Intranasal insulin improves memory in humans

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Items 101–200 of 698

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2. Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model
   Xu Wang, Wei Hui Zheng, Jingwei Xie, Tao Wang, Siling Wang, Weiping Teng, Zhan‐You Wang · 2010 · Molecular Neurodegeneration
3. Lysosomal enzyme replacement therapies: Historical development, clinical outcomes, and future perspectives
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4. Insulin and Alzheimer's Disease: Untangling the Web
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5. Crosstalk between obesity, diabetes, and alzheimer’s disease: Introducing quercetin as an effective triple herbal medicine
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6. Insulin transport across the blood–brain barrier can occur independently of the insulin receptor
   Elizabeth M. Rhea, Christian Rask‐Madsen, William A. Banks · 2018 · The Journal of Physiology
7. GluT4: A central player in hippocampal memory and brain insulin resistance
   Ewan C. McNay, Jiah Pearson-Leary · 2019 · Experimental Neurology
8. A Randomized Controlled Trial of High-Dose Vitamin D2 Followed by Intranasal Insulin in Alzheimer's Disease
   Mark S. Stein, Samuel C. Scherer, Kylie S. Ladd, Leonard C. Harrison · 2011 · Journal of Alzheimer s Disease
9. Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice
   Alexis M. Stranahan, Kim Lee, Kevin G. Becker, Yonqing Zhang, Stuart R. Maudsley, Bronwen Martin, Roy G. Cutler, Mark P. Mattson · 2008 · Neurobiology of Aging
10. Limited Alzheimer-type neurodegeneration in experimental obesity and type 2 diabetes mellitus
    Moroz, Natalie, Tong, Ming, Longato, Lisa, Xu, Haiyan, de la Monte, Suzanne M. · 2008 · Journal of Alzheimer s Disease
11. New therapeutic approach for brain tumors: Intranasal delivery of telomerase inhibitor GRN163
    Rintaro Hashizume, Tomoko Ozawa, Sergei M Gryaznov, Andrew W. Bollen, Kathleen R. Lamborn, William H. Frey, Dennis F. Deen · 2008 · Neuro-Oncology
12. Impairments in glucose tolerance can have a negative impact on cognitive function: A systematic research review
    Daniel Joseph Lamport, Clare Louise Lawton, Michael W. Mansfield, Louise Dye · 2008 · Neuroscience & Biobehavioral Reviews
13. Nose-to-brain delivery of insulin enhanced by a nanogel carrier
    Picone, Pasquale, Sabatino, Maria Antonietta, Ditta, Lorena Anna, Amato, Antonella, San Biagio, Pier Luigi, Mulè, Flavia, Giacomazza, Daniela, Dispenza, Clelia, Di Carlo, Marta · 2018 · Journal of Controlled Release
14. Metabolic Syndrome as a Risk Factor for Alzheimer’s Disease: A Focus on Insulin Resistance
    Amaia Ezkurdia, María Javier Ramírez, Maite Solas · 2023 · International Journal of Molecular Sciences
15. Distribution of insulin in trigeminal nerve and brain after intranasal administration
    Lochhead, Jeffrey J., Kellohen, Kathryn L., Ronaldson, Patrick T., Davis, Thomas P. · 2019 · Scientific Reports
16. Peripheral Hyperinsulinemia Promotes Tau Phosphorylation In Vivo
    Susanna Freude, Leona Plum, Jessika Schnitker, Uschi Leeser, Michael Udelhoven, Wilhelm Krone, Jens C. Brüning, M Schubert · 2005 · Diabetes
17. Metabolism-Centric Overview of the Pathogenesis of Alzheimer's Disease
    Somang Kang, Yong‐ho Lee, Jong Eun Lee · 2017 · Yonsei Medical Journal
18. Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced Alzheimer’s rat model
    Zhangyu Guo, Yanxing Chen, Yanfang Mao, Tingting Zheng, Yasi Jiang, Yaping Yan, Xinzhen Yin, Baorong Zhang · 2017 · Scientific Reports
19. Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration
    Ana Isabel Duarte, Emanuel Candeias, Sónia C. Correia, Renato X. Santos, Cristina Carvalho, Susana Cardoso, Ana I. Plácido, Maria S. Santos, Catarina Resende Oliveira, Paula Isabel Moreira · 2013 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
20. Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism
    Ott, V., Benedict, C., Schultes, B., Born, J., Hallschmid, M. · 2012 · Diabetes, Obesity and Metabolism
21. Intranasal insulin in Alzheimer’s dementia or mild cognitive impairment: a systematic review
    Konstantinos Ioannis Avgerinos, Grigorios Kalaitzidis, Antonia Malli, Dimitrios Kalaitzoglou, Evangelos Pavlos Myserlis, Vasileios‐Arsenios Lioutas · 2018 · Journal of Neurology
22. Obesity-related cognitive impairment: The role of endothelial dysfunction
    Joy N. Jones Buie, Luke S. Watson, Crystal J. Smith, Catrina Sims‐Robinson · 2019 · Neurobiology of Disease
23. Central Nervous System Delivery of Intranasal Insulin: Mechanisms of Uptake and Effects on Cognition
    Therese S. Salameh, Kristin M. Bullock, Isabel A. Hujoel, Michael L. Niehoff, Tami Wolden‐Hanson, Jung‐Hyun Kim, John Edward Morley, Susan A. Farr, William A. Banks · 2015 · Journal of Alzheimer s Disease
24. Obesity and insulin resistance are associated with reduced activity in core memory regions of the brain
    Lucy G. Cheke, Heidi M. Bonnici, Nicola Susan Clayton, Jon S. Simons · 2017 · Neuropsychologia
25. Lithium and Neuropsychiatric Therapeutics: Neuroplasticity via Glycogen Synthase Kinase-3β, β-Catenin, and Neurotrophin Cascades
    Akihiko Wada · 2009 · Journal of Pharmacological Sciences
26. Impaired Insulin Sensitivity as Indexed by the HOMA Score Is Associated With Deficits in Verbal Fluency and Temporal Lobe Gray Matter Volume in the Elderly
    Christian Benedict, Samantha Jane Brooks, Joel Kullberg, Jonathan Burgos, Matthew J. Kempton, Richard Nordenskjöld, Rūta Nylander, Lena Kilander, Suzanne Craft, Elna‐Marie Larsson et al. · 2012 · Diabetes Care
27. Intranasal Mucoadhesive Microemulsion of Tacrine to Improve Brain Targeting
    Viral V. Jogani, Pranav Shah, Pushpa Mishra, Anil Kumar Mishra, Ambikanandan R. Misra · 2008 · Alzheimer Disease & Associated Disorders
28. Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice
    Yanxing Chen, Zhao Yang, Chun‐Ling Dai, Zhihou Liang, Xiaoqin Run, Khalid Iqbal, Fei Liu, Cheng‐Xin Gong · 2014 · Experimental Neurology
29. Insulin, Aging, and the Brain: Mechanisms and Implications
    Abimbola A. Akintola, Diana van Heemst · 2015 · Frontiers in Endocrinology
30. The mechanism and efficacy of GLP-1 receptor agonists in the treatment of Alzheimer’s disease
    Du, Haiyang, Meng, Xiaoyu, Yao, Yu, Xu, Jun · 2022 · Frontiers in Endocrinology
31. Brain Insulin Dysregulation: Implication for Neurological and Neuropsychiatric Disorders
    Rasoul Ghasemi, Leila Dargahi, Ali Haeri, Maryam Moosavi, Zahurin Mohamed, Abolhassan Ahmadiani · 2013 · Molecular Neurobiology
32. Age-related slowing in cognitive processing speed is associated with myelin integrity in a very healthy elderly sample
    Po H. Lu, Grace J. Lee, Erika P. Raven, Kathleen Tingus, Theresa Khoo, Paul M. Thompson, George Bartzokis · 2011 · Journal of Clinical and Experimental Neuropsychology
33. Thyroid Hormone Signaling and Homeostasis During Aging
    Bowers, J., Terrien, J., Clerget-Froidevaux, M. S., Gothié, J. D., Rozing, M. P., Westendorp, R. G. J., van Heemst, D., Demeneix, B. A. · 2013 · Endocrine Reviews
34. Predictors of progression of cognitive decline in Alzheimer’s disease: the role of vascular and sociodemographic factors
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35. Brain delivery of proteins by the intranasal route of administration: A comparison of cationic liposomes versus aqueous solution formulations
    Mattia M. Migliore, Tushar K. Vyas, Robert B. Campbell, Mansoor M. Amiji, Barbara L. Waszczak · 2009 · Journal of Pharmaceutical Sciences
36. Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease
    Tomoko Wakabayashi, Kazuki Yamaguchi, Kentaro Matsui, Toshiharu Sano, Tetsuya Kubota, Tadafumi Hashimoto, Ayako Mano, Kaoru Yamada, Yuko Matsuo, Naoto Kubota et al. · 2019 · Molecular Neurodegeneration
37. Intranasal Insulin and Insulin-Like Growth Factor 1 as Neuroprotectants in Acute Ischemic Stroke
    Vasileios‐Arsenios Lioutas, Freddy Alfaro-Martinez, Francisco Javier Bedoya, Chen‐Chih Chung, Daniela Pimentel Maldonado, Vera Novak · 2015 · Translational Stroke Research
38. The Relevance of Insulin Action in the Dopaminergic System
    Francesca Fiory, Giuseppe Perruolo, Ilaria Cimmino, Serena Cabaro, Francesca Chiara Pignalosa, Claudia Miele, Francesco Bèguinot, Pietro Formisano, Francesco Oriente · 2019 · Frontiers in Neuroscience
39. Delivery of Galanin-Like Peptide to the Brain: Targeting with Intranasal Delivery and Cyclodextrins
    Naoko Nonaka, Susan A. Farr, Haruaki Kageyama, Seiji Shioda, William A. Banks · 2008 · Journal of Pharmacology and Experimental Therapeutics
40. Evolutionary origins of insulin resistance: a behavioral switch hypothesis
    Watve, Milind G, Yajnik, Chittaranjan S · 2007 · BMC Evolutionary Biology
41. Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction
    Luke E. Stoeckel, Zoe Arvanitakis, Sam Gandy, Dana Melanie Small, C. Ronald Kahn, Álvaro Pascual‐Leone, Aaron C. Pawlyk, Robert Sherwin, Philip Smith · 2016 · F1000Research
42. Mini-review: Impact of recurrent hypoglycemia on cognitive and brain function
    McNay, Ewan C., Cotero, Victoria E. · 2010 · Physiology & Behavior
43. Strategies for Intranasal Delivery of Therapeutics for the Prevention and Treatment of NeuroAIDS
    Leah R. Hanson, William H. Frey · 2006 · Journal of Neuroimmune Pharmacology
44. Safety of intranasal human insulin: A review
    Schmid, Vera, Kullmann, Stephanie, Gfrörer, Wieland, Hund, Verena, Hallschmid, Manfred, Lipp, Hans‐Peter, Häring, Hans‐Ulrich, Preissl, Hubert, Fritsche, Andreas, Heni, Martin · 2018 · Diabetes, Obesity and Metabolism
45. Intranasal insulin
    Hallschmid, Manfred · 2021 · Journal of Neuroendocrinology
46. Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions
    Martin Heni, Stephanie Kullmann, Caroline Ketterer, Martina Guthoff, Katarzyna Linder, Robert J. Wagner, Krunoslav T. Stingl, Ralf Veit, Harald Staiger, Hans‐Ulrich Häring et al. · 2012 · Diabetologia
47. Apolipoprotein E Affects Both Myelin Breakdown and Cognition: Implications for Age-Related Trajectories of Decline Into Dementia
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48. Insulin resistance, inflammation, and cognition in Alzheimer's Disease: Lessons for multiple sclerosis
    G. Stennis Watson, Suzanne Craft · 2006 · Journal of the Neurological Sciences
49. Intranasal Insulin Modulates Intrinsic Reward and Prefrontal Circuitry of the Human Brain in Lean Women
    Kullmann, Stephanie, Frank, Sabine, Heni, Martin, Ketterer, Caroline, Veit, Ralf, Häring, Hans-Ulrich, Fritsche, Andreas, Preissl, Hubert · 2013 · Neuroendocrinology
50. Can Nasal Drug Delivery Bypass the??Blood-Brain Barrier?
    Frans W. H. M. Merkus, Mascha P van den Berg · 2007 · Drugs in R&D
51. Inflammation and Insulin Resistance as Risk Factors and Potential Therapeutic Targets for Alzheimer’s Disease
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52. Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation
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53. Brain energy metabolism: A roadmap for future research
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54. A randomized, double‐blind, controlled trial evaluating the effect of intranasal insulin on neurocognitive function in euthymic patients with bipolar disorder
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55. How Can Insulin Resistance Cause Alzheimer’s Disease?
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56. The voltage-gated potassium channel Kv1.3 is a promising multitherapeutic target against human pathologies
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57. Interactions between metabolic, reward and cognitive processes in appetite control: Implications for novel weight management therapies
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58. Intranasal insulin in Alzheimer's disease: Food for thought
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59. Intranasal insulin protects against substantia nigra dopaminergic neuronal loss and alleviates motor deficits induced by 6-OHDA in rats
    Yi Pang, S. Lin, C. Wright, Jiangang Shen, K. Carter, A. Bhatt, L.-W. Fan · 2016 · Neuroscience
60. Depression and Cognitive Impairment—Extrahepatic Manifestations of NAFLD and NASH
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61. Focused ultrasound combined with microbubble-mediated intranasal delivery of gold nanoclusters to the brain
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62. Intracerebroventricular insulin improves spatial learning and memory in male Wistar rats.
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63. Increasing the Effciency of Parkinson’s Disease Treatment Using a poly(lactic-co-glycolic acid) (PLGA) Based L-DOPA Delivery System
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64. Intranasal Insulin Administration Ameliorates Streptozotocin (ICV)-Induced Insulin Receptor Dysfunction, Neuroinflammation, Amyloidogenesis, and Memory Impairment in Rats
    N. Rajasekar, Chandishwar Nath, Kashif Hanif, Rakesh Shukla · 2016 · Molecular Neurobiology
65. Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review
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66. Non-Invasive Strategies for Nose-to-Brain Drug Delivery.
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67. New Twist on Neuronal Insulin Receptor Signaling in Health, Disease, and Therapeutics
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68. Intranasal therapeutic strategies for management of Alzheimer’s disease
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69. Pathophysiological Mechanisms Linking Type 2 Diabetes and Dementia: Review of Evidence from Clinical, Translational and Epidemiological Research
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70. Insulin Promotes Neuronal Survival via the Alternatively Spliced Protein Kinase CδII Isoform
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71. Tissue selectivity of insulin detemir action in vivo
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72. Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial
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73. Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger
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74. Intranasal drug delivery for treatment of Alzheimer’s disease
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75. Neurodegeneration in Diabetes Mellitus
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76. Current state and future directions of intranasal delivery route for central nervous system disorders: a Scientometric and visualization analysis
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77. Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease
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78. Identification of the molecular mechanism of insulin-like growth factor-1 (IGF-1): a promising therapeutic target for neurodegenerative diseases associated with metabolic syndrome
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79. Central nervous insulin resistance: a promising target in the treatment of metabolic and cognitive disorders?
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80. Impact of insulin and insulin resistance on brain dopamine signalling and reward processing – An underexplored mechanism in the pathophysiology of depression?
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81. The effect of intrahippocampal insulin microinjection on spatial learning and memory
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82. A Genome-wide Screen Identifies PAPP-AA-Mediated IGFR Signaling as a Novel Regulator of Habituation Learning
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83. Intranasal insulin attenuates the hypothalamic–pituitary–adrenal axis response to psychosocial stress
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84. Intranasal delivery of stem cells to the brain
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85. Intranasal insulin treatment of an experimental model of moderate traumatic brain injury
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86. Rapid and reversible impairment of episodic memory by a high-fat diet in mice
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87. Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging
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88. Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling
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89. Metabolic Dysfunction in Alzheimer’s Disease: From Basic Neurobiology to Clinical Approaches
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90. Diabetes, a Contemporary Risk for Parkinson’s Disease: Epidemiological and Cellular Evidences
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91. Obesity, Insulin Resistance, and Alzheimer's Disease
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92. Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains
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93. Mechanisms of memory enhancement
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94. First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease
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95. Deregulation of brain insulin signaling in Alzheimer’s disease
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96. The paradox of neuronal insulin action and resistance in the development of aging‐associated diseases
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97. Insulin and Hippocampus Activation in Response to Images of High‐Calorie Food in Normal Weight and Obese Adolescents
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98. Insulin Treatment Prevents Neuroinflammation and Neuronal Injury with Restored Neurobehavioral Function in Models of HIV/AIDS Neurodegeneration
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99. GLP-1 receptor agonists show neuroprotective effects in animal models of diabetes
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100. Transnasal Delivery of Methotrexate to Brain Tumors in Rats: A New Strategy for Brain Tumor Chemotherapy
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