Activation of 5-HT1A autoreceptors in the dorsal raphe nucleus reduces the behavioral consequences of social defeat
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In animal models, serotonin (5-HT) activity contributes to stress-induced changes in behavior. Syrian hamsters (Mesocricetus auratus) exhibit a stress-induced change in behavior in which social defeat results in increased submissive and defensive behavior and a complete loss of normal territorial aggression directed toward a novel, non-aggressive opponent. We refer to this defeat-induced change in agonistic behavior as conditioned defeat. In this study we tested the hypothesis that 5-HT activity in the dorsal raphe nucleus (DRN) contributes to the acquisition and expression of conditioned defeat. We investigated whether injection of the selective 5-HT1A agonist flesinoxan (200 ng, 400 ng, or 800 ng in 200 nl saline) into the DRN would reduce the acquisition and expression of conditioned defeat. Additionally, we investigated whether injection of the selective 5-HT1A antagonist WAY 100635 (400 ng in 200 nl saline) into the DRN would enhance the acquisition and expression of conditioned defeat following a sub-optimal social defeat experience. We found that injection of flesinoxan into the DRN before exposure to a 15-min social defeat reduced the amount of submissive and defensive behavior shown at testing. We also found that injection of flesinoxan into the DRN before testing similarly reduced submissive and defensive behavior. In addition, we found that WAY 100635 enhanced conditioned defeat when injected either before social defeat or before testing. These data support the hypothesis that the activity of 5-HT cells in the DRN, as regulated by 5-HT1A autoreceptors, contributes to the formation and display of conditioned defeat. Further, our results suggest that 5-HT release in DRN projection regions augments defeat-induced changes in social behavior.
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Ethnic minority status can increase the risk of psychopathology through social isolation, experiences of discrimination, victimisation and social defeat, which are all considered stressors.
“It is also likely that ethnic minority status can increase the risk of psychopathology through social isolation, experiences of discrimination, victimisation and social defeat, which are all considered stressors (Morgan et al., 2010; Bécares et al., 2009; Cooper et al., 2008; Cooper et al., 2017; Selten and Cantor-Graae, 2005; Selten et al., 2012; Sharpley et al., 2001; Tidey and Miczek, 1996).”
From The effects of psychosocial stress on dopaminergic function and the acute stress response (2019) · cites this paper as Cooper et al., 2008
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Bloomfield, M. A., McCutcheon, R. A., Kempton, M., Freeman, T. P., & Howes, O. (2019) · eLife · doi:10.7554/elife.46797 · Cited by 112 · see citing works
“It is also likely that ethnic minority status can increase the risk of psychopathology through social isolation, experiences of discrimination, victimisation and social defeat, which are all considered stressors (Morgan et al., 2010; Bécares et al., 2009; Cooper et al., 2008; Cooper et al., 2017; Selten and Cantor-Gra…”
BackgroundSex differences in the regulation of offensive aggression and dominance by arginine-vasopressin
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Cognitive Control as a 5-HT1A-Based Domain That Is Disrupted in Major Depressive Disorder
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- Authors
- Cooper, M. A., McIntyre, K. E., & Huhman, K. L.
- Affiliations
- University of Tennessee at Knoxville (US)
- Georgia State University (US)
- Corresponding author
- Cooper, Matthew A.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 33
- Issue
- 9
- Pages
- 1236-1247
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC2572256
- OpenAlex
- W2041950072
- Cited by
- 52
- References
- 75
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 6 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 6
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH062044, MH 62044, F32 MH72085, F32MH072085)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- 5-HT1A autoreceptors, dorsal raphe nucleus, social defeat, serotonin, flesinoxan, WAY-100635, submissiveness, defensive behavior, territorial aggression, golden hamster
- MeSH terms
- Adaptation, Psychological, Aggression, Analysis of Variance, Animals, Association Learning, Behavior, Animal, Conditioning, Classical, Dominance-Subordination, Cricetinae, Male, Mesocricetus, Piperazines, Raphe Nuclei, Social Environment, Stress, Psychological, Territoriality, Serotonin Receptor Agonists, Receptor, Serotonin, 5-HT1A, Serotonin 5-HT1 Receptor Agonists
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