Is schizophrenia a syndrome of accelerated aging?

Kirkpatrick, B.; Messias, E.; Harvey, P. D.; Fernandez-Egea, E.; Bowie, C. R.

doi:10.1093/schbul/sbm140

Cited by 335Schizophrenia research and treatmentMental Health and PsychiatryGenetics, Aging, and Longevity in Model Organisms

Is schizophrenia a syndrome of accelerated aging?

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Kirkpatrick, B., Messias, E., Harvey, P. D., Fernandez-Egea, E., Bowie, C. R.·2008·Schizophrenia Bulletin

DOI 10.1093/schbul/sbm140PMC PMC2632500

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Abstract

Schizophrenia is associated with a number of anatomical and physiological abnormalities outside of the brain, as well as with a decrease in average life span estimated at 20% in the United States. Some studies suggest that this increased mortality is not entirely due to associated causes such as suicide and the use of psychotropic medications. In this article, in order to focus greater attention on the increased mortality associated with schizophrenia, we present a special case of the hypothesis that physiological abnormalities associated with schizophrenia make a contribution to the increased mortality of schizophrenia: specifically, the hypothesis that schizophrenia is a syndrome of accelerated aging. Evidence consistent with this hypothesis comes from several areas. The biological plausibility of the hypothesis is supported by the existence of established syndromes of accelerated aging and by the sharing of risk factors between schizophrenia and other age-related conditions. We propose methods for testing the hypothesis.

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According to the theory of accelerated aging, physiological changes associated with aging occur at an earlier age in people with schizophrenia compared to the general population.
“According to this theory, physiological changes associated with aging occur at an earlier age in people with schizophrenia compared to the general population (Kirkpatrick et al. 2008).”
From Excess early mortality in schizophrenia. (2014) · cites this paper as Kirkpatrick et al. 2008
Schizophrenia, like MDD and BD, may also be associated with premature biological aging.
“Schizophrenia, like MDD and BD, may also be associated with premature biological aging (Anthes, 2014; Jeste et al., 2011; Kirkpatrick et al., 2008; Kochunov et al., 2013; Koutsouleris et al., 2014; Okusaga, 2014; Shivakumar et al., 2014).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Kirkpatrick et al., 2008
An alternative explanation of the early excess mortality in persons with schizophrenia has been the theory of accelerated aging.
“An alternative explanation of the early excess mortality in persons with schizophrenia has been the theory of accelerated aging.”
From Excess early mortality in schizophrenia. (2014) · cites this paper as Kirkpatrick et al. 2008

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Authors: Kirkpatrick, B., Messias, E., Harvey, P. D., Fernandez-Egea, E., & Bowie, C. R.
Affiliations: Augusta University (US)
Emory University (US)
Icahn School of Medicine at Mount Sinai (US)
ORCID: Kirkpatrick, B.
Messias, E.
Harvey, P. D.
Bowie, C. R.
Venue: Schizophrenia Bulletin
Publisher: Oxford University Press (OUP)
Published: 2008-08-20
Volume: 34
Issue: 6
Pages: 1024-1032
ISSN: 0586-7614 (ISSN-L)
1745-1701
DOI: 10.1093/schbul/sbm140
PMC: PMC2632500
OpenAlex: W2151520443
Cited by: 335
References: 118
Citations by year: 2026: 22 · 2025: 19 · 2024: 36 · 2023: 26 · 2022: 20 · 2021: 19 · 2020: 21 · 2019: 17 · 2018: 17 · 2017: 23 · 2016: 20 · 2015: 16 · 2014: 18 · 2013: 17 · 2012: 16
FWCI: 0.84
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Schizophrenia Bulletin (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK069265)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: schizophrenia, accelerated aging
MeSH terms: Alzheimer Disease, Atrophy, Blood Pressure, Brain, Cognition Disorders, Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Life Expectancy, Male, Mental Status Schedule, Paternal Age, Pregnancy, Prenatal Exposure Delayed Effects, Progeria, Risk Factors, Schizophrenia

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