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The MCCB impairment profile for schizophrenia outpatients: Results from the MATRICS psychometric and standardization study
Open accessAbstract
The MATRICS Psychometric and Standardization Study was conducted as a final stage in the development of the MATRICS Consensus Cognitive Battery (MCCB). The study included 176 persons with schizophrenia or schizoaffective disorder and 300 community residents. Data were analyzed to examine the cognitive profile of clinically stable schizophrenia patients on the MCCB. Secondarily, the data were analyzed to identify which combination of cognitive domains and corresponding cut-off scores best discriminated patients from community residents, and patients competitively employed vs. those not. Raw scores on the ten MCCB tests were entered into the MCCB scoring program which provided age- and gender-corrected T-scores on seven cognitive domains. To test for between-group differences, we conducted a 2 (group)×7 (cognitive domain) MANOVA with follow-up independent t-tests on the individual domains. Classification and regression trees (CART) were used for the discrimination analyses. Examination of patient T-scores across the seven cognitive domains revealed a relatively compact profile with T-scores ranging from 33.4 for speed of processing to 39.3 for reasoning and problem-solving. Speed of processing and social cognition best distinguished individuals with schizophrenia from community residents; speed of processing along with visual learning and attention/vigilance optimally distinguished patients competitively employed from those who were not. The cognitive profile findings provide a standard to which future studies can compare results from other schizophrenia samples and related disorders; the classification results point to specific areas and levels of cognitive impairment that may advance work rehabilitation efforts.
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“Recently, the reliability, validity, and practicality of functionally meaningful co-primary measures was established,68 and the MCCB impairment profile for schizophrenia outpatients became available.69”
From Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far? (2013) · cites this paper as [69]
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Metadata
- Authors
- Kern, R. S., Gold, J. M., Dickinson, D., Green, M. F., Nuechterlein, K. H., Baade, L. E., Keefe, R. S. E., Mesholam-Gately, R. I., Seidman, L. J., Lee, C., Sugar, C. A., & Marder, S. R.
- Affiliations
- University of California, Los Angeles (US)
- University of Maryland, Baltimore (US)
- National Institutes of Health (US)
- University of Kansas (US)
- Duke University (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Kern, Robert S.
- ORCID
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 126
- Issue
- 1-3
- Pages
- 124-131
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC3050090
- OpenAlex
- W2128456675
- Cited by
- 251
- References
- 32
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 14 · 2023: 13 · 2022: 16 · 2021: 23 · 2020: 24 · 2019: 20 · 2018: 20 · 2017: 14 · 2016: 10 · 2015: 24 · 2014: 18 · 2013: 12 · 2012: 6
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01mh022006-001)
- National Institute of Mental Health (N01 MH022006)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, schizoaffective disorder
- MeSH terms
- Adolescent, Adult, Cognition Disorders, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Outpatients, Psychiatric Status Rating Scales, Psychometrics, Psychotic Disorders, Reference Values, Schizophrenia, Social Adjustment, Young Adult
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