CoChat
Sign Up
Cited by 237Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolismGenetics, Aging, and Longevity in Model Organisms

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Physiological role of autophagy as an intracellular recycling system: with an emphasis on nutrient metabolism.

Kuma, Akiko, Mizushima, Noboru·2010·Seminars in Cell & Developmental Biology
DOI 10.1016/j.semcdb.2010.03.002
Open this paper in CoChat — free account

Abstract

Autophagy is a major intracellular degradation system in which the cytoplasmic contents are degraded in the lysosome. Its fundamental and evolutionarily conserved role is adaptation to starvation. Recent studies using autophagy-defective mutants of various organisms including mammals have indeed demonstrated the importance of autophagy during starvation; however, the exact mechanism underlying this beneficial effect remains unclear. In addition, it is now apparent that autophagy is also important for cellular homeostasis even under non-starvation conditions, and both non-selective and selective types of autophagy appear to be critical for this function. Here, we discuss the role of this catabolic pathway in recycling intracellular components, with particular reference to nutrient metabolism.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.semcdb.2010.03.002

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 0 references

Research works printed but not linked: 75

  1. Mizushima, 2007, Autophagy: process and function, Genes Dev, 21, 2861, 10.1101/gad.1599207 · DOI
  2. Cecconi, 2008, The role of autophagy in mammalian development: cell makeover rather than cell death, Dev Cell, 15, 344, 10.1016/j.devcel.2008.08.012 · DOI
  3. Deretic, 2009, Multiple regulatory and effector roles of autophagy in immunity, Curr Opin Immunol, 21, 53, 10.1016/j.coi.2009.02.002 · DOI
  4. Takeshige, 1992, Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction, J Cell Biol, 119, 301, 10.1083/jcb.119.2.301 · DOI
  5. Lardeux, 1987, RNA degradation in perfused rat liver as determined from the release of [14C]cytidine, J Biol Chem, 262, 14507, 10.1016/S0021-9258(18)47824-6 · DOI
  6. Balavoine, 1990, Rates of RNA degradation in isolated rat hepatocytes. Effects of amino acids and inhibitors of lysosomal function, Eur J Biochem, 189, 617, 10.1111/j.1432-1033.1990.tb15530.x · DOI
  7. Mizushima, 2005, The pleiotropic role of autophagy: from protein metabolism to bactericide, Cell Death Differ, 12, 1535, 10.1038/sj.cdd.4401728 · DOI
  8. Onodera, 2005, Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation, J Biol Chem, 280, 31582, 10.1074/jbc.M506736200 · DOI
  9. Sou, 2008, The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice, Mol Biol Cell, 19, 4762, 10.1091/mbc.e08-03-0309 · DOI
  10. Komatsu, 2006, Loss of autophagy in the central nervous system causes neurodegeneration in mice, Nature, 441, 880, 10.1038/nature04723 · DOI · Paper page
  11. Liang, 2010, Neural specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration, J Biol Chem, 285, 3499, 10.1074/jbc.M109.072389 · DOI
  12. Mizushima, 2004, In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker, Mol Biol Cell, 15, 1101, 10.1091/mbc.e03-09-0704 · DOI · Paper page
  13. Ebato, 2008, Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet, Cell Metab, 8, 325, 10.1016/j.cmet.2008.08.009 · DOI · Paper page
  14. Jung, 2008, Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia, Cell Metab, 8, 318, 10.1016/j.cmet.2008.08.013 · DOI · Paper page
  15. Calvo-Garrido, 2010, Autophagy dysfunction and ubiquitin-positive protein aggregates in Dictyostelium cells lacking Vmp1, Autophagy, 6, 10.4161/auto.6.1.10697 · DOI
  16. Mathew, 2009, Autophagy suppresses tumorigenesis through elimination of p62, Cell, 137, 1062, 10.1016/j.cell.2009.03.048 · DOI
  17. Mizushima, 2006, Intracellular quality control by autophagy: how does autophagy prevent neurodegeneration?, Autophagy, 2, 302, 10.4161/auto.2945 · DOI
  18. Tsukada, 1993, Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae, FEBS Lett, 333, 169, 10.1016/0014-5793(93)80398-E · DOI
  19. Kohda, 2007, Fission yeast autophagy induced by nitrogen starvation generates a nitrogen source that drives adaptation processes, Genes Cells, 12, 155, 10.1111/j.1365-2443.2007.01041.x · DOI
  20. Mukaiyama, 2009, Autophagy-deficient Schizosaccharomyces pombe mutants undergo partial sporulation during nitrogen starvation, Microbiology, 155, 3816, 10.1099/mic.0.034389-0 · DOI
  21. Tsukamoto, 2008, Autophagy is essential for preimplantation development of mouse embryos, Science, 321, 117, 10.1126/science.1154822 · DOI
  22. Saitoh, 2009, Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response, Proc Natl Acad Sci USA, 106, 20842, 10.1073/pnas.0911267106 · DOI · Paper page
  23. Saitoh, 2008, Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production, Nature, 456, 264, 10.1038/nature07383 · DOI
  24. Hardie, 2007, AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy, Nat Rev Mol Cell Biol, 8, 774, 10.1038/nrm2249 · DOI
  25. Kanamori, 2009, Functional significance and morphological characterization of starvation-induced autophagy in the adult heart, Am J Pathol, 174, 1705, 10.2353/ajpath.2009.080875 · DOI
  26. Lum, 2005, Growth factor regulation of autophagy and cell survival in the absence of apoptosis, Cell, 120, 237, 10.1016/j.cell.2004.11.046 · DOI · Paper page
  27. Felig, 1973, The glucose-alanine cycle, Metabolism, 22, 179, 10.1016/0026-0495(73)90269-2 · DOI
  28. Shibata, 2009, The MAP1-LC3 conjugation system is involved in lipid droplet formation, Biochem Biophys Res Commun, 382, 419, 10.1016/j.bbrc.2009.03.039 · DOI · Paper page
  29. Baerga, 2009, Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice, Autophagy, 5, 1118, 10.4161/auto.5.8.9991 · DOI · Paper page
  30. Zhang, 2009, Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis, Proc Natl Acad Sci USA, 106, 19860, 10.1073/pnas.0906048106 · DOI · Paper page
  31. Singh, 2009, Autophagy regulates adipose mass and differentiation in mice, J Clin Invest, 119, 3329
  32. Kotoulas, 2006, Glycogen autophagy in glucose homeostasis, Pathol Res Pract, 202, 631, 10.1016/j.prp.2006.04.001 · DOI
  33. Schiaffino, 2008, The role of autophagy in neonatal tissues: just a response to amino acid starvation?, Autophagy, 4, 727, 10.4161/auto.6143 · DOI
  34. Raben, 1998, Targeted disruption of the acid alpha-glucosidase gene in mice causes an illness with critical features of both infantile and adult human glycogen storage disease type II, J Biol Chem, 273, 19086, 10.1074/jbc.273.30.19086 · DOI
  35. Bijvoet, 1998, Generalized glycogen storage and cardiomegaly in a knockout mouse model of Pompe disease, Hum Mol Genet, 7, 53, 10.1093/hmg/7.1.53 · DOI
  36. Onodera, 2004, Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiae, J Biol Chem, 279, 16071, 10.1074/jbc.M312706200 · DOI
  37. Yu, 2008, The selectivity of autophagy and its role in cell death and survival, Autophagy, 4, 567, 10.4161/auto.5902 · DOI
  38. Kraft, 2008, Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease, Nat Cell Biol, 10, 602, 10.1038/ncb1723 · DOI · Paper page
  39. Bjørkøy, 2005, p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death, J Cell Biol, 171, 603, 10.1083/jcb.200507002 · DOI · Paper page
  40. Kirkin, 2009, A role for NBR1 in autophagosomal degradation of ubiquitinated substrates, Mol Cell, 33, 505, 10.1016/j.molcel.2009.01.020 · DOI · Paper page
  41. Levine, 2005, Eating oneself and uninvited guests: autophagy-related pathways in cellular defense, Cell, 120, 159
  42. Wang, 2003, The molecular mechanism of autophagy, Mol Med, 9, 65, 10.1007/BF03402040 · DOI
  43. Kageyama, 2009, Lap3 is a selective target of autophagy in yeast, Saccharomyces cerevisiae, Biochem Biophys Res Commun, 378, 551, 10.1016/j.bbrc.2008.11.084 · DOI
  44. Noda, 2008, Structural basis of target recognition by Atg8/LC3 during selective autophagy, Genes Cells, 13, 1211, 10.1111/j.1365-2443.2008.01238.x · DOI
  45. Kanki, 2009, Atg32 is a mitochondrial protein that confers selectivity during mitophagy, Dev Cell, 17, 98, 10.1016/j.devcel.2009.06.014 · DOI
  46. Okamoto, 2009, Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy, Dev Cell, 17, 87, 10.1016/j.devcel.2009.06.013 · DOI · Paper page
  47. Wooten, 2006, Signaling, polyubiquitination, trafficking, and inclusions: sequestosome 1/p62's role in neurodegenerative disease, J Biomed Biotechnol, 2006, 1
  48. Seibenhener, 2007, Sequestosome 1/p62—more than just a scaffold, FEBS Lett, 581, 175, 10.1016/j.febslet.2006.12.027 · DOI
  49. Moscat, 2009, p62 at the crossroads of autophagy, apoptosis, and cancer, Cell, 137, 1001, 10.1016/j.cell.2009.05.023 · DOI · Paper page
  50. Komatsu, 2007, Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice, Cell, 131, 1149, 10.1016/j.cell.2007.10.035 · DOI · Paper page
  51. Zhang, 2009, SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans, Cell, 136, 308, 10.1016/j.cell.2008.12.022 · DOI
  52. Noda, 2010, Atg8-family interacting motif crucial for selective autophagy, FEBS Lett, 581, 1379, 10.1016/j.febslet.2010.01.018 · DOI
  53. Korolchuk, 2009, Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates, Mol Cell, 33, 517, 10.1016/j.molcel.2009.01.021 · DOI · Paper page
  54. Kim, 2008, Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes, Proc Natl Acad Sci USA, 105, 20567, 10.1073/pnas.0810611105 · DOI
  55. Kirkin, 2009, A role for ubiquitin in selective autophagy, Mol Cell, 34, 259, 10.1016/j.molcel.2009.04.026 · DOI
  56. Yoshikawa, 2009, Listeria monocytogenes ActA-mediated escape from autophagic recognition, Nat Cell Biol, 11, 1233, 10.1038/ncb1967 · DOI
  57. Dupont, 2009, Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy, Cell Host Microbe, 6, 137, 10.1016/j.chom.2009.07.005 · DOI
  58. Zheng, 2009, The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway, J Immunol, 183, 5909, 10.4049/jimmunol.0900441 · DOI
  59. Neufeld TP. TOR-dependent control of autophagy: biting the hand that feeds. Curr Opin Cell Biol (2009), doi:10.1016/j.ceb.2009.11.005. · DOI
  60. Scott, 2004, Role and regulation of starvation-induced autophagy in the Drosophila fat body, Dev Cell, 7, 167, 10.1016/j.devcel.2004.07.009 · DOI
  61. Jung, 2010, mTOR regulation of autophagy, FEBS Lett, 584, 1287, 10.1016/j.febslet.2010.01.017 · DOI · Paper page
  62. Lenk, 1992, Effects of streptozotocin-induced diabetes on rough endoplasmic reticulum and lysosomes of rat liver, Am J Physiol, 263, E856
  63. Liu, 2009, Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin, J Biol Chem, 284, 31484, 10.1074/jbc.M109.033936 · DOI · Paper page
  64. Mortimore, 1987, Intracellular protein catabolism and its control during nutrient deprivation and supply, Annu Rev Nutr, 7, 539, 10.1146/annurev.nu.07.070187.002543 · DOI
  65. Sancak, 2008, The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1, Science, 320, 1496, 10.1126/science.1157535 · DOI · Paper page
  66. Pattingre, 2005, Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy, Cell, 122, 927, 10.1016/j.cell.2005.07.002 · DOI · Paper page
  67. Maiuri, 2007, Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1, EMBO J, 26, 2527, 10.1038/sj.emboj.7601689 · DOI
  68. Wei, 2008, JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy, Mol Cell, 30, 678, 10.1016/j.molcel.2008.06.001 · DOI · Paper page
  69. Chikenji, 1983, Protein synthesis rates in rat muscle and skin based on Lysyl-tRNA radioactivity, J Surg Res, 34, 68, 10.1016/0022-4804(83)90023-9 · DOI
  70. Palou, 1981, Metabolic effects of short term food deprivation in the rat, Horm Metab Res, 13, 326, 10.1055/s-2007-1019258 · DOI
  71. Shenoy, 1977, Effect of starvation on the charging levels of transfer ribonucleic acid and total acceptor capacity in rat liver, Biochim Biophys Acta, 476, 218, 10.1016/0005-2787(77)90005-3 · DOI
  72. Wang, 2001, Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p, Mol Cell Biol, 21, 5742, 10.1128/MCB.21.17.5742-5752.2001 · DOI
  73. Meley, 2006, AMP-activated protein kinase and the regulation of autophagic proteolysis, J Biol Chem, 281, 34870, 10.1074/jbc.M605488200 · DOI · Paper page
  74. Liang, 2007, The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis, Nat Cell Biol, 9, 218, 10.1038/ncb1537 · DOI
  75. Papandreou, 2008, Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L, Cell Death Differ, 15, 1572, 10.1038/cdd.2008.84 · DOI · Paper page

Cited by

Sorted by citations

Metadata

Authors
Kuma, A., & Mizushima, N.
Affiliations
Tokyo Medical and Dental University (JP)
Corresponding author
Mizushima, Noboru
ORCID
Venue
Seminars in Cell & Developmental Biology
Publisher
Elsevier BV
Published
2010-09
Volume
21
Issue
7
Pages
683-690
ISSN
1084-9521 (ISSN-L)
DOI
10.1016/j.semcdb.2010.03.002
OpenAlex
W2062922078
Cited by
237
References
0
Citations by year
2026: 6 · 2025: 9 · 2024: 13 · 2023: 12 · 2022: 14 · 2021: 21 · 2020: 17 · 2019: 15 · 2018: 14 · 2017: 19 · 2016: 17 · 2015: 10 · 2014: 16 · 2013: 24 · 2012: 13
FWCI
12.57
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Seminars in Cell and Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • Takeda Science Foundation
  • Korea Toray Science Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
autophagy, nutrient metabolism, starvation adaptation, lysosomal degradation, selective autophagy, cellular homeostasis, catabolism
MeSH terms
Animals, Autophagy, Cell Physiological Phenomena, Humans, Saccharomyces cerevisiae, Starvation, Metabolic Networks and Pathways

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review