Paternal experience suppresses adult neurogenesis without altering hippocampal function in Peromyscus californicus
Abstract
Paternal care is rare among mammals, occurring in ≈6% of species. California mice (Peromyscus californicus) are unusual; fathers participate extensively in raising their young and display the same components of parental care as mothers, with the exception of nursing. Parenting is a complex experience, having stressful and enriching aspects. The hippocampus is sensitive to experience and responds to both stress and environmental enrichment with changes in structure and function. In rats, where females care exclusively for offspring, parenting is associated with suppressed hippocampal adult neurogenesis. Since this effect has been causally linked to lactation, it is unlikely that fathers would show a similar change. To investigate this issue, we examined adult neurogenesis in the hippocampus of California mouse fathers compared to males without pups and observed reduced adult neurogenesis. Similar effects were found in California mouse mothers. Next, we investigated whether behaviors linked to the hippocampus, namely, object recognition and novelty-suppressed feeding, were altered in fathers, and observed no substantial changes. During caregiving, suppressed adult neurogenesis does not appear to be related to changes in behaviors associated with the hippocampus, although it is possible that there are other effects on hippocampal function.
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Parenting has suppressive effects on adult neurogenesis in both mothers and fathers.
“In both mothers and fathers, parenting has suppressive effects on adult neurogenesis (Darnaudéry et al., 2007; Glasper et al., 2011; Hyer et al., 2016; Leuner et al., 2007; Pawluski and Galea, 2007; Mahmoud et al., 2016).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Glasper et al., 2011
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“A similar effect was observed among male mice interacting with pups for two days (Mak and Weiss, 2010), but three weeks of paternal behavior reduced neurogenesis among monogamous California mice (Glasper et al., 2011).”
BackgroundAdult mammalian neurogenesis and motivated behaviors
Jorgensen, C. (2018) · Integrative Zoology · doi:10.1111/1749-4877.12335 · Cited by 15 · see citing works
Castro, A. E., Domínguez‐Ordóñez, R., Young, L. J., Camacho, F., Ávila‐González, D., Paredes, R. G., Díaz, N. F., & Portillo, W. (2022) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2022.987229 · Cited by 14 · see citing works
“Fatherhood also decreases cell survival in the DG of monogamous California mice (Glasper et al., 2011) and prairie voles (Lieberwirth et al.”
BackgroundHyer, M. M., & Glasper, E. R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175713 · Cited by 13 · see citing works
Ruscio, M. G., King, S. B., & Haun, H. L. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.08.039 · Cited by 12 · see citing works
“Both markers are commonly used for designating neuronal phenotypes in rodents and have been used in the prairie vole and California mouse [3,4,6,7].”
BackgroundNeural stem cell heterogeneity in adult hippocampus
Liang, Z., Jin, N., & Guo, W. (2025) · Cell Regeneration · doi:10.1186/s13619-025-00222-4 · Cited by 11 · see citing works
“…to enhance the proliferation capacity of NSCs, while stress and depression (Czéh et al. 2002; Oomen et al. 2007; Li et al. 2008; Kim et al.2024), obesity (Park et al. 2010), and parenting (Glasper et al. 2011; Galea et al. 2014) negatively impact NSC proliferation (Opendak and Gould 2015).”
Byrnes, E. M., Casey, K. M., Carini, L. M., & Bridges, R. S. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12113 · Cited by 11 · see citing works
Madison, F. N., Palin, N., Whitaker, A. R., & Glasper, E. R. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.07.161 · Cited by 10 · see citing works
Fatherhood alters gene expression within the MPOA
Seelke, A. M. H., Bond, J. M., Simmons, T. C., Joshi, N., Settles, M. L., Stolzenberg, D. S., Rhemtulla, M., & Bales, K. L. (2018) · Current Zoology · doi:10.1093/eep/dvy026 · Cited by 10 · see citing works
Plasticity in auditory cortex during parenthood
Haimson, B., & Mizrahi, A. (2023) · Hearing Research · doi:10.1016/j.heares.2023.108738 · Cited by 9 · see citing works
In the pursuit of new social neurons. Neurogenesis and social behavior in mice: A systematic review
García-Gómez, L., Castillo-Fernández, I., & Pérez‐Villalba, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1011657 · Cited by 8 · see citing works
“Unfortunately, the neurogenic effect for progenitors was the opposite as parenting decreases BrdU cells in the DG in male and female parents compared to controls (Glasper et al., 2011).”
ResultSinks, M. R., Morrison, D. E., Ramdev, R. A., Lentzou, S., & Spritzer, M. D. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.05.018 · Cited by 3 · see citing works
Cognition and Neuroplasticity During Pregnancy and Postpartum
Blankers, S. A., Go, K. A., Surtees, D. C., Splinter, T. F. L., & Galea, L. A. M. (2024) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-51138-7_9 · Cited by 3 · see citing works
Wegener, A. J., Fulenwider, H. D., Stadtler, H., Howell, P. A., Abosamak, N., Turkson, S., Ream, C., Shah, N. H., Glasper, E. R., & Neigh, G. N. (2025) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2025.107647 · Cited by 2 · see citing works
Adult Neurogenesis and Social Behavior: A Reciprocal Relationship
Jorgensen, C., & Wang, Z. (2024) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-51112-7_6 · Cited by 2 · see citing works
Colt, M. E., Agarwal, P., Kolb, D., Glasper, E. R., & Fisher, H. S. (2025) · Animal Behaviour · doi:10.1016/j.anbehav.2025.123216 · Cited by 2 · see citing works
“Importantly, the Glasper et al. (2011) study did not include pup-sensitized nonfathers as an experimental group, leaving open the question of how caregiving behaviours independent of reproduction might in fl uence recognition memory.”
Neural Plasticity in Human Fathers
Grande, L. A., Tribble, R. C., & Kim, P. (2020) · Springer eBooks · doi:10.1007/978-3-030-51027-5_11 · Cited by 2 · see citing works
Remodelage neurobiologique pendant la transition vers la paternité
Newsome, P., Waizman, Y. H., Vavala, G., & Saxbe, D. (2025) · Sages-Femmes · doi:10.1016/j.sagf.2025.11.006 · Cited by 1 · see citing works
Bales, K. L., Finnerty-Haggerty, A., Guan, J., Meckler, L., Saenz, J., Sosnowski, M. J., Afrakhteh, S., Hung, C. L., Purewal, R. A., Oliinyk, S. L., et al. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1779750 · Cited by 1 · see citing works
“However, in contrast, California mouse fathers did not show differences in object recognition or exploration tasks (which reflect short-term memory and novelty-seeking behavior, respectively) as opposed to virgins (Glasper et al., 2011).”
Sex differences and parental experience contribute to hippocampal remodelling across the lifespan
Duarte‐Guterman, P., & Zugno-Gadea, N. (2023) · Current Opinion in Physiology · doi:10.1016/j.cophys.2023.100703 · Cited by 1 · see citing works
Shorter, K. R. (2014) · Scholar Commons (University of South Carolina) · Cited by 1 · see citing works
Social instability, hippocampal plasticity and resilience
Opendak, M. M. (2015)
Colt, M. E., Agarwal, P., Kolb, D., Glasper, E. R., & Fisher, H. S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.08.617085
Wegener, A. J., Stadtler, H., Fulenwider, H. D., Glasper, E. R., & Neigh, G. N. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101087
“The use of this species of mouse has increased our understanding of paternal behavior (Glasper et al., 2011, 2016), mate fidelity (Gubernick and Nordby, 1993; Pultorak et al., 2018), early life adverse experiences (Madison et al., 2022; Walker et al., 2023), and social decision making (Gleason et…”
- Authors
- Glasper, E. R., Kozorovitskiy, Y., Pavlic, A., & Gould, E.
- Affiliations
- Princeton University (US)
- Corresponding author
- Gould, Elizabeth
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2011-06-22
- Volume
- 519
- Issue
- 11
- Pages
- 2271-2281
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W2166372596
- Cited by
- 66
- References
- 52
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 8 · 2017: 5 · 2016: 10 · 2015: 7 · 2014: 5 · 2013: 2 · 2012: 3
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (F32AG033461)
- National Institute of Mental Health (5 RO1 MH0597405)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- paternal care, adult neurogenesis, hippocampus, California mouse, Peromyscus californicus, parental behavior, maternal care, object recognition, novelty-suppressed feeding, stress, environmental enrichment, hippocampal function
- MeSH terms
- Animals, Female, Hippocampus, Humans, Male, Neurons, Neuropsychological Tests, Paternal Behavior, Peromyscus, Social Behavior, Mice, Rats, Neurogenesis
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