PD-1 coinhibitory signals: the link between pathogenesis and protection

Kulpa, Deanna A.; Lawani, Mariam; Cooper, Anthony; Peretz, Yoav; Ahlers, Jeff; Sékaly, Rafick-Pierre

doi:10.1016/j.smim.2013.02.002

Cited by 70HIV Research and TreatmentCancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

PD-1 coinhibitory signals: the link between pathogenesis and protection

Open access

Kulpa, Deanna A., Lawani, Mariam, Cooper, Anthony, Peretz, Yoav, Ahlers, Jeff, Sékaly, Rafick-Pierre·2013·Seminars in Immunology

DOI 10.1016/j.smim.2013.02.002PMC PMC3795833

Open this paper in CoChat — free account

Abstract

In the majority of HIV-1 infected individuals, the adaptive immune response drives virus escape resulting in persistent viremia and a lack of immune-mediated control. The expression of negative regulatory molecules such as PD-1 during chronic HIV infection provides a useful marker to differentiate functional memory T cell subsets and the frequency of T cells with an exhausted phenotype. In addition, cell-based measurements of virus persistence equate with activation markers and the frequency of CD4 T cells expressing PD-1. High-level expression of PD-1 and its ligands PD-L1 and PD-L2 are found on hematopoietic and non-hematopoietic cells, and are upregulated by chronic antigen stimulation, Type 1 and Type II interferons (IFNs), and homeostatic cytokines. In HIV infected subjects, PD-1 levels on CD4 and CD8 T cells continue to remain high following combination anti-retroviral therapy (cART). System biology approaches have begun to elucidate signal transduction pathways regulated by PD-1 expression in CD4 and CD8 T cell subsets that become dysfunctional through chronic TCR activation and PD-1 signaling. In this review, we summarize our current understanding of transcriptional signatures and signal transduction pathways associated with immune exhaustion with a focus on recent work in our laboratory characterizing the role of PD-1 in T cell dysfunction and HIV pathogenesis. We also highlight the therapeutic potential of blocking PD-1-PD-L1 and other immune checkpoints for activating potent cellular immune responses against chronic viral infections and cancer.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.smim.2013.02.002

Cites

116 of 116 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Studies carried out on HIV, hepatitis B and hepatitis C infections have shown that blocking the interaction PD-1/PD-L1 has a positive effect on the effector functions of T cells.
“In fact, studies carried out on HIV, hepatitis B and hepatitis C infections have shown that blocking the interaction PD-1/PD-L1 has a positive effect on the effector functions of T cells.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [182]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Safety, activity, and immune correlates of anti–PD-1 antibody in cancer
Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., Powderly, J. D., Carvajal, R. D., Sosman, J. A., Atkins, M. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200690 · Cited by 12,628 · see citing works
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
Brahmer, J. R., Tykodi, S. S., Chow, L. Q. M., Hwu, W.-J., Topalian, S. L., Hwu, P., Drake, C. G., Camacho, L. H., Kauh, J., Odunsi, K., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200694 · Cited by 7,945 · see citing works
PD-1 and Its Ligands in Tolerance and Immunity
Keir, M. E., Butte, M. J., Freeman, G. J., & Sharpe, A. H. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090331 · Cited by 5,378 · see citing works
Restoring function in exhausted CD8 T cells during chronic viral infection
Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2005) · Nature · doi:10.1038/nature04444 · Cited by 3,960 · see citing works
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056 · see citing works
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Latchman, Y., Wood, C. R., Chernova, T., Chaudhary, D., Borde, M., Chernova, I., Iwai, Y., Long, A. J., Brown, J. A., Nunes, R., et al. (2001) · Nature Immunology · doi:10.1038/85330 · Cited by 2,955 · see citing works
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Day, C. L., Kaufmann, D. E., Kiepiela, P., Brown, J. A., Moodley, E. S., Reddy, S., Mackey, E. W., Miller, J. D., Leslie, A. J., DePierres, C., et al. (2006) · Nature · doi:10.1038/nature05115 · Cited by 2,680 · see citing works
The PD‐1 pathway in tolerance and autoimmunity
Francisco, L. M., Sage, P. T., & Sharpe, A. H. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00923.x · Cited by 2,300 · see citing works
Inferring Regulatory Networks from Expression Data Using Tree-Based Methods
Huynh-Thu, V. A., Irrthum, A., Wehenkel, L., & Geurts, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012776 · Cited by 2,131 · see citing works
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
Blackburn, S. D., Shin, H., Haining, W. N., Zou, T., Workman, C. J., Polley, A., Betts, M. R., Freeman, G. J., Vignali, D. A. A., & Wherry, E. J. (2009) · Nature Immunology · doi:10.1038/ni.1679 · Cited by 2,062 · see citing works
CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms
Parry, R. V., Chemnitz, J. M., Frauwirth, K. A., Lanfranco, A. R., Braunstein, I., Kobayashi, S. V., Linsley, P. S., Thompson, C. B., & Riley, J. L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9543-9553.2005 · Cited by 1,931 · see citing works
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
Betts, M. R. (2006) · Blood · doi:10.1182/blood-2005-12-4818 · Cited by 1,829 · see citing works
How Shelterin Protects Mammalian Telomeres
Palm, W., & de Lange, T. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130350 · Cited by 1,802 · see citing works
TRF2 Protects Human Telomeres from End-to-End Fusions
van Steensel, B., Smogorzewska, A., & de Lange, T. (1998) · Cell · doi:10.1016/s0092-8674(00)80932-0 · Cited by 1,709 · see citing works
Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment
Wherry, E. J., Blattman, J. N., Murali‐Krishna, K., der Most, R. G. V., & Ahmed, R. (2003) · Journal of Virology · doi:10.1128/jvi.77.8.4911-4927.2003 · Cited by 1,599 · see citing works
Ten Years of Pathway Analysis: Current Approaches and Outstanding Challenges
Khatri, P., Sirota, M., & Butte, A. J. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002375 · Cited by 1,569 · see citing works
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
Trautmann, L., Janbazian, L., Chomont, N., Said, E. A., Gimmig, S., Bessette, B., Boulassel, M.-R., Delwart, E., Sepulveda, H., Balderas, R. S., et al. (2006) · Nature Medicine · doi:10.1038/nm1482 · Cited by 1,565 · see citing works
Bcl6 mediates the development of T follicular helper cells
Nurieva, R. I., Chung, Y., Martinez, G. J., Yang, X. O., Tanaka, S., Matskevitch, T. D., Wang, Y.-H., & Dong, C. (2009) · Science · doi:10.1126/science.1176676 · Cited by 1,506 · see citing works
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients
Fourcade, J., Sun, Z., Benallaoua, M., Guillaume, P., Luescher, I. F., Sander, C., Kirkwood, J. M., Kuchroo, V., & Zarour, H. M. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100637 · Cited by 1,307 · see citing works
SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation
Chemnitz, J. M., Parry, R. V., Nichols, K. E., June, C. H., & Riley, J. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.945 · Cited by 1,246 · see citing works
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
Yokosuka, T., Takamatsu, M., Kobayashi-Imanishi, W., Hashimoto-Tane, A., Azuma, M., & Saito, T. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112741 · Cited by 1,161 · see citing works
Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients
Lee, P. P., Yee, C., Savage, P. A., Fong, L. H., Brockstedt, D. G., Weber, J. S., Johnson, D. L., Swetter, S. M., Thompson, J. A., Greenberg, P. D., et al. (1999) · Nature Medicine · doi:10.1038/9525 · Cited by 1,117 · see citing works
Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
Straus, D. B. (1992) · Cell · doi:10.1016/0092-8674(92)90428-f · Cited by 1,045 · see citing works
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
Migueles, S. A., Laborico, A. C., Shupert, W. L., Sabbaghian, M. S., Rabin, R. L., Hallahan, C. W., van Baarle, D., Kostense, S., Miedema, F. F., McLaughlin, M. E., et al. (2002) · Nature Immunology · doi:10.1038/ni845 · Cited by 1,004 · see citing works
Skewed maturation of memory HIV-specific CD8 T lymphocytes
Champagne, P., Ogg, G. S., King, A. S., Knabenhans, C., Ellefsen, K., Nobile, M., Appay, V., Rizzardi, G. P., Fleury, S., Lipp, M., et al. (2001) · Nature · doi:10.1038/35065118 · Cited by 1,002 · see citing works
Self-citation
Characterization of Hepatitis B Virus (HBV)-Specific T-Cell Dysfunction in Chronic HBV Infection
Boni, C., Fisicaro, P., Valdatta, C., Amadei, B., Di Vincenzo, P., Giuberti, T., Laccabue, D., Zerbini, A., Cavalli, A., Missale, G., et al. (2007) · Journal of Virology · doi:10.1128/jvi.02844-06 · Cited by 920 · see citing works
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
Petrovas, C., Casazza, J. P., Brenchley, J. M., Price, D. A., Gostick, E., Adams, W. C., Precopio, M. L., Schacker, T., Roederer, M., Douek, D. C., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061496 · Cited by 889 · see citing works
HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function
Appay, V., Nixon, D. F., Donahoe, S. M., Gillespie, G. M. A., Dong, T., King, A., Ogg, G. S., Spiegel, H. M. L., Conlon, C., Spina, C. A., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.1.63 · Cited by 871 · see citing works
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
Okazaki, T., Maeda, A., Nishimura, H., Kurosaki, T., & Honjo, T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231486598 · Cited by 849 · see citing works
PD‐1 inhibits T‐cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ
Sheppard, K.-A., Fitz, L. J., Lee, J. M., Benander, C., George, J. A., Wooters, J., Qiu, Y., Jussif, J. M., Carter, L. L., Wood, C. R., et al. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.083 · Cited by 791 · see citing works
PD-1 signaling in primary T cells
Riley, J. L. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00767.x · Cited by 778 · see citing works
Enhancing SIV-specific immunity in vivo by PD-1 blockade
Velu, V., Titanji, K., Zhu, B., Husain, S., Pladevega, A., Lai, L., Vanderford, T. H., Chennareddi, L. S., Silvestri, G., Freeman, G. J., et al. (2008) · Nature · doi:10.1038/nature07662 · Cited by 765 · see citing works
Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation
Shan, L., Deng, K., Shroff, N. S., Durand, C. M., Rabi, S. A., Yang, H., Zhang, H., Margolick, J. B., Blankson, J. N., & Siliciano, R. F. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.014 · Cited by 707 · see citing works
Impaired Effector Function of Hepatitis C Virus-Specific CD8+ T Cells in Chronic Hepatitis C Virus Infection
Wedemeyer, H. H., He, X.-S., Nascimbeni, M., Davis, A. R., Greenberg, H. B., Hoofnagle, J. H., Liang, T. J., Alter, H. J., & Rehermann, B. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.3447 · Cited by 635 · see citing works
Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines
Miller, J. D., van der Most, R. G., Akondy, R. S., Glidewell, J. T., Albott, S., Masopust, D., Murali-Krishna, K., Mahar, P. L., Edupuganti, S., Lalor, S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.020 · Cited by 601 · see citing works
Plasma Levels of Bacterial DNA Correlate with Immune Activation and the Magnitude of Immune Restoration in Persons with Antiretroviral‐Treated HIV Infection
Jiang, W., Lederman, M. M., Hunt, P. W., Sieg, S. F., Haley, K. P., Rodriguez, B. A., LANDAY, A. L., Martin, J. N., Sinclair, E., Asher, A. I., et al. (2009) · The Journal of Infectious Diseases · doi:10.1086/597476 · Cited by 591 · see citing works
Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory
Doering, T. A., Crawford, A., Angelosanto, J., Paley, M., Ziegler, C. G. K., & Wherry, E. J. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.021 · Cited by 542 · see citing works
Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation
Patsoukis, N., Brown, J., Petkova, V., Liu, F., Li, L., & Boussiotis, V. A. (2012) · Science Signaling · doi:10.1126/scisignal.2002796 · Cited by 529 · see citing works
Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction
Kaufmann, D., Kavanagh, D. G., Pereyra, F., Zaunders, J. J., Mackey, E. W., Miura, T., Palmer, S., Brockman, M. A., Rathod, A., Trocha, A. K., et al. (2007) · Nature Immunology · doi:10.1038/ni1515 · Cited by 522 · see citing works
The Common γ-Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Induce the Expression of Programmed Death-1 and Its Ligands
Kinter, A. L., Godbout, E. J., McNally, J. P., Sereti, I., Roby, G. A., O’Shea, M. A., & Fauci, A. S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.6738 · Cited by 513 · see citing works
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF
Quigley, M. M., Pereyra, F., Nilsson, B., Porichis, F., Fonseca, C., Eichbaum, Q. G., Jülg, B. D., Jesneck, J. L., Brosnahan, K., Imam, S., et al. (2010) · Nature Medicine · doi:10.1038/nm.2232 · Cited by 505 · see citing works
Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection
Kao, C., Oestreich, K. J., Paley, M., Crawford, A., Angelosanto, J., Ali, M.-A. A., Intlekofer, A. M., Boss, J. M., Reiner, S. L., Weinmann, A. S., et al. (2011) · Nature Immunology · doi:10.1038/ni.2046 · Cited by 484 · see citing works
Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression
Radziewicz, H., Ibegbu, C., Fernandez, M. L., Workowski, K., Obideen, K. M., Wehbi, M. A., Hanson, H. L., Steinberg, J. P., Masopust, D., Wherry, E. J., et al. (2006) · Journal of Virology · doi:10.1128/jvi.02021-06 · Cited by 482 · see citing works
Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection
Said, E. A., Dupuy, F. P., Trautmann, L., Zhang, Y., Shi, Y., Far, M. E., Hill, B. J., Noto, A., Ancuța, P., Peretz, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2106 · Cited by 474 · see citing works
Self-citation
HIV-1 Viremia Prevents the Establishment of Interleukin 2–producing HIV-specific Memory CD4+ T Cells Endowed with Proliferative Capacity
Younes, S., Yassine‐Diab, B., Dumont, A. R., Boulassel, M., Grossman, Z., Routy, J., & Sékaly, R. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20031598 · Cited by 459 · see citing works
Self-citation
integrOmics: an R package to unravel relationships between two omics datasets
Cao, K. L., González, I., & Dejean, S. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp515 · Cited by 459 · see citing works
The Inhibitory Receptor PD-1 Regulates IgA Selection and Bacterial Composition in the Gut
Kawamoto, S., Tran, T. H., Maruya, M., Suzuki, K., Doi, Y., Tsutsui, Y., Kato, L. M., & Fagarasan, S. (2012) · Science · doi:10.1126/science.1217718 · Cited by 451 · see citing works
PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver
Iwai, Y., Terawaki, S., Ikegawa, M., Okazaki, T., & Honjo, T. (2003) · Journal of Experimental Medicine · doi:10.1084/jem.20022235 · Cited by 426 · see citing works
Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells
Pepper, M., Pagán, A. J., Igyártó, B. Z., Taylor, J. J., & Jenkins, M. K. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.009 · Cited by 410 · see citing works
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells
Ise, W., Kohyama, M., Schraml, B. U., Zhang, T., Schwer, B., Basu, U., Alt, F. W., Tang, J., Oltz, E. M., Murphy, T. L., et al. (2011) · Nature Immunology · doi:10.1038/ni.2037 · Cited by 377 · see citing works
Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation
Bengsch, B., Seigel, B., Ruhl, M., Timm, J., Kuntz, M., Blum, H. E., Pircher, H., & Thimme, R. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000947 · Cited by 373 · see citing works
Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+T Cells Associated with Reversible Immune Dysfunction
Golden‐Mason, L., Palmer, B. E., Klarquist, J. S., Mengshol, J. A., Castelblanco, N., & Rosen, H. R. (2007) · Journal of Virology · doi:10.1128/jvi.00409-07 · Cited by 371 · see citing works
Bcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation
Kroenke, M. A., Eto, D. S., Locci, M., Cho, M., Davidson, T. M., Haddad, E. K., & Crotty, S. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103246 · Cited by 355 · see citing works
CD8 T cell dysfunction during chronic viral infection
Shin, H., & Wherry, E. J. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.06.004 · Cited by 346 · see citing works
Programmed death-1 (PD-1)–deficient mice are extraordinarily sensitive to tuberculosis
Lázár‐Molnár, E., Chen, B., Sweeney, K. A., Wang, E. J., Liu, W., Lin, J., Porcelli, S. A., Almo, S. C., Nathenson, S. G., & Jacobs, W. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007394107 · Cited by 339 · see citing works
HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS
Nilsson, J., Boasso, A., Velilla, P. A., et al. (2006) · Blood · doi:10.1182/blood-2006-05-021576 · Cited by 338 · see citing works
Loss of HIV-1–specific CD8+ T Cell Proliferation after Acute HIV-1 Infection and Restoration by Vaccine-induced HIV-1–specific CD4+ T Cells
Lichterfeld, M. D., Kaufmann, D., Yu, X. G., Mui, S. K., Addo, M. M., Johnston, M. N., Cohen, D., Robbins, G. K., Pae, E., Alter, G., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041270 · Cited by 338 · see citing works
HIV-1-specific IFN-γ/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells
Zimmerli, S. C., Harari, A., Cellerai, C., Vallelian, F., Bart, P., & Pantaleo, G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502393102 · Cited by 307 · see citing works
Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy
Marchetti, G. C., Bellistrì, G. M., Borghi, E., Tincati, C., Ferramosca, S., Francesca, M. L., Morace, G., Gori, A., & Monforte, A. D. (2008) · AIDS · doi:10.1097/qad.0b013e3283112d29 · Cited by 296 · see citing works
Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization
Nakamoto, N., Kaplan, D. E., Coleclough, J., Li, Y., Valiga, M. E., Kaminski, M., Shaked, A. A., Olthoff, K. M., Emma Gostick, D., Price, D. A., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.02.033 · Cited by 296 · see citing works
Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection
Angelosanto, J., Blackburn, S. D., Crawford, A., & Wherry, E. J. (2012) · Journal of Virology · doi:10.1128/jvi.00889-12 · Cited by 285 · see citing works
Sparse canonical methods for biological data integration: application to a cross-platform study
Cao, K. L., Martin, P. G. P., Robert-Granié, C., & Besse, P. C. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-34 · Cited by 284 · see citing works
Ablation of CD8 and CD4 T Cell Responses by High Viral Loads
Fuller, M. J., & Zajac, A. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.477 · Cited by 276 · see citing works
PD‐L1 co‐stimulation contributes to ligand‐induced T cell receptor down‐modulation on CD8+ T cells
Karwacz, K., Bricogne, C., MacDonald, D. C., Vargas, F. A., Bennett, C. L., Collins, M. K., & Escors, D. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100165 · Cited by 267 · see citing works
Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients
Rehermann, B., Chang, K., McHutchinson, J. G., Kokka, R. P., Houghton, M., Rice, C. M., & Chisari, F. V. (1996) · Journal of Virology · doi:10.1128/jvi.70.10.7092-7102.1996 · Cited by 260 · see citing works
Phenotype, Function, and Gene Expression Profiles of Programmed Death-1hi CD8 T Cells in Healthy Human Adults
Duraiswamy, J., Ibegbu, C., Masopust, D., Miller, J. D., Araki, K., Doho, G., Tata, P., Sk, G., Zilliox, M. J., Nakaya, H. I., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001783 · Cited by 246 · see citing works
PD-1 and CTLA-4 Inhibitory Cosignaling Pathways in HIV Infection and the Potential for Therapeutic Intervention
Kaufmann, D., & Walker, B. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803771 · Cited by 229 · see citing works
An efficient protein complex purification method for functional proteomics in higher eukaryotes
Forler, D., Köcher, T., Rode, M., Gentzel, M., Izaurralde, E., & Wilm, M. S. (2002) · Nature Biotechnology · doi:10.1038/nbt773 · Cited by 211 · see citing works
Simultaneous Blockade of Multiple Immune System Inhibitory Checkpoints Enhances Antitumor Activity Mediated by Interleukin-15 in a Murine Metastatic Colon Carcinoma Model
Yu, P., Steel, J. C., Zhang, M., Morris, J. C., & Waldmann, T. A. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-1966 · Cited by 208 · see citing works
Expression of the Interleukin-7 Receptor Alpha Chain (CD127) on Virus-Specific CD8+ T Cells Identifies Functionally and Phenotypically Defined Memory T Cells during Acute Resolving Hepatitis B Virus Infection
Boettler, T., Panther, E., Bengsch, B., Nazarova, N., Spangenberg, H., Blum, H., & Thimme, R. (2006) · Journal of Virology · doi:10.1128/jvi.80.7.3532-3540.2006 · Cited by 207 · see citing works
The Programmed Death-1 Ligand 1:B7-1 Pathway Restrains Diabetogenic Effector T Cells In Vivo
Paterson, A. M., Brown, K. E., Keir, M. E., Vanguri, V. K., Riella, L. V., Chandraker, A. K., Sayegh, M. H., Blazar, B. R., Freeman, G. J., & Sharpe, A. H. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003496 · Cited by 202 · see citing works
Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection
Yamamoto, T., Price, D. A., Casazza, J. P., Ferrari, G., Nason, M., Chattopadhyay, P. K., Roederer, M., Emma Gostick, D., Katsikis, P. D., Douek, D. C., et al. (2011) · Blood · doi:10.1182/blood-2010-11-317297 · Cited by 191 · see citing works
SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
Petrovas, C., Price, D. A., Mattapallil, J. J., Ambrozak, D. R., Geldmacher, C., Cecchinato, V., Vaccari, M., Tryniszewska, E. A., Emma Gostick, D., Roederer, M., et al. (2007) · Blood · doi:10.1182/blood-2007-01-069112 · Cited by 172 · see citing works
Responsiveness of HIV-specific CD4 T cells to PD-1 blockade
Porichis, F., Kwon, D. S., Zupkosky, J., Tighe, D. P., McMullen, A. M., Brockman, M. A., Pavlik, D. F., Rodríguez‐García, M., Pereyra, F., Freeman, G. J., et al. (2011) · Blood · doi:10.1182/blood-2010-12-328070 · Cited by 164 · see citing works
PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques
Shetty, R. D., Velu, V., Titanji, K., Bosinger, S. E., Freeman, G. J., Silvestri, G., & Amara, R. R. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60612 · Cited by 156 · see citing works
A novel method for autophagy detection in primary cells: Impaired levels of macroautophagy in immunosenescent T cells
Phadwal, K., Alegre-Abarrategui, J., Watson, A. S., Pike, L., Anbalagan, S., Hammond, E. M., Wade-Martins, R., McMichael, A., Klenerman, P., & Simon, A. K. (2012) · Autophagy · doi:10.4161/auto.18935 · Cited by 155 · see citing works
New insights into the molecular basis of T cell anergy: anergy factors, avoidance sensors, and epigenetic imprinting
Wells, A. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803917 · Cited by 153 · see citing works
CD160 and PD-1 Co-Expression on HIV-Specific CD8 T Cells Defines a Subset with Advanced Dysfunction
Peretz, Y., He, Z., Shi, Y., Yassine‐Diab, B., Goulet, J.-P., Bordi, R., Filali‐Mouhim, A., Loubert, J.-B., Far, M. E., Dupuy, F. P., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002840 · Cited by 148 · see citing works
Self-citation
Blockade of Programmed Death Ligand 1 Enhances the Therapeutic Efficacy of Combination Immunotherapy against Melanoma
Pilon‐Thomas, S., Mackay, A., Vohra, N. A., & Mulé, J. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904114 · Cited by 147 · see citing works
IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells
Peñaranda, C., Kuswanto, W. F., Hofmann, J., Kenefeck, R., Narendran, P., Walker, L. S. K., Bluestone, J. A., Abbas, A. K., & Dooms, H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203692109 · Cited by 143 · see citing works
Impact of Epitope Escape on PD-1 Expression and CD8 T-Cell Exhaustion during Chronic Infection
Blattman, J. N., Wherry, E. J., Ha, S., der Most, R. G. V., & Ahmed, R. (2009) · Journal of Virology · doi:10.1128/jvi.02524-08 · Cited by 142 · see citing works
LYP inhibits T-cell activation when dissociated from CSK
Vang, T., Liu, W. H., Delacroix, L., Wu, S., Vasile, S., Dahl, R. S., Yang, L., Musumeci, L., Francis, D. M., Landskron, J., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.916 · Cited by 140 · see citing works
Anti–IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function
Lee, L., Logronio, K. A., Tu, G. H., Zhai, W., Ni, I., Mei, L., Dilley, J., Yu, J., Rajpal, A., Brown, C. N., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203795109 · Cited by 136 · see citing works
The Novel Costimulatory Programmed Death Ligand 1/B7.1 Pathway Is Functional in Inhibiting Alloimmune Responses In Vivo
Yang, J., Riella, L. V., Chock, S., Liu, T., Zhao, X., Yuan, X., Paterson, A. M., Watanabe, T., Vanguri, V. K., Yagita∥, H., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100056 · Cited by 134 · see citing works
Receptor‐stimulated oxidation of SHP‐2 promotes T‐cell adhesion through SLP‐76–ADAP
Kwon, J., Qu, C., Maeng, J.-S., Falahati, R., Lee, C., & Williams, M. S. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600706 · Cited by 124 · see citing works
Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques
Titanji, K., Velu, V., Chennareddi, L. S., Vijay–Kumar, M., Gewirtz, A. T., Freeman, G. J., & Amara, R. R. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43271 · Cited by 123 · see citing works
Cutting Edge: Programmed Death-1 Expression Is Increased on Immunocytes in Chronic Hepatitis C Virus and Predicts Failure of Response to Antiviral Therapy: Race-Dependent Differences
Golden‐Mason, L., Klarquist, J. S., Wahed, A. S., & Rosen, H. R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.6.3637 · Cited by 110 · see citing works
MDC1 accelerates nonhomologous end-joining of dysfunctional telomeresPreprint
Dimitrova, N., & de Lange, T. (2006) · Genes & Development · doi:10.1101/gad.1496606 · Cited by 93 · see citing works
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses
Gottschalk, R. A., Hathorn, M. M., Beuneu, H., Corse, E., Dustin, M. L., Altan-Bonnet, G. Y., & Allison, J. P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119763109 · Cited by 91 · see citing works
Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections
Ha, S., West, E. E., Araki, K., Smith, K. A., & Ahmed, R. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00638.x · Cited by 90 · see citing works
Early T Cell Signalling Is Reversibly Altered in PD-1+ T Lymphocytes Infiltrating Human Tumors
Renault, S., Fouquet, S., Chapon, M., Salmon, H., Régnier, F., Labroquère, K., Badoual, C., Damotte, D., Validire, P., Maubec, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017621 · Cited by 87 · see citing works
T-cell exhaustion in HIV infection
Far, M. E., Halwani, R., Said, E. A., Trautmann, L., Doroudchi, M., Janbazian, L., Fonseca, S. G., van Grevenynghe, J., Yassine‐Diab, B., Sékaly, R., et al. (2008) · Current HIV/AIDS Reports · doi:10.1007/s11904-008-0003-7 · Cited by 87 · see citing works
Self-citation
Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling
Schoenborn, J. R., Tan, Y. X., Zhang, C., Shokat, K. M., & Weiss, A. (2011) · Science Signaling · doi:10.1126/scisignal.2001893 · Cited by 85 · see citing works
Telomerase activity of HIV-1–specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors
Lichterfeld, M. D., Mou, D., Cung, T. D. H., Williams, K. L., Waring, M. T., Huang, J., Pereyra, F., Piechocka‐Trocha, A., Freeman, G. J., Rosenberg, E. S., et al. (2008) · Blood · doi:10.1182/blood-2008-01-135442 · Cited by 82 · see citing works
E3 Ubiquitin Ligase Cbl-b Regulates Pten via Nedd4 in T Cells Independently of Its Ubiquitin Ligase Activity
Guo, H., Qiao, G., Ying, H., Li, Z., Zhao, Y., Liang, Y., Yang, L., Lipkowitz, S., Penninger, J. M., Langdon, W. Y., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.04.008 · Cited by 78 · see citing works
Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection
Trautmann, L., Mbitikon-Kobo, F. M., Goulet, J.-P., Peretz, Y., Shi, Y., van Grevenynghe, J., Procopio, F. A., Boulassel, M. R., Routy, J., Chomont, N., et al. (2012) · Blood · doi:10.1182/blood-2012-04-422550 · Cited by 74 · see citing works
Self-citation
Programmed Death 1 and Cytokine Inducible SH2-Containing Protein Dependent Expansion of Regulatory T Cells Upon Stimulation With Mycobacterium tuberculosis
Periasamy, S., Dhiman, R., Barnes, P. F., Paidipally, P., Tvinnereim, A., Bandaru, A., Valluri, V. L., & Vankayalapati, R. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir011 · Cited by 70 · see citing works
TGF-β in intestinal lymphoid organs contributes to the death of armed effector CD8 T cells and is associated with the absence of virus containment in rhesus macaques infected with the simian immunodeficiency virus
Cumont, M., Monceaux, V., Viollet, L., Lay, S., Parker, R., Hurtrel, B., & Estaquier, J. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402192 · Cited by 68 · see citing works
Expression of a Broad Array of Negative Costimulatory Molecules and Blimp-1 in T Cells following Priming by HIV-1 Pulsed Dendritic Cells
Shankar, E. M., Che, K. F., Messmer, D., Lifson, J. D., & Larsson, M. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00175 · Cited by 63 · see citing works
HIV-Induced T-Cell Activation/Exhaustion in Rectal Mucosa Is Controlled Only Partially by Antiretroviral Treatment
Rueda, C. M., Velilla, P. A., Chougnet, C. A., Montoya, C. J., & Rugeles, M. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030307 · Cited by 57 · see citing works
An airbone mold-derived product, β-1,3-D-glucan, potentiates airway allergic responses
Wan, G., Li, C.-S., Guo, S.-P., Rylander, R., & Lin, R. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199908)29:08 · Cited by 56 · see citing works
Lck and the nature of the T cell receptor trigger
Davis, S. J., & van der Merwe, P. A. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.11.003 · Cited by 52 · see citing works
Programmed death (PD)-1 molecule and its ligand PD-L1 distribution among memory CD4 and CD8 T cell subsets in human immunodeficiency virus-1-infected individuals
Rosignoli, G., Lim, C. H., Bower, M., Gotch, F., & Imami, N. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03960.x · Cited by 51 · see citing works
LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L
Lucas, C. L., Workman, C. J., Beyaz, S., LoCascio, S. A., Zhao, G., Vignali, D. A. A., & Sykes, M. (2011) · Blood · doi:10.1182/blood-2010-11-318675 · Cited by 46 · see citing works
Inhibitory TCR Coreceptor PD-1 Is a Sensitive Indicator of Low-Level Replication of SIV and HIV-1
Salisch, N. C., Kaufmann, D., Awad, A. S., Reeves, R. K., Tighe, D. P., Li, Y., Piatak, M., Lifson, J. D., Evans, D. T., Pereyra, F., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902781 · Cited by 45 · see citing works
A CD8 T cell–intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo
Fehr, T. H., Lucas, C. L., Kurtz, J. M., Onoe, T., Zhao, G., Hogan, T., Vallot, C., Rao, A., & Sykes, M. (2009) · Blood · doi:10.1182/blood-2009-07-230680 · Cited by 43 · see citing works
p38 Mitogen-Activated Protein Kinase/Signal Transducer and Activator of Transcription-3 Pathway Signaling Regulates Expression of Inhibitory Molecules in T Cells Activated by HIV-1-Exposed Dendritic Cells
Che, K. F., Shankar, E. M., Muthu, S., Zandi, S., Sigvardsson, M., Hinkula, J., Messmer, D., & Larsson, M. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00103 · Cited by 43 · see citing works
Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade
Henson, S. M., Macaulay, R., Franzese, O., & Akbar, A. N. (2012) · Immunology · doi:10.1111/j.1365-2567.2011.03550.x · Cited by 42 · see citing works
Rejuvenating exhausted T cells during chronic viral infection.
Okazaki, T., & Honjo, T. (2006) · Cell · doi:10.1016/j.cell.2006.01.022 · Cited by 40 · see citing works
Clonotype and Repertoire Changes Drive the Functional Improvement of HIV-Specific CD8 T Cell Populations under Conditions of Limited Antigenic Stimulation
Janbazian, L., Price, D. A., Canderan, G., Filali-Mouhim, A., Asher, T. E., Ambrozak, D. R., Scheinberg, P., Boulassel, M. R., Routy, J., Koup, R. A., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102610 · Cited by 40 · see citing works
Self-citation
Dominant Clonotypes within HIV-Specific T Cell Responses Are Programmed Death-1high and CD127low and Display Reduced Variant Cross-Reactivity
Conrad, J. A., Ramalingam, R. K., Smith, R. M., Barnett, L. D., Lorey, S. L., Wei, J., Simons, B. C., Sadagopal, S., Meyer‐Olson, D., & Kalams, S. A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004234 · Cited by 33 · see citing works
Immunogenic and tolerogenic signatures in human immunodeficiency virus (HIV)-infected controllers compared with progressors and a conversion strategy of virus control
Whittall, T., Peters, B., Rahman, D., et al. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04463.x · Cited by 32 · see citing works
Expression of PD-L1, a marker of disease status, is not reduced by HAART in aviraemic patients
Rosignoli, G., Cranage, A., Burton, C., Nelson, M. R., Steel, A., Gazzard, B., Gotch, F. M., & Imami, N. (2007) · AIDS · doi:10.1097/qad.0b013e3281de7296 · Cited by 32 · see citing works
Dissecting the HIV-specific immune response
Peretz, Y., Cameron, C., & Sékaly, R. (2011) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32834ddb0e · Cited by 20 · see citing works
Self-citation
DifferentIn VivoEffects of HIV-1 Immunodominant Epitope-Specific Cytotoxic T Lymphocytes on Selection of Escape Mutant Viruses
Koizumi, H., Hashimoto, M., Fujiwara, M., Murakoshi, H., Chikata, T., Borghan, M. A., Hachiya, A., Kawashima, Y., Takata, H., Ueno, T., et al. (2010) · Journal of Virology · doi:10.1128/jvi.02483-09 · Cited by 12 · see citing works
Shelterin Dysfunction and p16 <sup>INK4a</sup> -Mediated Growth Inhibition in HIV-1-Specific CD8 T Cells
Lichterfeld, M., Cung, T., Seiss, K., Rosenberg, E. S., Pereyra, F., & Yu, X. G. (2012) · Journal of Virology · doi:10.1128/jvi.00196-12 · Cited by 9 · see citing works

Flagged first, then by citations

Sorted by citations

Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention
Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693 · see citing works
Five Layers of Receptor Signaling in Î³Î´ T-Cell Differentiation and Activation
Ribeiro, S. T., Ribot, J. C., & Silva-Santos, B. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00015 · Cited by 116 · see citing works

Intermittent low-level viremia in very early primary HIV-1 infection.
Fiebig, E. W., Heldebrant, C. M., Smith, R. I. F., Conrad, A. J., Delwart, E., & Busch, M. P. (2005) · PubMed · Cited by 48 · see citing works
Diversity of Trends of Viremia and T-Cell Markers in Experimental Acute Feline Immunodeficiency Virus Infection
Roche, S., Garch, H. E., Brunet, S., Poulet, H., Iwaz, J., Écochard, R., & Vanhems, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056135 · Cited by 1 · see citing works
CD8+ clonality is associated with prolonged acute plasma viremia and altered mRNA cytokine profiles during the course of Feline Immunodeficiency Virus infection
Miller, M. M., Thompson, E. M., Suter, S. E., & Fogle, J. E. (2012) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2012.12.005 · Cited by 7 · see citing works
Immune Activation, Cd4+ T Cell Counts, and Viremia Exhibit Oscillatory Patterns over Time in Patients with Highly Resistant HIV Infection
Ramirez, C. M., Yeghiazarian, L., Hoh, R. A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021190 · Cited by 13 · see citing works
Effect of immunosuppressants on T-cell subsets observed in vivo using carboxy-fluorescein diacetate succinimidyl ester labeling1
Hu, H., Dong, Y., Feng, P., et al. (2003) · Transplantation · doi:10.1097/01.tp.0000055832.35337.e6 · Cited by 15 · see citing works

Authors: Kulpa, D. A., Lawani, M., Cooper, A., Peretz, Y., Ahlers, J., & Sékaly, R.-P.
Affiliations: Vaccine & Gene Therapy Institute of Florida (US)
Caprion (Canada) (CA)
Corresponding author: Sékaly, Rafick-Pierre
ORCID: Kulpa, Deanna A.
Cooper, Anthony
Sékaly, Rafick-Pierre
Venue: Seminars in Immunology
Publisher: Elsevier BV
Published: 2013-10
Volume: 25
Issue: 3
Pages: 219-227
ISSN: 1044-5323 (ISSN-L)
DOI: 10.1016/j.smim.2013.02.002
PMC: PMC3795833
OpenAlex: W2084266752
Cited by: 70
References: 116
Citations by year: 2026: 1 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 8 · 2013: 5
FWCI: 1.10
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (DP1DA028871)
National Institute of Allergy and Infectious Diseases (P01AI076174)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: PD-1, PD-L1, PD-L2, immune checkpoint blockade, HIV-1 infection, chronic viral infection, T cell exhaustion, CD4+ T cells, CD8+ T cells, PD-1 signaling, signal transduction, gene expression signatures, viral immune evasion, highly active antiretroviral therapy, interferon, T cell dysfunction
MeSH terms: Animals, Humans, Immunologic Memory, Lymphocyte Activation, T-Lymphocytes, Signal Transduction, Biomarkers, HIV Infections, T-Lymphocyte Subsets, Systems Biology, Immune Evasion, Molecular Targeted Therapy, Transcriptome, Programmed Cell Death 1 Receptor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

PD-1 coinhibitory signals: the link between pathogenesis and protection

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks