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Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness
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“Accordingly, proliferative signatures, which correspond to decreased self-renewal capacity, are downregulated in Tet2-KO HSCs relative to WT when treated with IL1β (Fig. 3e, Supplementary Fig. 8e)22,29.”
From Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells (2023) · cites this paper as [29]
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Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity
Mitroulis, I., Ruppova, K., Wang, B., Chen, L.-S., Grzybek, M., Grinenko, T., Eugster, A., Troullinaki, M., Palladini, A., Kourtzelis, I., et al. (2018) · Cell · doi:10.1016/j.cell.2017.11.034 · Cited by 1,100
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“2A), supporting a direct signaling mechanism via the MyD88 axis downstream of IL-1R (Fig.”
BackgroundInfluentialHernandez, G., Mills, T. S., Rabe, J. L., Chavez, J. S., Kuldanek, S., Kirkpatrick, G., Noetzli, L., Jubair, W. K., Zanche, M., Myers, J. R., et al. (2020) · Haematologica · doi:10.3324/haematol.2018.197210 · Cited by 58
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Metadata
- Authors
- Takizawa, H., Fritsch, K., Kovtonyuk, L. V., Saito, Y., Yakkala, C., Jacobs, K., Ahuja, A. K., Lopes, M., Hausmann, A., Hardt, W.-D., Gomariz, Á., Nombela-Arrieta, C., & Manz, M. G.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 21
- Issue
- 2
- Pages
- 225-240.e5
- ISSN
- 1934-5909
- Cited by
- 273
- References
- 17
- Language
- en
- Update notices
- erratum (2020-07-02)
- Licence
- Funders
- Research Institute for Microbial Diseases, Osaka University
- Osaka University (Myd88−/−)
- Universität Zürich
- SENSHIN Medical Research Foundation
- Kanae Foundation for the Promotion of Medical Science
- Universitätsspital Zürich
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (310030B_166673/1, 31003A_159597/1)
- Institute for Research in Biomedicine
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