Clinical burnout is not reflected in the cortisol awakening response, the day curve or the response to a low-dose dexamethasone suppression test

Mommersteeg, Paula M.C.; Heijnen, Cobi J.; Verbraak, Marc J.P.M.; van Doornen, Lorenz J.P.

doi:10.1016/j.psyneuen.2005.07.003

Cited by 111Stress Responses and CortisolStress and Burnout ResearchHealthcare professionals’ stress and burnout

Clinical burnout is not reflected in the cortisol awakening response, the day curve or the response to a low-dose dexamethasone suppression test

Mommersteeg, Paula M.C., Heijnen, Cobi J., Verbraak, Marc J.P.M., van Doornen, Lorenz J.P.·2006·Psychoneuroendocrinology

DOI 10.1016/j.psyneuen.2005.07.003

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Abstract

Burnout is presumed to be the result of chronic stress, and chronic stress is known to affect the HPA-axis. To date, studies on HPA-axis functioning in burnout have showed inconsistent results. In the present study, a large sample (n=74) of clinically diagnosed burnout individuals, mostly on sick-leave, were included and compared with 35 healthy controls. Salivary cortisol was sampled on 2 days to determine the cortisol awakening response (CAR) and the day-curve. In addition, the dexamethasone suppression test (DST) was applied to assess the feedback efficacy of the HPA-axis. There were no differences observed in the CAR, day-curve or CAR after DST in the burnout group as compared to a healthy control group. Burnout shows overlap in symptoms with chronic fatigue syndrome (CFS) and depression. Therefore, differential changes in HPA-axis functioning that resemble the hypo-functioning of the HPA-axis in CFS, or rather the hyper-functioning of the HPA-axis in depression, might have obscured the findings. However, no effect of fatigue or depressive mood on HPA-axis functioning was found in the burnout group. We concluded that HPA-axis functioning in clinically diagnosed burnout participants as tested in the present study, seems to be normal.

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Another study found a positive correlation between CAR measures and depression.
“but positively correlated in another (Mommersteeg et al., 2006)”
From Psychosocial functioning and the cortisol awakening response: meta-analysis, P-curve analysis, and evaluation of the evidential value in existing studies (2017) · cites this paper as Mommersteeg et al., 2006

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Authors: Mommersteeg, P. M. C., Heijnen, C. J., Verbraak, M. J. P. M., & van Doornen, L. J. P.
Affiliations: Utrecht University (NL)
University Medical Center Utrecht (NL)
HSK Groep (NL)
Corresponding author: Mommersteeg, Paula M.C.
ORCID: Mommersteeg, Paula M.C.
Heijnen, Cobi J.
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2006-02
Volume: 31
Issue: 2
Pages: 216-225
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/j.psyneuen.2005.07.003
OpenAlex: W2097041359
Cited by: 111
References: 52
Citations by year: 2026: 2 · 2025: 2 · 2024: 3 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 8
FWCI: 4.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Social Psychology › Stress and Burnout Research
Health Sciences › Health Professions › General Health Professions › Healthcare professionals’ stress and burnout
Keywords: burnout, cortisol awakening response, hypothalamic-pituitary-adrenal axis, dexamethasone suppression test, chronic stress, salivary cortisol, chronic fatigue syndrome, depression, fatigue, sick leave
MeSH terms: Adult, Analysis of Variance, Burnout, Professional, Circadian Rhythm, Dexamethasone, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Pituitary-Adrenal System, Reference Values, Saliva, Wakefulness, Chi-Square Distribution, Statistics, Nonparametric, Area Under Curve, Feedback, Physiological

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Clinical burnout is not reflected in the cortisol awakening response, the day curve or the response to a low-dose dexamethasone suppression test

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