Update on Alzheimer’s Disease Therapy and Prevention Strategies

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Alzheimer's disease: the amyloid cascade hypothesis

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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

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The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

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Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein

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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

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The amyloid state and its association with protein misfolding diseases.

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Tau in physiology and pathology

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Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease

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RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

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Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

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A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

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Defeating Alzheimer's disease and other dementias: a priority for European science and society

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Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

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Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

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Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease

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A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

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Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies

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Assembly of τ protein into Alzheimer paired helical filaments depends on a local sequence motif ( ³⁰⁶ VQIVYK ³¹¹ ) forming β structure

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Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

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Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

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Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

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Physical Activity, Diet, and Risk of Alzheimer Disease

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Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease

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Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

Wong, G. T., Manfra, D. J., Poulet, F. M., Zhang, Q., Josien, H. B., Bara, T. A., Engstrom, L., Pinzon-Ortiz, M. C., Fine, J. S., Lee, H.-J. J., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311652200 · Cited by 715 · see citing works

Dystrophic microglia in the aging human brain

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Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer’s disease

Risner, M. E., Saunders, A. M., Altman, J. F. B., Ormandy, G. C., Craft, S., Foley, I. M., Zvartau-Hind, M. E., Hosford, D. A., Roses, A. D., & for the Rosiglitazone in Alzheimer's Disease Study Group (2006) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500369 · Cited by 686 · see citing works

The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia

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Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice

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Targeting the β secretase BACE1 for Alzheimer’s disease therapy

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Clearing the brain's amyloid cobwebs

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Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis

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From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation

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Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.

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Gantenerumab: A Novel Human Anti-Aβ Antibody Demonstrates Sustained Cerebral Amyloid-β Binding and Elicits Cell-Mediated Removal of Human Amyloid-β

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Global Hairpin Folding of Tau in Solution

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Body Mass Index in Midlife and Risk of Alzheimer Disease and Vascular Dementia

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Disaggregation of Alzheimer β-amyloid by site-directed mAb

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Regulation of Microglial Proliferation during Chronic Neurodegeneration

Gómez-Nicola, D., Fransen, N. L., Suzzi, S., & Perry, V. H. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4440-12.2013 · Cited by 407 · see citing works

The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice

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Caloric restriction and intermittent fasting: Two potential diets for successful brain aging

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Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease

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Chemokines and Chemokine Receptors: Standing at the Crossroads of Immunobiology and Neurobiology

Ransohoff, R. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.010 · Cited by 372 · see citing works

Proteolytic Degradation of Amyloid -Protein

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Somatostatin regulates brain amyloid β peptide Aβ42 through modulation of proteolytic degradation

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Microglial Dynamics and Role in the Healthy and Diseased Brain: A Paradigm of Functional Plasticity

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Adipsin, a Biomarker of Gastrointestinal Toxicity Mediated by a Functional γ-Secretase Inhibitor

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Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

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Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice

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Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide.

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Antisense Reduction of Tau in Adult Mice Protects against Seizures

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Sensitive ELISA detection of amyloid‐β protofibrils in biological samples

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A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo

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Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

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Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model Tauopathy

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Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

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First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

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Tau immunotherapy for Alzheimer's disease

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The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

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Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease

Sun, B., Zhou, Y., Halabisky, B., Lo, I., Cho, S.-H., Mueller-Steiner, S., Devidze, N., Wang, X., Grubb, A., & Gan, L. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.001 · Cited by 231 · see citing works

Antimicrobial Properties of Amyloid Peptides

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Association between late-life body mass index and dementia

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Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

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Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau

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Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke

Li, T., Pang, S., Yu, Y., Wu, X., Guo, J., & Zhang, S. (2013) · Brain · doi:10.1093/brain/awt287 · Cited by 199 · see citing works

Non-Steroidal Anti-Inflammatory Drugs as a Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Treatment Effect

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The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush

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Regulation of human MAPT gene expression

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β-Secretase as a Therapeutic Target for Alzheimer’s Disease

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Hyperdynamic Microtubules, Cognitive Deficits, and Pathology Are Improved in Tau Transgenic Mice with Low Doses of the Microtubule-Stabilizing Agent BMS-241027

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Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease

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Immunization against Alzheimer's β-amyloid plaques via EFRH phage administration

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Lack of Tau Proteins Rescues Neuronal Cell Death and Decreases Amyloidogenic Processing of APP in APP/PS1 Mice

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Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade

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Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice

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Molecular cloning of nucleobindin, a novel DNA-binding protein that contains both a signal peptide and a leucine zipper structure

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Twenty years of Alzheimer’s disease‐causing mutations

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