The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor
Open accessAbstract
Mesenchymal stem cells (MSCs) are typically defined by their in vitro characteristics, and as a consequence the in vivo identity of MSCs and their niches are poorly understood. To address this issue, we used lineage tracing in a mouse incisor model and identified the neurovascular bundle (NVB) as an MSC niche. We found that NVB sensory nerves secrete Shh protein, which activates Gli1 expression in periarterial cells that contribute to all mesenchymal derivatives. These periarterial cells do not express classical MSC markers used to define MSCs in vitro. In contrast, NG2+ pericytes represent an MSC subpopulation derived from Gli1+ cells; they express classical MSC markers and contribute little to homeostasis but are actively involved in injury repair. Likewise, incisor Gli1+ cells but not NG2+ cells exhibit typical MSC characteristics in vitro. Collectively, we demonstrate that MSCs originate from periarterial cells and are regulated by Shh secretion from a NVB.
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Cites
Multilineage potential of adult human mesenchymal stem cells
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“In addition, stem cells in other organs usually comprise a very small percentage of the entire population, but the MSC definition has included the majority of the cell population on the culture dish based on their high expression of classical MSC markers including CD73, CD105, Sca1 and others (Bianco et al., 2013; Cov…”
BackgroundDefining the Epithelial Stem Cell Niche in Skin
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Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
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“cells have been characterized, suggesting that they may represent the same population, at least in some tissues (Covas et al., 2008; Schwab and Gargett, 2007).”
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The Tunica Adventitia of Human Arteries and Veins As a Source of Mesenchymal Stem Cells
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Tissue Stem Cells: New Tools and Functional Diversity
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Cited by
Mesenchymal stem cell perspective: cell biology to clinical progress
Pittenger, M. F., Discher, D. E., Péault, B. M., Phinney, D. G., Hare, J. M., & Caplan, A. I. (2019) · npj Regenerative Medicine · doi:10.1038/s41536-019-0083-6 · Cited by 2,008
Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications
Wang, Y., Chen, X., Cao, W., & Shi, Y. (2014) · Nature Immunology · doi:10.1038/ni.3002 · Cited by 1,452
Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis
Kramann, R., Schneider, R. K., DiRocco, D. P., Machado, F., Fleig, S., Bondzie, P. A., Henderson, J. M., Ebert, B. L., & Humphreys, B. D. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2014.11.004 · Cited by 922
Tissue clearing of both hard and soft tissue organs with the PEGASOS method
Jing, D., Zhang, S., Luo, W., Gao, X., Men, Y., Ma, C., Liu, X., Yi, Y., Bugde, A., Zhou, B. O., et al. (2018) · Cell Research · doi:10.1038/s41422-018-0049-z · Cited by 394
Self-citationKramann, R., Goettsch, C., Wongboonsin, J., Iwata, H., Schneider, R. K., Kuppe, C., Kaesler, N., Chang-Panesso, M., Machado, F. G., Gratwohl, S., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.08.001 · Cited by 308
Metadata
- Authors
- Zhao, H., Feng, J., Seidel, K., Shi, S., Klein, O., Sharpe, P., & Chai, Y.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 14
- Issue
- 2
- Pages
- 160-173
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2147822820
- Cited by
- 461
- References
- 9
- FWCI
- 18.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhao, H., Feng, J., Seidel, K., Shi, S., Klein, O., Sharpe, P., & Chai, Y. (2014). Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor. Cell Stem Cell. https://doi.org/10.1016/j.stem.2013.12.013
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