The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
TET Family Proteins and Their Role in Stem Cell Differentiation and Transformation
Open accessAbstract
One of the main regulators of gene expression during embryonegesis and stem cell differentiation is DNA methylation. The recent identification of hydroxymethylcytosine (5hmC) as a novel epigenetic mark sparked an intense effort to characterize its specialized enzymatic machinery and to understand the biological significance of 5hmC. The recent discovery of recurrent deletions and somatic mutations in the TET gene family, which includes proteins that can hydroxylate methylcytosine (5mC), in a large fraction of myeloid malignancies further suggested a key role for dynamic DNA methylation changes in the regulation of stem cell differentiation and transformation.
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Cites
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Cited by
Cancer epigenetics: from mechanism to therapy
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TET enzymes, TDG and the dynamics of DNA demethylation
Kohli, R. M., & Zhang, Y. (2013) · Nature · doi:10.1038/nature12750 · Cited by 1,623
Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions
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“Growing evidence suggests that impairment in TET-mediated DNA demethylation may contribute to tumorigenesis (Cimmino et al., 2011; Wu and Zhang, 2011a).”
Metabolic requirements for the maintenance of self-renewing stem cells
Ito, K., & Suda, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3772 · Cited by 1,014
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription
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“TET proteins are named after the ten-eleven translocation (t(10;11)(q22;q23)) that is found in rare cases of acute myeloid and lymphocytic leukaemia.”
Metadata
- Authors
- Cimmino, L., Abdel-Wahab, O., Levine, R. L., & Aifantis, I.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 9
- Issue
- 3
- Pages
- 193-204
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2095293920
- Cited by
- 234
- References
- 19
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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