STRUCTURAL AND FUNCTIONAL CONNECTIVITY IN POSTTRAUMATIC STRESS DISORDER: ASSOCIATIONS WITH FKBP5: 2015 Donald F Klein Investigator Award Finalist: Connectivity, PTSD, and FKBP5
Open accessAbstract
BACKGROUND: The integrity of connections between the hippocampus and the anterior cingulate cortex (ACC) is critical for adaptive cognitive and emotional processing; these connections may be compromised in posttraumatic stress disorder (PTSD). However, there is a lack of PTSD research that combines structural and functional connectivity data, and no studies have examined whether abnormal ACC-hippocampal connectivity is associated with genetic variability, particularly for polymorphisms of a gene that has been previously associated with PTSD, FKBP5. This was the goal of the present study. METHODS: Fifty-four women with and without PTSD underwent diffusion tensor imaging and resting-state MRI. Probabilistic tractography was used to examine ACC-hippocampal structural connectivity; mean fractional anisotropy (FA) values were extracted from connectivity streamlines, which represent the cingulum bundle. Genotype data were collected for a single nucleotide polymorphism (SNP) of FKBP5, rs1360780. RESULTS: Participants with PTSD demonstrated poorer structural connectivity (lower cingulum FA) compared to traumatized controls (F1, 50 = 6.77, P < .05). An interaction of FKBP5 genotype and diagnostic group was also observed (F1, 37 = 4.52, P = .04), indicating lower cingulum FA in carriers of two risk alleles for this SNP, compared to other diagnostic and genotype groups. Carriers of two FKBP5 risk alleles also demonstrated poorer hippocampus-ACC connectivity at rest (P < .05). When cingulum FA was used a regressor in a brain-wide, seed-based regression analysis, significant associations were found between the hippocampus and dorsal regions of the ACC (P < .05). CONCLUSIONS: Individuals with PTSD demonstrated compromised structural connectivity of the hippocampus-ACC pathway. Altered hippocampus-ACC connectivity may represent a highly salient intermediate neural phenotype for PTSD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Fani et al. found that civilians with PTSD had decreased structural connectivity via the cingulum bundle, which supports the hippocampus-dACC pathway.
“In addition, using DTI, Fani et al. [156] found that civilians with PTSD had decreased structural connectivity via the cingulum bundle, which supports the hippocampus-dACC pathway.”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [156]
The Methods (Participants; DTI Data Processing and Probabilistic Tractography) describe a civilian sample and DTI-derived hippocampus–ACC tracts constrained through the cingulum. The Results report poorer cingulum connectivity in participants with PTSD than in controls, but the structural analysis identifies the ACC generally, not the dACC specifically. (LLM, conf=0.85)
Experimental — accuracy not yet measuredIndividuals with the "risk" allele of the FKBP5 genetic biomarker, associated with childhood maltreatment and PTSD risk, also had decreased cingulum structural integrity.
“Further analyses of this cohort found that individuals with the “risk” allele of the FKBP5 genetic biomarker, associated with childhood maltreatment and PTSD risk, also had decreased cingulum structural integrity.”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [156]
The Results report the lowest cingulum FA in participants with PTSD who carried two FKBP5 risk alleles, compared with the other genotype and diagnostic groups. The claim broadens this to individuals with a risk allele generally. The Results also say cingulum connectivity was not significantly associated with childhood maltreatment; the passages do not establish the claimed link between this allele and childhood maltreatment. (LLM, conf=0.88)
Experimental — accuracy not yet measuredAltered hippocampus-ACC connectivity may represent a highly salient intermediate neural phenotype for PTSD.
“They suggest that altered hippocampus-ACC connectivity may represent a highly salient intermediate neural phenotype for PTSD.”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [156]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630 · see citing works
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913 · see citing works
Fast robust automated brain extraction
Smith, S. M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10062 · Cited by 10,496 · see citing works
Power, J. D., Barnes, K. A., Snyder, A. Z., Schlaggar, B. L., & Petersen, S. E. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.018 · Cited by 7,429 · see citing works
A global optimisation method for robust affine registration of brain images
Jenkinson, M., & Smith, S. M. (2001) · Medical Image Analysis · doi:10.1016/s1361-8415(01)00036-6 · Cited by 6,806 · see citing works
Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data
Smith, S. M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T. E., Mackay, C., Watkins, K., Ciccarelli, O., Cader, M., Matthews, P., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.024 · Cited by 6,035 · see citing works
The development of a Clinician-Administered PTSD Scale
Blake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Gusman, F. D., Charney, D. S., & Keane, T. M. (1995) · Journal of Traumatic Stress · doi:10.1002/jts.2490080106 · Cited by 5,024 · see citing works
Accurate and robust brain image alignment using boundary-based registration
Greve, D. N., & Fischl, B. R. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.06.060 · Cited by 3,553 · see citing works
Characterization and propagation of uncertainty in diffusion-weighted MR imaging
Behrens, T. E. J., Woolrich, M. W., Jenkinson, M., Johansen‐Berg, H., Nunes, R. G., Clare, S., Matthews, P. M., Brady, J. M., & Smith, S. M. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10609 · Cited by 3,038 · see citing works
Reliability and validity of a brief instrument for assessing post-traumatic stress disorder
Foa, E. B., Riggs, D. S., Dancu, C. V., & Rothbaum, B. O. (1993) · Journal of Traumatic Stress · doi:10.1002/jts.2490060405 · Cited by 2,537 · see citing works
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447 · see citing works
Self-citationBinder, E. B. (2008) · JAMA · doi:10.1001/jama.299.11.1291 · Cited by 1,362 · see citing works
Diffusion tensor imaging of white matter tract evolution over the lifespan
Lebel, C., Gee, M., Camicioli, R., Wieler, M., Martin, W., & Beaulieu, C. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.094 · Cited by 1,100 · see citing works
Schmahmann, J. D., Pandya, D. N., Wang, R., Dai, G., D'Arceuil, H. E., de Crespigny, A. J., & Wedeen, V. J. (2007) · Brain · doi:10.1093/brain/awl359 · Cited by 1,067 · see citing works
MRI atlas of human white matter
Ling, C. L., & Rumpel, H. (2006) · Concepts in Magnetic Resonance Part A · doi:10.1002/cmr.a.20052 · Cited by 1,021 · see citing works
Binder, E. B. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.021 · Cited by 968 · see citing works
“Voxel-Based Morphometry” Should Not Be Used with Imperfectly Registered Images
Bookstein, F. L. (2001) · NeuroImage · doi:10.1006/nimg.2001.0770 · Cited by 665 · see citing works
Diffusion Tensor MR Imaging and Fiber Tractography: Theoretic Underpinnings
Mukherjee, P., Berman, J., Chung, S. W., Hess, C. P., & Henry, R. G. (2008) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1051 · Cited by 510 · see citing works
Mapping sources of correlation in resting state FMRI, with artifact detection and removal
Jo, H. J., Saad, Z. S., Simmons, W. K., Milbury, L. A., & Cox, R. W. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.04.246 · Cited by 509 · see citing works
Changing Fear: The Neurocircuitry of Emotion Regulation
Hartley, C. A., & Phelps, E. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.121 · Cited by 492 · see citing works
The hippocampal–prefrontal pathway: The weak link in psychiatric disorders?
Godsil, B. P., Kiss, J., Spedding, M., & Jay, T. M. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.10.018 · Cited by 434 · see citing works
Bluhm, R. L., Williamson, P. C., Osuch, E. A., Frewen, P. A., Stevens, T. K., Boksman, K., Neufeld, R. W. J., Théberge, J., & Lanius, R. A. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0925 · Cited by 422 · see citing works
Jahanshad, N., Kochunov, P. V., Sprooten, E., Mandl, R. C., Nichols, T. E., Almasy, L., Blangero, J., Brouwer, R. M., Curran, J. E., de Zubicaray, G. I., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.061 · Cited by 393 · see citing works
Diffusion Tensor MR Imaging and Fiber Tractography: Technical Considerations
Mukherjee, P., Chung, S. W., Berman, J., Hess, C. P., & Henry, R. G. (2008) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1052 · Cited by 391 · see citing works
Kubicki, M., Westin, C.-F., Nestor, P. G., Wible, C. G., Frumin, M., Maier, S. E., Kikinis, R., Jolesz, F. A., McCarley, R. W., & Shenton, M. E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00419-0 · Cited by 376 · see citing works
Hosang, G. M., Shiles, C., Tansey, K. E., McGuffin, P., & Uher, R. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-7 · Cited by 292 · see citing works
Jo, H. J., Gotts, S. J., Reynolds, R. C., Bandettini, P. A., Martin, A. D., Cox, R. W., & Saad, Z. S. (2013) · Journal of Applied Mathematics · doi:10.1155/2013/935154 · Cited by 277 · see citing works
A Systematic Review of Diffusion Tensor Imaging Studies in Affective Disorders
Sexton, C. E., Mackay, C. E., & Ebmeier, K. P. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.05.024 · Cited by 266 · see citing works
Phan, K. L., Orlichenko, A., Boyd, E., Angstadt, M., Coccaro, E. F., Liberzon, I., & Arfanakis, K. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.028 · Cited by 226 · see citing works
Chen, A. C., & Etkin, A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.122 · Cited by 212 · see citing works
Daniels, J. K., Lamke, J.-P., Gaebler, M., Walter, H., & Scheel, M. (2013) · Depression and Anxiety · doi:10.1002/da.22044 · Cited by 190 · see citing works
Jones, D. K. (2008) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2008.922191 · Cited by 161 · see citing works
de Diego-Adeliño, J., Pires, P., Gómez‐Ansón, B., Serra-Blasco, M., Vives‐Gilabert, Y., Puigdemont, D., Martín‐Blanco, A., Álvarez, E., Pérez, V., & Portella, M. J. (2013) · Psychological Medicine · doi:10.1017/s003329171300158x · Cited by 147 · see citing works
PTSD risk is associated with BDNF Val66Met and BDNF overexpression
Zhang, L., Benedek, D. M., Fullerton, C. S., Forsten, R. D., Naifeh, J. A., Li, X., Hu, X.-Z., Li, H., Jia, M., Xing, G., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.180 · Cited by 141 · see citing works
Fox, R. J., Sakaie, K., Lee, J.-C., Debbins, J. P., Liu, Y., Arnold, D. L., Melhem, E. R., Smith, C. H., Philips, M. D., Lowe, M., et al. (2012) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2844 · Cited by 137 · see citing works
White Matter Integrity in Highly Traumatized Adults With and Without Post-Traumatic Stress Disorder
Fani, N., King, T. Z., Jovanovic, T., Glover, E. M., Bradley, B., Choi, K., Ely, T., Gutman, D. A., & Ressler, K. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.146 · Cited by 135 · see citing works
Self-citationFKBP5 and Attention Bias for Threat
Fani, N., Gutman, D. A., Tone, E. B., Almli, L. M., Mercer, K. B., Davis, J., Glover, E. M., Jovanović, T., Bradley, B., Dinov, I. D., et al. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.210 · Cited by 127 · see citing works
Self-citationSanjuan, P. M., Thoma, R., Claus, E. D., Mays, N., & Caprihan, A. (2013) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2013.09.002 · Cited by 125 · see citing works
Keedwell, P. A., Chapman, R., Christiansen, K., Richardson, H., Evans, J., & Jones, D. K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.022 · Cited by 106 · see citing works
Henderson, S. E., Johnson, A. R., Vallejo, A. I., Katz, L., Wong, E. W., & Gabbay, V. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00152 · Cited by 101 · see citing works
Carballedo, A., Amico, F., Ugwu, I., Fagan, A. J., Fahey, C., Morris, D., Meaney, J. F., Leemans, A., & Frodl, T. (2012) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32060 · Cited by 95 · see citing works
Hall, B. S., Moda, R. N., & Liston, C. M. (2014) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.10.008 · Cited by 90 · see citing works
Altered fimbria-fornix white matter integrity in anorexia nervosa predicts harm avoidance
Kazlouski, D., Rollin, M. D. H., Tregellas, J. R., Shott, M. E., Jappe, L. M., Hagman, J., Pryor, T. L., Yang, T. T., & Frank, G. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.12.006 · Cited by 82 · see citing works
FKBP5 Genotype and Structural Integrity of the Posterior Cingulum
Fani, N., King, T. Z., Reiser, E., Binder, E. B., Jovanović, T., Bradley, B., & Ressler, K. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.322 · Cited by 68 · see citing works
Self-citationFani, N., King, T. Z., Brewster, R. C., Srivastava, A., Stevens, J. S., Glover, E. M., Norrholm, S., Bradley, B., Ressler, K., & Jovanović, T. (2014) · Cortex; a journal devoted to the study of the nervous system and behavior · doi:10.1016/j.cortex.2014.11.006 · Cited by 62 · see citing works
Self-citationSimultaneous acquisition of gradient‐echo and asymmetric spin‐echo for single‐shot z‐shim: Z‐SAGA
Heberlein, K., & Hu, X. P. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10680 · Cited by 60 · see citing works
Alterations in white matter microstructure in women recovered from anorexia nervosa
Yau, W. W., Bischoff‐Grethe, A., Theilmann, R. J., Torres, L. A., Wagner, A., Kaye, W. H., & Fennema‐Notestine, C. (2013) · International Journal of Eating Disorders · doi:10.1002/eat.22154 · Cited by 51 · see citing works
Wang, H., Zhang, Z., Tan, Q., Yin, H. J., Chen, Y., Wang, H., Zhang, R., Wang, Z., Guo, L., Tang, L., et al. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.10.001 · Cited by 51 · see citing works
Hemmings, S. M. J., Martin, L. I., Klopper, M., van der Merwe, L., Aitken, L., de Wit, E., Black, G. F., Hoal, E. G., Walzl, G., & Seedat, S. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.10.011 · Cited by 40 · see citing works
Ly, M., Canu, E., Xu, G., Oh, J. M., McLaren, D. G., Dowling, N. M., Alexander, A. L., Sager, M. A., Johnson, S. C., & Bendlin, B. B. (2013) · Human Brain Mapping · doi:10.1002/hbm.22311 · Cited by 38 · see citing works
Cognitive impairment with and without depression history: an analysis of white matter microstructure
Duffy, S. L., Paradise, M., Hickie, I. B., Lewis, S. J. G., Naismith, S. L., & Lagopoulos, J. (2014) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130079 · Cited by 31 · see citing works
Byun, M. S., Choi, J., Yoo, S. Y., Kang, D., Choi, C., Jang, D. P., Jung, W. H., Jung, M. H., Jang, J. H., Lee, J., et al. (2009) · Psychiatry Investigation · doi:10.4306/pi.2009.6.4.264 · Cited by 21 · see citing works
FKBP5 and Attention Bias for Threat Associations With Hippocampal Function and Shape
Fani, N., Gutman, D., Tone, E., Almli, L., Mercer, K. B., Davis, J., Glover, E., Jovanovic, T., Bradley, B., Dinov, I., et al. (2013) · MPG.PuRe (Max Planck Society) · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
1 of the 54 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [40]Smith SM Jenkinson M Woolrich MW Beckmann CF Behrens TEJ Johansen-Berg H Advances in functional and structural MR image analysis and implementation as FSL Neuroimage 2004 23 Suppl 1 S208 S219 15501092
- [45]Binder EB Bradley RG Liu W Epstein MP Deveau TC Mercer KB Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults JAMA 2008 299 11 1291 1305 18349090 PMC2441757
Cited by
Sorted by citations
Akiki, T. J., Averill, C. L., & Abdallah, C. G. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0840-4 · Cited by 365 · see citing works
Prefrontal cortex, amygdala, and threat processing: implications for PTSD
Alexandra Kredlow, M., Fenster, R. J., Laurent, E. S., Ressler, K. J., & Phelps, E. A. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01155-7 · Cited by 346 · see citing works
“[156] found that civilians with PTSD had decreased structural connectivity via the cingulum bundle, which supports the hippocampus-dACC pathway.”
BackgroundSelf-citationGene × Environment Interactions: From Molecular Mechanisms to Behavior
Halldorsdottir, T., & Binder, E. B. (2016) · Annual Review of Psychology · doi:10.1146/annurev-psych-010416-044053 · Cited by 211 · see citing works
PTSD-related neuroimaging abnormalities in brain function, structure, and biochemistry
Harnett, N. G., Goodman, A. M., & Knight, D. C. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113331 · Cited by 185 · see citing works
Fries, G. R., Gassen, N. C., & Rein, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122614 · Cited by 167 · see citing works
Early Social Adversity, Altered Brain Functional Connectivity, and Mental Health
Holz, N. E., Berhe, O., Sacu, S., Schwarz, E., Tesarz, J., Heim, C. C., & Tost, H. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.10.019 · Cited by 114 · see citing works
Dennis, E. L., Disner, S. G., Fani, N., Salminen, L. E., Logue, M. W., Clarke‐Rubright, E. K., Haswell, C. C., Averill, C. L., Baugh, L. A., Bomyea, J. A., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0631-x · Cited by 108 · see citing works
Self-citationRethinking post-traumatic stress disorder – A predictive processing perspective
Κube, T., Berg, M., Kleim, B., & Herzog, P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.014 · Cited by 101 · see citing works
Antonenko, D., Fromm, A. E., Thams, F., Grittner, U., Meinzer, M., & Flöel, A. (2023) · Nature Communications · doi:10.1038/s41467-023-38910-x · Cited by 72 · see citing works
Belleau, E. L., Ehret, L. E., Hanson, J. L., Brasel, K. J., Larson, C. L., & deRoon‐Cassini, T. A. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100217 · Cited by 58 · see citing works
Racial Discrimination and White Matter Microstructure in Trauma-Exposed Black Women
Fani, N., Harnett, N. G., Bradley, B., Mekawi, Y., Powers, A. D., Stevens, J. S., Ressler, K. J., & Carter, S. E. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.08.011 · Cited by 52 · see citing works
Self-citationFani, N., King, T. Z., Clendinen, C., Hardy, R. A., Surapaneni, S., Blair, J., White, S. F., Powers, A. D., Ely, T. D., Jovanović, T., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.04.098 · Cited by 45 · see citing works
Self-citationCriado‐Marrero, M., Gebru, N. T., Gould, L. A., Smith, T. M., Kim, S., Blackburn, R. J., Dickey, C. A., & Blair, L. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112738 · Cited by 44 · see citing works
Genetic and Neuroimaging Approaches to Understanding Post-Traumatic Stress Disorder
Nisar, S., Bhat, A. A., Hashem, S., Syed, N., Yadav, S. K., Shahab Uddin, M. S., Fakhro, K. A., Bagga, P., Thompson, P. M., Reddy, R. D., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124503 · Cited by 48 · see citing works
FKBP5 and early life stress affect the hippocampus by an age-dependent mechanism
Criado‐Marrero, M., Smith, T. M., Gould, L. A., Kim, S., Penny, H. J., Sun, Z., Gulick, D., Dickey, C. A., & Blair, L. J. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100143 · Cited by 42 · see citing works
Antonenko, D., Fromm, A. E., Thams, F., Kuzmina, A. V., Backhaus, M., Knochenhauer, E., Li, S., Grittner, U., & Flöel, A. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01381-3 · Cited by 43 · see citing works
Sydnor, V. J., Sylvain Bouix, A., Pasternak, O., Härtl, E., Levin-Gleba, L., Reid, B. E., Tripodis, Y., Guenette, J. P., Kaufmann, D., Makris, N., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102190 · Cited by 41 · see citing works
Seligowski, A. V., Harnett, N. G., Merker, J. B., & Ressler, K. J. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.12.006 · Cited by 39 · see citing works
Self-citationStructural connectivity and risk for anhedonia after trauma: A prospective study and replication
Fani, N., Michopoulos, V., van Rooij, S. J. H., Clendinen, C., Hardy, R. A., Jovanović, T., ROTHBAUM, B. O., Ressler, K. J., & Stevens, J. S. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.05.009 · Cited by 35 · see citing works
Self-citationWhite matter microstructure varies with post-traumatic stress severity following medical trauma
Harnett, N. G., Ference, E. W., Knight, A. J., & Knight, D. C. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9995-9 · Cited by 35 · see citing works
Frontal Lobe Circuitry in Posttraumatic Stress Disorder
Selemon, L. D., Young, K. A., Cruz, D. A., & Williamson, D. E. (2019) · Chronic Stress · doi:10.1177/2470547019850166 · Cited by 31 · see citing works
Harnett, N. G., Stevens, J. S., Rooij, S. J. H., Ely, T. D., Michopoulos, V., Hudak, L., Jovanovic, T., Rothbaum, B. O., Ressler, K. J., & Fani, N. (2021) · Depression and Anxiety · doi:10.1002/da.23104 · Cited by 31 · see citing works
Self-citationBinder, E. B. (2017) · European Journal of Psychotraumatology · doi:10.1080/20008198.2017.1412745 · Cited by 29 · see citing works
Genetics of stress-related disorders
Gottschalk, M. G., & Domschke, K. (2020) · doi:10.1093/med/9780198713005.003.0080 · Cited by 29 · see citing works
Harnett, N. G., Stevens, J. S., Fani, N., van Rooij, S. J. H., Ely, T. D., Michopoulos, V., Hudak, L. A., Rothbaum, A. O., Hinrichs, R. C., Winters, S., et al. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.07.019 · Cited by 29 · see citing works
Self-citationZhang, K., Qu, S., Chang, S., Li, G., Cao, C., Fang, K., Olff, M., Wang, L., & Wang, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.021 · Cited by 28 · see citing works
Kang, H. J., Yoon, S. J., Lee, S. L., Choi, K., Seol, S., Park, S., Namgung, E., Kim, T. D., Chung, Y., Kim, J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-60334-6 · Cited by 27 · see citing works
Cognitive and neural facets of dissociation in a traumatized population.
Fani, N., King, T. Z., Powers, A. D., Hardy, R. A., Siegle, G. J., Blair, J., Surapaneni, S., van Rooij, S. J. H., Ressler, K. J., Jovanović, T., et al. (2018) · Emotion · doi:10.1037/emo0000466 · Cited by 27 · see citing works
Self-citationFerrer, Á., Labad, J., Salvat‐Pujol, N., Monreal, J. A., Urretavizcaya, M., Crespo, J. M., Menchón, J. M., Palao, D. J., & Soria, V. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109929 · Cited by 25 · see citing works
Ma, L., Steinberg, J. L., Cunningham, K. A., Bjork, J. M., Lane, S. D., Schmitz, J. M., Burroughs, T. K., Narayana, P. A., Kosten, T. R., Bechara, A., et al. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.10.012 · Cited by 24 · see citing works
Brain structural connectivity and context‐dependent extinction memory
Hermann, A., Stark, R. M., Blecker, C. R., Milad, M. R., & Merz, C. J. (2017) · Hippocampus · doi:10.1002/hipo.22738 · Cited by 23 · see citing works
Savulich, G., Riccelli, R., Passamonti, L., Correia, M., Deakin, J. F. W., Elliott, R., Flechais, R., Lingford-Hughes, A. R., McGonigle, J., Murphy, A., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.34 · Cited by 22 · see citing works
PTSD in Court II: Risk factors, endophenotypes, and biological underpinnings in PTSD
Young, G. C. (2017) · International Journal of Law and Psychiatry · doi:10.1016/j.ijlp.2017.02.002 · Cited by 22 · see citing works
Olson, E. A., Overbey, T., Ostrand, C., Pizzagalli, D. A., Rauch, S. L., & Rosso, I. M. (2019) · Brain and Behavior · doi:10.1002/brb3.1485 · Cited by 21 · see citing works
Yun, J., Jin, M. J., Kim, S., & Lee, S. (2020) · Psychological Medicine · doi:10.1017/s0033291720002949 · Cited by 20 · see citing works
Salminen, L. E., Morey, R. A., Riedel, B. C., Jahanshad, N., Dennis, E. L., & Thompson, P. M. (2019) · Journal of Neuroimaging · doi:10.1111/jon.12600 · Cited by 20 · see citing works
MicroRNAs as biomarker and novel therapeutic target for posttraumatic stress disorder in Veterans
Gupta, S., Guleria, R. S., & Szabo, Y. Z. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.114252 · Cited by 18 · see citing works
Stopyra, M. A., Simon, J. J., Rheude, C., & Nikendei, C. (2022) · Reviews in the Neurosciences · doi:10.1515/revneuro-2022-0014 · Cited by 17 · see citing works
FKBP5 polymorphisms influence pre‐learning stress‐induced alterations of learning and memory
Zoladz, P. R., Dailey, A. M., Nagle, H. E., Fiely, M. K., Mosley, B. E., Brown, C. M., Duffy, T. J., Scharf, A. R., Earley, M. B., & Rorabaugh, B. R. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13514 · Cited by 16 · see citing works
Dennis, E. L., Disner, S. G., Fani, N., Salminen, L. E., Logue, M. W., Clarke‐Rubright, E. K., Haswell, C. C., Averill, C. L., Baugh, L. A., Bomyea, J. A., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/677153 · Cited by 16 · see citing works
Self-citationFKBP51 modulates hippocampal size and function in post-translational regulation of Parkin
Qiu, B., Zhong, Z., Righter, S., Xu, Y., Wang, J., Deng, R., Wang, C., Williams, K. E., Ma, Y., Tsechpenakis, G., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04167-8 · Cited by 14 · see citing works
Liu, Y., Lian, J., Fu, Y., Wang, S., Liu, Y., Zhang, R., & Han, H. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100762 · Cited by 12 · see citing works
Vuong, E., Hemmings, S. M. J., Mhlongo, S., Chirwa, E. D., Lombard, C. J., Peer, N., Abrahams, N., & Seedat, S. (2022) · European Journal of Psychotraumatology · doi:10.1080/20008066.2022.2107820 · Cited by 12 · see citing works
Watson, I., Brüne, M., & Bradley, A. J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.010 · Cited by 13 · see citing works
Qi, R., Luo, Y., Zhang, L., Weng, Y., Surento, W., Jahanshad, N., Xu, Q., Yin, Y., Li, L., Cao, Z., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0770-5 · Cited by 10 · see citing works
Convergent neurobiological predictors of mood and anxiety symptoms and treatment response
Jabbi, M., & Nemeroff, C. B. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1620604 · Cited by 10 · see citing works
Gong, J., He, Y., Zhou, L., Mo, Y., Yu, F., Liu, M., Yang, L., & Liu, J. (2021) · Personality and Individual Differences · doi:10.1016/j.paid.2021.111293 · Cited by 10 · see citing works
The Role of Genetics and Epigenetics in the Pathogenesis of Posttraumatic Stress Disorder
Pape, J. C., & Binder, E. B. (2016) · Psychiatric Annals · doi:10.3928/00485713-20160729-02 · Cited by 9 · see citing works
White matter microstructure in trauma‐exposed children: Associations with pubertal stage
Fani, N., Stenson, A. F., van Rooij, S. J. H., Barrie, D. L. L., & Jovanović, T. (2021) · Developmental Science · doi:10.1111/desc.13120 · Cited by 9 · see citing works
Self-citationYoon, S. A., & Weierich, M. R. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.01.015 · Cited by 8 · see citing works
Womersley, J. S., Roeh, S., Martin, L. I., Ahmed-Leitao, F., Sauer, S., Rex‐Haffner, M., Hemmings, S. M. J., Binder, E. B., & Seedat, S. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02577-9 · Cited by 8 · see citing works
Ferrer, Á., Soria, V., Salvat‐Pujol, N., Martorell, L., Armario, A., Urretavizcaya, M., Gutiérrez‐Zotes, A., Monreal, J. A., Crespo, J. M., Massaneda‐Tuneu, C., et al. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105221 · Cited by 7 · see citing works
FKBP5 methylation predicts functional network architecture of the rostral anterior cingulate cortex
Muehlhan, M., Miller, R. E., Strehle, J., Smolka, M. N., & Alexander, N. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01980-z · Cited by 6 · see citing works
The rs1360780 Variant of FKBP5: Genetic Variation, Epigenetic Regulation, and Behavioral Phenotypes
Marcelo Arancibia, M., Manterola, M., Ríos, U., Moya, P. R., Morán, J., & Bustamante, M. L. (2025) · Genes · doi:10.3390/genes16030325 · Cited by 5 · see citing works
Arnold, A. R., Prochaska, T., Fickenwirth, M., Powers, A. D., Smith, A. K., Chahine, E. B., Stevens, J. S., & Michopoulos, V. (2024) · Journal of Mood and Anxiety Disorders · doi:10.1016/j.xjmad.2024.100082 · Cited by 5 · see citing works
Brain Structural Abnormalities in Posttraumatic Stress Disorder and Relations with Sleeping Problems
Liberzon, I., Wang, X., & Xie, H. (2017) · Springer eBooks · doi:10.1007/978-1-4939-7148-0_12 · Cited by 5 · see citing works
Ma, M., Fan, H. M., Zhang, H., Yin, Y., Wang, Y., & Gao, Y. (2025) · Brain Sciences · doi:10.3390/brainsci15050473 · Cited by 4 · see citing works
Impacts of FKBP5 variants on large-scale brain network connectivity in healthy adults
Zhang, H., Wang, Y. F., Zheng, L. J., Lin, L., Zhang, X. Y., Yang, Y. T., Liu, Y., Lu, G., & Zhang, L. J. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.04.007 · Cited by 4 · see citing works
Song, X., Liu, Q., Zhang, X., Liu, C., Lan, C., Zhang, X., Xu, T., Zhang, R., Kendrick, K. M., Becker, B., et al. (2024) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2024.100509 · Cited by 3 · see citing works
White matter correlates of dissociation in a diverse sample of trauma-exposed women
Kondas, A., McDermott, T. J., Ahluwalia, V., Haller, O. C., Karkare, M. C., Guelfo, A., Daube, A., Bradley, B., Powers, A. D., Stevens, J. S., et al. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.116231 · Cited by 4 · see citing works
Self-citationStructural equation modeling of treatment-related changes in neural connectivity for youth with PTSD
Garrett, A. S., Zhang, W., Price, L. R., Cross, J., Giuliani, N. G., van Hoof, M., Carrión, V. G., & Cohen, J. A. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.04.066 · Cited by 4 · see citing works
Mo, X., He, M.-R., Zhou, L., Liu, Y., Zhu, H., Huang, X., Zeng, G., Zhang, J., & Li, L. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.923572 · Cited by 3 · see citing works
Childhood Adversity Is Associated With Longitudinal White Matter Changes After Adulthood Trauma
Li, T., Huibregtse, M. E., Ely, T. D., van Rooij, S. J. H., Lebois, L. A. M., Webb, E. K., Jovanović, T., House, S. L., Bruce, S. E., Murty, V. P., et al. (2025) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2025.09.007 · Cited by 3 · see citing works
Self-citationKamarajan, C., Pandey, A. K., Chorlian, D. B., Meyers, J. L., Kinreich, S., Pandey, G., de Viteri, S. S., Zhang, J., Kuang, W., Barr, P. B., et al. (2023) · Behavioral Sciences · doi:10.3390/bs13050427 · Cited by 4 · see citing works
Savulich, G., Riccelli, R., Passamonti, L., Correia, M., Deakin, J. F. W., Elliott, R., Flechais, R., Lingford-Hughes, A. R., McGonigle, J., Murphy, A., et al. (2017) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(17)30130-x · Cited by 2 · see citing works
Chitrala, K. N., Nagarkatti, P. S., & Nagarkatti, M. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.03.048 · Cited by 2 · see citing works
Kamarajan, C., Pandey, A. K., Chorlian, D. B., Meyers, J. L., Kinreich, S., Pandey, G., de Viteri, S. S., Zhang, J., Kuang, W., Barr, P. B., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.30.522330 · Cited by 2 · see citing works
Neural Hypervigilance in Trauma-exposed Women
Yoon, S. A. (2018) · CUNY Academic Works (City University of New York)
The Role of Stress in the Etiology of PTSD
Pace-Schott, E. F., & Gazecki, S. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780190457136.003.0012
Persistent Post-Concussive Psychiatric Problems
Victoroff, J. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139696432.012
Structural and Functional Brain Markers of Trauma-related Symptoms
Blessington, G. (2020) · CUNY Academic Works (City University of New York)
Albert, A., & Chen, Y. Y. (2025) · Journal of Medical Case Reports · doi:10.1186/s13256-025-05323-x
Xu, L., Gao, M., Wang, B., Wang, L., & Zhang, K. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5383881
O’Connor, D. A., van Leent, M. M. T., Robson, P. M., Abohashem, S., Gharios, C., Kaufman, A. E., Osborne, M. T., Trivieri, M. G., Murrough, J. W., Shin, L. M., et al. (2025) · medRxiv · doi:10.1101/2025.08.29.25334386
Antonenko, D., Fromm, A. E., Thams, F., Kuzmina, A. V., Backhaus, M., Knochenhauer, E., Li, S.-C., Grittner, U., & Flöel, A. (2024) · Figshare · doi:10.6084/m9.figshare.26666461
Gerrans, P., McGovern, H. T., Hohwy, J., & Oestreich, L. (2026) · European Journal of Psychotraumatology · doi:10.1080/20008066.2026.2631358 · Cited by 1 · see citing works
Zhang, Y.-Y., Chen, H.-J., Qi, R.-F., Ke, J., Xu, Q., Zhong, Y., Zhang, L., Lu, G.-M., & Chen, F. (2026) · Brain and Behavior · doi:10.1002/brb3.71354
Liu, X., Jia, Y.-L., Wang, J.-Y., Yu, S.-S., Cai, C.-Y., Li, J.-X., Cheng, D., Kang, J., Wu, H., Yuan, T., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03680-7
DENYSOV, Y. (2026) · Ukrains kyi Visnyk Psykhonevrolohii · doi:10.36927/2079-0325-v34-is2-2026-12
Functional brain imaging in posttraumatic stress disorder: a review
Bremner, J. D. (2026) · Journal of Neural Transmission · doi:10.1007/s00702-026-03228-7
- Authors
- Fani, N., King, T. Z., Shin, J., Srivastava, A., Brewster, R. C., Jovanovic, T., Bradley, B., & Ressler, K. J.
- Affiliations
- Emory University (US)
- Georgia State University (US)
- Georgia Institute of Technology (US)
- Morehouse School of Medicine (US)
- Department of Psychiatry and Behavioral Sciences; Emory University School of Medicine; Atlanta Georgia
- Corresponding author
- Fani, Negar
- Venue
- Depression and Anxiety
- Publisher
- Wiley
- Published
- 2016-04
- Volume
- 33
- Issue
- 4
- Pages
- 300-307
- ISSN
- 1091-4269 (ISSN-L)
- PMC
- PMC4983452
- OpenAlex
- W2320359820
- Cited by
- 80
- References
- 54
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 15 · 2019: 12 · 2018: 4 · 2017: 11 · 2016: 4
- FWCI
- 13.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (UL1TR000454)
- National Institute of Mental Health (K23MH101380, MH092576, R21MH098212, MH101380, MH098212, R01MH071537, R01MH094757, R21MH092576)
- National Center for Research Resources (M01-RR00039, UL1RR025008, MH071537, P20-RR16435, P20RR016435, RR025008, M01RR000039)
- National Center for Advancing Translational Sciences
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- post-traumatic stress disorder, FKBP5, rs1360780, hippocampus, anterior cingulate cortex, cingulum, structural connectivity, functional connectivity, genetic polymorphism, fractional anisotropy, women
- MeSH terms
- Tacrolimus Binding Protein 5, Adult, Black or African American, Brain, Brain Mapping, Female, Genotype, Gyrus Cinguli, Hippocampus, Humans, Magnetic Resonance Imaging, Middle Aged, Stress Disorders, Post-Traumatic, Tacrolimus Binding Proteins, Cerebrum, Young Adult, Diffusion Tensor Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
