Effects of adjunctive intranasal oxytocin on olfactory identification and clinical symptoms in schizophrenia: Results from a randomized double blind placebo controlled pilot study
Open accessAbstract
Background Deficits in olfactory identification have been widely reported in patients with schizophrenia (SZ) and are associated with negative symptomatology. Adjunctive oxytocin delivered intranasally has been shown to improve some aspects of social cognition as well as positive and negative symptoms in patients with schizophrenia. Given the intranasal delivery route of oxytocin to olfactory pathways and that olfactory abnormalities are a potential endophenotype in SZ, we investigated the effect of intranasal oxytocin on olfactory identification as well as positive and negative symptoms in people with schizophrenia.Methods Individuals with schizophrenia or schizoaffective disorder (n=28; 16 outpatients, 12 inpatients) were randomized to receive adjunctive intranasal oxytocin 20 IU BID or placebo for 3 weeks.Results All 28 participants completed the clinical trial. Odor identification performance significantly improved on the University of Pennsylvania Smell Identification Test (UPSIT) total score and subscore for pleasant smells. UPSIT score (F=5.20, df=1,23, p=0.032) and subscore for pleasant smells (F=4.56, df=1,23, p=0.044), in patients treated with oxytocin were compared to placebo from baseline to endpoint. Global symptomatology as well as positive and negative symptoms were not improved by intranasal oxytocin. In fact, global symptoms, not positive or negative symptoms, improved in the placebo group. Secondary analysis shows that intranasal oxytocin improved negative symptoms in the small group of inpatients. Intranasal oxytocin was well tolerated during the three week trial.Conclusion Adjunctive intranasal oxytocin may improve olfactory identification, particularly in items of positive valence. Larger studies are needed to determine the effects of oxytocin on negative symptoms in SZ. (NCT00884897; http://www.clinicaltrials.gov).
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Intranasal oxytocin has been shown to improve olfactory detection performance in schizophrenia.
“intranasal oxytocin has been shown to improve olfactory detection performance in schizophrenia68”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [68]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Brief Psychiatric Rating Scale.
Overall, J. E., & Gorham, D. R. (1962) · Psychological Reports · doi:10.2466/pr0.1962.10.3.799 · Cited by 11,090 · see citing works
(1976) · Medical Entomology and Zoology · Cited by 8,899 · see citing works
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091 · see citing works
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523 · cited 3× · see citing works
“Given the potential of oxytocin as a treatment for disorders of social affiliation such as SZ and autism (Young and Wang, 2004; Hammock and Young, 2006; Meyer-Lindenberg et al., 2011), and the intranasal delivery route of oxytocin to olfactory pathways, abnormalities in the latter being a potential endophenotype in SZ…”
BackgroundMethodDeficit and nondeficit forms of schizophrenia: the concept
Carpenter, W. T., Heinrichs, D. W., & Wagman, A. M. I. (1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.5.578 · Cited by 1,329 · see citing works
The NIMH-MATRICS Consensus Statement on Negative Symptoms
Kirkpatrick, B., Fenton, W. S., Carpenter, W. T., & Marder, S. R. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj053 · Cited by 1,311 · see citing works
Doty, R. L., Shaman, P., Kimmelman, C. P., & Dann, M. S. (1984) · The Laryngoscope · doi:10.1288/00005537-198402000-00004 · Cited by 875 · see citing works
The Structure of Negative Symptoms Within Schizophrenia: Implications for Assessment
Blanchard, J. J., & Cohen, A. S. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj013 · Cited by 649 · see citing works
Buchanan, R. W., Javitt, D. C., Marder, S. R., Schooler, N. R., Gold, J. M., McMahon, R. P., Heresco-Levy, U., & Carpenter, W. T. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06081358 · Cited by 419 · see citing works
Self-citationGraustella, A. J., & MacLeod, C. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.002 · Cited by 379 · see citing works
Loup, F., Tribollet, E., Dubois-Dauphin, M., & Dreifuss, J. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90345-v · Cited by 378 · see citing works
Olfactory Dysfunction in Schizophrenia A Qualitative and Quantitative Review
Moberg, P. J. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00019-6 · Cited by 317 · see citing works
Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients
Feifel, D., Macdonald, K., Nguyen, A., Cobb, P., Warlan, H., Galangue, B., Minassian, A., Becker, O., Cooper, J., Perry, W., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.039 · Cited by 308 · see citing works
Pedersen, C. A., Gibson, C. M., Rau, S. W., Salimi, K., Smedley, K. L., Casey, R. L., Leserman, J., Jarskog, L. F., & Penn, D. L. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.07.027 · Cited by 305 · see citing works
Oxytocin, vasopressin and pair bonding: implications for autism
Hammock, E. A. D., & Young, L. J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1939 · Cited by 289 · see citing works
Neural Mechanisms of Anhedonia in Schizophrenia
Crespo‐Facorro, B., Paradiso, S., Andreasen, N. C., OʼLeary, D. S., Watkins, G. L., Ponto, L. L. B., & Hichwa, R. D. (2001) · JAMA · doi:10.1001/jama.286.4.427 · Cited by 232 · see citing works
Brewer, W., Wood, S., McGorry, P., Francey, S., Phillips, L., Yung, A., Anderson, V., Copolov, D., Singh, B. S., Velakoulis, D., et al. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.10.1790 · Cited by 195 · see citing works
Emotion recognition and oxytocin in patients with schizophrenia
Averbeck, B. B., Bobin, T., Evans, S., & Shergill, S. S. (2011) · Psychological Medicine · doi:10.1017/s0033291711001413 · Cited by 144 · see citing works
Neuropsychological, olfactory, and hygiene deficits in men with negative symptom schizophrenia
Brewer, W. J., Edwards, J., Anderson, V. A., Robinson, T., & Pantelis, C. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00594-3 · Cited by 140 · see citing works
Brewer, W. J., Pantelis, C., Anderson, V. A., Velakoulis, D., SINGH, B. S., Copolov, D., & McGorry, P. D. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.1.107 · Cited by 140 · see citing works
Assessment of capacity to give consent to research participation: state-of-the-art and beyond.
DeRenzo, E. G., Conley, R. R., & Love, R. (1998) · PubMed · Cited by 123 · see citing works
Kopala, L. C., Good, K. P., & Honer, W. G. (1994) · Schizophrenia Research · doi:10.1016/0920-9964(94)90030-2 · Cited by 122 · see citing works
Olfactory identification deficits in schizophrenia: correlation with duration of illness
Moberg, P. J., Doty, R. L., Turetsky, B. I., Arnold, S. E., Mahr, R. N., Gur, R. C., Bilker, W. B., & Gur, R. E. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.7.1016 · Cited by 118 · see citing works
Adjunctive intranasal oxytocin improves verbal memory in people with schizophrenia
Feifel, D., MacDonald, K. S., Cobb, P., & Minassian, A. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.05.018 · Cited by 117 · see citing works
Woodberry, K. A., Seidman, L. J., Giuliano, A. J., Verdi, M., Cook, W. L., & McFarlane, W. R. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.06.021 · Cited by 116 · see citing works
The human brain representation of odor identification
Kjelvik, G., Evensmoen, H. R., Brezova, V., & Haberg, A. K. (2012) · Journal of Neurophysiology · doi:10.1152/jn.01036.2010 · Cited by 114 · see citing works
Vasopressin, oxytocin, and social odor recognition
Wacker, D. W., & Ludwig, M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.08.014 · Cited by 112 · see citing works
Moberg, P. J., Arnold, S. E., Doty, R. L., Gur, R. E., Balderston, C. C., Roalf, D. R., Gur, R. C., Kohler, C. G., Kanes, S., Siegel, S. J., et al. (2006) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390500434409 · Cited by 106 · see citing works
Olfactory deficits, cognition and negative symptoms in early onset psychosis
Corcoran, C. M., Whitaker, A. H., Coleman, E. A., Fried, J., Feldman, J., Goudsmit, N., & Malaspina, D. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.07.028 · Cited by 99 · see citing works
Sex differences in olfactory function in schizophrenia
Kopala, L. C., Clark, C., & Hurwitz, T. A. (1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.10.1320 · Cited by 98 · see citing works
Olfaction and Social Drive in Schizophrenia
Malaspina, D., & Coleman, E. A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.6.578 · Cited by 95 · see citing works
Olfactory memory in unmedicated schizophrenics
Wu, J. C., Buchsbaum, M. S., Moy, K., Denlea, N., Kesslak, P. J., Tseng, H., Plosnaj, D., Hetu, M., Potkin, S. G., Bracha, H. S., et al. (1993) · Schizophrenia Research · doi:10.1016/0920-9964(93)90008-7 · Cited by 90 · see citing works
Impaired Olfactory Identification in Relatives of Patients With Familial Schizophrenia
Kopala, L. C., Good, K. P., Morrison, K., Bassett, A. S., Alda, M., & Honer, W. G. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.8.1286 · Cited by 87 · see citing works
Plailly, J., d’Amato, T., Saoud, M., & Royet, J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.06.056 · Cited by 75 · see citing works
Odor identification, eye tracking and deficit syndrome schizophrenia
Malaspina, D., Coleman, E. A., Goetz, R. R., Harkavy‐Friedman, J., Corcoran, C. M., AMADOR, X. F., Yale, S. A., & Gorman, J. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01319-1 · Cited by 71 · see citing works
Turetsky, B. I., & Moberg, P. J. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07071210 · Cited by 71 · see citing works
STEDMAN, T. J., & Clair, A. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00021-8 · Cited by 68 · see citing works
Nguyen, A. D., Shenton, M. E., & Levitt, J. J. (2010) · Harvard Review of Psychiatry · doi:10.3109/10673229.2010.511060 · Cited by 65 · see citing works
Various Bilateral Olfactory Deficits in Male Patients With Schizophrenia
Rupp, C. I. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbi018 · Cited by 65 · see citing works
Ishizuka, K., Tajinda, K., Colantuoni, C., Morita, M., Winicki, J. M., Le, C., Lin, S. Y., Schretlen, D. J., Sawa, A., & Cascella, N. G. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.10.001 · Cited by 62 · see citing works
Self-citationGood, K. P., Whitehorn, D., Rui, Q., Milliken, H., & Kopala, L. C. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.5.932 · Cited by 59 · see citing works
Olfactory identification ability in pre- and postmenopausal women with schizophrenia
Kopala, L. C., Good, K. P., & Honer, W. G. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00224-q · Cited by 59 · see citing works
Kamath, V. J., Turetsky, B. I., Calkins, M. E., Kohler, C. G., Conroy, C. G., Borgmann‐Winter, K. E., Gatto, D. E., Gur, R. E., & Moberg, P. J. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.615862 · Cited by 57 · see citing works
Olfactory Hedonic Judgment in Patients With Deficit Syndrome Schizophrenia
Strauss, G. P., Allen, D. N., Ross, S., Duke, L. A., & Schwartz, J. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn178 · Cited by 57 · see citing works
Self-citationKamath, V. J., Moberg, P. J., Kohler, C. G., Gur, R. C., & Turetsky, B. I. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr050 · Cited by 55 · see citing works
Olfactory Function in Monozygotic Twins Discordant for Schizophrenia
Kopala, L. C., Good, K. P., Torrey, Ε. F., & Honer, W. G. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.1.134 · Cited by 53 · see citing works
Scent of a disorder: Olfactory functioning in schizophrenia
Moberg, P. J., & Turetsky, B. I. (2003) · Current Psychiatry Reports · doi:10.1007/s11920-003-0061-x · Cited by 49 · see citing works
Olfactory impairment in monozygotic twins discordant for schizophrenia
Ugur, T., Weisbrod, M., Franzek, E., Pf�ller, U., & Sauer, H. (2004) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-004-0536-8 · Cited by 45 · see citing works
Unirhinal Olfactory Function in Schizophrenia Patients and First-Degree Relatives
Roalf, D. R., Turetsky, B. I., Owzar, K., Balderston, C. C., Johnson, S. C., Brensinger, C. M., Gur, R. E., Siegel, S. J., & Moberg, P. J. (2006) · Journal of Neuropsychiatry · doi:10.1176/jnp.2006.18.3.389 · Cited by 42 · see citing works
Cascella, N. G., Takaki, M., Lin, S. Y., & Sawa, A. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04628.x · Cited by 37 · see citing works
Self-citationIdentification of pleasant, neutral, and unpleasant odors in schizophrenia
Kamath, V. J., Turetsky, B. I., & Moberg, P. J. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2010.12.011 · Cited by 32 · see citing works
Coleman, E. A., Goetz, R. R., Leitman, D., Yale, S. A., Stanford, A. D., Gorman, J. M., & Malaspina, D. (2002) · CNS Spectrums · doi:10.1017/s1092852900022252 · Cited by 30 · see citing works
Psychotropic properties of oxytocin
Vd, B., Sm, T., & Lozhkina, T. K. (1986) · Neuroscience and Behavioral Physiology · doi:10.1007/bf01186517 · Cited by 27 · see citing works
Fleischhacker, W. W. (2000) · PubMed · Cited by 26 · see citing works
Dunn, T. P., & Weller, M. P. I. (1989) · Perceptual and Motor Skills · doi:10.2466/pms.1989.69.3.833 · Cited by 23 · see citing works
Olfactory identification in young relatives at risk for schizophrenia
Keshavan, M. S., Vora, A., Montrose, D. M., Diwadkar, V. A., & Sweeney, J. A. (2009) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2009.00390.x · Cited by 17 · see citing works
Is the odour identification deficit in schizophrenia influenced by odour hedonics?
Kamath, V. J., Bedwell, J. S., & Compton, M. T. (2011) · Cognitive Neuropsychiatry · doi:10.1080/13546805.2011.552561 · Cited by 12 · see citing works
[Psychotropic properties of oxytocin].
Vd, B., Sm, T., & Tk, L. (1984) · PubMed · Cited by 11 · see citing works
Flagged first, then by citations
2 of the 62 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- First MB S.R.G.M.a.W.J Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I/P) 2002 New York Biometrics Research
Cited by
Sorted by citations
Oxytocin pathway gene networks in the human brain
Quintana, D. S., Rokicki, J., van der Meer, D., Alnæs, D., Kaufmann, T., Córdova-Palomera, A., Dieset, I., Andreassen, O. A., & Westlye, L. T. (2019) · Nature Communications · doi:10.1038/s41467-019-08503-8 · Cited by 354 · see citing works
Millan, M. J., Fone, K. C. F., Steckler, T., & Horan, W. P. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.03.008 · Cited by 354 · see citing works
Oxytocin-Augmented Social Cognitive Skills Training in Schizophrenia
Davis, M. C., Green, M. F., Lee, J., Horan, W. P., Senturk, D., Clarke, A. D., & Marder, S. R. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.68 · Cited by 149 · see citing works
Oxytocin administration enhances controlled social cognition in patients with schizophrenia
Woolley, J. D., Chuang, B., Lam, O., Lai, W., O’Donovan, A., Rankin, K. P., Mathalon, D. H., & Vinogradov, S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.04.024 · Cited by 116 · see citing works
Agile delivery of protein therapeutics to CNS
Yi, X., Manickam, D. S., Brynskikh, A. M., & Kabanov, A. V. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.017 · Cited by 115 · see citing works
Quintana, D. S., Guastella, A. J., Westlye, L. T., & Andreassen, O. A. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.166 · Cited by 107 · see citing works
A Review of Oxytocin’s Effects on the Positive, Negative, and Cognitive Domains of Schizophrenia
Feifel, D., Shilling, P. D., & MacDonald, K. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.025 · Cited by 110 · see citing works
Pharmacological approaches to treating negative symptoms: A review of clinical trials
Arango, C., Garibaldi, G. M., & Marder, S. R. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.07.026 · Cited by 101 · see citing works
Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward
Bradley, E., & Woolley, J. D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.007 · Cited by 88 · see citing works
Potential of Oxytocin in the Treatment of Schizophrenia
Shilling, P. D., & Feifel, D. (2016) · CNS Drugs · doi:10.1007/s40263-016-0315-x · Cited by 82 · see citing works
Sex hormones and oxytocin augmentation strategies in schizophrenia: A quantitative review
Heringa, S. M., Begemann, M., Goverde, A. J., & Sommer, I. E. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.04.002 · Cited by 82 · see citing works
Bürkner, P., Williams, D. R., Simmons, T. C., & Woolley, J. D. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx053 · Cited by 80 · see citing works
Oxytocin in Schizophrenia: Pathophysiology and Implications for Future Treatment
Goh, K. K., Chen, C.-H., & Lane, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042146 · Cited by 78 · see citing works
Girgis, R. R., Zoghbi, A. W., Javitt, D. C., & Lieberman, J. A. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.07.006 · Cited by 73 · see citing works
Peled‐Avron, L., Abu-Akel, A. M., & Shamay‐Tsoory, S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.023 · Cited by 73 · see citing works
Effects of Oxytocin on Neural Response to Facial Expressions in Patients with Schizophrenia
Shin, N. Y., Park, H. Y., Jung, W. H., Park, J. W., Yun, J., Jang, J. H., Kim, S. N., Han, H. J., Kim, S.-Y., Kang, D., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.41 · Cited by 69 · see citing works
Oxytocin: Parallel Processing in the Social Brain?
Dölen, G. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12284 · Cited by 65 · see citing works
Horta, M., Kaylor, K., Feifel, D., & Ebner, N. C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.012 · Cited by 62 · see citing works
Psychopharmacology of the negative symptoms: Current status and prospects for progress
Davis, M. C., Horan, W. P., & Marder, S. R. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.10.010 · Cited by 59 · see citing works
Nawijn, L., van Zuiden, M., Koch, S. B. J., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.020 · Cited by 59 · see citing works
Effects of intranasal oxytocin on symptoms of schizophrenia: A multivariate Bayesian meta-analysis
Williams, D. R., & Bürkner, P. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.10.013 · Cited by 58 · see citing works
Intranasal delivery of antipsychotic drugs
Katare, Y. K., Piazza, J. E., Bhandari, J., Daya, R. P., Akilan, K., Simpson, M. J., Hoare, T. R., & Mishra, R. K. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.11.027 · Cited by 57 · see citing works
Strauss, G. P., Keller, W. R., Koenig, J. I., Gold, J. M., Ossenfort, K. L., & Buchanan, R. W. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.023 · Cited by 54 · see citing works
Self-citationBartholomeusz, C. F., Ganella, E. P., Labuschagne, I., Bousman, C., & Pantelis, C. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.06.007 · Cited by 54 · see citing works
Oxytocin and social cognition in affective and psychotic disorders
Pérez-Rodríguez, M. M., Mahon, K., Russo, M., Ungar, A. K., & Burdick, K. E. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.07.012 · Cited by 52 · see citing works
Oya, K., Matsuda, Y., Matsunaga, S., Kishi, T., & Iwata, N. (2015) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-015-0634-9 · Cited by 51 · see citing works
Plasma oxytocin levels predict social cue recognition in individuals with schizophrenia
Strauss, G. P., Keller, W. R., Koenig, J. I., Gold, J. M., Frost, K. H., & Buchanan, R. W. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.01.034 · Cited by 51 · see citing works
Self-citationHofmann, S. G., Fang, A., & Brager, D. N. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.05.039 · Cited by 44 · see citing works
RetractedZheng, W., Zhu, X.-M., Zhang, Q.-E., Yang, X.-H., Cai, D.-B., Li, L., Li, X.-B., Ng, C. H., Ungvari, G. S., Ning, Y.-P., et al. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.12.007 · Cited by 45 · see citing works
Haram, M., Tesli, M., Bettella, F., Djurovic, S., Andreassen, O. A., & Melle, I. S. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00009 · Cited by 42 · see citing works
Martins, D., Paduraru, M., & Paloyelis, Y. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15451 · Cited by 43 · see citing works
Do we need oxytocin to treat schizophrenia? A randomized clinical trial
Dagani, J., Sisti, D., Abelli, M., Paolo, L. D., Pini, S., Raimondi, S., Rocchi, M., Saviotti, F. M., Scocco, P., Totaro, S., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.02.011 · Cited by 41 · see citing works
Buchanan, R. W., Kelly, D. L., Weiner, E., Gold, J. M., Strauss, G. P., Koola, M. M., McMahon, R. P., & Carpenter, W. T. (2017) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000720 · Cited by 40 · see citing works
Self-citationSabé, M., Zhao, N., Crippa, A., Strauss, G. P., & Kaiser, S. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab020 · Cited by 40 · see citing works
Self-citationQuintana, D. S., Dieset, I., Elvsåshagen, T., Westlye, L. T., & Andreassen, O. A. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.004 · Cited by 39 · see citing works
Oxytocin and Behavior: Evidence for Effects in the Brain
Stevens, F. L., Wiesman, O., Feldman, R., Hurley, R. A., & Taber, K. H. (2013) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.13030061 · Cited by 35 · see citing works
Drug repurposing and emerging adjunctive treatments for schizophrenia
Bumb, J. M., Enning, F., & Leweke, F. M. (2015) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.1032248 · Cited by 34 · see citing works
Gumley, A. I., Braehler, C., & MacBeth, A. M. (2014) · British Journal of Clinical Psychology · doi:10.1111/bjc.12041 · Cited by 34 · see citing works
RetractedDecreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients
Liu, Y., Tao, H., Yang, X., Huang, K., Zhang, X., & Li, C. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00217 · Cited by 32 · see citing works
Schwartz, S. S., Gallagher, R. J., & Berkson, G. (1986) · PubMed · Cited by 32 · see citing works
Brambilla, M., Cotelli, M., Manenti, R., Dagani, J., Sisti, D., Rocchi, M., Balestrieri, M., Pini, S., Raimondi, S., Saviotti, F. M., et al. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.08.001 · Cited by 31 · see citing works
Efficacy of intranasal administration of artesunate in experimental cerebral malaria
Marijon, A., Bonnot, G., Fourier, A., Bringer, C., Lavoignat, A., Gagnieu, M., Bienvenu, A., & Picot, S. (2014) · Malaria Journal · doi:10.1186/1475-2875-13-501 · Cited by 30 · see citing works
The effects of adjunctive intranasal oxytocin in patients with schizophrenia
Ota, M., Yoshida, S., Nakata, M., Yada, T., & Kunugi, H. (2017) · Postgraduate Medicine · doi:10.1080/00325481.2018.1398592 · Cited by 27 · see citing works
Oxytocin improves probabilistic reversal learning but not effortful motivation in Brown Norway rats
Roberts, B. Z., Young, J. W., He, Y. V., Cope, Z. A., Shilling, P. D., & Feifel, D. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.02.028 · Cited by 24 · see citing works
Lee, M. R., Wehring, H. J., McMahon, R. P., Liu, F., Linthicum, J., Verbalis, J. G., Buchanan, R. W., Strauss, G. P., Rubin, L. H., & Kelly, D. L. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.02.014 · Cited by 24 · see citing works
Self-citationO’Tuathaigh, C. M. P., Fumagalli, F., Desbonnet, L., Perez-Branguli, F., Moloney, G., Loftus, S., O’Leary, C., Petit, E., Cox, R., Tighe, O., et al. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw120 · Cited by 22 · see citing works
Martins, D., Davies, C., Micheli, A. D., Oliver, D., Krawczun-Rygmaczewska, A., Fusar‐Poli, P., & Paloyelis, Y. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00890-7 · Cited by 24 · see citing works
Han, J., Li, Y., & Wang, X. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s148824 · Cited by 20 · see citing works
Ellenbogen, M. A., Cardoso, C., Serravalle, L., Vadaga, K. K., & Joober, R. (2024) · Psychological Medicine · doi:10.1017/s0033291724000217 · Cited by 20 · see citing works
Oxytocin and Schizophrenia Spectrum Disorders
Ettinger, U., Hurlemann, R., & Chan, R. C. K. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_27 · Cited by 16 · see citing works
Woolley, J. D., Lam, O., Chuang, B., Ford, J. M., Mathalon, D. H., & Vinogradov, S. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.12.018 · Cited by 14 · see citing works
Lee, M. R., Wehring, H. J., McMahon, R., Liu, F., Linthicum, J., Buchanan, R., Strauss, G., Rubin, L., & Kelly, D. (2019) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20190001 · Cited by 13 · see citing works
Self-citationPedersen, C. A. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.050 · Cited by 12 · see citing works
Quintana, D. S. (2018) · OSF Preprints (OSF Preprints) · Cited by 12 · see citing works
Quintana, D. S., Rokicki, J., van der Meer, D., Alnæs, D., Kaufmann, T., Córdova‐Palomera, A., Dieset, I., Andreassen, O. A., & Westlye, L. T. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/149526 · Cited by 12 · see citing works
Oxytocin, the panacea for long-COVID? a review
Diep, P.-T., Chaudry, M., Dixon, A., Chaudry, F., & Kasabri, V. N. (2022) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2021-0034 · Cited by 10 · see citing works
Cohen, A. S., Mitchell, K. R., Strauss, G. P., Blanchard, J. J., Buchanan, R. W., Kelly, D. L., Gold, J. M., McMahon, R. P., Adams, H. A., & Carpenter, W. T. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.01.028 · Cited by 10 · see citing works
Self-citationYang, X., Tang, Y., Wei, Q., Lang, B., Tao, H., Zhang, X., Liu, Y., & Tang, A. (2017) · Oncotarget · doi:10.18632/oncotarget.20252 · Cited by 9 · see citing works
The Use of Oxytocin in Personality Disorders: Rationale and Current Status
Pérez-Rodríguez, M. M., Derish, N. E., & New, A. S. (2014) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-014-0026-1 · Cited by 7 · see citing works
Winterton, A., Bettella, F., de Lange, A. G., Haram, M., Steen, N. E., Westlye, L. T., Andreassen, O. A., & Quintana, D. S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01725-9 · Cited by 6 · see citing works
Utility of Downstream Biomarkers to Assess and Optimize Intranasal Delivery of Oxytocin
DuBois, M. C., Tseng, A., Francis, S. M., Haynos, A. F., Peterson, C. B., & Jacob, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061178 · Cited by 5 · see citing works
Oxytocin administration versus emotion training in healthy males: considerations for future research
Daughters, K., Rees, A., Hunnikin, L. M., Wells, A. E., Hall, J., & van Goozen, S. H. M. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0056 · Cited by 3 · see citing works
Acute Management of Schizophrenia
Janicak, P. G. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0656-7_7 · Cited by 3 · see citing works
Winterton, A., Bettella, F., de Lange, A. G., Haram, M., Steen, N. E., Westlye, L. T., Andreassen, O. A., & Quintana, D. S. (2021) · doi:10.31219/osf.io/sw3fg · Cited by 3 · see citing works
Saporta, L., Feldman, R., Levi, L. W., Davidson, M., Burshtein, S., Gur, R. C., Zagoory‐Sharon, O., Amiaz, R., Park, J., Davis, J. M., et al. (2024) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgae022 · Cited by 2 · see citing works
Coding Errors Lead to Unsupported Conclusions
Williams, D. E., & Bürkner, P. (2020) · Meta-Psychology · doi:10.15626/mp.2018.872 · Cited by 2 · see citing works
Williams, D. R., & Bürkner, P. (2017) · British Journal of Clinical Psychology · doi:10.1111/bjc.12130 · Cited by 2 · see citing works
Coding errors lead to unsupported conclusions: a critique of Hofmann et al. (2015)Preprint
Williams, D. R., & Bürkner, P. (2017) · doi:10.31234/osf.io/2jpdb · Cited by 2 · see citing works
Symptômes négatifs de la schizophrénie : nouvelles approches pharmacologiques
Lodovighi, M.-A., Palomba, A., Belzeaux-R, R., Adida, M., & Azorin, J. (2015) · L Encéphale · doi:10.1016/s0013-7006(16)30010-0 · Cited by 1 · see citing works
Savardi, A., Ziogas, I., Bolla, M., & Cancedda, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815318-5.00021-2 · Cited by 1 · see citing works
Role of oxytocin in social cognition in psychosis spectrum disorders
Benavides, C., Fred-Torres, S., Rutter, S., Larsen, E. M., Fastman, J., Bulbena‐Cabré, A., Lepow, L., Mahon, K., Russo, M., Ungar, A. K., et al. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815315-4.00006-9 · Cited by 1 · see citing works
Oxytocin Effects on Chemosensory Function in a Clinical Setting—a Preliminary Study
Burke, S., Graf, R., Ochsenbein‐Kölble, N., & Hummel, T. R. (2015) · Chemosensory Perception · doi:10.1007/s12078-015-9185-8 · Cited by 1 · see citing works
Novel Approaches for Managing Schizophrenia
Rado, J. T., Hernandez, E. I., & Janicak, P. G. (2013) · Psychopharm Review · doi:10.1097/01.psyphr.0000437783.35936.18
Oxytocin, Schizophrenia, Social Recognition, and Odor Identification: Nothing to Sneeze At
Silver, J. (2013) · Journal watch · doi:10.1056/jp201303180000003
The genetic network underlying anxiety disorder and its small molecular level supports
Liao, J., Cheadle, C., Cao, H., & Rao, V. (2016) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20160013
Novel Approaches for Managing Schizophrenia
Janicak, P. G. (2013) · Psychopharm Review · doi:10.1097/01.psyphr.0000433989.65396.2b
Aromatherapy: A Novel Approach to Schizophrenia Treatment
Меркулова, Е. В. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/9781837672059-00133
Does intranasal oxytocin reduce symptoms of mental disorders? A meta-analysis of clinical trials
Bonnieux, J. N., Gumuchian, S. T., Harboun, A., Trespalacios, F., Bélisle, K.-A., Haddad, A., Quintus-Bosz, O., McLellan, A., Chester-Trudel, L., Garred, D., et al. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106749
Ji, L., (19312), X. W., Li, Y., Zhao, W., Du, X., Gao, Y., Li, J., & Liu, S. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-04145-9
- Authors
- Lee, M. R., Wehring, H. J., McMahon, R. P., Linthicum, J., Cascella, N., Liu, F., Bellack, A., Buchanan, R. W., Strauss, G. P., Contoreggi, C., & Kelly, D. L.
- Affiliations
- National Institutes of Health (US)
- University of Maryland, Baltimore (US)
- Sheppard Pratt Health System (US)
- VA Maryland Health Care System (US)
- National Institute on Drug Abuse (US)
- Corresponding author
- Lee, Mary R.
- ORCID
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 145
- Issue
- 1-3
- Pages
- 110-115
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC4125132
- OpenAlex
- W2009984993
- Cited by
- 80
- References
- 62
- Citations by year
- 2026: 2 · 2024: 3 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 12 · 2016: 9 · 2015: 16 · 2014: 10 · 2013: 6
- FWCI
- 9.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (N01 DA059909, N0-1DA-5-9909)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- intranasal oxytocin, schizophrenia
- MeSH terms
- Administration, Intranasal, Adolescent, Adult, Analysis of Variance, Olfaction Disorders, Double-Blind Method, Female, Humans, Male, Middle Aged, Oxytocin, Pilot Projects, Psychiatric Status Rating Scales, Retrospective Studies, Schizophrenia, Smell, Antipsychotic Agents, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review