ROS signaling and redox biology in endothelial cells
Open accessAbstract
The purpose of this review is to provide an overview of redox mechanisms, sources and antioxidants that control signaling events in ECs. In particular, we describe which molecules are involved in redox signaling and how they influence the relationship between ECs and other vascular component with regard to angiogenesis. Recent and new tools to investigate physiological ROS signaling will be also discussed. Such findings are providing an overview of the ROS biology relevant for endothelial cells in the context of normal and pathological angiogenic conditions.
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NOX5 appears to modulate proliferation and cell migration processes.
“NOX5 also appears to modulate proliferation and cell migration processes (371, 719).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [719]
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- Authors
- Panieri, E., & Santoro, M. M.
- Affiliations
- University of Turin (IT)
- Vlaams Instituut voor Biotechnologie (BE)
- Corresponding author
- Santoro, Massimo M.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2015-05-14
- Volume
- 72
- Issue
- 17
- Pages
- 3281-3303
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11113497
- OpenAlex
- W347357337
- Cited by
- 168
- References
- 261
- Citations by year
- 2026: 21 · 2025: 10 · 2024: 9 · 2023: 17 · 2022: 13 · 2021: 17 · 2020: 15 · 2019: 15 · 2018: 14 · 2017: 14 · 2016: 20 · 2015: 2 · 2014: 1
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- Fondazione Telethon (GGP10195)
- European Research Council (CoG - 647057)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- reactive oxygen species, redox signaling, endothelial cells, antioxidants, angiogenesis, oxidative stress, vascular component
- MeSH terms
- Animals, Humans, Mitochondria, Oxidation-Reduction, Signal Transduction, Protein Tyrosine Phosphatases, Reactive Oxygen Species, Neovascularization, Physiologic, NADPH Oxidases, Endothelial Cells
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