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Obesity and major depression: Body-mass index (BMI) is associated with a severe course of disease and specific neurostructural alterations
Abstract
Obesity is one of the most prevalent somatic comorbidities of major depressive disorder (MDD). Both disorders rank among the leading challenges in public health and have been independently characterized by gray matter alterations in partly overlapping brain structures. Hence, it appears crucial to investigate the possibility of a shared neurostructural correlate of this frequent comorbidity as well as its clinical implications. One hundred and fourty-four patients suffering from acute MDD and 141 healthy control subjects underwent structural MRI. Imaging data were analyzed using voxel-based morphometry (VBM). Body-mass-index (BMI) as well as state and course of disease were assessed. Higher BMI was associated with a highly comparable pattern of gray matter reductions in the medial prefrontal cortex, the orbitofrontal cortex, the caudate nucleus and the thalamus in MDD patients and healthy controls alike. In MDD-patients, BMI was associated with a more chronic course of disease and both BMI and chronicity of disorder were related to similar morphometric anomalies in medial prefrontal areas. In MDD, obese subjects might be characterized by a more chronic course of disease. Moreover, obesity and chronicity of disorder seem to share overlapping neurostructural anomalies in prefrontal areas involved in emotion regulation and impulse control. Hence, our data provide evidence for specific morphological alterations underlying this prevalent comorbidity. It further underlines the clinical importance of preventive measures against obesity accompanying MDD treatment.
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Obesity and depression share similar morphometric anomalies in medial prefrontal cortex.
“Both obesity and depression share similar morphometric anomalies in medial prefrontal cortex [104]”
From The menace of obesity to depression and anxiety prevalence (2022) · cites this paper as [104]
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The menace of obesity to depression and anxiety prevalence
Fulton, S., Décarie-Spain, L., Fioramonti, X., Guiard, B., & Nakajima, S. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2021.10.005 · Cited by 441
“Both obesity and depression share similar morphometric anomalies in medial prefrontal cortex [104], and chronic HFD exposure in rodents, leading to obesity, gives rise to impairments in prefrontal cortex-dependent functions that are accompanied by changes in dendritic spine density and synaptic remodeling [105].”
BackgroundAn overview of links between obesity and mental health
Avila, C., Holloway, A. C., Hahn, M. K., Morrison, K. M., Restivo, M., Anglin, R., & Taylor, V. H. (2015) · Current Obesity Reports · doi:10.1007/s13679-015-0164-9 · Cited by 366
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Metadata
- Authors
- Opel, N., Redlich, R., Grotegerd, D., Dohm, K., Heindel, W., Kugel, H., Arolt, V., & Dannlowski, U.
- Affiliations
- University of Münster (DE)
- Philipps University of Marburg (DE)
- Corresponding author
- Dannlowski, Udo
- ORCID
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 51
- Pages
- 219-226
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2168200555
- Cited by
- 138
- References
- 43
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 9 · 2023: 13 · 2022: 14 · 2021: 18 · 2020: 20 · 2019: 9 · 2018: 17 · 2017: 6 · 2016: 8 · 2015: 10
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Innovative Medizinische Forschung (IMF) of the Medical Faculty of Münster (DA120309, DA111107, DA211012)
- University Medical Center Giessen and Marburg (UKGM) (7/2013 MR)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- obesity, major depressive disorder, body mass index, gray matter reduction, chronicity of depression, medial prefrontal cortex, orbitofrontal cortex, caudate nucleus, thalamus, somatic comorbidity, emotion regulation, impulse control
- MeSH terms
- Adult, Brain, Major Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Obesity, Body Mass Index, Gray Matter
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