Synergistic Engineering: Organoids Meet Organs-on-a-Chip

Reconstituting organ-level lung functions on a chip

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Organogenesis in a dish: Modeling development and disease using organoid technologies

Lancaster, M. A., & Knoblich, J. A. (2014) · Science · doi:10.1126/science.1247125 · Cited by 2,931 · see citing works

Vascularized and functional human liver from an iPSC-derived organ bud transplant

Takebe, T., Sekine, K., Enomura, M., Koike, H., Kimura, M., Ogaeri, T., Zhang, R.-R., Ueno, Y., Zheng, Y.-W., Koike, N., et al. (2013) · Nature · doi:10.1038/nature12271 · Cited by 2,170 · see citing works

Cell diversity and network dynamics in photosensitive human brain organoids

Quadrato, G., Nguyen, T., Macosko, E. Z., Sherwood, J. L., Min Yang, S., Berger, D. R., Maria, N., Scholvin, J., Goldman, M., Kinney, J. P., et al. (2017) · Nature · doi:10.1038/nature22047 · Cited by 1,321 · see citing works

Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes

Nunes, S. S., Miklas, J. W., Liu, J., Aschar-Sobbi, R., Xiao, Y., Zhang, B., Jiang, J., Massé, S., Gagliardi, M., Hsieh, A., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2524 · Cited by 952 · see citing works

Guided self-organization and cortical plate formation in human brain organoids

Lancaster, M. A., Corsini, N. S., Wolfinger, S., Gustafson, E. H., Phillips, A. W., Burkard, T. R., Otani, T., Livesey, F. J., & Knoblich, J. A. (2017) · Nature Biotechnology · doi:10.1038/nbt.3906 · Cited by 783 · see citing works

Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis

Zhang, B., Montgomery, M., Chamberlain, M. D., Ogawa, S., Korolj, A., Pahnke, A., Wells, L. A., Massé, S., Kim, J., Reis, L., et al. (2016) · Nature Materials · doi:10.1038/nmat4570 · Cited by 593 · see citing works

Cytosystems dynamics in self-organization of tissue architecture

Sasai, Y. (2013) · Nature · doi:10.1038/nature11859 · Cited by 475 · see citing works

Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation

Takebe, T., Enomura, M., Yoshizawa, E., Kimura, M., Koike, H., Ueno, Y., Matsuzaki, T., Yamazaki, T., Toyohara, T., Osafune, K., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.03.004 · Cited by 457 · see citing works

Design and demonstration of a pumpless 14 compartment microphysiological system

Miller, P. G., & Shuler, M. L. (2016) · Biotechnology and Bioengineering · doi:10.1002/bit.25989 · Cited by 235 · see citing works

Engineering organoids

Hofer, M., & Lutolf, M. P. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00279-y · Cited by 1,184 · see citing works

Organs-on-chips: into the next decade

Low, L. A., Mummery, C., Berridge, B. R., Austin, C. P., & Tagle, D. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0079-3 · Cited by 1,029 · see citing works

Advances in organ-on-a-chip engineering

Zhang, B., Korolj, A., Lai, B. F. L., & Radisic, M. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0034-7 · Cited by 1,017 · see citing works

Organoids

Zhao, Z., Chen, X., Dowbaj, A. M., Sljukic, A., Bratlie, K., Lin, L., Fong, E. L. S., Balachander, G. M., Chen, Z., Soragni, A., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00174-y · Cited by 1,001 · see citing works

Organoids-on-a-chip

Park, S. E., Georgescu, A., & Huh, D. (2019) · Science · doi:10.1126/science.aaw7894 · Cited by 847 · see citing works

Organ-on-a-Chip: A New Paradigm for Drug Development

Ma, C., Peng, Y., Li, H., & Chen, W. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.11.009 · Cited by 589 · see citing works

Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids

Schuster, B., Junkin, M., Kashaf, S. S., Romero-Calvo, I., Kirby, K., Matthews, J., Weber, C. R., Rzhetsky, A., White, K. P., & Tay, S. (2020) · Nature Communications · doi:10.1038/s41467-020-19058-4 · Cited by 424 · see citing works

High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell–Derived Organoids

Shinozawa, T., Kimura, M., Cai, Y., Saiki, N., Yoneyama, Y., Ouchi, R., Koike, H., Maezawa, M., Zhang, R.-R., Dunn, A., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.10.002 · Cited by 378 · see citing works

The biological applications of DNA nanomaterials: current challenges and future directions

Ma, W., Zhan, Y., Zhang, Y., Mao, C., Xie, X., & Lin, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00727-9 · Cited by 336 · see citing works

Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond

Liu, C., Oikonomopoulos, A., Sayed, N., & Wu, J. C. (2018) · Development · doi:10.1242/dev.156166 · Cited by 271 · see citing works

Organs-on-a-chip models for biological research

Vunjak-Novakovic, G., Ronaldson-Bouchard, K., & Radisic, M. (2021) · Cell · doi:10.1016/j.cell.2021.08.005 · Cited by 248 · see citing works

<i>In situ</i> differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system

Wang, Y., Wang, H., Deng, P., Chen, W., Guo, Y., Tao, T., & Qin, J. (2018) · Lab on a Chip · doi:10.1039/c8lc00869h · Cited by 222 · see citing works

Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform

Rajan, S. A. P., Aleman, J., Wan, M., Zarandi, N. P., Nzou, G., Murphy, S. V., Bishop, C. E., Sadri‐Ardekani, H., Shupe, T., Atala, A., et al. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.02.015 · Cited by 205 · see citing works

Emerging organoid models: leaping forward in cancer research

Fan, H., Demirci, U., & Chen, P. (2019) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-019-0832-4 · Cited by 199 · see citing works

Engineering human islet organoids from iPSCs using an organ-on-chip platform

Tao, T., Wang, Y., Chen, W., Li, Z., Su, W., Guo, Y., Deng, P., & Qin, J. (2019) · Lab on a Chip · doi:10.1039/c8lc01298a · Cited by 198 · see citing works

Microengineered Multi‐Organoid System from hiPSCs to Recapitulate Human Liver‐Islet Axis in Normal and Type 2 Diabetes

Tao, T., Deng, P., Wang, Y., Zhang, X., Guo, Y., Chen, W., & Qin, J. (2022) · Advanced Science · doi:10.1002/advs.202103495 · Cited by 178 · see citing works

Patient-Derived Organoids in Precision Medicine: Drug Screening, Organoid-on-a-Chip and Living Organoid Biobank

Zhou, Z., Cong, L., & Cong, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.762184 · Cited by 181 · see citing works

Ageing, metabolism and the intestine

Funk, M. C., Zhou, J., & Boutros, M. (2020) · EMBO Reports · doi:10.15252/embr.202050047 · Cited by 166 · see citing works

IFlowPlate—A Customized 384‐Well Plate for the Culture of Perfusable Vascularized Colon Organoids

Rajasekar, S., Lin, D. S. Y., Abdul, L., Liu, A. W. K., Sotra, A., Zhang, F., & Zhang, B. (2020) · Advanced Materials · doi:10.1002/adma.202002974 · Cited by 167 · see citing works

Recapitulating Pancreatic Tumor Microenvironment through Synergistic Use of Patient Organoids and Organ‐on‐a‐Chip Vasculature

Lai, B. F. L., Lu, R. X. Z., Hu, Y., Davenport Huyer, L., Dou, W., Wang, E. Y., Radulovich, N., Tsao, M. S., Sun, Y., & Radisic, M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202000545 · Cited by 142 · see citing works

In vitro and ex vivo systems at the forefront of infection modeling and drug discovery

Shi, D., Mi, G., Wang, M., & Webster, T. J. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.10.030 · Cited by 141 · see citing works

Cell spheroids as a versatile research platform: formation mechanisms, high throughput production, characterization and applications

Decarli, M. C., do Amaral, R. L. F., dos Santos, D. P., Tofani, L. B., Katayama, E. T., Rezende, R. A., da Silva, J. V. L., Swiech, K., Suazo, C. A. T., Mota, C., et al. (2021) · Biofabrication · doi:10.1088/1758-5090/abe6f2 · Cited by 132 · see citing works

Emulating Human Tissues and Organs: A Bioprinting Perspective Toward Personalized Medicine

Fonseca, A. C., Melchels, F. P. W., Ferreira, M. J. S., Moxon, S. R., Potjewyd, G., Dargaville, T. R., Kimber, S. J., & Domingos, M. A. N. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00342 · Cited by 129 · see citing works

Applications of tumor chip technology

Hachey, S. J., & Hughes, C. C. W. (2018) · Lab on a Chip · doi:10.1039/c8lc00330k · Cited by 128 · see citing works

Use of three-dimensional organoids and lung-on-a-chip methods to study lung development, regeneration and disease

Gkatzis, K., Taghizadeh, S., Huh, D., Stainier, D. Y. R., & Bellusci, S. (2018) · European Respiratory Journal · doi:10.1183/13993003.00876-2018 · Cited by 127 · see citing works

An <i>in vitro</i> vascularized micro-tumor model of human colorectal cancer recapitulates <i>in vivo</i> responses to standard-of-care therapy

Hachey, S. J., Movsesyan, S., Nguyen, Q. H., Burton-Sojo, G., Tankazyan, A., Wu, J., Hoang, T., Zhao, D., Wang, S., Hatch, M. M., et al. (2021) · Lab on a Chip · doi:10.1039/d0lc01216e · Cited by 124 · see citing works

Advances in Spheroids and Organoids on a Chip

Fang, G., Chen, Y., Lu, H., & Jin, D. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202215043 · Cited by 127 · see citing works

Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors

Wan, L., Neumann, C. A., & LeDuc, P. R. (2020) · Lab on a Chip · doi:10.1039/c9lc00550a · Cited by 120 · see citing works

Individual Control and Quantification of 3D Spheroids in a High-Density Microfluidic Droplet Array

Tomasi, R. F.-X., Sart, S., Champetier, T., & Baroud, C. N. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107670 · Cited by 117 · see citing works

Controlled magnesium ion delivery system for in situ bone tissue engineering

Yuan, Z., Wan, Z., Gao, C., Wang, Y., Huang, J., & Cai, Q. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.08.036 · Cited by 118 · see citing works

Human biomimetic liver microphysiology systems in drug development and precision medicine

Gough, A., Soto-Gutierrez, A., Vernetti, L., Ebrahimkhani, M. R., Stern, A. M., & Taylor, D. L. (2021) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-020-00386-1 · Cited by 117 · see citing works

In Vitro Strategies to Vascularize 3D Physiologically Relevant Models

Dellaquila, A., Le Bao, C., Letourneur, D., & Simon‐Yarza, T. (2021) · Advanced Science · doi:10.1002/advs.202100798 · Cited by 115 · see citing works

Cancer Modeling‐on‐a‐Chip with Future Artificial Intelligence Integration

Fetah, K., DiPardo, B. J., Kongadzem, E.-M. L., Tomlinson, J. S., Elzagheid, A. I., Elmusrati, M. S., Khademhosseini, A., & Ashammakhi, N. A. (2019) · Small · doi:10.1002/smll.201901985 · Cited by 115 · see citing works

Modeling human nonalcoholic fatty liver disease (NAFLD) with an organoids-on-a-chip system

Wang, Y., Wang, H., Deng, P., Tao, T., Liu, H., Wu, S., Chen, W., & Qin, J. (2020) · ACS Biomaterials Science &amp; Engineering · doi:10.1021/acsbiomaterials.0c00682 · Cited by 109 · see citing works

Innervation: the missing link for biofabricated tissues and organs

Das, S., Gordián‐Vélez, W. J., Ledebur, H. C., Mourkioti, F., Rompolas, P., Chen, H.-C. I., Serruya, M. D., & Cullen, D. K. (2020) · npj Regenerative Medicine · doi:10.1038/s41536-020-0096-1 · Cited by 107 · see citing works

Composite Hydrogels in Three-Dimensional in vitro Models

Zhao, Z., Vizetto‐Duarte, C., Moay, Z. K., Setyawati, M. I., Rakshit, M., Kathawala, M. H., & Ng, K. W. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00611 · Cited by 109 · see citing works

Electrophysiological Analysis of Brain Organoids: Current Approaches and Advancements

Passaro, A. P., & Stice, S. L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.622137 · Cited by 111 · see citing works

Intestinal organoids: A new paradigm for engineering intestinal epithelium in vitro

Rahmani, S., Breyner, N. M., Su, H.-M., Verdu, E. F., & Didar, T. F. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.12.006 · Cited by 98 · see citing works

Towards chamber specific heart-on-a-chip for drug testing applications

Zhao, Y., Rafatian, N., Wang, E. Y., Wu, Q., Lai, B., Lu, R. X. Z., Savoji, H., & Radisic, M. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.12.002 · Cited by 97 · see citing works

Designing natural and synthetic immune tissues

Gosselin, E. A., Eppler, H. B., Bromberg, J. S., & Jewell, C. M. (2018) · Nature Materials · doi:10.1038/s41563-018-0077-6 · Cited by 99 · see citing works

Airway and alveolar epithelial cells in culture

Hiemstra, P. S., Tetley, T. D., & Janes, S. M. (2019) · European Respiratory Journal · doi:10.1183/13993003.00742-2019 · Cited by 94 · see citing works

Organ-on-a-chip technology for the study of the female reproductive system

Young, R. E., & Huh, D. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.010 · Cited by 95 · see citing works

Organ-on-a-chip technology for nanoparticle research

Kang, S., Park, S. E., & Huh, D. (2021) · Nano Convergence · doi:10.1186/s40580-021-00270-x · Cited by 106 · see citing works

Organs-on-a-chip: a union of tissue engineering and microfabrication

Zhao, Y., Wang, E. Y., Lai, F. B. L., Cheung, K., & Radisic, M. (2023) · Trends in Biotechnology · doi:10.1016/j.tibtech.2022.12.018 · Cited by 93 · see citing works

3D cancer models: One step closer to in vitro human studies

Manduca, N., Maccafeo, E., Maria, R. D., Sistigu, A., & Musella, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1175503 · Cited by 95 · see citing works

3d organ-on-a-chip: the convergence of microphysiological systems and organoids

Baptista, L. S., Porrini, C., Kronemberger, G. S., Kelly, D. J., & Perrault, C. M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1043117 · Cited by 90 · see citing works

Patient-derived cell line, xenograft and organoid models in lung cancer therapy

Huo, K.-G., D’Arcangelo, E., & Tsao, M. (2020) · Translational Lung Cancer Research · doi:10.21037/tlcr-20-154 · Cited by 93 · see citing works

Patient‐Specific Organoid and Organ‐on‐a‐Chip: 3D Cell‐Culture Meets 3D Printing and Numerical Simulation

Zheng, F., Xiao, Y., Liu, H., Fan, Y., & Dao, M. (2021) · Advanced Biology · doi:10.1002/adbi.202000024 · Cited by 92 · see citing works

A virus-induced kidney disease model based on organ-on-a-chip: Pathogenesis exploration of virus-related renal dysfunctions

Wang, J., Wang, C., Xu, N., Liu, Z., Pang, D., & Zhang, Z. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119367 · Cited by 88 · see citing works

Organoids are promising tools for species‐specific in vitro toxicological studies

Augustyniak, J., Bertero, A., Coccini, T., Baderna, D., Bużańska, L., & Caloni, F. (2019) · Journal of Applied Toxicology · doi:10.1002/jat.3815 · Cited by 85 · see citing works

Organoids and organs-on-chips: insights into predicting the efficacy of systemic treatment in colorectal cancer

Zhu, J., Ji, L., Chen, Y., Li, H., Huang, M., Dai, Z., Wang, J., Xiang, D., Fu, G., Lei, Z., et al. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01354-9 · Cited by 87 · see citing works

Microfabrication of AngioChip, a biodegradable polymer scaffold with microfluidic vasculature

Zhang, B., Lai, B. F. L., Xie, R., Huyer, L. D., Montgomery, M., & Radisic, M. (2018) · Nature Protocols · doi:10.1038/s41596-018-0015-8 · Cited by 84 · see citing works

Immunocompetent cancer-on-chip models to assess immuno-oncology therapy

Maulana, T. I., Kromidas, E., Wallstabe, L., Cipriano, M., Alb, M., Zaupa, C., Hudecek, M., Fogal, B., & Loskill, P. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.015 · Cited by 82 · see citing works

Stem cell-derived intestinal organoids: a novel modality for IBD

Tian, C., Yang, M., Xu, H., Zhu, M., Yue, N.-N., Zhang, Y., Shi, R., Yao, J., Wang, L., Liang, Y.-J., et al. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01556-1 · Cited by 85 · see citing works

Synovial joint-on-a-chip for modeling arthritis: progress, pitfalls, and potential

Li, Z. A., Sant, S., Cho, S. K., Goodman, S. B., Bunnell, B. A., Tuan, R. S., Gold, M. S., & Lin, H. (2022) · Trends in biotechnology · doi:10.1016/j.tibtech.2022.07.011 · Cited by 78 · see citing works

Organoid technology for tissue engineering

He, J., Zhang, X., Xia, X., Han, M., Li, F., Li, C., Li, Y., & Gao, D. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa012 · Cited by 77 · see citing works

Human stem cell-based retina on chip as new translational model for validation of AAV retinal gene therapy vectors

Achberger, K., Cipriano, M., Duechs, M. J., Schön, C., Michelfelder, S., Stierstorfer, B., Lamla, T., Kauschke, S. G., Chuchuy, J., Roosz, J., et al. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.08.008 · Cited by 73 · see citing works

Revolutionizing immune research with organoid-based co-culture and chip systems

Papp, D., Korcsmáros, T., & Hautefort, I. (2024) · Clinical & Experimental Immunology · doi:10.1093/cei/uxae004 · Cited by 73 · see citing works

Advances in organ-on-a-chip systems for modelling joint tissue and osteoarthritic diseases

Banh, L., Cheung, K. K., Chan, M. W. Y., Young, E. W. K., & Viswanathan, S. (2022) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2022.03.012 · Cited by 69 · see citing works

Patient‐derived cancer organoids for drug screening: Basic technology and clinical application

Ren, X., Chen, W., Yang, Q., Li, X., & Xu, L. (2022) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15930 · Cited by 69 · see citing works

Organoids and Colorectal Cancer

Barbáchano, A., Fernández‐Barral, A., Bustamante‐Madrid, P., Prieto, I., Rodrı́guez-Salas, N., Larriba, M. J., & Múñoz, A. (2021) · Cancers · doi:10.3390/cancers13112657 · Cited by 68 · see citing works

Engineered Vasculature for Organ-on-a-Chip Systems

Aazmi, A., Zhou, H., Li, Y., Yu, M., Xu, X., Wu, Y., Ma, L., Zhang, B., & Yang, H. (2021) · Engineering · doi:10.1016/j.eng.2021.06.020 · Cited by 65 · see citing works

Breaking the mold: 3D cell cultures reshaping the future of cancer research

Cordeiro, S. Z., Oliveira, B. B. P. P., Valente, R., Ferreira, D., Luz, A., Baptista, P. V., & Fernandes, A. R. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1507388 · Cited by 64 · see citing works

Monitoring of Microphysiological Systems: Integrating Sensors and Real-Time Data Analysis toward Autonomous Decision-Making

Young, A. T., Rivera, K. R., Erb, P. D., & Daniele, M. A.-A. (2019) · ACS Sensors · doi:10.1021/acssensors.8b01549 · Cited by 61 · see citing works

Engineering of vascularized 3D cell constructs to model cellular interactions through a vascular network

Sano, E., Mori, C., Nashimoto, Y., Yokokawa, R., Kotera, H., & Torisawa, Y. (2018) · Biomicrofluidics · doi:10.1063/1.5027183 · Cited by 60 · see citing works

Glioblastoma-on-a-chip construction and therapeutic applications

Xie, Z., Chen, M., Lian, J., Wang, H., & Ma, J. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1183059 · Cited by 59 · see citing works

Advancements in Microphysiological systems: Exploring organoids and organ-on-a-chip technologies in drug development -focus on pharmacokinetics related organs-

Kimura, H., Nishikawa, M., Kutsuzawa, N., Tokito, F., Kobayashi, T., Kurniawan, D. A., Shioda, H., Cao, W., Shinha, K., Nakamura, H., et al. (2024) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2024.101046 · Cited by 61 · see citing works

Overcoming the Dependence on Animal Models for Osteoarthritis Therapeutics – The Promises and Prospects of In Vitro Models

Singh, Y. P., Moses, J. C., Bhardwaj, N., & Mandal, B. B. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100961 · Cited by 55 · see citing works

Advances in human organoids-on-chips in biomedical research

Wang, Y., & Qin, J. (2023) · Life Medicine · doi:10.1093/lifemedi/lnad007 · Cited by 56 · see citing works

Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research

Mochel, J. P., Jergens, A. E., Kingsbury, D. D., Kim, H. J., Martı́n, M. G., & Allenspach, K. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0178-1 · Cited by 55 · see citing works

Screening Cancer Immunotherapy: When Engineering Approaches Meet Artificial Intelligence

Zhou, X., Qu, M., Tebon, P. J., Jiang, X., Wang, C., Xue, Y., Zhu, J., Zhang, S., Öklü, R., Sengupta, S., et al. (2020) · Advanced Science · doi:10.1002/advs.202001447 · Cited by 54 · see citing works

Early invasion of the bladder wall by solitary bacteria protects UPEC from antibiotics and neutrophil swarms in an organoid model

Sharma, K., Thacker, V. V., Dhar, N., Cabrer, M. C., Dubois, A., Signorino‐Gelo, F., Mullenders, J., Knott, G. W., Clevers, H. C., & McKinney, J. D. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109351 · Cited by 54 · see citing works

The NIH microphysiological systems program: developing in vitro tools for safety and efficacy in drug development

Tagle, D. A. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.09.007 · Cited by 54 · see citing works

Bioprinting of Cells, Organoids and Organs-on-a-Chip Together with Hydrogels Improves Structural and Mechanical Cues

Mierke, C. T. (2024) · Cells · doi:10.3390/cells13191638 · Cited by 54 · see citing works

Beyond PDMS and Membranes: New Materials for Organ-on-a-Chip Devices

Radisic, M., & Loskill, P. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00831 · Cited by 51 · see citing works

Clamping strategies for organ-on-a-chip devices

Carvalho, D. J., Moroni, L., & Giselbrecht, S. (2023) · Nature Reviews Materials · doi:10.1038/s41578-022-00523-z · Cited by 50 · see citing works

Developing organs‐on‐chips for biomedical applications

Sun, L., Chen, H., Xu, D., Liu, R., & Zhao, Y. (2024) · Smart Medicine · doi:10.1002/smmd.20240009 · Cited by 51 · see citing works

Mapping the structure and biological functions within mesenchymal bodies using microfluidics

Sart, S., Tomasi, R. F.-X., Barizien, A., Amselem, G., Cumano, A., & Baroud, C. N. (2020) · Science Advances · doi:10.1126/sciadv.aaw7853 · Cited by 49 · see citing works

Human Organoids and Organs‐on‐Chips for Addressing COVID‐19 Challenges

Wang, Y., Wang, P., & Qin, J. (2022) · Advanced Science · doi:10.1002/advs.202105187 · Cited by 48 · see citing works

Advanced Fabrication Techniques of Microengineered Physiological Systems

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Optimization of cerebral organoids: a more qualified model for Alzheimer’s disease research

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