Association between schizophrenia and genetic variation in DCC: a case–control study
Abstract
Schizophrenia is a highly heritable neurodevelopmental disorder associated with alterations in synaptic connectivity. Deleted in colorectal cancer (DCC), a receptor for the guidance cue netrin-1, plays a pivotal role in organizing neuronal circuitry by guiding growing axons and dendrites to their correct targets and by influencing synaptic connectivity. Results from experiments we previously conducted in dcc-heterozygous mice show that DCC plays a critical role in the developmental organization of the mesocorticolimbic dopamine (DA) circuitry. Furthermore we have shown that reduced expression of DCC during development and/or throughout life confers resilience to the development of schizophrenia-like DA and behavioural abnormalities. Importantly, this "protective" phenotype only emerges after puberty. Here we assess whether DCC may contribute to the risk of schizophrenia. We examined single nucleotide polymorphisms (SNPs) located in the DCC gene for association with schizophrenia using a case-control sample consisting of 556 unrelated schizophrenic patients and 208 healthy controls. We found one SNP, rs2270954, to be nominally associated with schizophrenia; patients were less likely to be heterozygous at this locus and more likely to be homozygous for the minor allele (χ(2)=9.84, df=2, nominal p=0.0071). Intriguingly, this SNP is located within the 3' untranslated region, an area known to contain a number of regulatory sequences that determine the stability and translation efficacy of mRNA. These results, together with our previous findings from studies in rodents, point at DCC as a promising novel candidate gene that may contribute to the genetic basis behind individual differences in susceptibility to schizophrenia.
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Several association studies have identified DCC as a promising candidate for schizophrenia.
“several association studies have identified DCC as a promising candidate for schizophrenia [109]”
From Self-domestication in Homo sapiens: Insights from comparative genomics (2017) · cites this paper as [109]
Cites
Genetic Alterations during Colorectal-Tumor Development
Vogelstein, B., Fearon, E. R., Hamilton, S. R., Kern, S. E., Preisinger, A. C., Leppert, M., de Vries-Smits, A. M. M., & Bos, J. L. (1988) · New England Journal of Medicine · doi:10.1056/nejm198809013190901 · Cited by 6,704 · see citing works
The Structure of Haplotype Blocks in the Human Genome
Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., Higgins, J., DeFelice, M., Lochner, A., Faggart, M., et al. (2002) · Science · doi:10.1126/science.1069424 · Cited by 5,863 · see citing works
The adolescent brain and age-related behavioral manifestations
Spear, L. P. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00014-2 · Cited by 5,433 · see citing works
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724 · see citing works
The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway
Howes, O. D., & Kapur, S. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp006 · Cited by 2,693 · see citing works
Human Brain: Left-Right Asymmetries in Temporal Speech Region
Geschwind, N., & Levitsky, W. (1968) · Science · doi:10.1126/science.161.3837.186 · Cited by 2,248 · see citing works
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020 · see citing works
Xie, X., Lu, J., Kulbokas, E. J., Golub, T. R., Mootha, V., Lindblad-Toh, K., Lander, E. S., & Kellis, M. (2005) · Nature · doi:10.1038/nature03441 · Cited by 1,872 · see citing works
Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers
Fearon, E. R., Cho, K. R., Nigro, J. M., Kern, S. E., Simons, J. W., Ruppert, J. M., Hamilton, S. R., Preisinger, A. C., Thomas, G., Kinzler, K. W., et al. (1990) · Science · doi:10.1126/science.2294591 · Cited by 1,738 · see citing works
Neuregulin 1 and Susceptibility to Schizophrenia
Stefánsson, H., Pétursson, H., Sigurðsson, E., Steinthórsdóttir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/342734 · Cited by 1,671 · see citing works
Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?
Feinberg, I. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90038-3 · Cited by 1,395 · see citing works
Laruelle, M., Abi-Dargham, A., van Dyck, C. H., Gil, R., D'Souza, C. D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S. S., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9235 · Cited by 1,291 · see citing works
Disruption of two novel genes by a translocation co-segregating with schizophrenia
Millar, J. K. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.9.1415 · Cited by 1,254 · see citing works
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Mei, L., & Xiong, W.-C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2392 · Cited by 1,030 · see citing works
Deleted in Colorectal Cancer (DCC) Encodes a Netrin Receptor
Keino‐Masu, K., Masu, M., Hinck, L., Leonardo, E. D., Chan, S. S.-Y., Culotti, J. G., & Tessier‐Lavigne, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81336-7 · Cited by 1,013 · see citing works
The reduced neuropil hypothesis: a circuit based model of schizophrenia
Selemon, L. D., & Goldman-Rakic, P. S. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00281-9 · Cited by 909 · see citing works
Straub, R. E., Jiang, Y., MacLean, C. J., Ma, Y., Webb, B. T., Myakishev, M. V., Harris‐Kerr, C., Wormley, B., Sadek, H., Kadambi, B., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/341750 · Cited by 857 · see citing works
Psychosis and Temporal Lobe Epilepsy; A Controlled Investigation
Flor-Henry, P. (1969) · Epilepsia · doi:10.1111/j.1528-1157.1969.tb03853.x · Cited by 797 · see citing works
Heritability Estimates for Psychotic Disorders
Cardno, A. G., Marshall, E. J., Coid, B., Macdonald, A. M., Ribchester, T., Davies, N., Venturi, P., Jones, L. A., Lewis, S. W., Sham, P. C., et al. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.2.162 · Cited by 789 · see citing works
Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene
Fazeli, A., Dickinson, S., Hermiston, M. L., Tighe, R., Steen, R. G., Small, C. G., Stoeckli, E. T., Keino‐Masu, K., Masu, M., Rayburn, H., et al. (1997) · Nature · doi:10.1038/386796a0 · Cited by 778 · see citing works
A decrease of reelin expression as a putative vulnerability factor in schizophrenia
Impagnatiello, F., Guidotti, A. R., Pesold, C., Dwivedi, Y., Caruncho, H. J., Pisu, M. G., Uzunov, D. P., Smalheiser, N. R., Davis, J. M., Pandey, G. N., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15718 · Cited by 753 · see citing works
Ross, C. A., Margolis, R. L., Reading, S. A. J., Pletnikov, M. V., & Coyle, J. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.015 · Cited by 697 · see citing works
Schizophrenia as a Disorder of Developmentally Reduced Synaptic Connectivity
McGlashan, T. H. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.7.637 · Cited by 655 · see citing works
Boksa, P. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.03.005 · Cited by 603 · see citing works
Schizophrenia as an Anomaly of Development of Cerebral Asymmetry
Crow, T. J. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810120087013 · Cited by 590 · see citing works
Increased Synaptic Dopamine Function in Associative Regions of the Striatum in Schizophrenia
Kegeles, L. S., Abi-Dargham, A., Frankle, W. G., Gil, R., Cooper, T. B., Slifstein, M., Hwang, D.-R., Huang, Y., Haber, S. N., & Laruelle, M. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.10 · Cited by 565 · see citing works
Temporal Lobe Asymmetries as the Key to the Etiology of Schizophrenia
Crow, T. J. (1990) · Schizophrenia Bulletin · doi:10.1093/schbul/16.3.433 · Cited by 399 · see citing works
Akil, M., Pierri, J. N., Whitehead, R. E., Edgar, C. L., Mohila, C., Sampson, A. R., & Lewis, D. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.10.1580 · Cited by 393 · see citing works
The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia
Tseng, K. Y., Chambers, R. A., & Lipska, B. K. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.039 · Cited by 336 · see citing works
Startle gating deficits occur across prepulse intensities in schizophrenic patients
Grillon, C., Ameli, R., Charney, D. S., Krystal, J. H., & BRAFF, D. L. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90183-z · Cited by 332 · see citing works
Jaaro-Peled, H., Hayashi‐Takagi, A., Seshadri, S., Kamiya, A., Brandon, N. J., & Sawa, A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.05.007 · Cited by 315 · see citing works
Incidence of Cancer Among Persons With Schizophrenia and Their Relatives
Lichtermann, D., Ekelund, J., Pukkala, E., Tanskanen, A., & Lönnqvist, J. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.573 · Cited by 292 · see citing works
Dent, E. W., Barnes, A. M., Tang, F., & Kalil, K. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4963-03.2004 · Cited by 290 · see citing works
Glia Promote Local Synaptogenesis Through UNC-6 (Netrin) Signaling in C. elegans
Colón-Ramos, D., Margeta, M. A., & Shen, K. (2007) · Science · doi:10.1126/science.1143762 · Cited by 284 · see citing works
Abi-Dargham, A., van de Giessen, E., Slifstein, M., Kegeles, L. S., & Laruelle, M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.12.007 · Cited by 213 · see citing works
Cancer incidence in patients with schizophrenia and their first‐degree relatives – a meta‐analysis
Catts, V. S., Catts, S. V., O’Toole, B. I., & Frost, A. D. J. (2008) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2008.01163.x · Cited by 209 · see citing works
Finger, J. H., Bronson, R. T., Harris, B. S., Johnson, K. R., Przyborski, S. A., & Ackerman, S. L. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10346.2002 · Cited by 189 · see citing works
Mutations in DCC Cause Congenital Mirror Movements
Srour, M., Rivière, J., Pham, J. M. T., Dubé, M., Girard, S., Morin, S., Dion, P. A., Asselin, G., Rochefort, D. L., Hince, P., et al. (2010) · Science · doi:10.1126/science.1186463 · Cited by 183 · see citing works
Self-citationUhlhaas, P. J., & Singer, W. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr034 · Cited by 176 · see citing works
DeLisi, L. E., Hoff, A. L., Neale, C., & Kushner, M. (1994) · Schizophrenia Research · doi:10.1016/0920-9964(94)90080-9 · Cited by 173 · see citing works
Reduced cancer incidence among patients with schizophrenia
Barak, Y., Achiron, A., Mandel, M., Mirecki, I., & Aizenberg, D. (2005) · Cancer · doi:10.1002/cncr.21574 · Cited by 159 · see citing works
Cancer in schizophrenia: is the risk higher or lower?
Grinshpoon, A., Barchana, M., Ponizovsky, A., Lipshitz, I., Nahon, D., Tal, O., Weizman, A., & Levav, I. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2004.06.016 · Cited by 157 · see citing works
Chen, J., Férec, C., & Cooper, D. N. (2006) · Human Genetics · doi:10.1007/s00439-006-0218-x · Cited by 143 · see citing works
The occurence of cancer in first admitted schizophrenic patients
Mortensen, P. B. (1994) · Schizophrenia Research · doi:10.1016/0920-9964(94)90028-0 · Cited by 142 · see citing works
Role of the Dependence Receptor DCC in Colorectal Cancer Pathogenesis
Mehlen, P., & Fearon, E. R. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.02.019 · Cited by 139 · see citing works
Oertel, V., Knöchel, C., Rotarska-Jagiela, A., Schönmeyer, R., Lindner, M., van de Ven, V. G., Haenschel, C., Uhlhaas, P. J., Maurer, K., & Linden, D. E. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4575-09.2010 · Cited by 138 · see citing works
The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry
Manitt, C., Mimee, A., Eng, C., Pokinko, M., Stroh, T., Cooper, H. M., Kolb, B., & Flores, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0606-11.2011 · Cited by 133 · see citing works
Self-citationTang, F., & Kalil, K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0871-05.2005 · Cited by 127 · see citing works
Animal models of obstetric complications in relation to schizophrenia.
Boksa, P. (2004) · Brain research. Brain research reviews · doi:10.1016/j.brainresrev.2004.01.001 · Cited by 125 · see citing works
Schizophrenia and cancer: an epidemiological study
Goldacre, M. J., Kurina, L. M., Wotton, C. J., Yeates, D., & Seagroatt, V. (2005) · British Journal of Psychiatry · doi:10.1192/bjp.187.4.334 · Cited by 123 · see citing works
Structural Asymmetries of the Human Brain and Their Disturbance in Schizophrenia
Petty, R. G. (1999) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033360 · Cited by 117 · see citing works
The association between schizophrenia and cancer: a population-based mortality study
Cohen, M. E., Dembling, B., & Schorling, J. B. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00308-5 · Cited by 114 · see citing works
Manitt, C., Nikolakopoulou, A. M., Almario, D. R., Nguyen, S. A., & Cohen‐Cory, S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0947-09.2009 · Cited by 111 · see citing works
LI, X., Branch, C. A., Ardekani, B. A., Bertisch, H. C., Hicks, C., & DeLisi, L. E. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.07.013 · Cited by 101 · see citing works
A novel DCC mutation and genetic heterogeneity in congenital mirror movements
Depienne, C., Cincotta, M., Billot, S., Bouteiller, D., Groppa, S., Brochard, V. B., Flamand‐Roze, C., Hubsch, C. A., Meunier, S., Giovannelli, F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e318207b1e0 · Cited by 97 · see citing works
Differential Outgrowth of Axons and their Branches Is Regulated by Localized Calcium Transients
Hutchins, B. I., & Kalil, K. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4548-07.2008 · Cited by 90 · see citing works
Language activation in monozygotic twins discordant for schizophrenia
Sommer, I. E., Ramsey, N. F., Mandl, R. C. W., van Oel, C. J., & Kahn, R. S. (2004) · The British Journal of Psychiatry · doi:10.1192/bjp.184.2.128 · Cited by 82 · see citing works
Flores, C., Manitt, C., Rodaros, D., Thompson, K. M., Rajabi, H., Luk, K. C., Tritsch, N. X., Sadikot, A. F., Stewart, J., & Kennedy, T. E. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001607 · Cited by 79 · see citing works
Self-citationRisk for Cancer in Parents of Patients With Schizophrenia
Dalton, S. O., Laursen, T. M., Mellemkjær, L., Johansen, C., & Mortensen, P. B. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.5.903 · Cited by 69 · see citing works
Grant, A., Hoops, D., Labelle‐Dumais, C., Prévost, M., Rajabi, H., Kolb, B. E., Stewart, J., Arvanitogiannis, A., & Flores, C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05888.x · Cited by 65 · see citing works
Self-citationRole of netrin-1 in the organization and function of the mesocorticolimbic dopamine system
Flores, C. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100171 · Cited by 64 · see citing works
Self-citationCancer risk among parents and siblings of patients with schizophrenia
Levav, I., Lipshitz, I., Novikov, I., Pugachova, I., Kohn, R., Barchana, M., Ponizovsky, A. M., & Werner, H. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.024943 · Cited by 59 · see citing works
Lim, Y.-S., Mallapur, S., Kao, G., Ren, X., & Wadsworth, W. G. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-16-07048.1999 · Cited by 46 · see citing works
Anatomical Asymmetries in the Adult and Developing Brain and their Implications for Function
Galaburda, A. M., & Geschwind, N. (1981) · Advances in Pediatrics · doi:10.1016/s0065-3101(22)00642-9 · Cited by 46 · see citing works
Abnormal neurochemical asymmetry in the temporal lobe of schizophrenia
Shirakawa, O., Kitamura, N., Lin, X., Hashimoto, T., & Maeda, K. (2001) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00149-x · Cited by 41 · see citing works
Whyte, M.-C., Whalley, H. C., Simonotto, E., et al. (2006) · Psychological Medicine · doi:10.1017/s0033291706008178 · Cited by 40 · see citing works
Regulation of netrin-1 receptors by amphetamine in the adult brain
Yetnikoff, L., Labelle‐Dumais, C., & Flores, C. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.069 · Cited by 38 · see citing works
Self-citationAbnormal projection of corticospinal tracts in a patient with congenital mirror movements
Cincotta, M., Ragazzoni, A., Scisciolo, G. D., et al. (1994) · Neurophysiologie Clinique · doi:10.1016/s0987-7053(05)80075-9 · Cited by 36 · see citing works
Netrin‐1 receptor in the ventral tegmental area is required for sensitization to amphetamine
Yetnikoff, L., Eng, C., Benning, S., & Flores, C. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07163.x · Cited by 33 · see citing works
Self-citationPost‐pubertal emergence of a dopamine phenotype in netrin‐1 receptor‐deficient mice
Grant, A., Speed, Z., Labelle‐Dumais, C., & Flores, C. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06919.x · Cited by 29 · see citing works
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- Authors
- Grant, A., Fathalli, F., Rouleau, G., Joober, R., & Flores, C.
- Affiliations
- Douglas Mental Health University Institute (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- Corresponding author
- Joober, Ridha
- Flores, Cecilia
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 137
- Issue
- 1-3
- Pages
- 26-31
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2001361721
- Cited by
- 53
- References
- 70
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 3
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institute for Health Research
- Natural Sciences and Engineering, Research Council of Canada
- Fonds de la Recherche en Santé du Québec
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- schizophrenia, DCC gene
- MeSH terms
- DCC Receptor, Adult, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Receptors, Cell Surface, Schizophrenia, Linkage Disequilibrium, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Tumor Suppressor Proteins, Genetic Association Studies
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