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Cited by 76Schizophrenia research and treatmentGenetic Associations and EpidemiologyProtease and Inhibitor Mechanisms

Functional polymorphism of the matrix metalloproteinase-9 (MMP-9) gene in schizophrenia.

Rybakowski, Janusz K., Skibinska, Maria, Kapelski, Pawel, Kaczmarek, Leszek, Hauser, Joanna·2009·Schizophrenia Research
DOI 10.1016/j.schres.2009.02.005
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Abstract

Matrix metalloproteinase-9 (MMP-9) plays a role in many pathological conditions (e.g. cancer and heart disease). Recently, MMP-9 has been implicated in the activity of the prefrontal cortex and we therefore hypothesized that the MMP-9 gene may be associated with schizophrenia. We genotyped the functional -1562C/T polymorphism in a group of 442 schizophrenia patients and in 558 healthy control subjects. A significant preponderance of C/C genotype and C allele was found in the schizophrenia subjects compared to healthy controls. The results may provide the first evidence for involvement of the MMP-9 gene in the pathogenesis of schizophrenia and could also contribute to explaining a genetic connection between schizophrenia and some somatic illnesses.

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Crossref · 10.1016/j.schres.2009.02.005

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  • A number of CNS diseases exhibit dysregulated expression of enzymes necessary for PNN cleavage and reorganization.

    “In parallel, a number of these CNS diseases exhibit dysregulated expression of enzymes necessary for PNN cleavage and reorganization (Backstrom et al., 1996; Lorenzl et al., 2003; Rybakowski et al., 2009; Kim et al., 2009; Zhang et al., 2011; Yamamori et al., 2013; Liu et al., 2014; Rankin-Gee et al., 2015; Lepeta et al., 2017).”

    From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Rybakowski et al., 2009

  • A functional polymorphism of the MMP-9 gene was discovered in human schizophrenia patients.

    “A functional polymorphism of the MMP-9 gene was discovered in human schizophrenia patients (Rybakowski et al., 2009; Lepeta et al., 2017).”

    From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Rybakowski et al., 2009

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Authors
Rybakowski, J. K., Skibinska, M., Kapelski, P., Kaczmarek, L., & Hauser, J.
Affiliations
  • Poznan University of Medical Sciences (PL)
  • Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
ORCID
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2009-04
Volume
109
Issue
1-3
Pages
90-93
ISSN
0920-9964 (ISSN-L)
DOI
10.1016/j.schres.2009.02.005
OpenAlex
W2117151736
Cited by
76
References
28
Citations by year
2026: 1 · 2024: 3 · 2023: 3 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 8 · 2013: 3 · 2012: 7
FWCI
3.44
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords
MMP-9
MeSH terms
Adult, Female, Gene Frequency, Genotype, Humans, Male, Polymorphism, Genetic, Schizophrenia, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Matrix Metalloproteinase 9

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