The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Oxytocin differentially modulates eye gaze to naturalistic social signals of happiness and anger
Abstract
A number of previous studies has shown that oxytocin (OT) promotes facial emotion recognition and enhances eye gaze to facial stimuli in humans. Other studies report valence-specific effects of OT, supporting the proposed prosocial role of OT in social interactions. In the present study, we tested the hypothesis whether OT might selectively enhance eye gaze to positive, approach-related, but not to negative, threat-related social cues. In a placebo-controlled, double-blind, between-subject design, we assessed the effects of intranasal OT administration (24 IU) in 62 healthy male volunteers on eye gaze toward the eyes of neutral, positive (happy) and negative (angry) facial expressions compared with placebo. In order to capture the dynamics of facial expressions, we used video sequences showing neutral faces gradually displaying a specific emotion. In line with previous studies, OT increased eye gaze toward neutral facial expressions. Moreover, under OT treatment, eye gaze remained increased when the face showed a happy facial expression, but in contrast decreased when the face displayed an angry expression. These results support the notion that OT differentially modulates visual attention toward social signals of positive approach and threat and thereby contributes to the modulation of non-verbal interpersonal communication.
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In the citing paper
“IN-OT increases gaze time or visual fixation toward the eye region and the face (Auyeung et al. 2015; Domes et al. 2013; Guastella et al. 2008).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Domes et al. 2013
In the citing paper
“Observed variability in behavioural effects of oxytocin may therefore be influenced by variability in oxytocin deposition onto the olfactory epithelium for optimal drug absorption.33”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [33]
In the citing paper
“There are at least three potential pathways by which intranasal administration of oxytocin may enter central and peripheral circulation to exert behavioural effects.33”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [33]
Citations
Cites
Comprehensive database for facial expression analysis
Takeo Kanade, A., Cohn, J. F., & Tian, Y. (2002) · International Conference on Automatic Face and Gesture Recognition · doi:10.1109/afgr.2000.840611 · Cited by 2,637
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
Self-citationOxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645
Recognizing emotion from facial expressions: psychological and neurological mechanisms
Adolphs, R. (2002) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582302001001003 · Cited by 1,432
Neuroendocrine perspectives on social attachment and love
Sue Carter, C. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00055-9 · Cited by 1,425
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298
Self-citationOxytocin, vasopressin, and human social behavior
Heinrichs, M., von Dawans, B., & Domes, G. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.005 · Cited by 799
Self-citationOxytocin increases gaze to the eye region of human faces
Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.026 · Cited by 798
Bal, E., Harden, E., Lamb, D., Van Hecke, A. V., Denver, J. W., & Porges, S. W. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-009-0884-3 · Cited by 575
Self-citationDifferent amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
Gamer, M., Zurowski, B., & Büchel, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000985107 · Cited by 487 · cited 6×
“Whereas a previous study showed that OT can enhance reflexive saccades toward the eye region of very briefly presented emotional faces regardless of valence (Gamer et al., 2010), our results seem to reflect a modulation of visual attention depending on the social signal communicated by the presented expression when th…”
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Metadata
- Authors
- Domes, G., Steiner, A., Porges, S. W., & Heinrichs, M.
- Affiliations
- University of Freiburg (DE)
- University of Illinois Chicago (US)
- Corresponding author
- Domes, Gregor
- Heinrichs, Markus
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 38
- Issue
- 7
- Pages
- 1198-1202
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2049589805
- Cited by
- 139
- References
- 18
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 10 · 2022: 6 · 2021: 13 · 2020: 10 · 2019: 12 · 2018: 7 · 2017: 18 · 2016: 12 · 2015: 15 · 2014: 14 · 2013: 10
- FWCI
- 18.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, gaze, facial expressions, happiness, anger, social signals, nonverbal communication, intranasal administration, social attention
- MeSH terms
- Administration, Intranasal, Adult, Anger, Attention, Double-Blind Method, Eye Movements, Facial Expression, Happiness, Humans, Male, Orientation, Oxytocin, Reaction Time, Recognition, Psychology
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