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Cited by 237Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolismGenetics, Aging, and Longevity in Model Organisms

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Physiological role of autophagy as an intracellular recycling system: with an emphasis on nutrient metabolism.

Kuma, Akiko, Mizushima, Noboru·2010·Seminars in Cell & Developmental Biology
DOI 10.1016/j.semcdb.2010.03.002
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Abstract

Autophagy is a major intracellular degradation system in which the cytoplasmic contents are degraded in the lysosome. Its fundamental and evolutionarily conserved role is adaptation to starvation. Recent studies using autophagy-defective mutants of various organisms including mammals have indeed demonstrated the importance of autophagy during starvation; however, the exact mechanism underlying this beneficial effect remains unclear. In addition, it is now apparent that autophagy is also important for cellular homeostasis even under non-starvation conditions, and both non-selective and selective types of autophagy appear to be critical for this function. Here, we discuss the role of this catabolic pathway in recycling intracellular components, with particular reference to nutrient metabolism.

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Metadata

Authors
Kuma, A., & Mizushima, N.
Affiliations
Tokyo Medical and Dental University (JP)
Corresponding author
Mizushima, Noboru
ORCID
Venue
Seminars in Cell & Developmental Biology
Publisher
Elsevier BV
Published
2010-09
Volume
21
Issue
7
Pages
683-690
ISSN
1084-9521 (ISSN-L)
DOI
10.1016/j.semcdb.2010.03.002
OpenAlex
W2062922078
Cited by
237
References
0
Citations by year
2026: 6 · 2025: 9 · 2024: 13 · 2023: 12 · 2022: 14 · 2021: 21 · 2020: 17 · 2019: 15 · 2018: 14 · 2017: 19 · 2016: 17 · 2015: 10 · 2014: 16 · 2013: 24 · 2012: 13
FWCI
12.57
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Seminars in Cell and Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • Takeda Science Foundation
  • Korea Toray Science Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
autophagy, nutrient metabolism, starvation adaptation, lysosomal degradation, selective autophagy, cellular homeostasis, catabolism
MeSH terms
Animals, Autophagy, Cell Physiological Phenomena, Humans, Saccharomyces cerevisiae, Starvation, Metabolic Networks and Pathways

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