiatry · doi:10.1159/000490464 · Cited by 22 · see citing works
Self-citation
A randomized controlled trial of Deep Brain Reorienting: a neuroscientifically guided treatment for post-traumatic stress disorder
Kearney, B. E., Corrigan, F. M., Frewen, P. A., Nevill, S., Harricharan, S., Andrews, K., Jetly, R., McKinnon, M. C., & Lanius, R. A. (2023) · European Journal of Psychotraumatology · doi:10.1080/20008066.2023.2240691 · Cited by 23 · see citing works
A roadmap of brain recovery in a mouse model of concussion: insights from neuroimaging
To, X. V., & Nasrallah, F. A. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01098-y · Cited by 21 · see citing works
The effects of orexin‐A and orexin receptors on anxiety‐ and depression‐related behaviors in a male rat model of post‐traumatic stress disorder
Han, D., Shi, Y., & Han, F. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25231 · Cited by 23 · see citing works
Reversed patterns of resting state functional connectivity for females vs. males in posttraumatic stress disorder
Helpman, L., Zhu, X., Zilcha‐Mano, S., Suarez‐Jimenez, B., Lazarov, A., Rutherford, B. R., & Neria, Y. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100389 · Cited by 24 · see citing works
Triple Network Functional Connectivity During Acute Stress in Adolescents and the Influence of Polyvictimization
Corr, R., Glier, S., Bizzell, J., Pelletier‐Baldelli, A., Campbell, A., Killian-Farrell, C., & Belger, A. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.03.003 · Cited by 23 · see citing works
Prefrontal Glutamate Neurotransmission in PTSD: A Novel Approach to Estimate Synaptic Strength in Vivo in Humans
Averill, L. A., Jiang, L., Purohit, P., Coppoli, A., Averill, C. L., Roscoe, J., Kelmendi, B., Feyter, H. M. D., de Graaf, R. A., Gueorguieva, R. V., et al. (2022) · Chronic Stress · doi:10.1177/24705470221092734 · Cited by 22 · see citing works
Self-citation
Trauma Memory Processing in Posttraumatic Stress Disorder Psychotherapy: A Unifying Framework
Ford, J. D. (2018) · Journal of Traumatic Stress · doi:10.1002/jts.22344 · Cited by 23 · see citing works

Neural Dysregulation in Posttraumatic Stress Disorder: Evidence for Disrupted Equilibrium Between Salience and Default Mode Brain Networks
Sripada, R. K., King, A. P., Welsh, R. C., Garfinkel, S. N., Wang, X., Sripada, C. S., & Liberzon, I. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318273bf33 · Cited by 412 · see citing works
Neurocircuitry models of posttraumatic stress disorder and beyond: A meta-analysis of functional neuroimaging studies
Patel, R., Spreng, R. N., Shin, L. M., & Girard, T. A. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.06.003 · Cited by 546 · see citing works
Altered large-scale functional brain organization in posttraumatic stress disorder: A comprehensive review of univariate and network-level neurocircuitry models of PTSD
Ross, M. C., & Cisler, J. M. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102319 · Cited by 68 · see citing works
Default mode network abnormalities in posttraumatic stress disorder: A novel network-restricted topology approach
Akiki, T. J., Averill, C. L., Wrocklage, K. M., Scott, J. C., Averill, L. A., Schweinsburg, B., Alexander-Bloch, A., Martini, B., Southwick, S. M., Krystal, J. H., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.05.005 · Cited by 188 · see citing works
Self-citation
Neurobiology of Posttraumatic Stress Disorder
Carletto, S., Panero, M., Cavallo, M., & Pagani, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-57231-0_11 · Cited by 3 · see citing works

Authors: Akiki, T. J., Averill, C. L., & Abdallah, C. G.
Affiliations: Yale University (US)
Corresponding author: Abdallah, Chadi G.
ORCID: Akiki, Teddy J.
Averill, Christopher L.
Abdallah, Chadi G.
Venue: Current Psychiatry Reports
Publisher: Springer Science and Business Media LLC
Published: 2017-09-19
Volume: 19
Issue: 11
Pages: 81-81
ISSN: 1523-3812 (ISSN-L)
1535-1645
DOI: 10.1007/s11920-017-0840-4
PMC: PMC5960989
OpenAlex: W2756085351
Cited by: 365
References: 84
Citations by year: 2026: 35 · 2025: 44 · 2024: 46 · 2023: 52 · 2022: 53 · 2021: 39 · 2020: 41 · 2019: 31 · 2018: 20 · 2017: 2
FWCI: 3.89
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (unspecified)
Locations: Current Psychiatry Reports (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Stanley Medical Research Institute
National Institutes of Health (5k23mh101498-05)
National Institute of Mental Health (K23MH-101498()
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Keywords: post-traumatic stress disorder, neurobiological model, brain networks, default mode network, frontoparietal network, salience network, network dysfunction, functional connectivity, structural neuroimaging, functional neuroimaging
MeSH terms: Brain, Humans, Magnetic Resonance Imaging, Models, Neurological, Nerve Net, Neurobiology, Stress Disorders, Post-Traumatic, Functional Neuroimaging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A network-based neurobiological model of PTSD: evidence from structural and functional neuroimaging studies

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks