Effects of illness duration and treatment resistance on grey matter abnormalities in majordepression
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Background: Findings of brain structural changes in major depressive disorder are still inconsistent, partly because some crucial clinical variables have not been taken into account. Aims: To investigate the effect of major depressive disorder on grey matter volumes. Method: Voxel-based morphometry was used to compare 66 patients with depression at different illness stages (22 each with first-episode, remitted-recurrent and treatment resistant/chronic depression) with 32 healthy controls. Brain volumes were correlated with clinical variables. Results: Voxel-based morphometry showed a significant group effect in right superior frontal gyrus, left medial frontal gyrus and left cingulate gyrus ( P <0.05, family wise error-corrected). Patients whose condition was treatment resistant/chronic exhibited the smallest volumes in frontotemporal areas. Longer illness duration was negatively correlated with decreases in right medial frontal cortex and left insula. Conclusions: Frontotemporolimbic areas are smaller in the patients with severe depression and are associated with duration of illness, but not with medication patterns, suggesting negative effects of long-lasting major depressive disorder on grey matter.
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Smaller hippocampal and medial prefrontal cortex volumes are consistently linked to longer duration of major depressive disorder.
“longer illness duration (24,26–30)”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [29]
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- Authors
- Serra-Blasco, M., Portella, M. J., Gómez-Ansón, B., de Diego-Adeliño, J., Vives-Gilabert, Y., Puigdemont, D., Granell, E., Santos, A., Álvarez, E., & Pérez, V.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2013-06
- Volume
- 202
- Issue
- 6
- Pages
- 434-440
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2070514824
- Cited by
- 87
- References
- 29
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 4 · 2023: 15 · 2022: 6 · 2021: 10 · 2020: 4 · 2019: 3 · 2018: 7 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 1
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Generalitat de Catalunya (00770, FI-DGR2012)
- Centro de Investigación Biomédica en Red de Salud Mental
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- Instituto de Salud Carlos III (CP10-00393)
- European Regional Development Fund (CP10-00393, 2007 – 2013)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- major depressive disorder, gray matter volume, disease duration, treatment resistance, chronic depression, first-episode depression, insula, medial frontal cortex, cingulate gyrus, superior frontal gyrus, brain structural changes
- MeSH terms
- Adult, Benzodiazepines, Brain, Cross-Sectional Studies, Major Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Psychotropic Drugs, Time Factors, Case-Control Studies
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