Sub-clinical psychosis symptoms in young adults are risk factors for subsequent common mental disorders
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Background Not all persons identified in the early stages to be at risk for psychosis eventually cross the threshold for a psychotic illness. However, sub-clinical symptoms may not only indicate a specific risk but also suggest a more general, underlying psychopathology that predisposes one to various common mental disorders.Methods Analyzing data from the prospective Zurich Cohort Study, we used two psychosis subscales - "schizotypal signs" and "schizophrenia nuclear symptoms" - derived from the SCL-90-R checklist that measured sub-clinical psychosis symptoms in 1979. We also assessed 10 different diagnoses of common mental disorders through seven interview waves between 1979 and 2008. This 30-year span, covering participant ages of 19/20 to 49/50, encompasses the period of highest risk for the occurrence of such disorders.Results Both psychosis scales from 1979, but especially "schizotypal signs", were significantly correlated with most mental disorders over the subsequent test period. Higher values on both subscales were associated with an increasing number of co-occurring disorders.Conclusions Our data demonstrate that sub-clinical psychosis generally represents a risk factor for the development of common mental disorders and a liability for co-occurring disorders. This refers in particular to dysthymia, bipolar disorder, social phobia, and obsessive-compulsive disorder. Proneness to psychosis could signal a fundamental tendency toward common mental disorders.
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Subthreshold symptoms put one at risk for subsequent mental disorder.
“Since it is known that subthreshold symptoms put one at risk for subsequent mental disorder (Karsten et al., 2011; Rössler et al., 2011)”
From Blended care in the treatment of subthreshold symptoms of depression and psychosis in emerging adults: A randomised controlled trial of Acceptance and Commitment Therapy in Daily-Life (ACT-DL) (2020) · cites this paper as Rössler et al., 2011
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- Authors
- Rössler, W., Hengartner, M. P., Ajdacic-Gross, V., Haker, H., Gamma, A., & Angst, J.
- Affiliations
- University of Zurich (CH)
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 131
- Issue
- 1-3
- Pages
- 18-23
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2001650818
- Cited by
- 103
- References
- 39
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 8 · 2020: 6 · 2019: 10 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 11 · 2014: 10 · 2013: 8 · 2012: 14
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zürcher Hochschule für Angewandte Wissenschaften digital collection (Zurich University of Applied Sciences) (submittedVersion, cc-by-nc-nd)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- schizotypy
- MeSH terms
- Adult, Mental Disorders, Bipolar Disorder, Female, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder, Phobic Disorders, Psychiatric Status Rating Scales, Psychotic Disorders, Retrospective Studies, Risk Factors, Cohort Studies, Logistic Models, Area Under Curve, Young Adult
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