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Cited by 35Down syndrome and intellectual disability researchAntioxidant Activity and Oxidative StressExercise and Physiological Responses

Antioxidant intervention attenuates oxidative stress in children and teenagers with Down syndrome

Parisotto, Eduardo Benedetti, Garlet, Thais Regina, Cavalli, Vera Lúcia de Liz Oliveira, Zamoner, Ariane, da Rosa, Julia Salvan, Bastos, Juliana, Micke, Gustavo Amadeu, Fröde, Tania Silvia +2 more·2014·Research in Developmental Disabilities
DOI 10.1016/j.ridd.2014.03.013
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Abstract

We previously demonstrated that systemic oxidative stress is present in Down syndrome (DS) patients. In the present study we investigated the antioxidant status in the peripheral blood of DS children and teenagers comparing such status before and after an antioxidant supplementation. Oxidative stress biomarkers were evaluated in the blood of DS patients (n=21) before and after a daily antioxidant intervention (vitamin E 400mg, C 500 mg) during 6 months. Healthy children (n=18) without DS were recruited as control group. The activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), gamma-glutamyltransferase (GGT), glucose-6-phosphate dehydrogenase (G6PD) and myeloperoxidase (MPO), as well as the contents of reduced glutathione (GSH), uric acid, vitamin E, thiobarbituric acid reactive substances (TBARS), and protein carbonyls (PC) were measured. Before the antioxidant therapy, DS patients presented decreased GST activity and GSH depletion; elevated SOD, CAT, GR, GGT and MPO activities; increased uric acid levels; while GPx and G6PD activities as well as vitamin E and TBARS levels were unaltered. After the antioxidant supplementation, SOD, CAT, GPx, GR, GGT and MPO activities were downregulated, while TBARS contents were strongly decreased in DS. Also, the antioxidant therapy did not change G6PD and GST activities as well as uric acid and PC levels, while it significantly increased GSH and vitamin E levels in DS patients. Our results clearly demonstrate that the antioxidant intervention with vitamins E and C attenuated the systemic oxidative damage present in DS patients.

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  • Children and teenagers (7-15 years) with Down syndrome supplemented with vitamins E and C or α-lipoic acid showed suppressed signs of oxidative damage; vitamins C and E suppressed lipid peroxidation in blood.

    “Children and teenagers (7–15 years of age) with Down syndrome supplemented with vitamins E and C or α-lipoic acid explored suppressed signs of oxidative damage. Vitamins C and E were able to suppress lipid peroxidation in the blood (Parisotto et al. 2014).”

    From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Parisotto et al. 2014

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Authors
Parisotto, E. B., Garlet, T. R., Cavalli, V. L. D. L. O., Zamoner, A., da Rosa, J. S., Bastos, J., Micke, G. A., Fröde, T. S., Pedrosa, R. C., & Wilhelm Filho, D.
Affiliations
Universidade Federal de Santa Catarina (BR)
ORCID
Venue
Research in Developmental Disabilities
Publisher
Elsevier BV
Published
2014-06
Volume
35
Issue
6
Pages
1228-1236
ISSN
0891-4222 (ISSN-L)
DOI
10.1016/j.ridd.2014.03.013
OpenAlex
W2035479776
Cited by
34
References
63
Citations by year
2026: 2 · 2025: 2 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 6 · 2015: 3 · 2014: 1
FWCI
3.30
Type
journal article
Language
en
Open access
closed
Locations
  • Research in Developmental Disabilities (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
Down syndrome, oxidative stress, antioxidant supplementation, vitamin E, vitamin C, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, reduced glutathione, lipid peroxidation, protein carbonyls, uric acid, children and adolescents
MeSH terms
Adolescent, Antioxidants, Ascorbic Acid, Catalase, Child, Child, Preschool, Down Syndrome, Female, gamma-Glutamyltransferase, Glucosephosphate Dehydrogenase, Glutathione, Glutathione Peroxidase, Glutathione Reductase, Glutathione Transferase, Humans, Male, Peroxidase, Superoxide Dismutase, Uric Acid, Vitamin E, Biomarkers, Case-Control Studies, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Dietary Supplements, Protein Carbonylation

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