Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development

Al-Gubory, Kaïs H.

doi:10.1016/j.rbmo.2014.03.002

Cited by 222Antioxidant Activity and Oxidative StressEffects and risks of endocrine disrupting chemicalsHealth, Environment, Cognitive Aging

Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development

Al-Gubory, Kaïs H.·2014·Reproductive BioMedicine Online

DOI 10.1016/j.rbmo.2014.03.002

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Abstract

Developmental toxicity caused by exposure to a mixture of environmental pollutants has become a major health concern. Human-made chemicals, including xenoestrogens, pesticides and heavy metals, as well as unhealthy lifestyle behaviours, mainly tobacco smoking, alcohol consumption and medical drug abuse, are major factors that adversely influence prenatal development and increase susceptibility of offspring to diseases. There is evidence to suggest that the developmental toxicological mechanisms of chemicals and lifestyle factors involve the generation of reactive oxygen species (ROS) and cellular oxidative damage. Overproduction of ROS induces oxidative stress, a state where increased ROS generation overwhelms antioxidant protection and subsequently leads to oxidative damage of cellular macromolecules. Data on the involvement of oxidative stress in the mechanism of developmental toxicity following exposure to environmental pollutants are reviewed in an attempt to provide an updated basis for future studies on the toxic effect of such pollutants, particularly the notion of increased risk for developmental toxicity due to combined and cumulative exposure to various environmental pollutants. The aims of such studies are to better understand the mechanisms by which environmental pollutants adversely affect conceptus development and to elucidate the impact of cumulative exposures to multiple pollutants on post-natal development and health outcomes. Developmental toxicity caused by exposure to mixture of environmental pollutants has become a major health concern. Human-made chemicals, including xenoestrogens, pesticides and heavy metals, as well as unhealthy lifestyle behaviors, mainly tobacco smoking, alcohol consumption and medical drug abuse, are major factors that adversely influence prenatal development and increase the susceptibility of offspring to development complications and diseases. There is evidence to suggest that the developmental toxicological mechanisms of human-made chemicals and unhealthy lifestyle factors involve the generation of reactive oxygen species (ROS) and cellular oxidative damage. Overproduction of ROS induces oxidative stress, a state where increased generation of ROS overwhelms antioxidant protection and subsequently leads to oxidative damage of cellular macromolecules. Exposure to various environmental pollutants induces synergic and cumulative dose-additive adverse effects on prenatal development, pregnancy outcomes and neonate health. Data from the literature on the involvement of oxidative stress in the mechanism of developmental toxicity following in vivo exposure to environmental pollutants will be reviewed in an attempt to provide an updated basis for future studies on the toxic effect of such pollutants, particularly the notion of increased risk for developmental toxicity due to combined and cumulative exposure to various environmental pollutants. The aims of such studies are to better understand the mechanisms by which environmental pollutants adversely affect conceptus development and to elucidate the impact of cumulative exposures to multiple pollutants on postnatal development and health outcomes.

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Exposure to sunlight, chemicals, pesticides, heavy metals, or other contaminants, plus various diseases, disorders, or trauma, along with unhealthy lifestyles (tobacco smoking, alcohol consumption, poor diet), influence the generation of ROS.
“In regards to environmental factors exposure to sunlight, chemicals, pesticides, heavy metals, or other contaminants, plus various diseases, disorders, or trauma, along with unhealthy lifestyles, like tobacco smoking, alcohol consumption, and poor choice of diet, influence the generation of reactive oxygen species (ROS) [9].”
From Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation (2018) · cites this paper as [9]
Environmental assaults (including pollutants, wind, cold, UV) are associated with oxidative stress and intracellular generation of ROS, which damage DNA, lipids, proteins, and mitochondrial function.
“All of these environmental assaults are associated with oxidative stress and the intracellular generation of reactive oxygen species (ROS), which damage DNA, lipids, proteins and mitochondrial function.”
From Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation (2018) · cites this paper as [9]
If generation of ROS overwhelms endogenous antioxidant protection within the body, this leads to oxidative stress or damage.
“If the generation of ROS overwhelms endogenous antioxidant protection within the body, this subsequently leads to oxidative stress or damage [9].”
From Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation (2018) · cites this paper as [9]
Dietary intake of food sources containing antioxidants decreases ROS.
“In this regard, the dietary intake of food sources containing antioxidants are known to decrease ROS [2,7,9,22].”
From Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation (2018) · cites this paper as [9]

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Authors: Al-Gubory, K. H.
Affiliations: Biologie de la Reproduction, Environnement, Epigénétique et Développement (FR)
Corresponding author: Al-Gubory, Kaïs H.
ORCID: Al-Gubory, Kaïs H.
Venue: Reproductive BioMedicine Online
Publisher: Elsevier BV
Published: 2014-07
Volume: 29
Issue: 1
Pages: 17-31
ISSN: 1472-6483 (ISSN-L)
DOI: 10.1016/j.rbmo.2014.03.002
OpenAlex: W2172026762
Cited by: 222
References: 183
Citations by year: 2026: 13 · 2025: 16 · 2024: 20 · 2023: 19 · 2022: 27 · 2021: 28 · 2020: 19 · 2019: 20 · 2018: 12 · 2017: 17 · 2016: 20 · 2015: 7 · 2014: 4
FWCI: 1.54
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Reproductive BioMedicine Online (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords: environmental pollutants, developmental toxicity, oxidative stress, reactive oxygen species, prenatal development, xenoestrogens, pesticides, heavy metals, lifestyle factors, smoking, alcohol consumption, drug abuse, cumulative exposure, synergistic effect, antioxidant defense, pregnancy outcomes, newborn health
MeSH terms: Alcohol Drinking, Environmental Pollutants, Female, Humans, Pesticides, Pregnancy, Prenatal Exposure Delayed Effects, Smoking, Xenobiotics, Free Radical Scavengers, Reactive Oxygen Species, Oxidative Stress, Maternal Exposure, Metals, Heavy, Fetal Development

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Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development

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