Treatment of vitamin D depletion after Roux-en-Y gastric bypass: a randomized prospective clinical trial
Abstract
Background A high prevalence (60%) of vitamin D (VitD) depletion, defined as a serum 25-hydroxyvitamin D level of < or =20 ng/mL, is present in preoperative morbidly obese patients. Despite daily supplementation with 800 IU VitD and 1500 mg calcium after Roux-en-Y gastric bypass (RYGB), VitD depletion persists in almost one half (44%) of patients. However, the optimal management of VitD depletion after RYGB and the potential benefits of such treatment are currently unknown.Methods A total of 60 VitD-depleted morbidly obese women were randomly assigned to receive 50,000 IU of VitD weekly after RYGB (group 1; n = 30) or no additional VitD after RYGB (group 2; n = 30). All patients received a daily supplement of 800 IU VitD and 1500 mg calcium. The serum calcium, parathyroid hormone, 25-hydroxyvitamin D, bone-specific alkaline phosphatase, urinary N-telopeptide, and bone mineral density were measured preoperatively and 1 year after RYGB. Questionnaires were used to assess other potential sources of VitD, including sunlight exposure and ingestion of VitD-containing foods/liquids.Results At 1 year after RYGB, VitD depletion and mean 25-hydroxyvitamin D level had improved significantly in group 1 (14% and 37.8 ng/mL, respectively) compared with the values in group 2 (85% and 15.2 ng/mL, respectively; P <.001 for both). A significant 33% retardation in hip bone mineral density decline (P = .043) and a significantly greater resolution of hypertension was seen in group 1 (75% versus 32%; P = .029). No significant adverse effects were encountered from pharmacologic VitD therapy.Conclusion The results of our study have shown that 50,000 IU of VitD weekly after RYGB safely corrects VitD depletion in most women, attenuates cortical bone loss, and improves resolution of hypertension.
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In another study, subjects randomized to high dose vitamin D had less hip bone loss than those who received only 800 IU daily.
“In another study, subjects randomized to high dose vitamin D had less hip bone loss than those who received only 800 IU daily98.”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [98]
Parent vitamin D in doses up to 800 IU daily has been shown to be inadequate in restoring vitamin D sufficiency after RYGB.
“Parent vitamin D in doses up to 800 IU daily have been shown to be inadequate in restoring vitamin D sufficiency after RYGB 66, 98, 108.”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [98]
Patients randomized to 50,000 IU weekly of ergocalciferol after RYGB had higher 25OHD levels at one year than those who received 800 IU daily.
“Patients randomized to 50,000 IU weekly of ergocalciferol after RYGB had higher 25OHD levels at one year than those who received 800 IU daily.98”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [98]
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- Authors
- Carlin, A. M., Rao, D. S., Yager, K. M., Parikh, N. J., & Kapke, A.
- Affiliations
- Henry Ford Health (US)
- Henry Ford Hospital (US)
- ORCID
- Carlin, Arthur M.
- Venue
- Surgery for Obesity and Related Diseases
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 5
- Issue
- 4
- Pages
- 444-449
- ISSN
- 1550-7289 (ISSN-L)
- OpenAlex
- W2124633433
- Cited by
- 128
- References
- 28
- Citations by year
- 2025: 1 · 2024: 9 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 10 · 2019: 3 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 10 · 2014: 13 · 2013: 13 · 2012: 11
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Surgery for Obesity and Related Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- vitamin D deficiency, Roux-en-Y gastric bypass
- MeSH terms
- Adult, Female, Humans, Middle Aged, Obesity, Morbid, Parathyroid Hormone, Risk Factors, Vitamin D, Vitamin D Deficiency, Vitamins, Gastric Bypass, Weight Loss, Bone Density, Treatment Outcome, Dietary Supplements
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