Structural brain differences and cognitive functioning related to body mass index in older females
Open accessAbstract
Little is known about the effect of obesity on brain structures and cognition in healthy older adults. This study examined the association between body mass index (BMI), regional volume differences in gray and white matter measured by magnetic resonance imaging (MRI), and cognitive functioning in older females. Participants included 95 community‐dwelling older females (ages 52–92 years) who underwent extensive neuropsychological testing and high‐resolution MRI scanning. Optimized voxel‐based morphometry techniques were employed to determine the correlation between BMI and regional gray and white matter volumes. Volumes of significant regions were then correlated with cognitive functioning. Higher BMI was associated with decreased gray matter volumes in the left orbitofrontal, right inferior frontal, and right precentral gyri, a right posterior region including the parahippocampal, fusiform, and lingual gyri, and right cerebellar regions, as well as increased volumes of white matter in the frontal, temporal, and parietal lobes, even when hypertension was considered. Compared to normal weight women, obese women performed poorer on tests of executive functioning. Smaller gray matter volume in the left orbitofrontal region was associated with lower executive functioning. Additionally, despite the lack of significant group differences in memory and visuomotor speed, gray and white matter volumes predicted performance on these measures. The results provide additional evidence for a negative link between increased body fat and brain functioning in older females. Hum Brain Mapp, 2010. © 2009 Wiley‐Liss, Inc.
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An MRI study in elderly women using voxel-based morphometry found a negative correlation between BMI and grey matter volumes including frontal regions, which in the OFC was associated with impaired executive function.
“For example, an MRI study done in elderly women, using voxel-based morphometry, found a negative correlation between BMI and grey matter volumes (including frontal regions), which, in the OFC, was associated with impaired executive function (126).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [126]
An MRI study of elderly women found negative correlation between BMI and gray matter volumes including frontal regions, which in OFC correlated with impaired executive function.
“For example, a magnetic resonance imaging study of elderly women found a negative correlation between BMI and gray matter volumes (including frontal regions), which, in the OFC, correlated with impaired executive function (83).”
From The Addictive Dimensionality of Obesity (2013) · cites this paper as [83]
An MRI study in elderly women using voxel-wise morphometry found a negative correlation between BMI and gray matter volumes, including frontal regions, which in the OFC was associated with impaired executive function.
“For example, an MRI study done in elderly women, using voxel-wise morphometry, found a negative correlation between BMI and gray matter volumes (including frontal regions), which, in the OFC, was associated with impaired executive function (Walther et al 2010).”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Walther et al 2010
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- Authors
- Walther, K., Birdsill, A. C., Glisky, E. L., & Ryan, L.
- Affiliations
- University of Arizona (US)
- Corresponding author
- Ryan, Lee
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2010-06-11
- Volume
- 31
- Issue
- 7
- Pages
- 1052-1064
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6870943
- OpenAlex
- W2148824609
- Cited by
- 290
- References
- 64
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 11 · 2023: 12 · 2022: 17 · 2021: 21 · 2020: 12 · 2019: 26 · 2018: 13 · 2017: 16 · 2016: 17 · 2015: 21 · 2014: 26 · 2013: 23 · 2012: 28
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McKnight Foundation
- Arizona Biomedical Research Commission
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- body mass index, obesity, older women, gray matter volume, white matter volume, brain structure, cognitive function, executive function, orbitofrontal cortex, cerebellum, memory, visuomotor speed, hypertension
- MeSH terms
- Aged, Aged, 80 and over, Brain, Cognition, Female, Humans, Hypertension, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Middle Aged, Nerve Fibers, Myelinated, Neuropsychological Tests, Obesity, Organ Size, Body Mass Index, Nerve Fibers, Unmyelinated, Overweight
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