Cited by 54Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchDevelopmental Biology and Gene Regulation

Tissue Stem Cells: New Tools and Functional Diversity

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Grompe, Markus·2012·Cell Stem Cell

Abstract

The detailed understanding of adult tissue stem cells has significance for both regenerative medicine and oncology. This perspective will discuss how major advances in our ability to identify and monitor these cells, which include genetic lineage tracing, FACS purification, and robust in vitro clonogenic assays, have changed our view of their roles in many organs. Label retention and quiescence are no longer considered obligatory stem cell features. Furthermore, some tissues have more than one type of stem cell, each used in only particular situations of regenerative stress. Thus, there is no "one size fits all" adult tissue stem cell paradigm.

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Crossref · 10.1016/j.stem.2012.04.006

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  • Reserve quiescent and active proliferating stem cell pools coexist in high-turnover tissues.

    “Recently, evidence has suggested the coexistence of reserve (quiescent) and active (proliferating) stem cell pools in high-turnover tissue compartments2,27.”

    From Molecular regulation of stem cell quiescence (2013) · cites this paper as [27]

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Authors
Grompe, M.
Affiliations
Oregon Health & Science University (US)
Corresponding author
Grompe, Markus
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2012-06
Volume
10
Issue
6
Pages
685-689
ISSN
  • 1875-9777 (ISSN-L)
  • 1934-5909
OpenAlex
W2035151165
Cited by
54
References
56
Citations by year
2024: 1 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 6 · 2018: 8 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 6 · 2013: 6 · 2012: 4
FWCI
1.11
Type
journal article
Language
en
Open access
Locations
  • Cell stem cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (DK 51592, R01DK051592)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
stem cell identification, lineage tracing, clonogenic assay, label retention, stem cell quiescence, regenerative medicine, tissue regeneration
MeSH terms
Adult, Humans, Regeneration, Adult Stem Cells, Cell- and Tissue-Based Therapy

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