Cited by 80Schizophrenia research and treatmentOlfactory and Sensory Function StudiesNeuroendocrine regulation and behavior

Effects of adjunctive intranasal oxytocin on olfactory identification and clinical symptoms in schizophrenia: Results from a randomized double blind placebo controlled pilot study

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Lee, Mary R., Wehring, Heidi J., McMahon, Robert P., Linthicum, Jared, Cascella, Nicola, Liu, Fang, Bellack, Alan, Buchanan, Robert W. +3 more·2013·Schizophrenia Research

Abstract

Background Deficits in olfactory identification have been widely reported in patients with schizophrenia (SZ) and are associated with negative symptomatology. Adjunctive oxytocin delivered intranasally has been shown to improve some aspects of social cognition as well as positive and negative symptoms in patients with schizophrenia. Given the intranasal delivery route of oxytocin to olfactory pathways and that olfactory abnormalities are a potential endophenotype in SZ, we investigated the effect of intranasal oxytocin on olfactory identification as well as positive and negative symptoms in people with schizophrenia.Methods Individuals with schizophrenia or schizoaffective disorder (n=28; 16 outpatients, 12 inpatients) were randomized to receive adjunctive intranasal oxytocin 20 IU BID or placebo for 3 weeks.Results All 28 participants completed the clinical trial. Odor identification performance significantly improved on the University of Pennsylvania Smell Identification Test (UPSIT) total score and subscore for pleasant smells. UPSIT score (F=5.20, df=1,23, p=0.032) and subscore for pleasant smells (F=4.56, df=1,23, p=0.044), in patients treated with oxytocin were compared to placebo from baseline to endpoint. Global symptomatology as well as positive and negative symptoms were not improved by intranasal oxytocin. In fact, global symptoms, not positive or negative symptoms, improved in the placebo group. Secondary analysis shows that intranasal oxytocin improved negative symptoms in the small group of inpatients. Intranasal oxytocin was well tolerated during the three week trial.Conclusion Adjunctive intranasal oxytocin may improve olfactory identification, particularly in items of positive valence. Larger studies are needed to determine the effects of oxytocin on negative symptoms in SZ. (NCT00884897; http://www.clinicaltrials.gov).

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  • Intranasal oxytocin has been shown to improve olfactory detection performance in schizophrenia.

    “intranasal oxytocin has been shown to improve olfactory detection performance in schizophrenia68”

    From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [68]

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  1. First MB S.R.G.M.a.W.J Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I/P) 2002 New York Biometrics Research

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Authors
Lee, M. R., Wehring, H. J., McMahon, R. P., Linthicum, J., Cascella, N., Liu, F., Bellack, A., Buchanan, R. W., Strauss, G. P., Contoreggi, C., & Kelly, D. L.
Affiliations
  • National Institutes of Health (US)
  • University of Maryland, Baltimore (US)
  • Sheppard Pratt Health System (US)
  • VA Maryland Health Care System (US)
  • National Institute on Drug Abuse (US)
Corresponding author
Lee, Mary R.
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2013-04
Volume
145
Issue
1-3
Pages
110-115
ISSN
0920-9964 (ISSN-L)
OpenAlex
W2009984993
Cited by
80
References
62
Citations by year
2026: 2 · 2024: 3 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 12 · 2016: 9 · 2015: 16 · 2014: 10 · 2013: 6
FWCI
9.68
Type
journal article
Language
en
Open access
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (N01 DA059909, N0-1DA-5-9909)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
intranasal oxytocin, schizophrenia
MeSH terms
Administration, Intranasal, Adolescent, Adult, Analysis of Variance, Olfaction Disorders, Double-Blind Method, Female, Humans, Male, Middle Aged, Oxytocin, Pilot Projects, Psychiatric Status Rating Scales, Retrospective Studies, Schizophrenia, Smell, Antipsychotic Agents, Young Adult

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