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Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds
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OCT4 overexpression alone is sufficient to induce pluripotency when other canonical reprogramming factors are endogenously expressed or are in the presence of other chromatin remodeling chemical factors.
“as OCT4 overexpression alone is sufficient to induce pluripotency when other canonical reprogramming factors are endogenously expressed or are in the presence of other chromatin remodeling chemical factors 32,34,35 .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [35]
The paper’s introduction reports OCT4-only reprogramming of neural stem cells that endogenously express SOX2 and cMYC, and its results show reprogramming of primary human cells using OCT4 as the sole introduced factor plus a chemical cocktail (page unavailable in our copy). But the cocktail is not simply chromatin-remodeling chemicals: it includes a histone deacetylase inhibitor alongside compounds targeting signaling and metabolism. (LLM, conf=0.86)
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Cites
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“Keratinocytes also endogenously express KLF4 and cMYC, and can be reprogrammed efficiently using the conventional four TFs or three TFs (without cMYC) (Aasen et al., 2008; Maherali et al., 2008).”
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Research works printed but not linked: 21
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Yu, C., Liu, Y., Ma, T., Liu, K., Xu, S., Zhang, Y., Liu, H., La Russa, M., Xie, M., Ding, S., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.01.003 · Cited by 455
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Yang, B., Zhang, F., Cheng, F., Ying, L., Wang, C., Shi, K., Wang, J., Xia, K., Gong, Z., Huang, X., et al. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2620-z · Cited by 128
Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming
Cipriano, A., Moqri, M., Maybury-Lewis, S. Y., Rogers-Hammond, R., de Jong, T. A., Parker, A., Rasouli, S., Schöler, H. R., Sinclair, D. A., & Sebastiano, V. (2023) · Nature Aging · doi:10.1038/s43587-023-00539-2 · Cited by 66
Chemical compound-based direct reprogramming for future clinical applications.
Takeda, Y., Harada, Y., Yoshikawa, T., & Dai, P. (2018) · Bioscience Reports · doi:10.1042/bsr20171650 · Cited by 57
Zhang, Z., Xiang, D., & Wu, W.-S. (2014) · Cellular Reprogramming · doi:10.1089/cell.2013.0070 · Cited by 20
Querfurth, H., Marshall, J., Parang, K., Rioult-Pedotti, M. S., Tiwari, R., Kwon, B., Reisinger, S., & Lee, H.-K. (2022) · PLOS ONE · doi:10.1371/journal.pone.0261696 · Cited by 9
Metadata
- Authors
- Zhu, S., Li, W., Zhou, H., Wei, W., Ambasudhan, R., Lin, T., Kim, J., Zhang, K., & Ding, S.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 7
- Issue
- 6
- Pages
- 651-655
- ISSN
- 1934-5909
- PMC
- PMC3812930
- Cited by
- 597
- References
- 4
- Language
- en
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