Regulation of microglial survival and proliferation in health and diseases
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Microglia play an important role in the development and maintenance of the central nervous system (CNS) under homeostatic conditions as well as during neurodegenerative diseases. Recent observations in human genomics and advances in genetic mouse models have provided insights into signaling pathways that control development, survival, proliferation and function of microglia. Alteration of these pathways contributes to the pathogenesis of CNS diseases. Here we review the current literature regarding the roles of these microglial pathways in both the normal and diseased brain and discuss areas that require further investigation.
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Microglia receive survival and proliferation signals following stimulation of CSF1R with CSF1 or IL-34.
“Microglia receive signals for survival and proliferation following stimulation of the CSF1 receptor (CSF1R) with CSF1 or IL-34 (142).”
From Microglia in Alzheimer's disease (2017) · cites this paper as [142]
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- Authors
- Ulland, T. K., Wang, Y., & Colonna, M.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Colonna, Marco
- Venue
- Seminars in Immunology
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 27
- Issue
- 6
- Pages
- 410-415
- ISSN
- 1044-5323 (ISSN-L)
- PMC
- PMC5084693
- OpenAlex
- W2316322054
- Cited by
- 43
- References
- 72
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 7 · 2017: 5 · 2016: 2
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Seminars in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P50AG005681, RF1AG051485, P01AG003991)
- National Cancer Institute (T32CA009547)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- microglia, microglial survival, microglial proliferation, microglial development, neurodegenerative diseases, CNS homeostasis, signaling pathways, genetic mouse models, human genomics
- MeSH terms
- Animals, Cell Survival, Central Nervous System, Humans, Microglia, Neurodegenerative Diseases, Cell Proliferation
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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