Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation
Open accessAbstract
Individuals with Down syndrome over age 40 years are at risk for developing dementia of the Alzheimer type and have evidence for chronic oxidative stress. There is a paucity of treatment trials for dementia in Down syndrome in comparison to Alzheimer disease in the general (non‐Down syndrome) population. This 2‐year randomized, double‐blind, placebo‐controlled trial assessed whether daily oral antioxidant supplementation (900 IU of alpha‐tocopherol, 200 mg of ascorbic acid and 600 mg of alpha‐lipoic acid) was effective, safe and tolerable for 53 individuals with Down syndrome and dementia. The outcome measures comprised a battery of neuropsychological assessments administered at baseline and every 6 months. Compared to the placebo group, those individuals receiving the antioxidant supplement showed neither an improvement in cognitive functioning nor a stabilization of cognitive decline. Mean plasma levels of alpha‐tocopherol increased ∼2‐fold in the treatment group and were consistently higher than the placebo group over the treatment period. Pill counts indicated good compliance with the regimen. No serious adverse events attributed to the treatment were noted. We conclude that antioxidant supplementation is safe, though ineffective as a treatment for dementia in individuals with Down syndrome and Alzheimer type dementia. Our findings are similar to studies of antioxidant supplementation in Alzheimer disease in the general population. The feasibility of carrying out a clinical trial for dementia in Down syndrome is demonstrated. © 2011 Wiley‐Liss, Inc.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In one trial lasting 2 years, antioxidant supplementation with vitamin C, vitamin E, and α-lipoic acid in subjects with Down syndrome did not prevent cognitive decline nor improved cognitive function.
“In one of the trials lasting 2 years, antioxidant supplementation with vitamin C, vitamin E, and α-lipoic acid in subjects with Down syndrome did not prevent cognitive decline nor improved cognitive function (Lott et al. 2011).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Lott et al. 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Longitudinal data analysis using generalized linear models
LIANG, K.-Y., & ZEGER, S. L. (1986) · Biometrika · doi:10.1093/biomet/73.1.13 · Cited by 18,550 · see citing works
(1967) · Project Euclid (Cornell University) · Cited by 4,720 · see citing works
Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability; Vol. IV
Roy, H. L. L., LeCam, L. M., & Neyman, J. (1969) · Revue de l Institut International de Statistique / Review of the International Statistical Institute · doi:10.2307/1402306 · Cited by 2,878 · see citing works
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380 · see citing works
Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment
Petersen, R. C., Thomas, R. G., Grundman, M., Bennett, D., Doody, R., Ferris, S., Galasko, D., Jin, S., Kaye, J., Levey, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050151 · Cited by 1,844 · see citing works
Dietary Intake of Antioxidants and Risk of Alzheimer Disease
Engelhart, M. J. (2002) · JAMA · doi:10.1001/jama.287.24.3223 · Cited by 1,080 · see citing works
Oxidative Alterations in Alzheimer's Disease
Markesbery, W. R., & Carney, J. M. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00215.x · Cited by 789 · see citing works
Bucks, R. S., Ashworth, D. L., Wilcock, G. K., & Siegfried, K. (1996) · Age and Ageing · doi:10.1093/ageing/25.2.113 · Cited by 581 · see citing works
Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant
Bowry, V. W., Ingold, K. U., & Stocker, R. (1992) · Biochemical Journal · doi:10.1042/bj2880341 · Cited by 511 · see citing works
Action of ascorbic acid as a scavenger of active and stable oxygen radicals
Niki, E. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.6.1119s · Cited by 489 · see citing works
Cognitive deficits and associated neurological complications in individuals with Down's syndrome
Lott, I. T., & Dierssen, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70112-5 · Cited by 484 · see citing works
Self-citationNeuroanatomy of Down’s Syndrome: A High-Resolution MRI Study
Pinter, J. D., Eliez, S., Schmitt, J. E., Capone, G. T., & Reiss, A. L. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.10.1659 · Cited by 452 · see citing works
Ribosome Dysfunction Is an Early Event in Alzheimer's Disease
Ding, Q., Markesbery, W. R., Chen, Q., Li, F., & Keller, J. N. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3040-05.2005 · Cited by 433 · see citing works
Vitamin E for Alzheimer's dementia and mild cognitive impairment
Farina, N., Llewellyn, D. J., Isaac, M. G. E. K. N., & Tabet, N. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002854.pub5 · Cited by 421 · see citing works
Antioxidant Vitamin Intake and Risk of Alzheimer Disease
Luchsinger, J. A., Tang, M.-X., Shea, S., & Mayeux, R. (2003) · Archives of Neurology · doi:10.1001/archneur.60.2.203 · Cited by 414 · see citing works
Butterfield, D. A., Poon, H. F., St. Clair, D., Keller, J. N., Pierce, W. M., Klein, J. B., & Markesbery, W. R. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.11.002 · Cited by 377 · see citing works
Suarna, C., Dean, R. T., May, J. M., & Stocker, R. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.10.1616 · Cited by 356 · see citing works
Vitamin E and Cognitive Decline in Older Persons
Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., & Wilson, R. S. (2002) · Archives of Neurology · doi:10.1001/archneur.59.7.1125 · Cited by 346 · see citing works
Ascorbic acid protects lipids in human plasma and low-density lipoprotein against oxidative damage.
Frei, B. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.6.1113s · Cited by 326 · see citing works
Panisset, M. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540130067012 · Cited by 321 · see citing works
Selective neuroanatornic abnormalities in Down's syndrome and their cognitive correlates
Raz, N., Torres, I. J., Briggs, S. D., Spencer, W. D., Thornton, A. E., Loken, W. J., Gunning, F. M., McQuain, J., Driesen, N. R., & Acker, J. D. (1995) · Neurology · doi:10.1212/wnl.45.2.356 · Cited by 287 · see citing works
Hess, D., Keller, H., Oberlin, B., Bonfanti, R., & Schüep, W. (1991) · PubMed · Cited by 283 · see citing works
Alzheimer's disease in Down syndrome: Neurobiology and risk
Zigman, W. B., & Lott, I. T. (2007) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20163 · Cited by 279 · see citing works
Self-citationGuidi, S., Bonasoni, P., Ceccarelli, C., Santini, D., Gualtieri, F., Ciani, E., & Bartesaghi, R. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00113.x · Cited by 276 · see citing works
Neužil, J., Thomas, S. R., & Stocker, R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00224-9 · Cited by 263 · see citing works
Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment
Wang, J., Markesbery, W. R., & Lovell, M. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03615.x · Cited by 260 · see citing works
Dementia and mortality in persons with Down’s syndrome
Coppus, A. M. W., Evenhuis, H. M., Verberne, G., Visser, F. E., van Gool, W. A., Eikelenboom, P., & van Duijn, C. M. (2006) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2006.00842.x · Cited by 260 · see citing works
Oral α-Tocopherol Supplements Decrease Plasma γ-Tocopherol Levels in Humans
Handelman, G. J., Machlin, L. J., Fitch, K., Weiter, J. J., & Dratz, E. A. (1985) · The Journal of Nutrition · doi:10.1093/jn/115.6.807 · Cited by 260 · see citing works
A Randomized Trial of Vitamin E Supplementation and Cognitive Function in Women
Kang, J. H. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.22.2462 · Cited by 226 · see citing works
Lloret, A., Badía, M.-C., Mora, N. J., Pallardó, F. V., Alonso, M.-D., & Viña, J. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1033 · Cited by 222 · see citing works
Devaraj, S., Leonard, S., Traber, M. G., & Jialal, I. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.12.018 · Cited by 214 · see citing works
Prevention of Tocopherol-mediated Peroxidation in Ubiquinol-10-free Human Low Density Lipoprotein
Bowry, V. W., Mohr, D., Cleary, J., & Stocker, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.11.5756 · Cited by 212 · see citing works
Milgram, N. W., Head, E., Zicker, S. C., Ikeda-Douglas, C. J., Murphey, H. L., Muggenburg, B. A., Siwak, C. T., Tapp, D., & Cotman, C. W. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.014 · Cited by 208 · see citing works
Self-citationOpii, W. O., Joshi, G., Head, E., Milgram, N. W., Muggenburg, B. A., Klein, J. B., Pierce, W. M., Cotman, C. W., & Butterfield, D. A. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.09.012 · Cited by 202 · see citing works
Self-citationHuang, H.-Y., & Appel, L. J. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3137 · Cited by 189 · see citing works
Cotman, C. W., & Head, E. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15413 · Cited by 188 · see citing works
Self-citationBrain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction
Cotman, C. W., Head, E., Muggenburg, B. A., Zicker, S. C., & Milgram, N. W. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00073-8 · Cited by 186 · see citing works
Self-citationFaster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation
Bruno, R. S., Leonard, S. W., Atkinson, J., Montine, T. J., Ramakrishnan, R., Bray, T. Μ., & Traber, M. G. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.10.051 · Cited by 185 · see citing works
Prevalence of dementia in intellectual disability using different diagnostic criteria
Strydom, A., Livingston, G., King, M., & Hassiotis, A. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.028845 · Cited by 171 · see citing works
Dementia in people with Down's syndrome
Tyrrell, J., Cosgrave, M., McCarron, M., McPherson, J., Calvert, J., Kelly, A., McLaughlin, M., Gill, M., & LAWLOR, B. A. (2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.502 · Cited by 169 · see citing works
Coskun, P. E., Wyrembak, J., Derbereva, O., Melkonian, G., Doran, E. W., Lott, I. T., Head, E., Cotman, C. W., & Wallace, D. C. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100351 · Cited by 158 · see citing works
Self-citationα-Lipoic acid as a new treatment option for Alzheimer’s disease — a 48 months follow-up analysis
Häger, K., Kenklies, M., McAfoose, J., Engel, J., & Münch, G. W. (2007) · Springer eBooks · doi:10.1007/978-3-211-73574-9_24 · Cited by 155 · see citing works
Further evaluation of the Dementia Questionnaire for Persons with Mental Retardation (DMR)
Evenhuis, H. M. (1996) · Journal of Intellectual Disability Research · doi:10.1046/j.1365-2788.1996.786786.x · Cited by 148 · see citing works
Impact of antioxidants, zinc, and copper on cognition in the elderly
Age-Related Eye Disease Study Research Group (2004) · Neurology · doi:10.1212/01.wnl.0000142969.19465.8f · Cited by 147 · see citing works
Evaluation of a screening instrument for dementia in ageing mentally retarded persons
Evenhuis, H. M. (1992) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1992.tb00532.x · Cited by 138 · see citing works
Polidori, M. C., Mattioli, P., Aldred, S., Cecchetti, R., Stahl, W., Griffiths, H. R., Senin, U., Sies, H., & Mecocci, P. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000080027 · Cited by 134 · see citing works
Vitamin E for Alzheimer's disease and mild cognitive impairment
Isaac, M. G. E. K. N., Quinn, R., & Tabet, N. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002854.pub2 · Cited by 131 · see citing works
Antioxidant Vitamin Supplement Use and Risk of Dementia or Alzheimer's Disease in Older Adults
Gray, S. L., Anderson, M. L., Crane, P. K., Breitner, J. C. S., McCormick, W., Bowen, J. D., Teri, L., & Larson, E. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01531.x · Cited by 127 · see citing works
Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model
Lockrow, J. P., Prakasam, A., Huang, P., Bimonte‐Nelson, H. A., Sambamurti, K., & Granholm, A. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.11.021 · Cited by 123 · see citing works
Down's syndrome: A pathology involving the lack of balance of reactive oxygen species
Kȩdziora, J., & Bartosz, G. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90052-4 · Cited by 122 · see citing works
Slonim, D. K., Koide, K., Johnson, K. L., Tantravahi, U., Cowan, J. M., Jarrah, Z., & Bianchi, D. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903909106 · Cited by 117 · see citing works
Early Glycoxidation Damage in Brains from Down's Syndrome
Odetti, P. R., Angelini, G., Dapino, D., Zaccheo, D., Garibaldi, S., Dagna-Bricarelli, F., Piombo, G., Perry, G. L., Smith, M. A., Traverso, N., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8186 · Cited by 116 · see citing works
Molecular basis of pharmacotherapies for cognition in Down syndrome
Gardiner, K. (2009) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.10.010 · Cited by 113 · see citing works
Dementia and Alzheimer's Disease in Community-Dwelling Elders Taking Vitamin C and/or Vitamin E
Fillenbaum, G. G., Kuchibhatla, M. N., Hanlon, J. T., Artz, M. B., Pieper, C. F., Schmader, K. E., Dysken, M. W., & Gray, S. L. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1g280 · Cited by 113 · cited 3× · see citing works
“…beenmixedwith some studies showing beneficial effects [Sano et al., 1997; Engelhart et al., 2002;Morris et al., 2002;Maxwell et al., 2005] and others absence of therapeutic efficacy [Luchsinger et al., 2003; Yaffe et al., 2004; Fillenbaum et al., 2005; Petersen et al., 2005; Kang et al., 2006].”
BackgroundVitamins in human arteriosclerosis with emphasis on vitamin C and vitamin E
Abudu, N., Miller, J. J., Attaelmannan, M., & Levinson, S. S. (2003) · Clinica Chimica Acta · doi:10.1016/j.cccn.2003.09.018 · Cited by 111 · see citing works
Ishihara, K., Amano, K., Takaki, E., Shimohata, A., Sago, H., Epstein, C. J., & Yamakawa, K. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp176 · Cited by 106 · see citing works
Supplemental Use of Antioxidant Vitamins and Subsequent Risk of Cognitive Decline and Dementia
Maxwell, C. J., Hicks, M. S., Hogan, D. B., Basran, J., & Ebly, E. M. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000085074 · Cited by 105 · see citing works
Antioxidant approaches for the treatment of Alzheimer’s disease
Lee, H. P., Zhu, X., Casadesús, G., Castellani, R. J., Nunomura, A., Smith, M. A., Lee, H., & Perry, G. L. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.74 · Cited by 104 · see citing works
Ellis, J., Tan, H. K., Gilbert, R. E., Muller, D. P. R., Henley, W., Moy, R. J., Pumphrey, R., Ani, C. C., Davies, S., Edwards, V., et al. (2008) · BMJ · doi:10.1136/bmj.39465.544028.ae · Cited by 101 · see citing works
Vitamin E for Alzheimer's disease and mild cognitive impairment
Isaac, M. G. E. K. N., Quinn, R., & Tabet, N. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002854 · Cited by 96 · see citing works
ets-2 Promotes the Activation of a Mitochondrial Death Pathway in Down's Syndrome Neurons
Helguera, P., Pelsman, A., Pigino, G., Wolvetang, E., Head, E., & Busciglio, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5107-04.2005 · Cited by 88 · see citing works
Self-citationAlpha-tocopherol in the ventricular cerebrospinal fluid of Parkinson's disease patients
Pappert, E. J., Tangney, C., Goetz, C. G., Ling, Z. D., Lipton, J. W., Stebbins, G. T., & Carvey, P. M. (1996) · Neurology · doi:10.1212/wnl.47.4.1037 · Cited by 77 · see citing works
Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease
Siedlak, S. L., Casadesús, G., Webber, K. M., Pappolla, M. A., Atwood, C., Smith, M. A., & Perry, G. L. (2009) · Free Radical Research · doi:10.1080/10715760802644694 · Cited by 77 · see citing works
Dhitavat, S., Ortiz, D., Rogers, E. J., Rivera, E. R., & Shea, T. B. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.074 · Cited by 73 · see citing works
Pop, V., Head, E., Hill, M., Gillen, D. L., Berchtold, N. C., Muggenburg, B. A., Milgram, N. W., Murphy, M. P., & Cotman, C. W. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6194-09.2010 · Cited by 68 · see citing works
Self-citationOxidative stress and cognitive ability in adults with Down syndrome
Strydom, A., Dickinson, M. J., Shende, S., Praticò, D., & Walker, Z. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.10.006 · Cited by 62 · see citing works
Coenzyme Q10 (Ubiquinol-10) Supplementation Improves Oxidative Imbalance in Children With Trisomy 21
Miles, M. V., Patterson, B. J., Chalfonte-Evans, M., Horn, P. S., Hickey, F. J., Schapiro, M. B., Steele, P. E., Tang, P., & Hotze, S. L. (2007) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2007.08.003 · Cited by 52 · see citing works
Roat, E., Prada, N., Ferraresi, R., Giovenzana, C., Nasi, M., Troiano, L., Pinti, M., Nemes, E., Lugli, E., Biagioni, O., et al. (2007) · FEBS Letters · doi:10.1016/j.febslet.2006.12.058 · Cited by 51 · see citing works
Bléhaut, H., Mircher, C., Ravel, A., Conte, M., de Portzamparc, V., Poret, G., de Kermadec, F. H., Rethoré, M. O., & Sturtz, F. G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008394 · Cited by 51 · see citing works
Mitochondrial dysfunction in mouse trisomy 16 brain
Bambrick, L. L., & Fiskum, G. M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.10.045 · Cited by 48 · see citing works
Stress, Aging, and Neurodegenerative Disorders: Molecular Mechanismsa
Busciglio, J. A., Andersen, J. K., Schipper, H. M., Gilad, G. M., McCarty, R. C., Marzatico, F., & Toussaint, O. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09021.x · Cited by 45 · see citing works
The response of γ vitamin E to varying dosages of α vitamin E plus vitamin C
Gutierrez, A., de Serna, D. G., Robinson, I., & Schade, D. S. (2009) · Metabolism · doi:10.1016/j.metabol.2008.11.003 · Cited by 38 · see citing works
Sparrow, S. S., & Cicchetti, D. V. (1984) · Applied Research in Mental Retardation · doi:10.1016/s0270-3092(84)80003-x · Cited by 35 · see citing works
Aguiar, A. S., Tuon, T., Albuquerque, M. M., Rocha, G. S., Speck, A. E., Araújo, J. C., Dafré, A. L., Prediger, R. D., & Pinho, R. A. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0120-x · Cited by 32 · see citing works
Gardette, V., Andrieu, S., Lapeyre‐Mestre, M., Coley, N., Cantet, C., Ousset, P., Grand, A., Monstastruc, J.-L., & Vellas, B. J. (2010) · CNS Drugs · doi:10.2165/11318010-000000000-00000 · Cited by 31 · see citing works
Assessment of Aging Individuals with Down Syndrome in Clinical Trials: Results of Baseline Measures
Sano, M. C., Aisen, P. S. S., Dalton, A. J., Andrews, H., & Tsai, W. (2005) · Journal of Policy and Practice in Intellectual Disabilities · doi:10.1111/j.1741-1130.2005.00021.x · Cited by 28 · see citing works
Complementary and alternative medicine in developmental disabilities
Brown, K., & Patel, D. R. (2005) · The Indian Journal of Pediatrics · doi:10.1007/bf02731671 · Cited by 27 · see citing works
Tiano, L., Carnevali, P., Padella, L., Santoro, L., Principi, F., Brugè, F., Carle, F., Gesuita, R., Gabrielli, O., & Littarru, G. P. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.11.016 · Cited by 27 · see citing works
Bialowas‐McGoey, L. A., Lesicka, A., & Whitaker‐Azmitia, P. M. (2008) · Glia · doi:10.1002/glia.20727 · Cited by 25 · see citing works
β-Amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome
Head, E., Lott, I. T., Cribbs, D. H., Cotman, C. W., & Rohn, T. T. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00705-x · Cited by 23 · see citing works
Self-citationEdland, S. D., Emond, J. A., Aisen, P. S. S., & Petersen, R. C. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181c9983f · Cited by 22 · see citing works
Retana-Ugalde, R., Casanueva, E., Altamirano-Lozano, M. A., González-Torres, C., & Mendoza-Núñez, V. M. (2008) · Annals of Nutrition and Metabolism · doi:10.1159/000129652 · Cited by 21 · see citing works
(2010) · Nature Neuroscience · doi:10.1038/nn0610-651 · Cited by 19 · see citing works
The Dyspraxia Scale for adults with Down syndrome
Dalton, A. J. (2008) · Springer eBooks · doi:10.1007/978-1-84800-249-4_5 · Cited by 14 · see citing works
Christie, L., Opii, W. O., & Head, E. (2008) · AGE · doi:10.1007/s11357-008-9063-2 · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The role of antioxidants in the chemistry of oxidative stress: A review
Pisoschi, A. M., & Pop, A. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.04.040 · Cited by 2,844 · see citing works
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
Wiseman, F. K., Al-Janabi, T., Hardy, J., Karmiloff-Smith, A., Nizetic, D., Tybulewicz, V. L. J., Fisher, E. M. C., & Strydom, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3983 · Cited by 562 · see citing works
Vitamin E for Alzheimer's dementia and mild cognitive impairment
Farina, N., Llewellyn, D. J., Isaac, M. G. E. K. N., & Tabet, N. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002854.pub5 · Cited by 421 · see citing works
Gomes, M. B., & Negrato, C. A. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-80 · Cited by 273 · see citing works
Ballard, C. G., Mobley, W. C., Hardy, J., Williams, G. H., & Corbett, A. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00063-6 · Cited by 274 · see citing works
Atypical aging in down syndrome
Zigman, W. B. (2013) · Developmental Disabilities Research Reviews · doi:10.1002/ddrr.1128 · Cited by 262 · see citing works
Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer’s Disease: The Role of APP
Doran, E., Keator, D., Head, E., Phelan, M. J., Kim, R., Totoiu, M., Barrio, J. R., Small, G. W., Potkin, S. G., & Lott, I. T. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160836 · Cited by 244 · see citing works
Self-citationValenti, D., Lidia de, B. A. R. I., Filippis, B. D., Henrion‐Caude, A., & Vacca, R. A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.012 · Cited by 189 · see citing works
Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia
Marzia Perluigi, A., & Butterfield, D. A. (2011) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/724904 · Cited by 180 · see citing works
Mouse models of Down syndrome: gene content and consequences
Gupta, M., Dhanasekaran, A. R., & Gardiner, K. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9661-8 · Cited by 167 · see citing works
Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities
Rueda, N., Flórez, J., & Martínez-Cué, C. (2012) · Neural Plasticity · doi:10.1155/2012/584071 · Cited by 171 · see citing works
Outcome Measures for Clinical Trials in Down Syndrome
Esbensen, A. J., Hooper, S. R., Fidler, D., Hartley, S. L., Edgin, J., d'Ardhuy, X. L., Capone, G., Conners, F. A., Mervis, C. B., Abbeduto, L., et al. (2017) · American Journal on Intellectual and Developmental Disabilities · doi:10.1352/1944-7558-122.3.247 · Cited by 153 · see citing works
Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome
Hamlett, E. D., Goetzl, E. J., Ledreux, A., Vasilevko, V., Boger, H. A., LaRosa, A., Clark, D., Carroll, S. L., Carmona‐Iragui, M., Fortea, J., et al. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.08.012 · Cited by 129 · see citing works
Self-citationVitamin E for Alzheimer's dementia and mild cognitive impairment
Farina, N., Isaac, M. G. E. K. N., Clark, A. R., Rusted, J. M., & Tabet, N. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002854.pub3 · Cited by 120 · see citing works
Zabel, M., Nackenoff, A., Kirsch, W. M., Harrison, F. E., Perry, G., & Schrag, M. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.12.016 · Cited by 115 · see citing works
Gardiner, K. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s51476 · Cited by 114 · see citing works
The effect of N-acetylcysteine (NAC) on human cognition – A systematic review
Skvarc, D., Dean, O. M., Byrne, L. K., Gray, L. J., Lane, S. E., Lewis, M., Fernandes, B. S., Berk, M., & Marriott, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.013 · Cited by 108 · see citing works
Mitochondria-Targeted Antioxidants as Promising Drugs for Treatment of Age-Related Brain Diseases
Skulachev, V. P. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111391 · Cited by 106 · see citing works
Neurologic complications of Down syndrome: a systematic review
Santoro, J. D., Pagarkar, D., Chu, D. T., Rosso, M., Paulsen, K. C., Levitt, P. R., & Rafii, M. S. (2020) · Journal of Neurology · doi:10.1007/s00415-020-10179-w · Cited by 106 · see citing works
Vitamin E for Alzheimer's dementia and mild cognitive impairment
Farina, N., Llewellyn, D., Isaac, M. G. E. K. N., & Tabet, N. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002854.pub4 · Cited by 104 · see citing works
Metabolic Routes in Inflammation: The Citrate Pathway and its Potential as Therapeutic Target
Infantino, V., Pierri, C. L., & Iacobazzi, V. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180510124558 · Cited by 96 · see citing works
Down Syndrome and Dementia: Seizures and Cognitive Decline
Lott, I. T., Doran, E. W., Nguyen, V. Q., Tournay, A. E., Movsesyan, N., & Gillen, D. L. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111613 · Cited by 94 · see citing works
Self-citationHead, E., Silverman, W. P., Patterson, D. W., & Lott, I. T. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/412536 · Cited by 94 · see citing works
Self-citationGodfrey, M., & Lee, N. (2018) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-017-9220-y · Cited by 91 · see citing works
Frontal white matter integrity in adults with Down syndrome with and without dementia
Powell, D. K., Caban‐Holt, A., Jicha, G. A., Robertson, W. C., Davis, R., Gold, B. T., Schmitt, F. A., & Head, E. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.137 · Cited by 87 · see citing works
Self-citationLott, I. T. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.12.010 · Cited by 82 · see citing works
Self-citationFranceschi, C., Garagnani, P., Gensous, N., Bacalini, M. G., Conte, M., & Salvioli, S. (2019) · Aging Cell · doi:10.1111/acel.12903 · Cited by 80 · see citing works
Cuevas-Cianca, S. I., Romero-Castillo, C., Gálvez-Romero, J. L., Juárez, Z. N., & Hernández, L. R. (2023) · Molecules · doi:10.3390/molecules28031488 · Cited by 87 · see citing works
Prospects for Improving Brain Function in Individuals with Down Syndrome
Costa, A. C. S., & Scott-McKean, J. J. (2013) · CNS Drugs · doi:10.1007/s40263-013-0089-3 · Cited by 81 · see citing works
Older adults with intellectual disability
Sinai, A., Bohnen, I., & Strydom, A. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328355ab26 · Cited by 78 · see citing works
Oxidative Stress and Mitochondrial Dysfunction in Down’s Syndrome: Relevance to Aging and Dementia
Coskun, P. E., & Busciglio, J. A. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/383170 · Cited by 73 · see citing works
Florbetapir PET, FDG PET, and MRI in Down syndrome individuals with and without Alzheimer's dementia
Sabbagh, M. N., Chen, K., Rogers, J., Fleisher, A., Liebsack, C., Bandy, D., Belden, C. M., Protas, H. D., Thiyyagura, P., Liu, X., et al. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.01.006 · Cited by 69 · see citing works
The Role of Oxidative Stress in the Pathomechanism of Congenital Malformations
Laforgia, N., Mauro, A. D., Guarnieri, G. F., Varvara, D., Cosmo, L. D., Panza, R., Capozza, M., Baldassarre, M. E., & Resta, N. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7404082 · Cited by 69 · see citing works
Mulhall, P., Taggart, L., COATES, V. E., McAloon, T., & Hassiotis, A. (2018) · Social Science & Medicine · doi:10.1016/j.socscimed.2018.01.032 · Cited by 66 · see citing works
Prenatal treatment of Down syndrome
Guedj, F., Bianchi, D. W., & Delabar, J. M. (2014) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000056 · Cited by 62 · see citing works
Systemic oxidative stress in children and teenagers with Down syndrome
Garlet, T. R., Parisotto, E. B., de Medeiros, G. D. S., Pereira, L. C. R., Moreira, E. A. D. M., Dalmarco, E. M., Dalmarco, J. B., & Filho, D. W. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.08.017 · Cited by 62 · see citing works
Vitamin E in aging persons with Down syndrome
Sano, M. C., Aisen, P. S. S., Andrews, H., Tsai, W., Lai, F., Dalton, A. J., McCallion, P., Zendell, A. L., Mintz, M., Young, J. M., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002714 · Cited by 61 · see citing works
Oxidative Stress and Down Syndrome. Do Antioxidants Play a Role in Therapy?
Muchová, J., Žitňanová, I., & Ďuračková, Z. (2014) · Physiological Research · doi:10.33549/physiolres.932722 · Cited by 60 · see citing works
Osugo, M., & Cooper, S. (2016) · Journal of Intellectual Disability Research · doi:10.1111/jir.12285 · Cited by 55 · see citing works
Hart, S. J., Visootsak, J., Tamburri, P., Phuong, P., Baumer, N., Hernandez, M., Skotko, B. G., Ochoa‐Lubinoff, C., Liogier D'Ardhuy, X., Kishnani, P. S., et al. (2017) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.38465 · Cited by 54 · see citing works
Pathways to cognitive deficits in Down syndrome
Sturgeon, X., Le, T., Ahmed, M. M., & Gardiner, K. (2012) · Progress in brain research · doi:10.1016/b978-0-444-54299-1.00005-4 · Cited by 51 · see citing works
Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome
Hamlett, E. D., Boger, H. A., Ledreux, A., Kelley, C. M., Mufson, E. J., Falangola, M. F., Guilfoyle, D. N., Nixon, R. A., Patterson, D., Duval, N., et al. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150921095505 · Cited by 51 · see citing works
Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging
Patterson, D. W., & Cabelof, D. C. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.10.001 · Cited by 48 · see citing works
Oxidative Stress and Memory Decline in Adults with Down Syndrome: Longitudinal Study
Zis, P., Dickinson, M. J., Shende, S., Walker, Z., & Strydom, A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120073 · Cited by 46 · see citing works
The contribution of the citrate pathway to oxidative stress in Down syndrome
Convertini, P., Menga, A., Andria, G., Scala, I., Santarsiero, A., Morelli, M. A. C., Iacobazzi, V., & Infantino, V. (2016) · Immunology · doi:10.1111/imm.12659 · Cited by 45 · see citing works
Pharmacological interventions for cognitive decline in people with Down syndrome
Livingstone, N., Hanratty, J., McShane, R. H., & Macdonald, G. M. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011546.pub2 · Cited by 44 · see citing works
Anderson-Mooney, A. J., Schmitt, F. A., Head, E., Lott, I. T., & Heilman, K. M. (2016) · Brain and Cognition · doi:10.1016/j.bandc.2016.02.007 · Cited by 44 · see citing works
Self-citationProtein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain
Ahmed, M. M., Dhanasekaran, A. R., Tong, S., Wiseman, F. K., Fisher, E., Tybulewicz, V. L. J., & Gardiner, K. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt017 · Cited by 42 · see citing works
Alpha-lipoic acid in the treatment of psychiatric and neurological disorders: a systematic review
de Sousa, C. N. S., Leite, C. M. G. D. S., Medeiros, I. D. S., Vasconcelos, L. C., Cabral, L. M., Patrocínio, C. F. V., Patrocínio, M. L. V., Mouaffak, F., Kébir, O., Macêdo, D. S., et al. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0344-x · Cited by 42 · see citing works
The Impact of Oxidative Stress on Pediatrics Syndromes
Micangeli, G., Menghi, M., Profeta, G., Tarani, F., Mariani, A., Petrella, C., Barbato, C., Ferraguti, G., Ceccanti, M., Tarani, L., et al. (2022) · Antioxidants · doi:10.3390/antiox11101983 · Cited by 44 · see citing works
Pecze, L., Randi, E. B., & Szabó, C. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00225-8 · Cited by 41 · see citing works
Redox Processes in Neurodegenerative Disease Involving Reactive Oxygen Species
Kovacic, P., & Somanathan, R. (2012) · Current Neuropharmacology · doi:10.2174/157015912804499429 · Cited by 41 · see citing works
Ageing of people with Down’s syndrome
Covelli, V., Raggi, A., Meucci, P., Paganelli, C., & Leonardi, M. (2015) · International Journal of Rehabilitation Research · doi:10.1097/mrr.0000000000000147 · Cited by 40 · see citing works
Redox Processes in Neurodegenerative Disease Involving Reactive Oxygen Species
Kovacic, P., & Somanathan, R. (2012) · Current Neuropharmacology · doi:10.2174/157015912804143487 · Cited by 38 · see citing works
Stress Responses in Down Syndrome Neurodegeneration: State of the Art and Therapeutic Molecules
Lanzillotta, C., & Domenico, F. D. (2021) · Biomolecules · doi:10.3390/biom11020266 · Cited by 35 · see citing works
Antioxidants in Down Syndrome: From Preclinical Studies to Clinical Trials
Rueda Revilla, N., & Martínez-Cué, C. (2020) · Antioxidants · doi:10.3390/antiox9080692 · Cited by 35 · see citing works
Huang, C.-C., Sun, J. H., Ji, H., Oku, H., Chang, Z.-G., Tian, J., Yu, E., & Xie, J. (2019) · Aquaculture · doi:10.1016/j.aquaculture.2019.02.054 · Cited by 35 · see citing works
Obeid, R., Hartmuth, K., Herrmann, W., Gortner, L., Rohrer, T. R., Geisel, J., Reed, M. C., & Nijhout, H. F. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200162 · Cited by 35 · see citing works
Antioxidant intervention attenuates oxidative stress in children and teenagers with Down syndrome
Parisotto, E. B., Garlet, T. R., Cavalli, V. L. D. L. O., Zamoner, A., da Rosa, J. S., Bastos, J., Micke, G. A., Fröde, T. S., Pedrosa, R. C., & Wilhelm Filho, D. (2014) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2014.03.013 · Cited by 34 · see citing works
Walsh, D. M. A., Doran, E. W., Silverman, W. P., Tournay, A. E., Movsesyan, N., & Lott, I. T. (2015) · Journal of Intellectual Disability Research · doi:10.1111/jir.12200 · Cited by 32 · see citing works
Self-citationTranslational validity and implications of pharmacotherapies in preclinical models of Down syndrome
Rueda, N., Flórez, J., Dierssen, M., & Martínez‐Cué, C. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.10.001 · Cited by 29 · see citing works
Kida, E., Rabe, A., Walus, M., Albertini, G., & Golabek, A. A. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.11.022 · Cited by 30 · see citing works
Nachvak, S. M., Neyestani, T. R., Mahboob, S., Sabour, S., Keshavarz, S.-A., & Speakman, J. R. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.97 · Cited by 29 · see citing works
Pagano, G., Talamanca, A. A., Castello, G., Cordero, M. D., d’Ischia, M., Gadaleta, M. N., Pallardó, F. V., Petrović, S. Ž., Tiano, L., & Zatterale, A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151120169 · Cited by 27 · see citing works
Apoptosis in Down’s syndrome: lessons from studies of human and mouse models
Rueda, N., Flórez, J., & Martínez-Cué, C. (2013) · Apoptosis · doi:10.1007/s10495-012-0785-3 · Cited by 25 · see citing works
Baxter, L. L., Marugán, J., Xiao, J., Incao, A. A., McKew, J. C., Zheng, W., & Pavan, W. J. (2012) · Nutrients · doi:10.3390/nu4060467 · Cited by 25 · see citing works
Chemopreventive Effects of Alpha Lipoic Acid on Obesity-Related Cancers
Moon, H.-S. (2016) · Annals of Nutrition and Metabolism · doi:10.1159/000443994 · Cited by 25 · see citing works
Day, S. M., Yang, W., Wang, X., Stern, J. E., Zhou, X., Macauley, S. L., & Ma, T. (2019) · eNeuro · doi:10.1523/eneuro.0031-19.2019 · Cited by 21 · see citing works
Wallace, E. R., Harp, J. P., Pelt, K. L. V., Koehl, L., Caban‐Holt, A., Anderson-Mooney, A. J., Jicha, G. A., Lightner, D. D., Robertson, W. C., Head, E., et al. (2021) · Journal of Intellectual Disability Research · doi:10.1111/jir.12901 · Cited by 17 · see citing works
Self-citationIshihara, K., Kawashita, E., Shimizu, R., Nagasawa, K., Yasui, H., Sago, H., Yamakawa, K., & Akiba, S. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.015 · Cited by 17 · see citing works
The Role of Oxidative Stress in Trisomy 21 Phenotype
Buczyńska, A., Sidorkiewicz, I., Kretowski, A. J., & Zbucka-Krętowska, M. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01417-6 · Cited by 18 · see citing works
Rachubinski, A. L., Maclean, K. N., Evans, J. R., & Bjugstad, K. B. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.06.013 · Cited by 16 · see citing works
Fonseca, L. M., Navatta, A. C. R., Bottino, C. M. C., & Miotto, E. C. (2015) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000438858 · Cited by 16 · see citing works
Bi-stream CNN Down Syndrome screening model based on genotyping array
Feng, B. J., Hoskins, W., Zhang, Y., Meng, Z., Samuels, D. C., Wang, J., Xia, R., Liu, C., Tang, J., & Guo, Y. P. (2018) · BMC Medical Genomics · doi:10.1186/s12920-018-0416-0 · Cited by 16 · see citing works
Bartesaghi, R., Vicari, S., & Mobley, W. C. (2022) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-041521-103641 · Cited by 15 · see citing works
Portaro, S., Cacciola, A., Naro, A., Cavallaro, F., Gemelli, G., Aliberti, B., Luca, R. D., Calabrò, R. S., & Milardi, D. (2019) · Developmental Neurorehabilitation · doi:10.1080/17518423.2019.1646830 · Cited by 15 · see citing works
Triplication of HSA21 on alterations in structure and function of mitochondria
Ganguly, B. B., & Kadam, N. N. (2022) · Mitochondrion · doi:10.1016/j.mito.2022.05.007 · Cited by 15 · see citing works
Anagnostopoulou, A., Styliadis, C., Kartsidis, P. E., Romanopoulou, E. D., Zilidou, V. I., Karali, C., Karagianni, M. A., Klados, M. A., Paraskevopoulos, E., & Bamidis, P. D. (2021) · Network Neuroscience · doi:10.1162/netn_a_00177 · Cited by 12 · see citing works
Ivain, P., Baksh, R. A., Saini, F., Idris, M., Tamayo‐Elizalde, M., Wells, J., Benejam, B., Loosli, S. V., Sandkühler, K., Wlasich, E., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70071 · Cited by 12 · see citing works
Gomes, M. B., & Negrato, C. A. (2015) · Medicine of Ukraine · doi:10.37987/1997-9894.2015.2(188).222520 · Cited by 11 · see citing works
Carnib, B. L., de Souza, E. A., Floresta, L. R. S., Lage, T. M., Pedro, I. D. R., Muniz, F. C., Silva, A. C. A., & de Oliveira, J. M. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118480 · Cited by 10 · see citing works
Block, A., Ahmed, M. M., Rueda, N., Hernandez, M., Martínez‐Cué, C., & Gardiner, K. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.12.038 · Cited by 11 · see citing works
Challenges faced in managing dementia in Alzheimer’s disease in patients with Down syndrome
Prasher, V. P., Mahmood, H., & Mitra, M. (2016) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s91754 · Cited by 9 · see citing works
Explores the role of fast fashion in sustainability: stylish killer for the environment
Guru, R., Grewal, D., & Thennarasu, P. (2022) · Journal of Textile Engineering & Fashion Technology · doi:10.15406/jteft.2022.08.00302 · Cited by 9 · see citing works
Effect of the one-carbon unit cycle on overall DNA methylation in children with Down's syndrome
Song, C., He, J., Chen, J., Liu, Y., Xiong, F., Wang, Y., & Li, T. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4439 · Cited by 9 · see citing works
Brain amyloid and the transition to dementia in Down syndrome
Keator, D. B., Doran, E. W., Taylor, L., Phelan, M. J., Hom, C. L., Tseung, K., van Erp, T. G. M., Potkin, S. G., Brickman, A. M., Rosas, H. D., et al. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12126 · Cited by 9 · see citing works
Self-citationde Oliveira, L. C., & Faria, D. D. P. (2022) · Molecules · doi:10.3390/molecules27103244 · Cited by 8 · see citing works
Fidler, D. J., Riggs, N. R., Esbensen, A. J., Jackson‐Cook, C. K., Rosser, T. C., & Cohen, A. D. (2022) · International review of research in developmental disabilities · doi:10.1016/bs.irrdd.2022.09.006 · Cited by 8 · see citing works
Protective Effect of Alpha Lipoic Acid against Phenytoin Induced Behavioral Abnormalities in Rats
E, S. G. M. (2015) · Journal of Molecular Biomarkers & Diagnosis · doi:10.4172/2155-9929.1000241 · Cited by 8 · see citing works
Improving Alzheimer's disease outcomes in Down's syndrome
Livingston, G., & Strydom, A. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61929-6 · Cited by 7 · see citing works
Advances in Research on Down Syndrome
Dey, S. (2018) · InTech eBooks · doi:10.5772/intechopen.68260 · Cited by 6 · see citing works
DOWN SENDROMLU BİREYLERDE BESLENME DURUMU
Yoldaş, K., & Yılmazer, Y. (2021) · European Journal of Science and Technology · doi:10.31590/ejosat.831542 · Cited by 7 · see citing works
Baumer, N., & Capone, G. T. (2023) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.32069 · Cited by 6 · see citing works
The Role of Vitamin E in Aging and Alzheimer’s Disease
Eckert, G. P. (2019) · Springer eBooks · doi:10.1007/978-3-030-05315-4_24 · Cited by 6 · see citing works
Harp, J. P., Koehl, L., Pelt, K. L. V., Hom, C. L., Doran, E. W., Head, E., Lott, I. T., & Schmitt, F. A. (2021) · Brain Sciences · doi:10.3390/brainsci11091128 · Cited by 6 · see citing works
Self-citationTiny Toes to Tau Tangles: Down's Syndrome and Its Association With Alzheimer's Disease
Puttagunta, S. M., Islam, R., Kundu, S., Jha, S. B., Rivera, A. P., Monar, G. V. F., Islam, H., & Sange, I. (2022) · Cureus · doi:10.7759/cureus.22125 · Cited by 5 · see citing works
Antioxidant Plant Polyphenols and Cognitive Disorders
Nowak, D. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_26 · Cited by 5 · see citing works
Kida, E., Walus, M., Albertini, G., & Golabek, A. A. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147535 · Cited by 4 · see citing works
Hasina, Z., & Wang, C. C. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.910424 · Cited by 4 · see citing works
- Authors
- Lott, I. T., Doran, E., Nguyen, V. Q., Tournay, A., Head, E., & Gillen, D. L.
- Affiliations
- University of California, Irvine (US)
- University of Kentucky (US)
- Corresponding author
- Lott, Ira T.
- Venue
- American Journal of Medical Genetics Part A
- Publisher
- Wiley
- Published
- 2011-07-07
- Volume
- 155
- Issue
- 8
- Pages
- 1939-1948
- ISSN
- 1552-4825 (ISSN-L)
- 1552-4833
- PMC
- PMC3410645
- OpenAlex
- W2027752708
- Cited by
- 136
- References
- 85
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 7 · 2022: 14 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 10 · 2017: 8 · 2016: 12 · 2015: 12 · 2014: 15 · 2013: 5 · 2012: 22
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Medical Genetics Part A (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of California, Irvine
- National Institute on Aging (AG 21912, AG 16573, P50AG016573, R01AG021912, P50-AG-21912)
- National Center for Research Resources (UL1RR031985)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD065160)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Down syndrome, dementia, Alzheimer-type dementia, antioxidant supplementation, alpha-tocopherol, vitamin C, alpha-lipoic acid, oxidative stress, cognitive decline, plasma vitamin E, treatment efficacy, trial feasibility
- MeSH terms
- Alzheimer Disease, Antioxidants, Ascorbic Acid, Down Syndrome, Drug Combinations, Feasibility Studies, Female, Humans, Thioctic Acid, Male, Middle Aged, Pilot Projects, Treatment Outcome, alpha-Tocopherol
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
