Tissue Stem Cells: New Tools and Functional Diversity
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The detailed understanding of adult tissue stem cells has significance for both regenerative medicine and oncology. This perspective will discuss how major advances in our ability to identify and monitor these cells, which include genetic lineage tracing, FACS purification, and robust in vitro clonogenic assays, have changed our view of their roles in many organs. Label retention and quiescence are no longer considered obligatory stem cell features. Furthermore, some tissues have more than one type of stem cell, each used in only particular situations of regenerative stress. Thus, there is no "one size fits all" adult tissue stem cell paradigm.
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Reserve quiescent and active proliferating stem cell pools coexist in high-turnover tissues.
“Recently, evidence has suggested the coexistence of reserve (quiescent) and active (proliferating) stem cell pools in high-turnover tissue compartments2,27.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [27]
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Liu, X., Liu, H., Sun, L., Chen, Z., Nie, H., Sun, A., Liu, G., & Guan, G. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0324-1 · Cited by 7 · see citing works
Transplantation and Culture of Spermatogonial Stem Cells
Kubota, H., & Brinster, R. L. (2017) · Springer eBooks · doi:10.1007/978-1-4939-7505-1_11 · Cited by 7 · see citing works
Stem Cell Differentiation and Therapeutic Use
Alexander, M. S., Casar, J. C., & Motohashi, N. (2015) · Stem Cells International · doi:10.1155/2015/308128 · Cited by 5 · see citing works
Methods to identify epithelial stem cells
Jeong, Y. (2022) · Organoid · doi:10.51335/organoid.2022.2.e24 · Cited by 5 · see citing works
Suppressing Pitx2 inhibits proliferation and promotes differentiation of iHepSCs
Chen, F., Yao, H., Wang, M., Yu, B., Liu, Q., Li, J., He, Z., & Hu, Y. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.09.024 · Cited by 5 · see citing works
Stem and Progenitor Cells of the Trachea and Proximal Airways
Hegab, A. E., Betsuyaku, T., & Gomperts, B. N. (2015) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-21082-7_6 · Cited by 4 · see citing works
Cutting-edge therapies in the treatment of surgical wounds
Zepeda, J. M., Contreras-Cárdenas, J., Gutiérrez, F. O., Jimenez, M., & Murrieta, A. (2021) · International Surgery Journal · doi:10.18203/2349-2902.isj20214821 · Cited by 2 · see citing works
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Cardiovascular Stem Cell Niche
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Chromosome Instability in Stem Cells
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Stem Cell Transplantation in Diabetes Mellitus Type I and Type II
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The many fates of tissue regeneration
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Göktuna, S. İ., Chau, T. L., & Xhafa, E. (2019) · Trakya University Journal of Natural Sciences · doi:10.23902/trkjnat.483577
Regulation for regenerative medicine-based therapies
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Cytogenetic studies of mesenchymal stem cells in rabbit: a mini-review.
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СОМАТИКАЛЫҚ БАҒАНАЛЫ ЖАСУШАЛАРДЫҢ ҚАРТАЮ
Umbayev, B. A., & Сафарова, Ю. И. (2022) · Vestnik · doi:10.53065/kaznmu.2022.16.11.012
- Authors
- Grompe, M.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Grompe, Markus
- ORCID
- Grompe, Markus
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 10
- Issue
- 6
- Pages
- 685-689
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC3940056
- OpenAlex
- W2035151165
- Cited by
- 54
- References
- 56
- Citations by year
- 2024: 1 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 6 · 2018: 8 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 6 · 2013: 6 · 2012: 4
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 51592, R01DK051592)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- stem cell identification, lineage tracing, clonogenic assay, label retention, stem cell quiescence, regenerative medicine, tissue regeneration
- MeSH terms
- Adult, Humans, Regeneration, Adult Stem Cells, Cell- and Tissue-Based Therapy
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