Cited by 128Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroendocrine regulation and behavior

Early motherhood in rats is associated with a modification of hippocampal function

Darnaudéry, Muriel, Perez-Martin, Margarita, Del Favero, Fabien, Gomez-Roldan, Carmen, Garcia-Segura, Luis Miguel, Maccari, Stefania·2007·Psychoneuroendocrinology

Abstract

The transition to motherhood results in a number of hormonal, neurological and behavioral changes necessary to ensure offspring survival. However, little attention has been paid to changes not directly linked to reproductive function in the early mother. In this study, we demonstrate that spatial performances during the learning phase were impaired after the delivery in rats, while spatial retention ability was improved 2 weeks later. In addition, we also report that early motherhood reduced the cell proliferation in the dentate gyrus of the hippocampus without inducing a decrease in the newborn cells 2 weeks later. The decrease of estradiol levels and high levels of glucocorticoids after delivery could in part explain the changes in the hippocampal function. In summary, our findings suggest that early postpartum period is associated with a modification of hippocampal function. This may reflect a homeostatic form of hippocampal plasticity in response to the onset of the maternal experience.

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Crossref · 10.1016/j.psyneuen.2007.05.012

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  • Parenting has suppressive effects on adult neurogenesis in both mothers and fathers.

    “In both mothers and fathers, parenting has suppressive effects on adult neurogenesis (Darnaudéry et al., 2007; Glasper et al., 2011; Hyer et al., 2016; Leuner et al., 2007; Pawluski and Galea, 2007; Mahmoud et al., 2016).”

    From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Darnaudéry et al., 2007

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Authors
Darnaudéry, M., Perez-Martin, M., Del Favero, F., Gomez-Roldan, C., Garcia-Segura, L. M., & Maccari, S.
Affiliations
  • Université de Lille (FR)
  • Universidad de Málaga (ES)
Corresponding author
Darnaudéry, Muriel
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2007-08
Volume
32
Issue
7
Pages
803-812
ISSN
0306-4530 (ISSN-L)
OpenAlex
W2088366321
Cited by
128
References
56
Citations by year
2026: 2 · 2025: 2 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 12 · 2018: 8 · 2017: 4 · 2016: 11 · 2015: 10 · 2014: 9 · 2013: 9 · 2012: 4
FWCI
1.64
Type
journal article
Language
en
Open access
closed
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders
Université de Lille
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
early motherhood, postpartum period, hippocampus, spatial learning, dentate gyrus, cell proliferation, estradiol, glucocorticoids, maternal behavior, hippocampal plasticity, rats
MeSH terms
Animals, Antimetabolites, Bromodeoxyuridine, Cell Survival, Cognition, Corticosterone, Estradiol, Female, Hippocampus, Immunohistochemistry, Mothers, Neuronal Plasticity, Pregnancy, Space Perception, Rats, Sprague-Dawley, Maze Learning, Dentate Gyrus, Cell Proliferation, Rats

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