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Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds

Zhu, Saiyong, Li, Wenlin, Zhou, Hongyan, Wei, Wanguo, Ambasudhan, Rajesh, Lin, Tongxiang, Kim, Janghwan, Zhang, Kang, Ding, Sheng·2010·Cell Stem Cell

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Crossref · 10.1016/j.stem.2010.11.015

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  • OCT4 overexpression alone is sufficient to induce pluripotency when other canonical reprogramming factors are endogenously expressed or are in the presence of other chromatin remodeling chemical factors.

    “as OCT4 overexpression alone is sufficient to induce pluripotency when other canonical reprogramming factors are endogenously expressed or are in the presence of other chromatin remodeling chemical factors 32,34,35 .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [35]

    The paper’s introduction reports OCT4-only reprogramming of neural stem cells that endogenously express SOX2 and cMYC, and its results show reprogramming of primary human cells using OCT4 as the sole introduced factor plus a chemical cocktail (page unavailable in our copy). But the cocktail is not simply chromatin-remodeling chemicals: it includes a histone deacetylase inhibitor alongside compounds targeting signaling and metabolism. (LLM, conf=0.86)

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Research works printed but not linked: 21

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  11. Li, 2009, Stem Cells, 27, 2992, 10.1002/stem.240 · DOI
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  21. Yoshida, 2009, Cell Stem Cell, 5, 237, 10.1016/j.stem.2009.08.001 · DOI

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Metadata

Authors
Zhu, S., Li, W., Zhou, H., Wei, W., Ambasudhan, R., Lin, T., Kim, J., Zhang, K., & Ding, S.
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2010-12
Volume
7
Issue
6
Pages
651-655
ISSN
1934-5909
Cited by
597
References
4
Language
en

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