The Development of Neural Synchrony and Large-Scale Cortical Networks During Adolescence: Relevance for the Pathophysiology of Schizophrenia and Neurodevelopmental Hypothesis
Open accessAbstract
Recent data from developmental cognitive neuroscience highlight the profound changes in the organization and function of cortical networks during the transition from adolescence to adulthood. While previous studies have focused on the development of gray and white matter, recent evidence suggests that brain maturation during adolescence extends to fundamental changes in the properties of cortical circuits that in turn promote the precise temporal coding of neural activity. In the current article, we will highlight modifications in the amplitude and synchrony of neural oscillations during adolescence that may be crucial for the emergence of cognitive deficits and psychotic symptoms in schizophrenia. Specifically, we will suggest that schizophrenia is associated with impaired parameters of synchronous oscillations that undergo changes during late brain maturation, suggesting an important role of adolescent brain development for the understanding, treatment, and prevention of the disorder.
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- Authors
- Uhlhaas, P. J., & Singer, W.
- Affiliations
- Max Planck Institute for Brain Research (DE)
- Goethe University Frankfurt (DE)
- Corresponding author
- Uhlhaas, P. J.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-04-19
- Volume
- 37
- Issue
- 3
- Pages
- 514-523
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC3080681
- OpenAlex
- W2136396374
- Cited by
- 176
- References
- 9
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 6 · 2023: 7 · 2022: 11 · 2021: 12 · 2020: 12 · 2019: 11 · 2018: 9 · 2017: 10 · 2016: 11 · 2015: 10 · 2014: 12 · 2013: 29 · 2012: 15
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Bulletin (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- neuronal synchronization, cortical oscillations
- MeSH terms
- Adolescent, Brain, Critical Period, Psychological, Humans, Nerve Net, Neural Pathways, Schizophrenia, Age of Onset, Adolescent Development
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