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Cited by 128Neurogenesis and neuroplasticity mechanismsStress Responses and CortisolMemory and Neural Mechanisms

Extended voluntary running inhibits exercise-induced adult hippocampal progenitor proliferation in the spontaneously hypertensive rat.

Naylor, Andrew S., Persson, Anders I., Eriksson, Peter S., Jonsdottir, Ingibjörg H., Thorlin, Thorleif·2005·Journal of Neurophysiology
DOI 10.1152/jn.01085.2004
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Abstract

Previous work has shown that voluntary running increases cell proliferation and neurogenesis in the dentate gyrus of the adult hippocampus. Here we report that long-term running for 24 days results in a down-regulation of hippocampal progenitor proliferation to one-half the level of nonrunning controls compared with a fivefold increase in progenitor proliferation seen after 9 days of voluntary running (short-term running). The negative effects seen on proliferation after 24 days of running were prevented by restricting daily running distances (by 30-50%) during 24 days. Long-term running for 24 days increases the response of the hypothalamic-pituitary-adrenal axis, with an increase in adrenal gland weight and increased plasma corticosterone levels, as well as decreased thymus weight, indicating a stress response as a possible mediator of decreased progenitor proliferation. Furthermore, the negative effects seen on the observed stress response after 24 days of running were prevented by restricting daily running distance. Short-term running did not alter these stress parameters compared with nonrunning controls. However, it increased phosphorylated cyclic AMP response element binding protein (pCREB) in the dentate gyrus, an increase that was not seen in nonrunning controls or after 24 days of running. Taken together, these data suggest that voluntary running does not always enhance proliferation and that the decrease in progenitor proliferation seen in long-term running is possibly mediated by mechanisms involving a stress response in the animal. However, a moderate level of long-term running was able to prevent the negative stress-related changes seen in unrestricted long-term running.

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  • The effect of aerobic exercise on hippocampus dependent task performance in animal models depends on aspects of aerobic exercise such as duration and intensity.

    “Using hippocampus dependent paradigms, AE has been reliably demonstrated to improve task performance in animal models (van Praag, 2009; Voss et al., 2013a), although this does also depend on others aspects of AE such as the duration and intensity of AE (Naylor et al., 2005; Ploughman et al., 2007; O’Callaghan et al., 2009).”

    From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Naylor et al., 2005

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Authors
Naylor, A. S., Persson, A. I., Eriksson, P. S., Jonsdottir, I. H., & Thorlin, T.
Affiliations
University of Gothenburg (SE)
ORCID
Persson, Anders I.
Venue
Journal of Neurophysiology
Publisher
American Physiological Society
Published
2005-05
Volume
93
Issue
5
Pages
2406-2414
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
DOI
10.1152/jn.01085.2004
OpenAlex
W2054113947
Cited by
127
References
50
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 3 · 2019: 1 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 7 · 2014: 4 · 2013: 12 · 2012: 6
FWCI
1.60
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
voluntary running, adult neurogenesis, dentate gyrus, spontaneously hypertensive rats, hypothalamic-pituitary-adrenal axis, corticosterone, stress response, thymus, CREB phosphorylation, exercise duration
MeSH terms
Adrenal Glands, Analysis of Variance, Animals, Animals, Newborn, Behavior, Animal, Bromodeoxyuridine, Cell Count, Corticosterone, Female, Hippocampus, Immunohistochemistry, Inhibition, Psychological, Phosphorylation, Physical Conditioning, Animal, Random Allocation, Rats, Inbred SHR, Running, Stem Cells, Thymus Gland, Time Factors, Cyclic AMP Response Element-Binding Protein, Cell Proliferation, Rats

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