Intranasal oxytocin enhances emotion recognition from dynamic facial expressions and leaves eye-gaze unaffected
Abstract
Previous studies have shown that oxytocin improves the encoding and recognition of facial expressions, which has been proposed to be mediated by an increased exploration of the eye region during face processing. In the present study, we used eye tracking to assess visual attention to the eye region while participants performed a dynamic facial emotion recognition task. In a double-blind, placebo-controlled between-subjects design participants received 24 IU intranasal oxytocin (n = 23) or a placebo (n = 24). Although oxytocin administration had no effect on participants' visual scanning of emotional faces, it generally enhanced recognition performance, as the oxytocin group recognized emotional expressions at lower intensity levels. These findings suggest that oxytocin-induced improvement of facial emotion recognition is independent of modulations in overt visual attention.
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Some studies found improvements in facial emotion recognition were unaffected by eye-gaze.
“others suggesting that improvements in facial emotion recognition are unaffected by eye-gaze (Hubble et al., 2016;Lischke et al., 2012; )”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Lischke et al., 2012
Lischke and colleagues found no evidence that oxytocin altered eye-gaze in healthy participants, which contrasts with the present results.
“These results contrast with those reported by Lischke et al. (2012), who found no evidence that OXT altered eye-gaze in healthy participants.”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Lischke et al. (2012)
Intranasal OT enhances the identification of emotions regardless of valence, relative to placebo.
“others indicate that OT enhances the identification of emotions regardless of valence [14], relative to placebo.”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [14]
Findings from studies using lower level tasks administered after OT ingestion (RTs to emotion stimuli and emotion recognition tasks) tend to be mixed and sometimes inconsistent.
“findings from studies using lower level tasks administered after OT ingestion (RTs to emotion stimuli and emotion recognition tasks, for example) tend to be mixed and sometimes inconsistent [13], [10], [14], [11], [12].”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [14]
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- Authors
- Lischke, A., Berger, C., Prehn, K., Heinrichs, M., Herpertz, S. C., & Domes, G.
- Affiliations
- Heidelberg University (DE)
- University of Rostock (DE)
- Freie Universität Berlin (DE)
- University of Freiburg (DE)
- ORCID
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 37
- Issue
- 4
- Pages
- 475-481
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2128782393
- Cited by
- 221
- References
- 31
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 8 · 2023: 16 · 2022: 13 · 2021: 19 · 2020: 16 · 2019: 12 · 2018: 19 · 2017: 22 · 2016: 16 · 2015: 19 · 2014: 13 · 2013: 25 · 2012: 10
- FWCI
- 20.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, intranasal administration, facial emotion recognition, dynamic facial expressions, gaze, visual attention, emotional intensity, social cognition
- MeSH terms
- Administration, Intranasal, Adult, Attention, Double-Blind Method, Emotions, Eye Movements, Facial Expression, Humans, Male, Oxytocin, Photic Stimulation, Recognition, Psychology
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