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Cited by 23Cardiac electrophysiology and arrhythmiasNeuroscience and Neural EngineeringTissue Engineering and Regenerative Medicine

A spheroid-based biosensor for the label-free detection of drug-induced field potential alterations

Daus, Andreas W., Layer, Paul G., Thielemann, Christiane·2012·Sensors and Actuators B: Chemical
DOI 10.1016/j.snb.2012.02.011
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Crossref · 10.1016/j.snb.2012.02.011

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55 of 55 references verified0 citation errors · 0 not checkable

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  • Daus et al. discovered that a 3D network of primary cardiac myocytes continued emitting action potentials for multiple weeks, as opposed to the 2D network's cessation after 9-11 divisions.

    “Daus et al. studied action potential emissions from 2D and 3D cellular networks of primary cardiac myocytes and discovered that the 3D network continued emitting action potentials for multiple weeks, as opposed to the 2D network's cessation after 9-11 divisions, thus expanding the ability of cardioactive drug discovery studies to predict long-term in vivo responses. 79”

    From Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors (2014) · cites this paper as [79]

  • The finding that 3D cardiac myocyte networks continued emitting action potentials for multiple weeks expands the ability of cardioactive drug discovery studies to predict long-term in vivo responses.

    “thus expanding the ability of cardioactive drug discovery studies to predict long-term in vivo responses. 79”

    From Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors (2014) · cites this paper as [79]

  • Only 3D cultures exhibit a hierarchical structure and cellular heterogeneity that can closely mimic in vivo cell morphology and function, cell-cell interactions, and diffusion barriers.

    “only 3D cultures exhibit a hierarchical structure and cellular heterogeneity that can closely mimic in vivo cell morphology and function (proliferation, differentiation, gene expression, etc.), 78,79 cell-cell interactions, and diffusion barriers.”

    From Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors (2014) · cites this paper as [79]

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Authors
Daus, A. W., Layer, P. G., & Thielemann, C.
Affiliations
  • Technische Universität Darmstadt (DE)
  • Aschaffenburg University of Applied Sciences (DE)
Corresponding author
Daus, Andreas W.
ORCID
Venue
Sensors and Actuators B: Chemical
Publisher
Elsevier BV
Published
2012-04
Volume
165
Issue
1
Pages
53-58
ISSN
0925-4005 (ISSN-L)
DOI
10.1016/j.snb.2012.02.011
OpenAlex
W2054839826
Cited by
23
References
55
Citations by year
2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
FWCI
1.03
Type
journal article
Language
en
Open access
closed
Licence
Locations
Sensors and Actuators B Chemical (publishedVersion)
Funders
Bundesministerium für Bildung und Forschung (17N2208 PT-AIF)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
cardiac spheroids, label-free biosensor, action potential recording, microelectrode arrays, cardiac electrophysiology, primary cardiomyocytes, cardiac arrhythmias, drug safety assessment

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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