Cited by 343Probiotics and Fermented FoodsReproductive tract infections researchBacterial Genetics and Biotechnology

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Importance of lactobacilli in food and feed biotechnology

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Giraffa, Giorgio, Chanishvili, Nina, Widyastuti, Yantyati·2010·Research in Microbiology

DOI 10.1016/j.resmic.2010.03.001

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Abstract

The genus Lactobacillus is a heterogeneous group of lactic acid bacteria (LAB) with important implications in food fermentation. The ability to colonize a variety of habitats is a direct consequence of the wide metabolic versatility of this group of LAB. Consequently, lactobacilli have been used for decades in food preservation, as starters for dairy products, fermented vegetables, fish and sausages as well as silage inoculants. Lactobacilli have also been proposed as probiotics and microbial cell factories for the production of nutraceuticals. However, a wide range of applications of lactobacilli in food biotechnology remains potential, whereas a number of important strains still need to be discovered and characterized. This article provides an overview of the taxonomy of lactobacilli and describes four of the most significant case studies on the application of this group of LAB in food and feed biotechnology, including their use as probiotics, dairy starters, silage inoculants, and microbial cell factories. The importance of access to and exchange of biological material within and between different strain collections as a crucial step in expanding the range of different biotechnological applications of lactobacilli is also emphasized.

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Bergey's Manual of Systematic Bacteriology
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-5-391_3 · Cited by 15,633
Lactic acid bacteria as functional starter cultures for the food fermentation industry
Leroy, F., & De Vuyst, L. (2004) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2003.09.004 · Cited by 1,852
Guidelines for the evaluation of probiotics in food
Who, F. (2002) · Medical Entomology and Zoology · Cited by 1,843
The biochemistry of silage
McDonald, P. (1981) · Medical Entomology and Zoology · Cited by 1,473
Probiotics and their fermented food products are beneficial for health
Parvez, S., Malik, K. A., Ah Kang, S., & Kim, H.-Y. (2006) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2006.02963.x · Cited by 1,435
Cheese: Chemistry, Physics and Microbiology
Fox, P. F. (1993) · Springer eBooks · doi:10.1007/978-1-4615-2648-3 · Cited by 1,425
Probiotics: an overview of beneficial effects
Ouwehand, A. C., Salminen, S., & Isolauri, E. (2002) · Antonie van Leeuwenhoek · doi:10.1023/a:1020620607611 · Cited by 1,066
Technological challenges for future probiotic foods
Mattila, T., Myllärinen, P., Crittenden, R. G., Mogensen, G., Fondén, R., & Saarela, M. (2002) · International Dairy Journal · doi:10.1016/s0958-6946(01)00099-1 · Cited by 726
The Genera of Lactic Acid Bacteria
(1995) · doi:10.1007/978-1-4615-5817-0 · Cited by 685
Protection from gastrointestinal diseases with the use of probiotics
Marteau, P. R., de Vrese, M., Cellier, C., & Schrezenmeir, J. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.430s · Cited by 596
The genus Lactobacillus
Hammes, W. P., & Vogel, R. F. (1995) · Springer eBooks · doi:10.1007/978-1-4615-5817-0_3 · Cited by 521
Lactobacillus plantarum—survival, functional and potential probiotic properties in the human intestinal tract
de Vries, M. C., Vaughan, E. E., Kleerebezem, M., & de Vos, W. M. (2006) · International Dairy Journal · doi:10.1016/j.idairyj.2005.09.003 · Cited by 516
Non-dairy probiotic products
Rivera‐Espinoza, Y., & Navarro, Y. G. (2008) · Food Microbiology · doi:10.1016/j.fm.2008.06.008 · Cited by 491
Phylogenetic analysis of the genusLactobacillusand related lactic acid bacteria as determined by reverse transcriptase sequencing of 16S rRNA
Collins, M. D., Rodrigues, U. M., Ash, C., Aguirre, M., Farrow, J. A. E., Martı́nez-Murcia, A., PHILLIPS, B. A., Williams, A. M., & Wallbanks, S. (1991) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1991.tb04313.x · Cited by 383
Modulation of the microbial ecology of the human colon by probiotics, prebiotics and synbiotics to enhance human health: An overview of enabling science and potential applications
Rastall, R. A., Gibson, G. R., Gill, H. S., Guarner, F., Klaenhammer, T. R., Pot, B., Reid, G., Rowland, I. R., & Sanders, M. E. (2005) · FEMS Microbiology Ecology · doi:10.1016/j.femsec.2005.01.003 · Cited by 379
Effect of Applying Lactic Acid Bacteria Isolated from Forage Crops on Fermentation Characteristics and Aerobic Deterioration of Silage
Cai, Y., Benno, Y., Ogawa, M., & Kumai, S. (1999) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(99)75263-x · Cited by 328
Fermentation characteristics and aerobic stability of grass silage inoculated with Lactobacillus buchneri, with or without homofermentative lactic acid bacteria
Driehuis, F., Oude Elferink, S. J. W. H., & Van Wikselaar, P. G. (2001) · Grass and Forage Science · doi:10.1046/j.1365-2494.2001.00282.x · Cited by 314
The Effect of Lactobacillus buchneri and Lactobacillus plantarum on the Fermentation, Aerobic Stability, and Ruminal Degradability of Low Dry Matter Corn and Sorghum Silages
Filya, I. (2003) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(03)73963-0 · Cited by 287
Probiotic Dairy Products
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van Kranenburg, R., Kleerebezem, M., Vlieg, J. V. H., Ursing, B. M., Boekhorst, J., Smit, B., Ayad, E. H. E., Smit, G., & Siezen, R. J. (2002) · International Dairy Journal · doi:10.1016/s0958-6946(01)00132-7 · Cited by 222
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Ennahar, S., Cai, Y., & Fujita, Y. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.1.444-451.2003 · Cited by 215
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Epiphytic lactic acid bacteria succession during the pre‐ensiling and ensiling periods of alfalfa and maize
Lin, C., Bolsen, K. K., Brent, B. E., & Fung, D. Y. C. (1992) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1992.tb04992.x · Cited by 161
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Tamime, A. Y., Saarela, M., Søndergaard, A. K., Mistry, V. V., & Shah, N. P. (2006) · Wiley eBooks · doi:10.1002/9780470995785.ch3 · Cited by 155
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Reid, G. (2008) · International Dairy Journal · doi:10.1016/j.idairyj.2007.11.025 · Cited by 148
Phylogeny of the Genus Lactobacillus and Related Genera
Schleifer, K. H., & Ludwig, W. (1995) · Systematic and Applied Microbiology · doi:10.1016/s0723-2020(11)80404-2 · Cited by 147
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Kylä-Nikkilä, K., Hujanen, M., LEISOLA, M. S. A., & Palva, A. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.9.3835-3841.2000 · Cited by 143
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Parente, E., & Cogan, T. M. (2004) · Cheese · doi:10.1016/s1874-558x(04)80065-4 · Cited by 139
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Pot, B., Ludwig, W., Kersters, K., & SCHLEIFER, K. H. (1994) · Springer eBooks · doi:10.1007/978-1-4615-2668-1_2 · Cited by 116
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Hayes, M., Ross, R. P., Fitzgerald, G. F., & Stanton, C. (2007) · Biotechnology Journal · doi:10.1002/biot.200600246 · Cited by 111
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Weinberg, Z. G., Muck, R. E., Weimer, P. J., Chen, Y., & Gamburg, M. (2004) · Applied Biochemistry and Biotechnology · doi:10.1385/abab:118:1-3:001 · Cited by 105
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Gollop, N., Zakin, V., & Weinberg, Z. G. (2005) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2004.02504.x · Cited by 102
The status of the species Lactobacillus casei (Orla-Jensen 1916) Hansen and Lessel 1971 and Lactobacillus paracasei Collins et al. 1989. Request for an opinion.
Dellaglio, F., Felis, G. E., & Torriani, S. (2002) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-52-1-285 · Cited by 100
Recent developments in cheese cultures with protective and probiotic functionalities
Grattepanche, F., Schwenninger, S. M., Meile, L., & Lacroix, C. (2008) · Dairy Science and Technology · doi:10.1051/dst:2008013 · Cited by 88
The effect of Lactobacillus buchneri and L. plantarum, applied at ensiling, on the ensiling fermentation and aerobic stability of wheat and sorghum silages
Weinberg, Z. G., Szakacs, G., Ashbell, G., & Hen, Y. (1999) · Journal of Industrial Microbiology and Biotechnology · doi:10.1038/sj.jim.2900726 · Cited by 79
Total lipid content and fatty acid composition of oilseed from lesser known sweet pomegranate clones
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The Passage of Lactic Acid Bacteria from Silage into Rumen Fluid, In Vitro Studies
Weinberg, Z. G., Chen, Y., & Gamburg, M. (2004) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(04)73474-8 · Cited by 69
Genome data mining of lactic acid bacteria: the impact of bioinformatics
Siezen, R. J., van Enckevort, F. H. J., Kleerebezem, M., & Teusink, B. (2004) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2004.02.002 · Cited by 68
Discrimination of Dairy Industry Isolates of the Lactobacillus casei Group
Desai, A. R., Shah, N. P., & Powell, I. B. (2006) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(06)72371-2 · Cited by 61
Metabolic engineering of Lactobacillus fermentum for production of mannitol and pure L ‐lactic acid or pyruvate
Aarnikunnas, J., von Weymarn, N., Rönnholm, K., LEISOLA, M. S. A., & Palva, A. (2003) · Biotechnology and Bioengineering · doi:10.1002/bit.10615 · Cited by 57
Effects of Lactobacillus buchneri and Lactobacillus plantarum on fermentation, aerobic stability, bacteria diversity and ruminal degradability of alfalfa silage
Zhang, T., Li, L., Wang, X., Zeng, Z., Hu, Y., & Cui, Z. (2009) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-009-9973-x · Cited by 52
Metabolic Engineering ofLactobacillus plantarumfor Production of l -Ribulose
Helanto, M., Kiviharju, K., LEISOLA, M. S. A., & Nyyssölä, A. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01180-07 · Cited by 52
Judicial Commission of the International Committee on Systematics of Prokaryotes; Xth International (IUMS) Congress of Bacteriology and Applied Microbiology; Minutes of the meetings, 28, 29 and 31 July and 1 August 2002, Paris, France
de Vos, P., Trüper, H. G., & Tindall, B. J. (2005) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.63585-0 · Cited by 40
Fluorescent-BOX-PCR for resolving bacterial genetic diversity, endemism and biogeography
Brusetti, L., Malkhazova, I., Gtari, M., Tamagnini, I., Borin, S., Merabishvili, M., Чанішвілі, Н., Mora, D., Cappitelli, F., & Daffonchio, D. G. (2008) · BMC Microbiology · doi:10.1186/1471-2180-8-220 · Cited by 38
Characterization of probiotic properties ofLactobacillusstrains
Millette, M., Luquet, F. M., Ruiz, M. T., & Lacroix, M. (2008) · Dairy Science and Technology · doi:10.1051/dst:2008018 · Cited by 36
Vector-free cloning of a bacterial endo-1,4-β-glucanase in Lactobacillus plantarum and its effect on the acidifying activity in silage: Use of recombinant cellulolytic Lactobacillus plantarum as silage inoculant
Rossi, F., Rudella, A., Marzotto, M., & Dellaglio, F. (2001) · Antonie van Leeuwenhoek · doi:10.1023/a:1012223220427 · Cited by 33
Inducible Gene Expression in Lactobacillus reuteri LTH5531 during Type II Sourdough Fermentation
Bello, F. D., Walter, J., Roos, S., Jonsson, H., & Hertel, C. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.10.5873-5878.2005 · Cited by 26
Ensilage characteristics of three tropical grasses as influenced by stage of growth and addition of molasses
Tjandraatmadja, M., Norton, B. W., & Rae, I. C. M. (1994) · World Journal of Microbiology and Biotechnology · doi:10.1007/bf00357568 · Cited by 24
Health Claims Associated with Probiotics
O’May, G. A., & Macfarlane, G. T. (2006) · Wiley eBooks · doi:10.1002/9780470995785.ch7 · Cited by 21
Short Communication: The Effect of Water Temperature on the Viability of Silage Inoculants
Mulrooney, C. N., & Kung, L. (2007) · Journal of Dairy Science · doi:10.3168/jds.2007-0449 · Cited by 18
Major microbiota of lactic acid bacteria from Matsoni, a traditional Georgian fermented milk
Uchida, K., Urashima, T., Чанішвілі, Н., Ikiti, A. R. A. I., & Motoshima, H. (2007) · Animal Science Journal · doi:10.1111/j.1740-0929.2006.00409.x · Cited by 13
Ensilage of tropical grasses mixed with legumes and molasses
Tjandraatmadja, M., Norton, B. W., & Rae, I. C. M. (1994) · World Journal of Microbiology and Biotechnology · doi:10.1007/bf00357569 · Cited by 11
9th International Symposium on Lactic Acid Bacteria , Egmond aan Zee, The Netherlands, 31 August-4 September 2008
Kuipers, O. P., Poolman, B., & Hugenholtz, J. (2008) · Applied and Environmental Microbiology · Cited by 2

Research works printed but not linked: 3

Kandler, 1986, Genus Lactobacillus Beijerinck 1901, 212A.L, vol. 2, 1209
Mannetje, 1999, Introduction to the conference on silage making in the tropics
Merabishvili, M., Prochkhidze, K., Natroshvili, G., Chanishvili N., 1999. Traditional Caucasian yogurt-like food product Matsoni – chemical and microbial characteristics. In: Proceedings of the 17th International Conference of the International Committee on Food Microbiology and Hygiene, September 13–17, Veldhoven, the Netherlands.

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Ramos, C. L., Thorsen, L., Schwan, R. F., & Jespersen, L. (2013) · Food Microbiology · doi:10.1016/j.fm.2013.03.010 · Cited by 360
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Authors: Giraffa, G., Chanishvili, N., & Widyastuti, Y.
Affiliations: Foraggere e Lattiero Casearie (IT)
Indonesian Institute of Sciences (ID)
Corresponding author: Giraffa, Giorgio
ORCID: Giraffa, Giorgio
Widyastuti, Yantyati
Venue: Research in Microbiology
Publisher: Elsevier BV
Published: 2010-07
Volume: 161
Issue: 6
Pages: 480-487
ISSN: 0769-2609 (ISSN-L)
0923-2508
DOI: 10.1016/j.resmic.2010.03.001
OpenAlex: W2043135685
Semantic Scholar: 7c94ad85e7853296dc5fd78ec87607810aa0200c
Cited by: 341
References: 60
Citations by year: 2026: 8 · 2025: 23 · 2024: 26 · 2023: 21 · 2022: 32 · 2021: 31 · 2020: 32 · 2019: 21 · 2018: 23 · 2017: 27 · 2016: 19 · 2015: 17 · 2014: 26 · 2013: 18 · 2012: 9
FWCI: 17.15
Type: journal article
Language: en
Open access: bronze
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Locations: Research in Microbiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: Lactobacillus, lactic acid bacteria, food biotechnology, probiotics, dairy starter cultures, silage inoculants, fermented vegetables, microbial cell factories, nutraceuticals, strain collection
MeSH terms: Agriculture, Animal Feed, Biotechnology, Dairy Products, Dairying, Fermentation, Food Microbiology, Food Preservation, Food Technology, Lactobacillus, Silage, Lactic Acid, Probiotics, Cultured Milk Products

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Importance of lactobacilli in food and feed biotechnology

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