Can oxytocin treat autism?

Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

Tyzio, R., Nardou, R., Ferrari, D. C., Tsintsadze, T., Shahrokhi, A., Eftekhari, S., Khalilov, I., Tsintsadze, V., Brouchoud, C., Chazal, G., et al. (2014) · Science · doi:10.1126/science.1247190 · Cited by 601 · see citing works

Exogenous and evoked oxytocin restores social behavior in the <i>Cntnap2</i> mouse model of autism

Peñagarikano, O., Lázaro, M. T., Lu, X.-H., Gordon, A., Dong, H., Lam, H. A., Peles, E., Maidment, N. T., Murphy, N. P., Yang, X. W., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010257 · Cited by 378 · see citing works

The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: a meta-analysis

LoParo, D., & Waldman, I. D. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.77 · Cited by 343 · see citing works

Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons

Owen, S. F., Tuncdemir, S. N., Bader, P. L., Tirko, N. N., Fishell, G., & Tsien, R. W. (2013) · Nature · doi:10.1038/nature12330 · Cited by 339 · see citing works

Oxytocin enhances brain function in children with autism

Gordon, I., Vander Wyk, B. C., Bennett, R. H., Cordeaux, C., Lucas, M. V., Eilbott, J. A., Zagoory-Sharon, O., Leckman, J. F., Feldman, R., & Pelphrey, K. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312857110 · Cited by 336 · see citing works

The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: a randomized controlled trial

Guastella, A. J., Gray, K. M., Rinehart, N. J., Alvares, G. A., Tonge, B. J., Hickie, I. B., Keating, C. M., Cacciotti‐Saija, C., & Einfeld, S. L. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12305 · Cited by 299 · see citing works

Plasma oxytocin concentrations and <i>OXTR</i> polymorphisms predict social impairments in children with and without autism spectrum disorder

Parker, K. J., Garner, J. P., Libove, R. A., Hyde, S. A., Hornbeak, K. B., Carson, D. S., Liao, C.-P., Phillips, J. M., Hallmayer, J. F., & Hardan, A. Y. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402236111 · Cited by 215 · see citing works

Common polymorphism in the oxytocin receptor gene ( <i>OXTR</i> ) is associated with human social recognition skills

Skuse, D. H., Lori, A., Cubells, J. F., Lee, I., Conneely, K. N., Puura, K., Lehtimäki, T., Binder, E. B., & Young, L. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302985111 · Cited by 207 · see citing works

Chronic and acute intranasal oxytocin produce divergent social effects in mice

Huang, H., Michetti, C., Busnelli, M., Managò, F., Sannino, S., Scheggia, D., Giancardo, L., Sona, D., Murino, V., Chini, B., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.310 · Cited by 199 · see citing works

Oxytocin improves behavioural and neural deficits in inferring others’ social emotions in autism

Aoki, Y., Yahata, N., Watanabe, T., Takano, Y., Kawakubo, Y., Kuwabara, H., Iwashiro, N., Natsubori, T., Inoue, H., Suga, M., et al. (2014) · Brain · doi:10.1093/brain/awu231 · Cited by 187 · see citing works

The neuroanatomical distribution of oxytocin receptor binding and mRNA in the male rhesus macaque (Macaca mulatta)

Freeman, S. M., Inoue, K., Smith, A. L., Goodman, M. M., & Young, L. J. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.03.023 · Cited by 185 · see citing works

Intranasal oxytocin in the treatment of autism spectrum disorders: A review of literature and early safety and efficacy data in youth

Anagnostou, E., Soorya, L., Brian, J., Dupuis, A., Mankad, D., Smile, S., & Jacob, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.049 · Cited by 155 · see citing works

Prosocial effects of oxytocin in two mouse models of autism spectrum disorders

Teng, B. L., Nonneman, R. J., Agster, K. L., Nikolova, V. D., Davis, T. T., Riddick, N. V., Baker, L. K., Pedersen, C. A., Jarstfer, M. B., & Moy, S. S. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.038 · Cited by 98 · see citing works

Melanocortin receptor agonists facilitate oxytocin-dependent partner preference formation in the Prairie Vole

Modi, M. E., Inoue, K., Barrett, C. E., Kittelberger, K. A., Smith, D. G., Landgraf, R., & Young, L. J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.35 · Cited by 82 · see citing works

Neonatal melanocortin receptor agonist treatment reduces play fighting and promotes adult attachment in prairie voles in a sex-dependent manner

Barrett, C. E., Modi, M. E., Zhang, B. C., Walum, H., Inoue, K., & Young, L. J. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.041 · Cited by 34 · see citing works

Neural circuit mechanisms of social behavior

Chen, P., & Hong, W. (2018) · Neuron · doi:10.1016/j.neuron.2018.02.026 · Cited by 527 · see citing works

Gating of social reward by oxytocin in the ventral tegmental area

Hung, L. W., Neuner, S., Polepalli, J. S., Beier, K. T., Wright, M., Walsh, J. J., Lewis, E. M., Luo, L., Deisseroth, K., Dölen, G., et al. (2017) · Science · doi:10.1126/science.aan4994 · Cited by 578 · see citing works

Clinical assessment of social cognitive function in neurological disorders

Henry, J. D., von Hippel, W., Molenberghs, P., Lee, T., & Sachdev, P. S. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.229 · Cited by 488 · see citing works

Oxytocin, Neural Plasticity, and Social Behavior

Froemke, R. C., & Young, L. J. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-102320-102847 · Cited by 487 · see citing works

Growing a social brain

Atzil, S., Gao, W., Fradkin, I., & Barrett, L. F. (2018) · Nature Human Behaviour · doi:10.1038/s41562-018-0384-6 · Cited by 415 · see citing works

Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders

Kang, D.-W., Ilhan, Z. E., Isern, N. G., Hoyt, D. W., Howsmon, D. P., Shaffer, M., Lozupone, C. A., Hahn, J., Adams, J. B., & Krajmalnik-Brown, R. (2018) · Anaerobe · doi:10.1016/j.anaerobe.2017.12.007 · Cited by 381 · see citing works

The neural mechanisms and circuitry of the pair bond

Walum, H., & Young, L. J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0072-6 · Cited by 353 · see citing works

Neural mechanisms of mother–infant bonding and pair bonding: Similarities, differences, and broader implications

Numan, M., & Young, L. J. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.015 · Cited by 355 · see citing works

Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies

Walum, H., Waldman, I. D., & Young, L. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.016 · Cited by 345 · see citing works

Does Oxytocin Increase Trust in Humans? A Critical Review of Research

Nave, G., Camerer, C., & McCullough, M. (2015) · Perspectives on Psychological Science · doi:10.1177/1745691615600138 · Cited by 309 · see citing works

Assembling the puzzle: pathways of oxytocin signaling in the brain

Grinevich, V., Knobloch-Bollmann, H. S., Eliava, M., Busnelli, M., & Chini, B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.04.013 · Cited by 309 · see citing works

Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience

Johnson, Z. V., & Young, L. J. (2017) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.034 · Cited by 242 · see citing works

Endocannabinoid signaling mediates oxytocin-driven social reward

Wei, D., Lee, D., Cox, C. D., Karsten, C. A., Peñagarikano, O., Geschwind, D. H., Gall, C. M., & Piomelli, D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509795112 · Cited by 218 · see citing works

Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice

Ferretti, V., Maltese, F., Contarini, G., Nigro, M., Bonavia, A., Huang, H., Gigliucci, V., Morelli, G., Scheggia, D., Managò, F., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.04.070 · Cited by 212 · see citing works

Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications

Freeman, S. M., & Young, L. J. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12382 · Cited by 196 · see citing works

Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment

King, L. B., Walum, H., Inoue, K., Eyrich, N. W., & Young, L. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.008 · Cited by 191 · see citing works

The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2

Leonzino, M., Busnelli, M., Antonucci, F., Verderio, C., Mazzanti, M., & Chini, B. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.013 · Cited by 191 · see citing works

Oxytocin and Social Relationships: From Attachment to Bond Disruption

Bosch, O. J., & Young, L. J. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_10 · Cited by 162 · see citing works

Intranasal oxytocin, social cognition and neurodevelopmental disorders: A meta-analysis

Keech, B., Crowe, S., & Hocking, D. R. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.09.022 · Cited by 145 · see citing works

Oxytocin and the Neurobiology of Prosocial Behavior

Marsh, N., Marsh, A. A., Lee, M. R., & Hurlemann, R. (2020) · The Neuroscientist · doi:10.1177/1073858420960111 · Cited by 149 · see citing works

Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors

Grinevich, V., & Stoop, R. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.016 · Cited by 139 · see citing works

Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy

Woensel, M. V., Mathivet, T., Wauthoz, N., Rosière, R., Garg, A. D., Agostinis, P., Mathieu, V., Robert Kiss, A., Lefranc, F., Boon, L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-01279-1 · Cited by 140 · see citing works

Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans

Blevins, J. E., & Baskin, D. G. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.023 · Cited by 132 · see citing works

Empathy in autism Spectrum disorder

Harmsen, I. E. (2019) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-019-04087-w · Cited by 129 · see citing works

A phase 2 clinical trial of a vasopressin V1a receptor antagonist shows improved adaptive behaviors in men with autism spectrum disorder

Bolognani, F., del Valle Rubido, M., Squassante, L., Wandel, C., Derks, M., Murtagh, L., Sevigny, J., Khwaja, O., Umbricht, D., & Fontoura, P. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aat7838 · Cited by 128 · see citing works

Epigenetics of Autism Spectrum Disorder

Siu, M. T., & Weksberg, R. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-53889-1_4 · Cited by 121 · see citing works

The oxytocin system promotes resilience to the effects of neonatal isolation on adult social attachment in female prairie voles

Barrett, C. E., Arambula, S. E., & Young, L. J. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.73 · Cited by 115 · see citing works

RDoC-based categorization of amygdala functions and its implications in autism

Hennessey, T., Andari, E., & Rainnie, D. G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.007 · Cited by 105 · see citing works

Social Decision-Making and the Brain: A Comparative Perspective

Tremblay, S., Sharika, K. M., & Platt, M. L. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.01.007 · Cited by 105 · see citing works

Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection

Bakos, J., Srancikova, A., Havranek, T., & Bacova, Z. (2018) · Neural Plasticity · doi:10.1155/2018/4864107 · Cited by 104 · see citing works

Activation of oxytocin receptors, but not arginine-vasopressin V1a receptors, in the ventral tegmental area of male Syrian hamsters is essential for the reward-like properties of social interactions

Song, Z., Borland, J. M., Larkin, T. E., O’Malley, M., & Albers, H. E. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.001 · Cited by 101 · see citing works

Epigenetic modification of the oxytocin receptor gene: implications for autism symptom severity and brain functional connectivity

Andari, E., Nishitani, S., Gopinath, K., Caceres, G. A., Morrier, M. J., Ousley, O., Smith, A. K., Cubells, J. F., & Young, L. J. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0610-6 · Cited by 97 · see citing works

Insular function in autism: Update and future directions in neuroimaging and interventions

Nomi, J. S., Molnar-Szakacs, I., & Uddin, L. Q. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.10.015 · Cited by 95 · see citing works

Lost connections: Oxytocin and the neural, physiological, and behavioral consequences of disrupted relationships

Pohl, T. T., Young, L. J., & Bosch, O. J. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2017.12.011 · Cited by 83 · see citing works

Melanocortin receptor agonists facilitate oxytocin-dependent partner preference formation in the Prairie Vole

Modi, M. E., Inoue, K., Barrett, C. E., Kittelberger, K. A., Smith, D. G., Landgraf, R., & Young, L. J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.35 · Cited by 82 · see citing works

Body fluid levels of neuroactive amino acids in autism spectrum disorders: a review of the literature

Zheng, H.-F., Wang, W.-Q., Li, X., Rauw, G. A., & Baker, G. B. (2016) · Amino Acids · doi:10.1007/s00726-016-2332-y · Cited by 82 · see citing works

Oxytocin Enhancement of Emotional Empathy: Generalization Across Cultures and Effects on Amygdala Activity

Geng, Y., Zhao, W., Zhou, F., Ma, X., Yao, S., Hurlemann, R., Becker, B., & Kendrick, K. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00512 · Cited by 78 · see citing works

Oxytocin receptor knockout prairie voles generated by CRISPR/Cas9 editing show reduced preference for social novelty and exaggerated repetitive behaviors

Horie, K., Inoue, K., Suzuki, S., Adachi, S., Yada, S., Hirayama, T., Hidema, S., Young, L. J., & Nishimori, K. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.10.011 · Cited by 77 · see citing works

Are gastrointestinal and sleep problems associated with behavioral symptoms of autism spectrum disorder?

Yang, X.-L., Liang, S., Zou, M.-Y., Sun, C.-H., Han, P.-P., Jiang, X.-T., Xia, W., & Wu, L.-J. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2017.10.040 · Cited by 76 · see citing works

Refining oxytocin therapy for autism: context is key

Ford, C. L., & Young, L. J. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-021-00602-9 · Cited by 73 · see citing works

The role of oxytocin and vasopressin dysfunction in cognitive impairment and mental disorders

Abramova, O. V., Zorkina, Y., Ushakova, V. M., Zubkov, E. A., Morozova, A. Y., & Chekhonin, V. P. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102079 · Cited by 74 · see citing works

Exogenous effects of oxytocin in five psychiatric disorders: a systematic review, meta-analyses and a personalized approach through the lens of the social salience hypothesis

Peled‐Avron, L., Abu-Akel, A. M., & Shamay‐Tsoory, S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.023 · Cited by 73 · see citing works

Design and characterization of superpotent bivalent ligands targeting oxytocin receptor dimers via a channel-like structure

Busnelli, M., Kleinau, G., Muttenthaler, M., Stoev, S., Manning, M., Bibic, L., Howell, L. A., McCormick, P. J., Di Lascio, S., Braida, D., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00564 · Cited by 67 · see citing works

Oxytocin–Oxytocin Receptor Systems Facilitate Social Defeat Posture in Male Mice

Nasanbuyan, N., Yoshida, M., Takayanagi, Y., Inutsuka, A., Nishimori, K., Yamanaka, A., & Onaka, T. (2017) · Endocrinology · doi:10.1210/en.2017-00606 · Cited by 69 · see citing works

Neuropeptide diversity and the regulation of social behavior in New World primates

French, J. A., Taylor, J. H., Mustoe, A. C., & Cavanaugh, J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.03.004 · Cited by 66 · see citing works

Oxytocin: Parallel Processing in the Social Brain?

Dölen, G. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12284 · Cited by 65 · see citing works

Activation of Supraoptic Oxytocin Neurons by Secretin Facilitates Social Recognition

Takayanagi, Y., Yoshida, M., Takashima, A., Takanami, K., Yoshida, S., Nishimori, K., Nishijima, I., Sakamoto, H., Yamagata, T., & Onaka, T. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.021 · Cited by 66 · see citing works

Thalamic integration of social stimuli regulating parental behavior and the oxytocin system

Dobolyi, A., Cservenák, M., & Young, L. J. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.05.002 · Cited by 64 · see citing works

The Anorexigenic Neural Pathways of Oxytocin and Their Clinical Implication

Maejima, Y., Yokota, S., Nishimori, K., & Shimomura, K. (2018) · Neuroendocrinology · doi:10.1159/000489263 · Cited by 65 · see citing works

Oxytocin Influences Male Sexual Activity via Non-synaptic Axonal Release in the Spinal Cord

Oti, T., Satoh, K., Uta, D., Nagafuchi, J., Tateishi, S., Ueda, R., Takanami, K., Young, L. J., Galione, A., Morris, J. F., et al. (2021) · Current Biology · doi:10.1016/j.cub.2020.09.089 · Cited by 63 · see citing works

A randomized trial shows dose-frequency and genotype may determine the therapeutic efficacy of intranasal oxytocin

Kou, J., Zhang, Y., Zhou, F., Sindermann, C., Montag, C., Becker, B., & Kendrick, K. M. (2020) · Psychological Medicine · doi:10.1017/s0033291720003803 · Cited by 63 · see citing works

The effectiveness of physical activity interventions on communication and social functioning in autistic children and adolescents: A meta-analysis of controlled trials

Chan, J. S. Y., Deng, K., & Yan, J. H. (2020) · Autism · doi:10.1177/1362361320977645 · Cited by 58 · see citing works

Promising evidence and remaining issues regarding the clinical application of oxytocin in autism spectrum disorders

Yamasue, H. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12364 · Cited by 58 · see citing works

Psychopathy to Altruism: Neurobiology of the Selfish–Selfless Spectrum

Sonne, J., & Gash, D. M. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00575 · Cited by 61 · see citing works

Oxytocin enhances gaze-following responses to videos of natural social behavior in adult male rhesus monkeys

Putnam, P. T., Roman, J. M., Zimmerman, P. E., & Gothard, K. M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.05.016 · Cited by 53 · see citing works

Role of oxytocin in the ventral tegmental area in social reinforcement

Borland, J. M., Grantham, K. N., Aiani, L. M., Frantz, K. J., & Albers, H. E. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.028 · Cited by 51 · see citing works

Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial

Yamasue, H., Kojima, M., Kuwabara, H., Kuroda, M., Matsumoto, K., Kanai, C., Inada, N., Owada, K., Ochi, K., Ono, N., et al. (2021) · Brain · doi:10.1093/brain/awab291 · Cited by 51 · see citing works

Beta-carotene as a novel therapy for the treatment of “Autistic like behavior” in animal models of Autism

Avraham, Y., Berry, E. M., Donskoy, M., Ahmad, W. A., Vorobiev, L., Albeck, A., & Mankuta, D. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.041 · Cited by 48 · see citing works

Cannabidiol for the treatment of autism spectrum disorder: hope or hype?

Pedrazzi, J. F. C., Ferreira, F. R., Silva-Amaral, D., Lima, D. D. A., Hallak, J. E. C., Zuardi, A. W., Bel, E. A. D., Guimarães, F. S., Costa, K. C. M., Campos, A. C., et al. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06196-4 · Cited by 52 · see citing works

Translational opportunities for circuit-based social neuroscience: advancing 21st century psychiatry

Ford, C. L., & Young, L. J. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.11.007 · Cited by 46 · see citing works

Multidimensional assessment of empathic abilities in patients with insular glioma

Chen, P., Wang, G., Ma, R., Jing, F., Zhang, Y., Wang, Y., Zhang, P., Niu, C., & Zhang, X. (2016) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-016-0445-0 · Cited by 46 · see citing works

The neurocircuitry involved in oxytocin modulation of methamphetamine addiction

Baracz, S. J., & Cornish, J. L. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.08.001 · Cited by 46 · see citing works

A Volumetric and Functional Connectivity MRI Study of Brain Arginine-Vasopressin Pathways in Autistic Children

Shou, X., Xu, X., Zeng, X., Liu, Y., Yuan, H., Xing, Y., Jia, M., Wei, Q.-Y., Han, S., Zhang, R., et al. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0109-2 · Cited by 44 · see citing works

Neuropeptide Regulation of Social Attachment: The Prairie Vole Model

Tabbaa, M., Paedae, B., Liu, Y., & Wang, Z. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150055 · Cited by 53 · see citing works

Additive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism

Hernandez, L. M., Krasileva, K., Green, S. A., Sherman, L. E., Ponting, C., McCarron, R., Lowe, J. K., Geschwind, D. H., Bookheimer, S. Y., & Dapretto, M. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.209 · Cited by 43 · see citing works

Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice

Zhong, J., Amina, S., Liang, M., Akther, S., Yuhi, T., Nishimura, T., Tsuji, C., Tsuji, T., Liu, H.-X., Hashii, M., et al. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00304 · Cited by 42 · see citing works

Oxytocin improves facial emotion recognition in young adults with antisocial personality disorder

Timmermann, M., Jeung, H., Schmitt, R., Boll, S., Freitag, C. M., Bertsch, K., & Herpertz, S. C. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.07.483 · Cited by 41 · see citing works

Neurochemical evidence for differential effects of acute and repeated oxytocin administration

Benner, S., Aoki, Y., Watanabe, T., Endo, N., Abe, O., Kuroda, M., Kuwabara, H., Kawakubo, Y., Takao, H., Kunimatsu, A., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-018-0249-4 · Cited by 40 · see citing works

A role for the endocannabinoid 2-arachidonoyl-sn-glycerol for social and high-fat food reward in male mice

Don, W., Lee, D., Li, D., Daglian, J. M., Jung, K., & Piomelli, D. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4222-0 · Cited by 40 · see citing works

Intranasal Oxytocin and Vasopressin Modulate Divergent Brainwide Functional Substrates

Galbusera, A., Felice, A. D., Girardi, S., Bassetto, G., Maschietto, M., Nishimori, K., Chini, B., Papaleo, F., Vassanelli, S., & Gozzi, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.283 · Cited by 38 · see citing works

Intranasal oxytocin modulates neural functional connectivity during human social interaction

Rilling, J. K., Chen, X., Chen, X., & Haroon, E. (2018) · American Journal of Primatology · doi:10.1002/ajp.22740 · Cited by 40 · see citing works

Understanding the Oxytocin System and Its Relevance to Psychiatry

Shamay‐Tsoory, S., & Young, L. J. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.10.014 · Cited by 39 · see citing works

Genetic and epigenetic regulatory mechanisms of the oxytocin receptor gene (OXTR) and the (clinical) implications for social behavior

Tops, S., Habel, U., & Radke, S. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.03.002 · Cited by 39 · see citing works

Autism Spectrum Disorder

Bertelli, M. O., Azeem, M. W., Underwood, L., Scattoni, M. L., Persico, A. M., Ricciardello, A., Sappok, T., Bergmann, T. J., Keller, R., Bianco, A., et al. (2022) · Springer eBooks · doi:10.1007/978-3-319-95720-3_16 · Cited by 41 · see citing works

Participatory Art Activities Increase Salivary Oxytocin Secretion of ASD Children

Tanaka, S., Komagome, A., Iguchi-Sherry, A., Nagasaka, A., Yuhi, T., Higashida, H., Rooksby, M., Kikuchi, M., Arai, O., Minami, K., et al. (2020) · Brain Sciences · doi:10.3390/brainsci10100680 · Cited by 38 · see citing works

Adaptive crossover designs for assessment of symptomatic treatments targeting behaviour in neurodegenerative disease: a phase 2 clinical trial of intranasal oxytocin for frontotemporal dementia (FOXY)

Finger, E. C., Berry, S. M., Cummings, J. L., Coleman, K. K. L., Hsiung, G. R., Feldman, H., & Boxer, A. L. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0427-2 · Cited by 37 · see citing works

In the nose or on the tongue? Contrasting motivational effects of oral and intranasal oxytocin on arousal and reward during social processing

Kou, J., Lan, C., Zhang, Y., Wang, Q., Zhou, F., Zhao, Z., Montag, C., Yao, S., Becker, B., & Kendrick, K. M. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01241-w · Cited by 37 · see citing works

Interplay between the oxytocin and opioid systems in regulating social behaviour

Putnam, P. T., & Chang, S. W. C. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0050 · Cited by 33 · see citing works

The Role of Oxytocin in Parenting and as Augmentative Pharmacotherapy: Critical Issues and Bold Conjectures

van IJzendoorn, M. H., & Bakermans‐Kranenburg, M. J. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12355 · Cited by 34 · see citing works

Oxytocin administration suppresses hypothalamic activation in response to visual food cues

van der Klaauw, A. A., Ziauddeen, H., Keogh, J. M., Henning, E., Dachi, S. V., Fletcher, P. C., & Farooqi, I. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-04600-0 · Cited by 34 · see citing works

Dysfunctional d-aspartate metabolism in BTBR mouse model of idiopathic autism

Nuzzo, T., Sekine, M., Punzo, D., Miroballo, M., Katane, M., Saitoh, Y., Galbusera, A., Pasqualetti, M., Errico, F., Gozzi, A., et al. (2020) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2020.140531 · Cited by 33 · see citing works

Is Oxytocin Application for Autism Spectrum Disorder Evidence-Based?

Lee, S. Y., Lee, A. R., Hwangbo, R., Han, J., Hong, M., & Bahn, G. H. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.312 · Cited by 32 · see citing works

Helping behavior in prairie voles: a model of empathy and the importance of oxytocin

Kitano, K., Yamagishi, A., Horie, K., Nishimori, K., & Sato, N. (2022) · iScience · doi:10.1016/j.isci.2022.103991 · Cited by 31 · see citing works

Initial investigation of three selective and potent small molecule oxytocin receptor PET ligands in New World monkeys

Smith, A. L., Freeman, S. M., Barnhart, T. E., Abbott, D. H., Ahlers, E. O., Kukis, D. L., Bales, K. L., Goodman, M. M., & Young, L. J. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.04.097 · Cited by 29 · see citing works

Oxytocin as an Anti-obesity Treatment

Niu, J., Tong, J., & Blevins, J. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.743546 · Cited by 30 · see citing works

Pharmacological rescue of nociceptive hypersensitivity and oxytocin analgesia impairment in a rat model of neonatal maternal separation

Melchior, M., Juif, P., Gazzo, G., Petit-Demoulière, N., Chavant, V., Lacaud, A., Goumon, Y., Charlet, A., Lelièvre, V., & Poisbeau, P. (2018) · Pain · doi:10.1097/j.pain.0000000000001375 · Cited by 29 · see citing works

Investigational drugs in early-stage clinical trials for autism spectrum disorder

Hong, M. P., & Erickson, C. A. (2019) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2019.1649656 · Cited by 27 · see citing works

Progress and Pitfalls in Developing Agents to Treat Neurocognitive Deficits Associated with Schizophrenia

Veselinović, T., & Neuner, I. (2022) · CNS Drugs · doi:10.1007/s40263-022-00935-z · Cited by 28 · see citing works

Retracing our steps: A review on autism research in children, its limitation and impending pharmacological interventions

Salloum‐Asfar, S., Zawia, N., & Abdulla, S. A. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108564 · Cited by 27 · see citing works

Sialic acid and anti-ganglioside antibody levels in children with autism spectrum disorders

Yang, X., Liang, S., Wang, L., Han, P., Jiang, X.-T., Wang, J., Hao, Y., & Wu, L. (2017) · Brain Research · doi:10.1016/j.brainres.2017.10.027 · Cited by 26 · see citing works

Neuroimaging Markers of Risk and Pathways to Resilience in Autism Spectrum Disorder

Molnar-Szakacs, I., Kupis, L. B., & Uddin, L. Q. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.06.017 · Cited by 28 · see citing works

Development of a thermostable oxytocin microneedle patch

Gomaa, Y. A., Kolluru, C., Milewski, M., Lee, D., Zhang, J., Saklatvala, R., & Prausnitz, M. R. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.07.011 · Cited by 26 · see citing works

Oxytocin and social context moderate social support seeking in women during negative memory recall

Cardoso, C., Valkanas, H., Serravalle, L., & Ellenbogen, M. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.05.001 · Cited by 26 · see citing works

MAGEL2 (patho‐)physiology and Schaaf–Yang syndrome

Schubert, T., & Schaaf, C. P. (2024) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.16018 · Cited by 25 · see citing works

Dynamic regulation of oxytocin neuronal circuits in the sequential processes of prosocial behavior in rodent models

Arakawa, H. (2021) · Current Research in Neurobiology · doi:10.1016/j.crneur.2021.100011 · Cited by 24 · see citing works

The Anti‐Depressive Effects of Ultra‐High Static Magnetic Field

Lv, Y. M., Fan, Y., Tian, X., Yu, B., Song, C., Feng, C., Zhang, L., Ji, X., Zablotskii, V., & Zhang, X. (2021) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.28035 · Cited by 25 · see citing works

The association between NCAM1 levels and behavioral phenotypes in children with autism spectrum disorder

Yang, X., Zou, M., Pang, X., Liang, S., Sun, C., Wang, J., Fan, L., Xia, W., & Wu, L. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.012 · Cited by 24 · see citing works

Overexpression of chloride importer NKCC1 contributes to the sensory-affective and sociability phenotype of rats following neonatal maternal separation

Gazzo, G., Melchior, M., Caussaint, A., Gieré, C., Lelièvre, V., & Poisbeau, P. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.12.010 · Cited by 22 · see citing works

Beta-Carotene derivatives as novel therapy for the prevention and treatment of autistic symptoms

Avraham, Y., Mankuta, D., Lipsker, L., Vorobiev, L., Patael, S., Hassid, G., Berry, E. M., & Albeck, A. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105224 · Cited by 22 · see citing works

Suppressed play behaviour and decreased oxytocin receptor binding in the amygdala after prenatal exposure to low-dose valproic acid

Bertelsen, F., Folloni, D., Møller, A., Landau, A. M., Scheel‐Krüger, J., & Winterdahl, M. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000316 · Cited by 19 · see citing works

The Efficacy of Oxytocin in the Treatment of Autism Spectrum Disorder

Flannagan, L. (2020)

Intranasal Oxytocin for Emotional Responses in Adults with Autism

Yager, J. (2017) · Journal watch · doi:10.1056/nejm-jw.na44228

Oxytocin treatment, circuitry and autism: a critical review of the literature placing oxytocin into the autism context

Guastella, A. J., & Hickie, I. B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.028 · Cited by 223 · see citing works

Oxytocin-based pharmacotherapy for Autism Spectrum Disorders: Investigating the immediate and long-term effects from a neural and behavioral perspective

Prinsen, J., Bernaerts, S., Dillen, C., Berra, E., Brams, S., Wenderoth, N., & Alaerts, K. (2016) · Lirias · Cited by 1 · see citing works

The potential application of oxytocin in autism spectrum disorders

Staicu, I. (2019)