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Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss
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Cites
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473
Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L., & Fuchs, E. (2004) · Cell · doi:10.1016/j.cell.2004.08.012 · Cited by 1,428
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106
p16INK4a induces an age-dependent decline in islet regenerative potential
Krishnamurthy, J., Ramsey, M. R., Ligon, K. L., Torrice, C., Koh, A., Bonner-Weir, S., & Sharpless, N. E. (2006) · Nature · doi:10.1038/nature05092 · Cited by 1,003
ATR and ATRIP: Partners in Checkpoint Signaling
Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science · doi:10.1126/science.1065521 · Cited by 985
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature05091 · Cited by 972
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
Brown, E. J., & Baltimore, D. (2000) · Genes & Development · doi:10.1101/gad.14.4.397 · Cited by 951
Self-citationDNA Repair, Genome Stability, and Aging
Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M., & Alt, F. W. (2005) · Cell · doi:10.1016/j.cell.2005.01.028 · Cited by 944
O'Driscoll, M., Ruiz-Perez, V. L., Woods, C. G., Jeggo, P. A., & Goodship, J. A. (2003) · Nature Genetics · doi:10.1038/ng1129 · Cited by 794
Stem cells, ageing and the quest for immortality
Rando, T. A. (2006) · Nature · doi:10.1038/nature04958 · Cited by 695
Research works printed but not linked: 25
- Alonso, 2006, The hair cycle, J. Cell Sci., 119, 391, 10.1242/jcs.02793 · DOI
- Arnold, 1999, Seckel-like syndrome in three siblings, Pediatr. Dev. Pathol., 2, 180, 10.1007/s100249900107 · DOI
- Boscherini, 1981, Intrauterine growth retardation. A report of two cases with bird-headed appearance, skeletal changes and peripheral GH resistance, Eur. J. Pediatr., 137, 237, 10.1007/BF00441325 · DOI
- Butler, 1987, Do some patients with Seckel syndrome have hematological problems and/or chromosome breakage?, Am. J. Med. Genet., 27, 645, 10.1002/ajmg.1320270318 · DOI
- Casper, 2002, ATR regulates fragile site stability, Cell, 111, 779, 10.1016/S0092-8674(02)01113-3 · DOI · Paper page
- Chao, 2006, Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression, EMBO J., 25, 2615
- de Boer, 2002, Premature aging in mice deficient in DNA repair and transcription, Science, 296, 1276, 10.1126/science.1070174 · DOI · Paper page
- de Klein, 2000, Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice, Curr. Biol., 10, 479, 10.1016/S0960-9822(00)00447-4 · DOI · Paper page
- Fathizadeh, 1979, Pigmentary changes in Seckel's syndrome, J. Am. Acad. Dermatol., 1, 52, 10.1016/S0190-9622(79)70004-1 · DOI
- Feil, 1997, Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains, Biochem. Biophys. Res. Commun., 237, 752, 10.1006/bbrc.1997.7124 · DOI · Paper page
- Ito, 2004, Hair follicle stem cells in the lower bulge form the secondary germ, a biochemically distinct but functionally equivalent progenitor cell population, at the termination of catagen, Differentiation, 72, 548, 10.1111/j.1432-0436.2004.07209008.x · DOI
- Kipling, 2004, What can progeroid syndromes tell us about human aging?, Science, 305, 1426, 10.1126/science.1102587 · DOI
- Kujoth, 2005, Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging, Science, 309, 481, 10.1126/science.1112125 · DOI · Paper page
- Lois, 2002, Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors, Science, 295, 868, 10.1126/science.1067081 · DOI
- Lopes, 2001, The DNA replication checkpoint response stabilizes stalled replication forks, Nature, 412, 557, 10.1038/35087613 · DOI
- Morris, 2004, Capturing and profiling adult hair follicle stem cells, Nat. Biotechnol., 22, 411, 10.1038/nbt950 · DOI · Paper page
- Nabarra, 1996, Ultrastructural study of thymic microenvironment involution in aging mice, Exp. Gerontol., 31, 489, 10.1016/0531-5565(95)02038-1 · DOI
- O'Driscoll, 2003, Clinical impact of ATR checkpoint signalling failure in humans, Cell Cycle, 2, 194
- O'Driscoll, 2006, The role of double-strand break repair—insights from human genetics, Nat. Rev. Genet., 7, 45, 10.1038/nrg1746 · DOI · Paper page
- Osborn, 2002, Checking on the fork: the DNA-replication stress-response pathway, Trends Cell Biol., 12, 509, 10.1016/S0962-8924(02)02380-2 · DOI · Paper page
- Pelicci, 2004, Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?, J. Clin. Invest., 113, 4, 10.1172/JCI200420750 · DOI
- Sharpless, 2004, Telomeres, stem cells, senescence, and cancer, J. Clin. Invest., 113, 160, 10.1172/JCI20761 · DOI · Paper page
- Van Zant, 2003, The role of stem cells in aging, Exp. Hematol., 31, 659, 10.1016/S0301-472X(03)00088-2 · DOI
- Wilson, 2006, Bone-marrow haematopoietic-stem-cell niches, Nat. Rev. Immunol., 6, 93, 10.1038/nri1779 · DOI · Paper page
- Zediak, 2005, Aging and T cell development: interplay between progenitors and their environment, Semin. Immunol., 17, 337, 10.1016/j.smim.2005.05.004 · DOI
Cited by
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Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
Tauriello, D. V. F., Palomo-Ponce, S., Stork, D., Berenguer-Llergo, A., Badia-Ramentol, J., Iglesias, M., Sevillano, M., Ibiza, S., Cañellas, A., Hernando-Momblona, X., et al. (2018) · Nature · doi:10.1038/nature25492 · Cited by 1,851
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Shiloh, Y., & Ziv, Y. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3546 · Cited by 1,649
Price, N. L., Gomes, A. P., Ling, A. J. Y., Duarte, F. V., Martin-Montalvo, A., North, B. J., Agarwal, B., Ye, L., Ramadori, G., Teodoro, J. S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.003 · Cited by 1,602
Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G., & Morrison, S. J. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.06.008 · Cited by 1,381
“Mice All mice were maintained in a C57BL/6 background, including Lepr-cre (DeFalco et al., 2001), Leprfl/fl (Cohen et al., 2001), Ptenfl/fl (Groszer et al., 2001), Scf-GFP (Ding et al., 2012), Cxcl12-DsRed (Ding and Morrison, 2013), Ubc-creER (Ruzankina et al., 2007), Rosa26-CAG-loxp-stop-loxp-tdTomato (Madisen et al.…”
Influential
Metadata
- Authors
- Ruzankina, Y., Pinzon-Guzman, C., Asare, A., Ong, T., Pontano, L., Cotsarelis, G., Zediak, V. P., Velez, M., Bhandoola, A., & Brown, E. J.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 1
- Issue
- 1
- Pages
- 113-126
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2075234503
- Cited by
- 795
- References
- 16
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2238 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
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- CoChat. (2026). Citation check: Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss. https://app.cochat.ai/papers/10.1016/j.stem.2007.03.002
- The paper
- Ruzankina, Y., Pinzon-Guzman, C., Asare, A., Ong, T., Pontano, L., Cotsarelis, G., Zediak, V. P., Velez, M., Bhandoola, A., & Brown, E. J. (2007). Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss. Cell Stem Cell. https://doi.org/10.1016/j.stem.2007.03.002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.